• Journal of Radiopharmaceuticals and Molecular Probes
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• v.5 no.1
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• pp.54-60
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• 2019

Sentinel lymph node (SLN) imaging plays an important role in surgery of patients with breast cancer and melanoma. In this study, avidin (Av), a tetrameric protein glycosylated with mannose and N-acetylglucosamine molecules, was labeled with $^{64}Cu$ and then evaluated for LN imaging. $^{64}Cu$-Labeled $NeutrAvidin^{TM}$ (NAv), a non-glycosylated form of Av, was used for comparison. 1,4,7,10-Tetraazacyclododecane-N,N',N'',N'''-tetraacetic acid (DOTA)-conjugated Av and NAv were prepared from the corresponding proteins and DOTA-NHS ester, which were then labeled with copper-64 and purified using PD-10 columns. The numbers of DOTA molecules conjugated to Av and NAv were 4.9 and 3.3, respectively. [$^{64}Cu$]Cu-DOTA-conjugated Av and NAv were prepared in 93% and 73% radiochemical yields, respectively. In vitro serum stability study showed that copper-64 remained stable on all radiotracers for 24 h (>97%). MicroPET/CT images showed that high radioactivity was accumulated in LNs within 15 min after footpad-injection of radiotracers. Tissue distribution data of mice demonstrated significantly higher uptake in the popliteal (PO) LN than lumbar (LU) LN for $^{64}Cu$-labeled Av (relative % ID/g excluding the injection sites: 66.2% and 26.0%, respectively) compared with those of $^{64}Cu$-labeled NAv (43.0% and 49.2%, respectively). The results of this study suggest that mannose molecules on Av enabled the radiotracer to retain in the first LN after mouse footpad-injection.

• Aerospace Industry
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• s.95
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• pp.24-27
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• 2007

• The Journal of Korean Obstetrics and Gynecology
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• v.28 no.3
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• pp.11-20
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• 2015

Objectives This study is performed to recognize the relationship between atrophic vaginitis and stress that have an affect on autonomic nervous system. Methods We studied 47 patients who visited Kangnam Kyunghee Korean Hospital Medical Examination Center from November, 2013 to June, 2014. They were devided into two groups, atrophic vaginitis group (AV, n=18) and non-atrophic vaginitis group (NAV, n=29). We compared the result of HRV between the two groups. Results The mean of The standard deviation of NN intervals (SDNN), the square root of the mean squared difference of successive NNs (RMSSD) in AV group was lower than NAV group, but there was no significant difference between the two groups. Total power (TP), low frequency (LF) and very low frequency (VLF) of AV group was significantly lower than NAV group. There was no significant difference in high frequency (HF). Conclusions Women with atrophic vaginitis is expected to have low adaptive capacity against stress.

• Proceedings of the Korean Institute of Navigation and Port Research Conference
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• v.2
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• pp.451-454
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• 2006

본 논문에서는 헬기의 인공 시계 시스템용 DGPS/INS 통합 항법 플랫폼을 설계하였다. DGPS/INS 통합 항법 플랫폼 하드웨어는 PowerPC CPU와 Flash ROM과 DDR SDRAM를 이용하여 설계하였다. DGPS 수신기와 IMU와의 연결을 위한 외부 인터페이스부는 직렬 통신을 사용하는 DGPS수신기와 IMU는 모두 사용할 수 있도록 하기 위하여 직렬 통신 방식인 UART 컨트롤러와 SDLC 컨트롤러를 사용하여 설계하였다. 실시간 운영체제를 기반으로 하는 플랫폼의 소프트웨어는 초기 정렬, 자세 계산, 속도 계산, 위치 계산, 통합 필터, 명령 처리 각각에 대하여 태스크로 구성하고 세마포어를 이용하여 태스크간의 동기가 이루어지도록 설계하였다. 통합 항법 플랫폼의 성능 평가를 위하여 차량 실험을 수행하였으며 상용 항법 시스템의 결과와 비교를 하였다.