• Transactions of the Korean Society for Noise and Vibration Engineering
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• v.20 no.12
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• pp.1147-1152
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• 2010

The wet brakes used in an industrial forklift often produce noise on braking. Elimination or reduction of this squeal noise is an important task for the improvement of comforts. In this paper, a test rig was developed which was possible for testing of brake noise and an experimental measurement on squeal noise was performed. The causes of the brake noise are identified by experimenting how the factors such as automatic transmission fluid, the groove of friction-plate pad and the material of friction-plate pad affect the squeal noise. In order to identify the squeal characteristics, the signal analyses for noise are performed by using frequency spectrums. Experimental results showed that the viscosity of automatic transmission fluid and the groove pattern of friction-plate pad largely affect the reduction of the wet brake squeal noise in an industrial forklift.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2013.04a
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• pp.347-352
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• 2013

Seoul National University Flap (SNUF) blade is a small-scaled rotor blade incorporating a small trailing-edge flap control surface driven by piezoelectric actuators at higher harmonics for vibration attenuation. Initially, the blade was designed using two-dimensional cross-section analysis and a geometrically exact one-dimensional beam analysis, and material configuration was finalized. Flap deflection angle of ${\pm}45^{\circ}$ was established as the criterion for better vibration reduction performance based on an earlier simulation. Flap linkage mechanism design is carried out and static bench tests are conducted to verify the flap actuation mechanism performance. Different versions of test beds are developed and tested with the flap and chosen APA 200M piezoelectric actuators. Through significant improvements, a maximum deflection of ${\pm}3.7^{\circ}$ was achieved. High frequency experiments are conducted to evaluate the performance and transfer function of the test bed is determined experimentally. As the static tests are almost completed, rotor power required for testing the blade in whirl tower (centrifugal environment) is calculated and further preparations are under way.

• Transactions of the Korean Society of Automotive Engineers
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• v.24 no.6
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• pp.702-708
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• 2016

The torque converter is deformed according to the rotating speed and control pressure when engine power is transferred to the transmission. This deformation, which is called ballooning phenomenon, occurs mainly at the outer side by the centrifugal force of the automatic transmission fluid (ATF) and the control pressure from the valve body. Although the torque converter is slightly deformed when rotating, the ballooning phenomenon affects fluid performance, efficiency and durability. Thus, expansion characteristics analysis is important in determining torus size, control pressure and structure. In this paper, an analysis equation and FEM model was developed to investigate the expansion characteristics. Using this model, structural analysis was performed to investigate the relationships between deformation and the torus diameter. The results were confirmed by comparing with the test results.

• Genomics & Informatics
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• v.7 no.2
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• pp.97-106
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• 2009

Epigallocatechin gallate (EGCG), a well-known antioxidant molecule, has been reported to cause hepatotoxicity when used in excess. However, the mechanism underlying EGCG-induced hepatotoxicity is still unclear. To better understand the mode of action of EGCG-induced hepatotoxicity, we examined the effect of EGCG on human hepatic gene expression in HepG2 cells using microarrays. Analyses of microarray data revealed more than 1300 differentially expressed genes with a variety of biological processes. Upregulated genes showed a primary involvement with protein-related biological processes, such as protein synthesis, protein modification, and protein trafficking, while downregulated genes demonstrated a strong association with lipid transport. Genes involved in cellular stress responses were highly upregulated by EGCG treatment, in particular genes involved in endoplasmic reticulum (ER) stress, such as GADD153, GADD34, and ATF3. In addition, changes in genes responsible for cholesterol synthesis and lipid transport were also observed, which explains the high accumulation of EGCG-induced lipids. We also identified other regulatory genes that might aid in clarifying the molecular mechanism underlying EGCG-induced hepatotoxicity.

• Biomedical Science Letters
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• v.26 no.1
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• pp.37-41
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• 2020

The hemolymph of Korean rhinoceros Allomyrina dichotoma consists of blood and lymph in which various kinds of proteins function physiologically. We have previously demonstrated that A. dichotoma hemolymph has the potential to treatment and prevent diabetes through activating transcription factor 3-gene (ATF3) regulation. In this study, we investigate the expression of Kruppel-like factor 4 (KLF4) in A. dichotoma hemolymph-treated INS-1 pancreatic β-cells. The new findings show that A. dichotoma hemolymph, which upregulates KLF4 gene expression in a dose-dependent and time-dependent manner. In addition, hemolymph combine with mild endoplasmic reticulum (ER) stress, which also differentially regulates KLF4 gene expression. These results may provide insights to KLF4 gene-related disease therapies through KLF4 gene regulation.

• Development and Reproduction
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• v.22 no.1
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• pp.65-72
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• 2018

Cyclic AMP-response element binding protein zhangfei (CREBZF), a member of ATF/CREB (activating transcription factor/ cAMP response element binding protein) family, regulates numerous cellular functions and development of cells by interacting transcription factors. This study discovered the expression pattern of CREBZF in seminiferous tubule of testes during the postnatal development of mice. In testis, CREBZF mRNA expression was the highest among other organs. Immunofluorescence analyses showed that the CREBZF was specifically expressed on spermatocyte but not in spermatogonia and Sertoli cells in seminiferous epithelium of mouse testis. Semi-quantitative polymerase chain reaction (PCR) analysis showed that CREBZF transcript level was significantly elevated during postnatal development of mouse testis. Confocal imaging analysis indicated that the protein expression of CREBZF in seminiferous tubule remained low until postnatal day (PD) 14, and was dramatically increased in PD 21. Interestingly, only one type of the spermatocyte expressed CREBZF specifically among SCP3-positive spermatocytes. Taken together, these results suggest that CREBZF may be novel putative marker of the spermatocyte and regulate meiosis during postnatal development of mice.

• 한국정보통신설비학회:학술대회논문집
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• 2008.08a
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• pp.441-446
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• 2008

In this papers, a PLDRO(Phase Locked Dielectric Resonator Oscillator) is designed and implemented at the oscillator in which fundamental frequency is 18.3 GHz. The proposed PLDRO so as to improve the PLDRO of the general structure is designed to the goal of the minimize of the size and the performance improvement. Three VCO(Voltage controlled Oscillator) and the power combiner improved the output power. A VCDRO(Voltage Controlled Dielectric Resonator Oscillator) is manufactured using a varactor diode to tune oscillating frequency electrically, and its phase is locked to reference frequency by SPD(Sampling Phase Detector). This product is fabricated on Teflon substrate with dielectric constant 2.2 and device is ATF -13786 of Ka-band using. This PLDRO generates an output power of 5.67 dBm at 18.3 GHz and has the characteristics of a phase noise of -80.10 dBc/Hz at 1 kHz offset frequency from carrier, the second harmonic suppression of -33 dBc. The proposed PLDRO can be used in Ka-band satellite applications

• Nuclear Engineering and Technology
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• v.51 no.1
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• pp.1-12
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• 2019

One of proposed Accident Tolerant Fuel (ATF) concept is fully ceramic micro-encapsulated fuel (FCMF). FCMF using uranium mononitride (UN) has better safety aspects than $UO_2$ pellet fuel although it might not have a better neutronic performance due to the presence of matrix and high neutron-induced interaction of $^{14}N$. Before implementing UN-FCMF technology in Small-PWR, further research must be taken place to make sure the proposed design of fuel assembly has inherent safety features and maintain the fuel performance. This study focusses on the neutronic analysis of UN-FCMF based fuel assembly using Serpent and SCALE codes. It is shown in the proposed fuel assembly design has inherent safety features with respect to the fuel temperature reactivity coefficient, void reactivity coefficient, and moderator temperature reactivity coefficient. It is noted that the use of FCMF leads to a lower ratio of burnup to $^{235}U$ enrichment ratio compared to the $UO_2/Zr$ fuel.

• Nuclear Engineering and Technology
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• v.55 no.9
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• pp.3464-3471
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• 2023

The Uranium/Molybdenum metallic fuel has been proposed as promising advanced fuel concept especially in the dispersed fuel geometry. The fuel is manufactured in the form of small fuel droplets (particles) placed in a fuel pin covered by a matrix. In addition to fuel particles, the pin contains voids necessary to compensate material swelling and release of fission gases from the fuel particles. When investigating this advanced fuel design, two important questions were raised. Can the dispersed fuel performance be analyzed using homogenization without significant inaccuracy and what size of fuel drops should be used for the fuel design to achieve optimal utilization? To answer, 2D burnup calculations of fuel assemblies with different fuel particle sizes were performed. The analysis was supported by an additional 3D fuel pin calculation with the dispersed fuel particle size variations. The results show a significant difference in the multiplication factor between the homogenized calculation and the detailed calculation with precise fuel particle geometry. The recommended fuel particle size depends on the final burnup to be achieved. As shown in the results, for lower burnup levels, larger fuel drops offer better multiplication factor. However, when higher burnup levels are required, then smaller fuel drops perform better.

• Journal of Microbiology and Biotechnology
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• v.28 no.1
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• pp.109-114
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• 2018

Coxsackievirus Type B3 (CVB3) is an enterovirus that belongs to the Picornaviridae and causes various diseases such as myocarditis and hand-foot-mouth disease. However, an effective antiviral drug is still not developed. In this study, we looked for potential inhibitors of CVB3 replication by examining the survival of CVB3-infected HeLa cells. We detected an antiviral effect by cholic acid and identified it as a candidate inhibitor of CVB3 replication. Cholic acid circulates in the liver and intestines, and it helps the digestion and absorption of lipids in the small intestine. HeLa cells were cultured in 12-well plates and treated with cholic acid (1 and $10{\mu}g/ml$) and $10^6PFU/ml$ of CVB3. After 16 h post-infection, the cells were lysed and subjected to western blot analysis and RT-PCR. The production of the viral capsid protein VP1 was dramatically decreased, and translation initiation factor eIF4G1 cleavage was significantly inhibited by treatment with $10{\mu}g/ml$ cholic acid. Moreover, cholic acid inhibited ERK signaling in CVB3-infected HeLa cells. RT-PCR showed that the amounts of the CVB3 RNA genome and mRNA for the ER stress-related transcription factor ATF4 were significantly reduced. These results showed that cholic acid strongly reduced ER stress and CVB3 proliferation. This compound can be developed as a safe natural therapeutic agent for enterovirus infections.