• Title/Summary/Keyword: ASO

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Epidemiology and Clinical Manifestations of $Henoch-Sch\"{o}nlein$ Purpura in Children (소아 $Henoch-Sch\"{o}nlein$ 자반증의 역학 및 임상양상)

  • Kim Se-Hun;Lee Chong-Guk
    • Childhood Kidney Diseases
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    • v.7 no.2
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    • pp.166-173
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    • 2003
  • Purpose : The cause and pathogenesis of $Henoch-Sch\"{o}nlein$ purpura has been studied for many years but the results are disappointing. Recently the hypothesis that abnormalities involving the glycosylation of the hinge region of immunoglobulin Al(IgAl) may have an important role in the pathogenesis of $Henoch-Sch\"{o}nlein$ purpura is being approved. $Henoch-Sch\"{o}nlein$ purpura is the most common vasculitis Ihat affects children and the prognosis is good. But if kidney invovement occurs, the course may be chronic and troublesome. So we evaluated children with $Henoch-Sch\"{o}nlein$ purpura especially from the point of epidemiology and clinical manifestations. Methods : Investigation of 124 children who were diagnosed with $Henoch-Sch\"{o}nlein$ purpura at Inje University Ilsan Paik Hospital from December 1999 to July 2003 was performed retrospectively through chart review. Efforts were made to get informations about the profile, epidemiology, clinical manifestations, progress of the disease and recurrence rate of patients. Results : The patients were 69 boys and 55 girls, with a mean age of $6.1{\pm}2.7$ years at the time of data collection. The male to female ratio was 1.25 : 1. The occurrence rate was much higher in autumn(from September to November, 31.5%) and winter(from December to February, 28.2%) than in spring and summer, with a peak in November. Joint involvement was shown in 66.9% of patients mostly on the foot/ankle(75.9%), knee(39.8%). Seventy(56.5%) out of 124 patients had abdominal pain and 10 patients(8.1%) showed bloody stools. Renal involvement was observed in 24 patients(19.4%) after 21.1 days on the average. IgA was elevated in 10 of 21 patients(47.6%). $C_3$ and $C_4$ levels were normal in 40 of 49 patients (81.7%) and 47 of 48 patients(97.9%), respectively Antistreptolysin-O(ASO) titer was elevated over 250 Todd units in 29 of 62 Patients(46.8%). Mycoplasma antibody titer was elevated in 21 of 49 patients(42.9%) equal or greater than 1:80. Radiologic studies were peformed in 23 patients. Seven patients(30.4%) showed bowel wall thickening and one of them received intestinal resection and anastomosis operation due to terminal ileum necrosis. Eighty four patients took steroid 1.4 mg/kg/day in average. Recurrence rate was 2.5 in 37 patients(29.8%). Conclusion : $Henoch-Sch\"{o}nlein$ purpura in childhood appears most in about 6 years of age. The occurrence rate is much higher in autumn and winter relatively. Diagnosis can be made through the perspective history taking and the inspection of clinical manifestations, but the laboratory findings are not of great help. A small portion of the patients might show abdominal pain or arthritis before purpura develops, therfore various diagnosis can be made. Radiologic evaluation should be performed to avoid surgical complications in cases accompanying abdominal pain, and long term follow up should be needed especially in patients suffering from kidney involvement. In about 30% of the patients $Henoch-Sch\"{o}nlein$ purpura would recur. Steroid can be used safely without side effects.

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Improvement of Non-linear Estimation Equation of Rainfall Intensity over the Korean Peninsula by using the Brightness Temperature of Satellite and Radar Reflectivity Data (기상위성 휘도온도와 기상레이더 반사도 자료를 이용한 한반도 영역의 강우강도 추정 비선형 관계식 개선)

  • Choi, Haklim;Seo, Jong-Jin;Bae, Juyeon;Kim, Sujin;Lee, Kwang-Mog
    • Journal of the Korean earth science society
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    • v.39 no.2
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    • pp.131-138
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    • 2018
  • The purpose of this study is to improve the quantitative precipitation estimation method based on satellite brightness temperature. The non-linear equation for rainfall estimation is improved by analysing precipitation cases around the Korean peninsula in summer. Radar reflectivity is adopted the CAPPI 1.5 and CMAX composite fields that provided by the Korea Meteorological Agency (KMA). In addition, the satellite data are used infrared, water vapor and visible channel measured from meteorological imager sensor mounted on the Chollian satellite. The improved algorithm is compared with the results of the A-E method and CRR analytic function. POD, FAR and CSI are 0.67, 0.76 and 0.21, respectively. The MAE and RMSE are 2.49 and 6.18 mm/h. As the quantitative error was reduced in comparison to A-E and qualitative accuracy increased in compare with CRR, the disadvantage of both algorithms are complemented. The method of estimating precipitation through a relational expression can be used for short-term forecasting because of allowing precipitation estimation in a short time without going through complicated algorithms.

The Comparative Study of Clinical Manifestations in Acute Poststreptococcal Glomerulonephritis with Gross Hematuria or Microscopic Hematuria (연쇄상구균 감염후 급성 사구체신염에서 육안적 혈뇨와 현미경적 혈뇨에 따른 임상양상의 비교)

  • Park Su-Hwa;Chung Eun-Soo;Sim Chang-Eun;Kim Kee-Hyuck;Lee Chong-Guk
    • Childhood Kidney Diseases
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    • v.8 no.2
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    • pp.159-165
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    • 2004
  • Purpose: This study aimed to compare the clinical outcome of acute poststreptocaccal glomerulonephritis (APSGN) between patients who had presented with gross hematuria and those with microscopic hematuria. Methods: Thirty-nine patients with acute poststreptococcal glomerulonephritis, who were diagnosed from January 2000 to April 2003 were enrolled. Results: The mean age was 8.85 years and the male to female ratio was 1.1:1 Seventeen patients presented with gross hematuria at diagnosis(group A) and twenty-two patients had microscopic hematuria only(group B). There were no significant differences between the two groups in the incidence of edema, fever or history of respiratory infection and oliguria. But hypertension was more frequent in group B. Laboratory data showed decreased C3 and C4 level in group B. Spot urine protein/creatinine ratio and 24hr urine protein showed higher levels in group A. Conclusion; Patients with gross hematuria at diagnosis had lower incidence of hypertension and a higher rate of nephrotic range of proteinuna than patients with microscopic hematuria. However, no difference in the duration of admission or complication rate was observed. All patients had clinical improvement during follow-up. We conclude that gross hematuria is not a significant prognostic factor for poststreptococcal glomerulonephritis.

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A Study on the Effects of Local Factors on the Oral Ulcers Observed in Behcet s Disease (베체트 병의 구강궤양에 대한 국소인자의 영향에 관한 연구)

  • Myoung-Chan Kim;Chong-Youl Kim
    • Journal of Oral Medicine and Pain
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    • v.17 no.2
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    • pp.75-86
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    • 1992
  • Of the many first-occuring major manifestations of Behcet's disease, the oral ulcer is most frequently observed, shows the highest mean recurrence rate, and the longest mean duration period. A study of the relationship between mechanical irritation buy local factors and the recurrence of oral ulcers was carried out to see if there is a correlation. The subjects chosen for the study were 81 patients who were referred to the Department of Oral Diagnosis at Yonsei University Dental Hospital from the Behcet clinic of Severace Hospital after being diagnosed as Behcet's disease patients. 1. By Shimuzu's classification, possible type was the most numerous with 55.55% ; while suspected type was 19.76% ; incomplete type, 17,28% ; and complete type, 7.41% were observed in that order. The male to female ration was 1 to 1.61, and the average age of onset was 17.63 years. 2. Oral ulcers developed most frequently on the tongue (48.28%), and lip(23.15%), buccal mucosa (20.69%), palate\pharynx(4.43%), and gingiva(3.45%) also showed ulceration. 3. 38.27% of the patients were HSV positive : 27.16% were CRP positive ; 12.34% were ASO positive ; 9.87% were RF positive ; and 3.7% were ANA positive. 4. According to the answers to the survey, fatigue(85.18%) was most frequently associated with Behcet's diseage. Trauma by tooth brushing (22.22%), un specified reasons (20.98%), hard food chewing (12.35%), and irritation by dentition and/or prosthesis (13.58%) were observed in association with Behcet's disease. 23.46% had a history of tonsilitis. 5. Oral ulcers on the anterior part of tongue and buccal mucosa were associated with local irritatants. 6. Oral ulcers on the lip and posterior portion of tongue were not associated with local irritants. Local irritation by dentition and oral ulcer on the anterior part of tongue and buccal mucosa was observed to coexit with one another : in other words, lo9cal factors can act to cause of recurrence of an oral ulcer and to delay the healing process in Behcet's disease. Therefore, elimination of local factors along with systemic therapy must be recommended when treating oral ulcers.

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Case of Combined Acute Poststreptococcal Glomerulonephritis and Acute Invasive Meningococcal Disease (A군 연구균 감염 후 급성 사구체 신염과 동반된 침습성 수막구균감염증 1례)

  • Jeon, Hosang;Hahn, Wonho;Park, Dongkyun;Cha, Sungho
    • Pediatric Infection and Vaccine
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    • v.11 no.1
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    • pp.126-130
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    • 2004
  • Neisseria meningitidis is a leading cause of meningitis and septicemia in children and young adults. Meningococcemia, the most severe form of infection, represents a part of the various spectrum of the illness, and its clinical manifestations varied from mild fever and occult bacteriemia to fulminant catastrophic events(e.g., sepsis, shock, and death) within a few hours after onset of symptoms. Complement deficiencies, either congenital or acqired, increase the risk for invasive meningococcal disease. Since C3 plays a critical role in the complement cascade, congenital C3 deficiency or conditions that decrease C3(e.g., systemic lupus erythematosus, cirrhosis, nephritis, C3 nephritic factor) increase the risk for invasive disease due to pyogenic bacteria including N. meningitidis. We had experienced a case of meningococcemia and meningococcal meningitis presenting with mild fever, petechiae, and purpura. The patient was a 7-year old male. He had mild fever, vomiting, headache, nuchal rigidity, petechiae and purpura on both lower extremities, which spreaded to the whole body. His blood culture grew Neisseria meningitidis. The diagnosis of meningococcal meningitis was confirmed by examination of cerebrospinal fluid. The clinical symptoms of the illness were improved after treatment of antibiotics(cefotaxime) for 12 days. However the patient had developed generalized edema, microscopic hematuria & proteinuria on the third day after admission. High ASO titer and low serum C3 level were also noted. The microscopic hematuria returned to normal about 2 months after discharge. The C3 level returned to normal range about 3~4 months after discharge. we report a case of combined acute poststreptococcal glomerulonephritis and acute invasive meningococcal disease with reference review.

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A Study of the Method for Estimating the Missing Data from Weather Measurement Instruments (인공신경망을 이용한 기상관측장비 결측 보완 기술에 관한 연구)

  • Min, Jae-Sik;Lee, Moo-Hun;Jee, Joon-Bum;Jang, Min
    • Journal of Digital Convergence
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    • v.14 no.8
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    • pp.245-252
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    • 2016
  • The purpose of this study is to make up for missing of weather informations from ASOS and AWS using artificial neural networks. We collected temperature, relative humidity and wind velocity for August during 5-yr (2011-2015) and sample designed artificial neural networks, assuming the Seoul weather station was missing. The result of sensitivity study on number of epoch shows that early stopping appeared at 2,000 epochs. Correlation between observation and prediction was higher than 0.6, especially temperature and humidity was higher than 0.9, 0.8 respectively. RMSE decreased gradually and training time increased exponentially with respect to increase of number of epochs. The predictability at 40 epoch was more than 80% effect on of improved results by the time the early stopping. It is expected to make it possible to use more detailed weather information via the rapid missing complemented by quick learning time within 2 seconds.

Deterioration Evaluation and Material Characteristics of the Usuki Stone Buddha Statues in Oita, Japan (일본 오이타현 우스키 마애불상군의 재질특성 및 손상도 평가)

  • Cho, Ji-Hyun;Lee, Chan-Hee;Kim, Ji-Young;Morii, Masayuki;Lee, Myeong-Seong;Kim, Sa-Dug
    • Journal of Conservation Science
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    • v.28 no.1
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    • pp.39-52
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    • 2012
  • The Usuki Stone Buddha Statues in Oita are consisted of 60 Buddhas which represent of Japan carved on the rock-cliff in the 12 to 14th centuries. The basement rock of the statues is dark gray welded lapilli tuff that containing the Aso-4 pyroclastic rock group. Deterioration maps for the Hoki I and the Furuzono Buddha Statues group show multi-directional fissures on the Cakra, and sheeting-off zone at the margin of uprising water. Deterioration rate of the Hoki I group was calculated fissure about 121 in number, 19% of sheeting-off zone and 51% of biological weathering in surface of area. And the Furuzono group was also evaluated as about 48 of fissures in number, 24% of sheeting-off zone and 41% biological weathering. The slope stability assessment results, the Hoki I developed discontinuous planes has possibility of planar, toppling and wedge failures in all caves. Ultrasonic velocity of the Aizen-myooh (basement rock) ranges from 1,520 to 2,794 (average 2,298m/s). And pedestal of Amita-yeorae which has been replaced by new fresh rock is measured as 3,242 to 4,141 (average 3,813m/s). Therefore, we establish of planing conservation treatment and reinforcement methods to fissure, cavity, sheeting-off zone in the Buddha surface.

Evaluation of the Accuracy of IMERG at Multiple Temporal Scales (시간 해상도 변화에 따른 IMERG 정확도 평가)

  • KIM, Joo-Hun;CHOI, Yun-Seok;KIM, Kyung-Tak
    • Journal of the Korean Association of Geographic Information Studies
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    • v.20 no.4
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    • pp.102-114
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    • 2017
  • The purpose of this study was the assessment of the accuracy of Global Precipitation Measurement (GPM) Integrated Multi-Satellite Retrievals for GPM (IMERG), a rainfall data source derived from satellite images, for evaluation of its applicability to use in ungauged or inaccessible areas. The study area was the overall area of the Korean peninsula divided into six regions. Automated Surface Observing System (ASOS) rainfall data from the Korean Meteorological Administration and IMERG satellite rainfall were used. Their average correlation coefficient was 0.46 for a 1-h temporal resolution, and it increased to 0.69 for a 24-h temporal resolution. The IMERG data quantitatively estimated less than the rainfall totals from ground gauges, and the bias decreased as the temporal resolution was decreased. The correlation coefficients of the two rainfall events, which had relatively greater rainfall amounts, were 0.68 and 0.69 for a 1-h temporal resolution. Additionally, the spatial distributions of the ASOS and IMERG data were similar to each other. The study results showed that the IMERG data were very useful in the assessment of the hydro-meteorological characteristics of ungauged or inaccessible areas. In a future study, verification of the accuracy of satellite-derived rainfall data will be performed by expanding the analysis periods and applying various statistical techniques.

Urban Runoff According to Rainfall Observation Locations (강우 측정 지점에 따른 도시 유역 유출량 변화 분석)

  • Hyun, Jung Hoon;Chung, Gunhui
    • Journal of Wetlands Research
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    • v.21 no.4
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    • pp.305-311
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    • 2019
  • Recently, global climate change causes abnormal weather and disaster countermeasures do not provide sufficient defense and mitigation because they were established according to the historical climate condition. Repeated torrential rains, in particular, are causing damage even in the robust urban flood defense system. Therefore, in this study, the change of runoff considering the spatial distribution of rainfall and urban characteristics was analyzed. For rainfall concentrated in small catchment, rainfall in the watershed must be accurately measured. This study is based on the rainfall data observed with Automated Surface Observing System (ASOS) and Automatic Weather Stations (AWS) provided by the Seoul Meteorological Administration. Effluent from the pumping station was estimated using the EPA-SWMM model and compared and analyzed. Catchments with rainwater pumping station are small with large portion of impermeable areas. Thus, when the ASOS data where is located from from the chatchment, runoff is often calculated using rainfall data that is different from rainfall in the catchment. In this study, the difference between rainfall data observed in the AWS near the catchment and ASOS away from the catchment was calculated. It was found that accurate rainfall should be used to operate rainwater pumping stations or forecast urban flooding floods. In addition, the results of this study may be helpful for estimating design rainfall and runoff calculation.

A Study on the Volcanic Ash Damage Sector Selection based on the Analysis of Overseas Cases and Domestic Spatial Information (해외 사례 분석과 국내 공간정보 분석을 통한 화산재 피해 분야 선정)

  • Han, Hyeon-gyeong;Baek, Won-kyung;Jung, Hyung-sup;Kim, Miri;Lee, Moungjin
    • Korean Journal of Remote Sensing
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    • v.35 no.5_1
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    • pp.751-761
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    • 2019
  • Mt. Baekdu, Mt. Aso, Mt. Sakurajima, Mt. Kikai and etc are distributed around the Korean Peninsula. Recently signs of eruption of Mt. Baekdu are increasing, raising concerns over possible damage to volcanic ash from seasonal winds during the winter eruption. Therefore, detailed procedures for investigation and countermeasures for volcanic ash spread and damage are required. But the standards for the warning and alarm signal of volcanic ash presented by Korea Ministry of Government Legislation are vague, with "when damage is expected" and "when serious damage is expected". In this study, to analyze the damage threshold and to apply the cases of overseas damage to the country, a survey was conducted on the establishment of domestic spatial information by public institutions with public confidence. As a result of the investigation of damage from volcanic ash overseas, the details of the damage cases were different depending on the type of life or income sources of each country. Therefore, instead of applying the volcanic ash damage cases abroad in Korea, spatial information analysis was performed to reflect domestic social and natural characteristics. In addition, we selected the areas to be considered in the event of volcanic ash damage in Korea. Finally, domestic volcanic ash damages should be classified as health, residential, road, railroad, aviation, power, water, agriculture, livestock, forest, and soil. When establishing the volcanic ash alarm optimized for Korea in the future, overseas volcanic ash damage cases and domestic spatial information construction in this study will be helpful in policy establishment.