• Asian Pacific Journal of Cancer Prevention
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• v.15 no.8
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• pp.3507-3511
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• 2014

Background: The prostaglandin-endoperoxide synthase 2 [PTGS2, commonly known as cyclooxygenase-2 (COX-2)] is an enzyme induced by proinflammatory stimuli that is often overexpressed in malignant tissue and involved in the synthesis of prostaglandins and thromboxanes, regulators of processes such as inflammation, cell proliferation, and angiogenesis, all relevant for cancer development. We investigated whether a functional genetic polymorphism, rs5277, in COX-2 may have a risk-modifying effect on sporadic colorectal cancer in an Iranian population. Materials and Methods: We conducted a case-control study on 167 patients with colorectal cancer and 197 cancer-free controls in Taleghani Hospital in Tehran, Iran, between 2007 and 2011. Peripheral blood samples of both groups were processed for DNA extraction and genotyping of the COX-2 gene polymorphism (rs5277) using PCR-RFLP. RFLP results were confirmed by direct sequencing. Logistic regression analysis was performed to calculate the adjusted odds ratio (OR) and 95% confidence interval (95% CI). Results: There was no significant difference in the distribution of COX-2 gene rs5277 polymorphism genotype and the allelic form, among CRC patients compared with the healthy control group (p: 0.867). Conclusions: Our results suggest that rs5277 polymorphism in COX2 could not be a good prognostic indicator for patients with CRC.

• Journal of Digital Contents Society
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• v.14 no.2
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• pp.191-197
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• 2013

To complete the "anywhere" mobile service there should not be shaded areas. However, it is never economical to deploy BS's (Base Stations) in a low population density area due to the low resource utilization. We propose a design technique to install RS's(Relay Stations) which are cheaper than BS's and find the condition in which the proposed technique is acceptible. The proposed design technique aims to allocate the frequency and time resources to RS's to minimize the transmission rate degradation due to interferences between RS's as well as to maximize the parallelism in transmission. We showed by simulation that the proposed technique achieves cost benefits when the expected traffic is less than 20.32 percent of the total BS capacity. The proposed technique is compatible with the IEEE 802.16j, thus can be extended to multi-hop configuration.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.35 no.3C
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• pp.255-263
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• 2010

In this paper, we present an efficient cooperative transmission scheme for high speed 60GHz WPAN system. In 60GHz, the cooperative transmission with relay is effective scheme because signals are exceedingly attenuated according to the distance and the transmission is impossible when there is no LOS between transmitter and receiver. Moreover, the reliability of signal in destination can be improved by receiving data from a relay as well as a transmitter. However, the overall data rate is reduced because transmission time is more required for relay. To solve this problem, we propose a cooperative transmission scheme with RS-CC serial concatenated codes. In the proposed cooperative transmission scheme, the relay can reduce the transmission data size because the only parity bits of systematic RS code are transmitted after encoding by CC. But the computational complexity is increased at the relay and the destination.

• Genomics & Informatics
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• v.7 no.4
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• pp.187-194
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• 2009

Cytochrome P450 2E1 (CYP2E1) is a member of the cytochrome P450 superfamily, and it is a key enzyme responsible for the metabolic activation of many smallmolecular-weight compounds such as alcohol, which is classified as a human carcinogen. In this study, we identified 19 single nucleotide polymorphisms (SNPs) in CYP2E1 in Korean population. In these SNPs, we examined possible genetic association of CYP2E1 polymorphisms with HBV clearance and the risk of hepatocellular carcinoma (HCC). Five common polymorphic sites were selected, CYP2E1 polymorphisms at rs381-3867, rs3813870, rs2070673, rs2515641 and rs2480257, considering their allele frequencies, haplotype-tagging status and LDs for genotyping in larger-scale subjects (n=1,092). Statistical analysis demonstrated that CYP2E1 polymorphisms and haplotypes show no significant association with HBV clearance, HCC occurrence and onset age of HCC (p>0.05). Previous studies, however, have shown contradictory findings on associations of CYP2E1 polymorphisms with CYP2E1 activities and HCC risk. Comparing the contrasting results of previous researches suggest that CYP2E1 polymorphism is associated with CYP2E1 activity induced by ethanol, but is not directly associated with HCC risk. CYP2E1 variation/haploype information identified in this study will provide valuable information for future studies on CYP2E1.

• Nutrition Research and Practice
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• v.13 no.6
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• pp.498-508
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• 2019

BACKGROUND/OBJECTIVES: Lower circulating 25-hydroxyvitamin D [25(OH)D] levels are associated with a higher risk of hypertension (HTN); however, it remains unclear whether the relationship is causal. We aimed to evaluate the causal effects of circulating 25(OH)D levels on the prevalence of HTN in the Korean population using the Mendelian randomization (MR) approach. SUBJECTS/METHODS: Epidemiological data, serum 25(OH)D data, and genomic DNA biospecimens were obtained from 2,591 participants, a subset of the study population in the Korea National Health and Nutrition Survey 2011-2012. Five 25(OH)D-related single nucleotide polymorphisms (SNPs; DHCR7 rs12785878, CYP2R1 rs10741657, CYP2R1 rs12794714, CYP24A1 rs6013897, and GC rs2282679), identified a priori from genome-wide association studies, were used as instrument variables (IVs) for serum 25(OH)D levels. In the MR analysis, we performed IV analyses using the two-stage least squares method. RESULTS: In the observational analysis, circulating 25(OH)D levels were found to be inversely associated with the HTN prevalence in ordinary least squares models (odds ratio: 0.97, 95% confidence interval: 0.96, 0.99) after adjusting for the potential confounders. There were differences in the circulating 25(OH)D levels across genotypes of individual SNPs. In the MR analysis, using individual SNPs as IVs, 25(OH)D levels were not associated with the HTN prevalence. CONCLUSIONS: We found no association between genetically determined circulating 25(OH)D levels and HTN in Korean adults. Our results are listed owing to the relatively small sample size and possible weak instrument bias; therefore, further studies are needed to confirm these results.

• International Journal of Computer Science & Network Security
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• v.22 no.2
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• pp.214-222
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• 2022

Convolutional Neural networks (CNNs) are a category of deep learning networks that have proven very effective in computer vision tasks such as image classification. Notwithstanding, not much has been seen in its use for remote sensing image classification in developing countries. This is majorly due to the scarcity of training data. Recently, transfer learning technique has successfully been used to develop state-of-the art models for remote sensing (RS) image classification tasks using training and testing data from well-known RS data repositories. However, the ability of such model to classify RS test data from a different dataset has not been sufficiently investigated. In this paper, we propose a deep CNN model that can classify RS test data from a dataset different from the training dataset. To achieve our objective, we first, re-trained a ResNet-50 model using EuroSAT, a large-scale RS dataset to develop a base model then we integrated Augmentation and Ensemble learning to improve its generalization ability. We further experimented on the ability of this model to classify a novel dataset (Nig_Images). The final classification results shows that our model achieves a 96% and 80% accuracy on EuroSAT and Nig_Images test data respectively. Adequate knowledge and usage of this framework is expected to encourage research and the usage of deep CNNs for land cover mapping in cases of lack of training data as obtainable in developing countries.

• 연구논문집
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• s.25
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• pp.99-104
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• 1995

At present, a lot of researches on AS/RS(Automatic Storage and Retrival System) are being performed and also applied to realization of FA, FMS and CIM. Especially facility management and diagnosis of stacker crane that is major equipment of AS/RS, is recognized more importantly. In this paper, Case Base is designed for manager that is non-expert and it is implemented according to possible trouble case for the purpose of trouble diagnosis and maintenance of stacker crane.

• Korean Management Science Review
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• v.26 no.1
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• pp.93-112
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• 2009

In this paper, a model is presented to estimate a cycle time for completing an operation in a new type of AS/RS which can handle very heavy loads by separating the mechnisms for vertical and horizontal movements. Considering loading/unloading time between devices, we generalize the previous work, Hu et al. [9], which neglected the transfer time. Through the numerical experiments for various situations, we find that the difference of the cycle times between two models is fairly large and conclude that the transfer time between devices cannot be neglected at all.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.22 no.50
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• pp.75-90
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• 1999

이 논문은 전자 부품 조립산업에서의 통합 물류 시스템의 효율적인 선택과 최적의 설계를 위해 객체지향형 전문가 시스템과 해석적 모델을 결합한 방법론을 제시한다. 물류시스템의 선택과 설계 (마이크로로드 AS/)RS 선정)를 위해 지능형 물류시스템 (IMHSS:Intelligent Material Handling and Storage System)을 개발하여, 그 결과를 시뮬레이션 결과와 비교함으로써 지능형 물류시스템 모델의 적합성을 나타내고자 한다.

• Journal of the Korean Society of Manufacturing Technology Engineers
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• v.22 no.2
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• pp.318-323
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• 2013

For fast and accurate motion of 6-axis articulated robot, more noble motion control strategy is needed. In general, the movement strategy of industrial robots can be divided into two kinds, PTP (Point to Point) and CP (Continuous Path). Recently, industrial robots which should be co-worked with machine tools are increasingly needed for performing various jobs, as well as simple handling or welding. Therefore, in order to cope with high-speed handling of the cooperation of industrial robots with machine tools or other devices, CP should be implemented so as to reduce vibration and noise, as well as decreasing operation time. This paper will realize CP motion (especially joint-linear) blending in 3-dimensional space for a 6-axis articulated (lab-manufactured) robot (called as "RS2") by using LabVIEW$^{(R)}$ (6) programming, based on a parametric interpolation. Another small contribution of this paper is the proposal of motion blending simulation technique based on Recurdyn$^{(R)}$ V7 and Solidworks$^{(R)}$, in order to figure out whether the joint-linear blending motion can generate the stable motion of robot in the sense of velocity magnitude at the end-effector of robot or not. In order to evaluate the performance of joint-linear motion blending, simple PTP (i.e., linear-linear) is also physically implemented on RS2. The implementation results of joint-linear motion blending and PTP are compared in terms of vibration magnitude and travel time by using the vibration testing equipment of Medallion of Zonic$^{(R)}$. It can be confirmed verified that the vibration peak of joint-linear motion blending has been reduced to 1/10, compared to that of PTP.