• Asian Pacific Journal of Cancer Prevention
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• 제15권17호
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• pp.7443-7447
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• 2014

Aim: Little is known about the genetic associations with Basal cell carcinoma (BCC) risk in non-Caucasian populations, in which BCC is rare, as in Korea. We here conducted a pilot genome-wide association study (GWAS) in 12 patients and 48 standard controls. Method: A total of 263,511 SNPs were analyzed with the Illumina HumanOmni1 Quad v1.0 DNA Analysis BeadChip for cases and Korean HapMap 570K for controls. Results: SNP-based analyses, based on the allele genetic model with adjustment for sex and age showed suggestive associations with BCC risk for 6 SNPs with a P-value (P < 0.0005). However, these associations were not statistically significant after Bonferroni correction: rs1040503, rs2216491, rs13407683, rs4751072, rs9891263, and rs1368474. In addition, results from gene-based analyses showed suggestive associations with BCC risk for 33 candidate genes with a P-value (P <0.0005). Consistent with previous GWAS and replication studies in Caucasian populations, PADI6, RHOU and SLC45A2 were identified as having null associations with BCC (P > 0.05), likely due to the smaller sample size. Conclusions: Although this was a small-scale negative study, to our knowledge, we have conducted the first GWAS for BCC risk in an Asian population. Further large studies in non-Caucasian populations are required to achieve statistical significance and confirm these findings.

• Molecules and Cells
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• 제21권3호
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• pp.418-427
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• 2006

Ionotropic glutamate receptors (iGluRs) are ligand-gated nonselective cation channels that mediate fast excitatory neurotransmission. Although homologues of the iGluRs have been identified in higher plants, their roles are largely unknown. In this work we isolated a full-length cDNA clone (RsGluR) encoding a putative glutamate receptor from small radish. An RsGluR:mGFP fusion protein was localized to the plasma membrane. In Arabidopsis thaliana overexpressing the fulllength cDNA, glutamate treatment triggered greater $Ca^{2+}$ influx in the root cells of transgenic seedlings than in those of the wild type. Transgenic plants exhibited multiple morphological changes such as necrosis at their tips and the margins of developing leaves, dwarf stature with multiple secondary inflorescences, and retarded growth, as previously observed in transgenic Arabidopsis overexpressing AtGluR3.2 [Kim et al. (2001)]. Microarray analysis showed that jasmonic acid (JA)-responsive genes including defensins and JA-biosynthetic genes were up-regulated. RsGluR overexpression also inhibited growth of a necrotic fungal pathogen Botrytis cinerea possibly due to up-regulation of the defensins. Based on these results, we suggest that RsGluR is a glutamate-gated $Ca^{2+}$ channel located in the plasma membrane of higher plants and plays a direct or indirect role in defense against pathogen infection by triggering JA biosynthesis.

• Biomolecules & Therapeutics
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• 제26권2호
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• pp.130-138
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• 2018

Quercetin and resveratrol are known to have beneficial effects on the diabetes and diabetic complication, however, the effects of combined treatment of these compounds on diabetes are not fully revealed. Therefore, the present study was designed to investigate the combined antidiabetic action of quercetin (QE) and resveratrol (RS) in streptozotocin (STZ)-induced diabetic rats. To test the effects of co-treated with these compounds on diabetes, serum glucose, insulin, lipid profiles, oxidative stress biomarkers, and ions were determined. Additionally, the activities of hepatic glucose metabolic enzymes and histological analyses of pancreatic tissues were evaluated. 50 male Sprague-Dawley rats were divided into five groups; normal control, 50 mg/kg STZ-induced diabetic, and three (30 mg/kg QE, 10 mg/kg RS, and combined) compound-treated diabetic groups. The elevated serum blood glucose levels, insulin levels, and dyslipidemia in diabetic rats were significantly improved by QE, RS, and combined treatments. Oxidative stress and tissue injury biomarkers were dramatically inhibited by these compounds. They also shown to improve the hematological parameters which were shown to the hyperlactatemia and ketoacidosis as main causes of diabetic complications. The compounds treatment maintained the activities of hepatic glucose metabolic enzymes and structure of pancreatic ${\beta}-cells$ from the diabetes, and it is noteworthy that cotreatment with QE and RS showed the most preventive effect on the diabetic rats. Therefore, our study suggests that cotreatment with QE and RS has beneficial effects against diabetes. We further suggest that cotreatment with QE and RS has the potential for use as an alternative therapeutic strategy for diabetes.

• 한국항해항만학회:학술대회논문집
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• 한국항해항만학회 2006년도 International Symposium on GPS/GNSS Vol.1
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• pp.221-226
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• 2006

Around 2002, the United States Coast Guard (USCG) identified a need to re-capitalize their Reference Station (RS) and Integrity Monitor (IM) equipment used in the Nationwide Differential Global Position System (NDGPS). Commercially available off-the-shelf differential RS and IM equipment lacked the open architecture required to support long-term goals that include future system improvements such as use of new civil frequencies on L2 and L5 and realization of a higher rate NDGPS beacon data channel intended to support RTK. The first step in preparing for this future NDGPS was to port current RTCM SC-104 compatible RS and IM functionality onto an open architecture PC-based platform. Trimble's product Charisma is a PC-based RS and IM software designed to meet these USCG goals. In fact USCG engineers provided key designs and design insights throughout the development. We cannot overstate the contribution of the USCG engineers. Fundamental requirements for this effort were that it be sufficiently flexible in hardware and software design to support fluid growth and exploitation of new signals and technologies as they become available, yet remain backward compatible with legacy user receivers and existing site hardware and system architecture. These fundamental goals placed an implicit adaptability requirement on the design of the replacement RS and IM. Additionally, project engineers were to remain focused on sustaining the high level of differential GPS service that 1.5 million legacy users have come to depend on. This paper will present new hardware and software (i.e., Trimble's Charisma software) architecture for the next generation NDGPS RS and IM. This innovative approach to engineering on an open architecture PC-based platform allows the system to continue to fulfill legacy NDGPS system requirements and allows the USCG and others to pursue a scalable hardware re-capitalization strategy. We will use the USCG's recapitalization project to explain the essential role of the Charisma software.

• 대한원격탐사학회:학술대회논문집
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• 대한원격탐사학회 2003년도 Proceedings of ACRS 2003 ISRS
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• pp.1377-1379
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• 2003

Satellite and aerial remote sensing (RS) techniques have been provided to collect spatial data globally over the last few decades. However in developing countries such as China, there is still an urgent need for low cost and high resolution RS data. As an emerging RS platform, commercial Unmanned Aerial Vehicle (UAV) integrated with state-of-the-art sensors and information technologies has the potential to become a low cost tool to meet application demands. In this paper, the architecture of UAV RS operation system is mentioned. Moreover, key technologies in UAV RS system are analyzed and current work is reported.

• 대한기계학회논문집A
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• 제26권10호
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• pp.2122-2129
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• 2002

Creep damage using a reference stress(RS) was analyzed for type 316LN stainless steel. The generalized K-R equation was reconstructed into the RS equation using a critical stress value $\sigma$. The RS equation was derived from the critical stress in failure time $t_f$ instead of material damage parameter $\omega$, which indicates the critical condition of collapse or approach to gross instability of materials during creep. For obtaining the reference stress, a series of creep tests and tensile tests were conducted with at 55$0^{\circ}C$ and $600^{\circ}C$. The stress-time data obtained from creep tests were applied to the RS equations to characterize the creep damage of type 316LN stainless steel. The value of creep constant r with stress levels was about 18 at 55$0^{\circ}C$ and 21 at $600^{\circ}C$. This value was almost similar with r = 24 in the K-R equation, which was obtained by using damage parameter $\omega$. Relationship plots of creep failure strain and life fraction $(t_f /t_r)$ were also obtained with different λ values. The RS equation was therefore more convenient than the generalized K-R equation, because the measuring process to quantify the damage parameter $\omega$ such as voids or micro cracks in crept materials was omitted. The RS method can be easily used by designers and plant operator as a creep design tool.

• Genomics & Informatics
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• 제21권4호
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• pp.48.1-48.8
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• 2023

Liver cancer is the fourth leading cause of death worldwide. Well-known risk factors include hepatitis B virus and hepatitis C virus, along with exposure to aflatoxins, excessive alcohol consumption, obesity, and type 2 diabetes. Genomic variants play a crucial role in mediating the associations between these risk factors and liver cancer. However, the specific variants involved in this process remain under-explored. This study utilized a bioinformatics approach to identify genetic variants associated with liver cancer from various continents. Single-nucleotide polymorphisms associated with liver cancer were retrieved from the genome-wide association studies catalog. Prioritization was then performed using functional annotation with HaploReg v4.1 and the Ensembl database. The prevalence and allele frequencies of each variant were evaluated using Pearson correlation coefficients. Two variants, rs2294915 and rs2896019, encoded by the PNPLA3 gene, were found to be highly expressed in the liver tissue, as well as in the skin, cell-cultured fibroblasts, and adipose-subcutaneous tissue, all of which contribute to the risk of liver cancer. We further found that these two SNPs (rs2294915 and rs2896019) were positively correlated with the prevalence rate. Positive associations with the prevalence rate were more frequent in East Asian and African populations. We highlight the utility of this population-specific PNPLA3 genetic variant for genetic association studies and for the early prognosis and treatment of liver cancer. This study highlights the potential of integrating genomic databases with bioinformatic analysis to identify genetic variations involved in the pathogenesis of liver cancer. The genetic variants investigated in this study are likely to predispose to liver cancer and could affect its progression and aggressiveness. We recommend future research prioritizing the validation of these variations in clinical settings.

• Animal Bioscience
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• 제35권7호
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• pp.999-1009
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• 2022

Objective: To improve the feeding value of rice straw (RS), this study evaluated the potential of rice straw fermented with Pleurotus sajor-caju (FRS) as dairy goat feed. Methods: Spent Pleurotus sajor-caju mushroom substrate was used as fungi inoculum to break the lignocellulose linkage of rice straw, which was solid-fermented at 25℃ to 30℃ for 8 weeks. The ruminal degradation of pangolagrass hay (PG), FRS, and RS were measured in situ for 96 hours in three dry Holstein cows, respectively. Effect of fungi fermented RS on milking performance was studied in feeding trials. A total of 21 Alpine goats a trial were divided into 3 groups: a control group in which PG accounted for 15% of the diet dry matter, and FRS or RS was used to replace the PG in the control group. Goats were fed twice a day under two 28-day trial in individual pens. Meanwhile, a 3×3 Latin square trial (14 days/period) was conducted to study the rumen digestion of three diets by using three fistulated dry goats. Rumen contents were collected for metabolite analyses every one to three hours on the last two days. Results: In situ study showed that fermentation could elevate the rumen degradable fraction and effective degradability of RS (p<0.05). Effective degradability of FRS dry matter was significantly increased from 29.5% of RS to 41.7%. Lactating trial results showed that dry matter intake and milk yield in the PG group and FRS group were similar and higher than those in RS group (p<0.05). The concentration of propionic acid and total volatile fatty acid in the RS group tended to be lower than those in PG group (p<0.10). There were no differences in rumen pH value and ammonia nitrogen level among the groups tested. Conclusion: Fermentation of rice straw by spent Pleurotus sajor-caju mushroom substrate could substantially enhance its feeding value to be equivalent to PG as an effective fiber source for dairy goat. The fermented rice straw is recommended to account for 15% in diet dry matter.

• The Korean Journal of Pain
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• 제36권1호
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• pp.113-127
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• 2023

Background: Resting-state functional connectivity (rs-FC) may aid in understanding the link between painmodulating brain regions and the descending pain modulatory system (DPMS) in fibromyalgia (FM). This study investigated whether the differences in rs-FC of the primary somatosensory cortex in responders and non-responders to the conditioned pain modulation test (CPM-test) are related to pain, sleep quality, central sensitization, and the impact of FM on quality of life. Methods: This cross-sectional study included 33 females with FM. rs-FC was assessed by functional magnetic resonance imaging. Change in the numerical pain scale during the CPM-test assessed the DPMS function. Subjects were classified either as non-responders (i.e., DPMS dysfunction, n = 13) or responders (n = 20) to CPM-test. A generalized linear model (GLM) and a receiver operating characteristic (ROC) curve analysis were performed to check the accuracy of the rs-FC to differentiate each group. Results: Non-responders showed a decreased rs-FC between the left somatosensory cortex (S1) and the periaqueductal gray (PAG) (P < 0.001). The GLM analysis revealed that the S1-PAG rs-FC in the left-brain hemisphere was positively correlated with a central sensitization symptom and negatively correlated with sleep quality and pain scores. ROC curve analysis showed that left S1-PAG rs-FC offers a sensitivity and specificity of 85% or higher (area under the curve, 0.78, 95% confidence interval, 0.63-0.94) to discriminate who does/does not respond to the CPM-test. Conclusions: These results support using the rs-FC patterns in the left S1-PAG as a marker for predicting CPM-test response, which may aid in treatment individualization in FM patients.

• 대한전자공학회논문지TC
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• 제44권2호
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• pp.22-28
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• 2007

높은 PAPR (peak-to-average power ratio)은 OFDM (orthogonal frequency division multiplexing) 신호의 주된 문제점이다. 본 논문에서는 RS (Reed-Solomon) 부호의 소실 복호 기능을 이용한 수정된 SLM (selective mapping) 기법을 제안한다. 송신기에서 RS 부호화된 OFDM 데이터 블록에 일련의 위상 시퀀스를 곱하여 일부의 체크 심볼의 위상을 천이시킨다. 수신기에서 위상 천이된 체크 심볼들을 소실로 간주하여 RS 복호를 수행한다. 그러므로 가장 낮은 PAPR을 갖도록 선택된 위상 시퀀스에 대한 부가 정보를 전송할 필요가 없다. 또한 선택된 위상 시퀀스에 대한 추정 과정이 더 이상 수신기에 필요하지 않게 되어 복잡도와 성능이 향상된다. 제안한 수정된 SLM 기법의 성능을 평가하기 위해 PAPR의 CCDF(complementary cumulative distribution function), BER(bit error rate) 그리고 복호 실패 확률을 기존의 SLM 기법과 비교한다.