• 제어로봇시스템학회:학술대회논문집
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• 2003.10a
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• pp.1480-1484
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• 2003

This paper presents the design and development of network for housing estate security system. The system can cover up to 961 houses which can be up to 1,200 meters long transfer rate of 9,600 bps. This system uses checking and warning the abnormal situation. More over this system has ability to control switch on/off the electrical equipment in the house via AC line control system. The system consists of 4 parts. The first part is a security system of each house using MCS-51 microcontroller as a central processing unit scan 32 sensors and control 8 appliances and send alarm. The MCS-51 microcontroller received control signal via telephone used DTMF circuit. The second part is distributed two levels master/slave network implementing after RS-485 serial communication standard. The protocol its base on the OSI (Open Systems Interconnection) 7 layers protocol model design focus on speed, reliability and security of data that is transferred. The network security using encrypt by DES algorithm, message sequence, time stamp checking and authentication system when user to access and when connect new device to this system. Flow control in system is Poll/Select and Stop-and-Wait method. The third part is central server that using microcomputer which its main function are storing event data into database and can check history event. The final part is internet system which users can access their own homes via the Internet. This web service is based on a combination of SOAP, HTTP and TCP/IP protocols. Messages are exchanged using XML format [6]. In order to save the number of IP address, the system uses 1 IP address for the whole village in which all homes and appliance in this village are addressed using internal identification numbers. This proposed system gives the data transfer accuracy over 99.8% and maximum polling time is 1,120 ms.

• Journal of the Korean Association of Geographic Information Studies
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• v.9 no.4
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• pp.224-232
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• 2006

This study investigates to detect Sea Surface Temperature (SST) and land cover change after tide embankment construction using Landsat Thematic Mapper (TM) Thermal Infrared (TIR) band data at Shihwa Lake and surrounding area. SST measurement is important for studies of both the structure of the ocean and as the thermal boundary between the ocean and the atmosphere. Since 1970s, the derivation of SST by satellite remote sensing (RS) has been applied to earth surface using Advanced Very High Resolution Radiometer (AVHRR) and Landsat TM. However, AVHRR has restriction in deriving SST in the area whose shoreline is complicated like western coast in South Korea because of coarse spatial resolution. The TIR band of TM images can be used to detect SST change whose shoreline is complicated and narrow like the study site. Thus, multi-temporal TM images were used for SST change detection in this study.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.11
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• pp.5865-5869
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• 2012

RHOXF1 has been shown to be expressed in embryonic stem cells, adult germline stem cells and some cancer lines. It has been proposed as a candidate gene to encode transcription factors regulating downstream genes in the human testis with antiapoptotic effects. Its expression in cancer cell lines has implied a similar role in the process of tumorigenesis. The human breast cancer cell lines MDA-MB-231 and MCF-7 were cultured in DMEM medium and transfected with a pGFP-V-RS plasmid bearing an RHOXF1 specific shRNA. Quantitative real-time RT-PCR was performed for RHOXF1, CASP8, BCL2 and HPRT genes. Decreased RHOXF1 expression was confirmed in cells after transfection. shRNA knock down of RHOXF1 resulted in significantly decreased BCL2 expression in both cell lines but no change in CASP8 expression. shRNA targeting RHOXF1 was shown to specifically mediate RHOXF1 gene silencing, so RHOXF1 can mediate transcriptional activation of the BCL2 in cancers and may render tumor cells resistant to apoptotic cell death induced by anticancer therapy. shRNA mediated knock down of RHOXF1 can be effective in induction of apoptotic pathway in cancer cells via BCL2 downregulation, so it can have potential therapeutic utility for human breast cancer.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.1
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• pp.255-260
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• 2012

Patients with non-small cell lung cancer (NSCLC) who have activating epidermal growth factor receptor (EGFR) mutations derive clinical benefit from treatment with EGFR-tyrosine kinase inhibitors ((EGFR-TKIs)-namely gefitinib and erlotinib. However, these patients eventually develop resistance to EGFR-TKIs. Despite the fact that this acquired resistance may be the result of a secondary mutation in the EGFR gene, such as T790M or amplification of the MET proto-oncogene, there are other mechanisms which need to be explored. MicroRNAs (miRs) are a class of small non-coding RNAs that play pivotal roles in tumorigenesis, tumor progression and chemo-resistance. In this study, we firstly successfully established a gefitinib resistant cell line-HCC827/GR, by exposing normal HCC827 cells (an NSCLC cell line with a 746E-750A in-frame deletion of EGFR gene) to increasing concentrations of gefitinib. Then, we found that miR-214 was significantly up-regulated in HCC827/GR. We also showed that miR-214 and PTEN were inversely expressed in HCC827/GR. Knockdown of miR-214 altered the expression of PTEN and p-AKT and re-sensitized HCC827/GR to gefitinib. Taken together, miR-214 may regulate the acquired resistance to gefitinib in HCC827 via PTEN/AKT signaling pathway. Suppression of miR-214 may thus reverse the acquired resistance to EGFR-TKIs therapy.

• Korean Journal of Computational Design and Engineering
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• v.15 no.3
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• pp.212-221
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• 2010

Proposed in the paper is a methodology to generate kinematic template for 3D JIG models. Recently, according to increase of the rate of automatic facility in manufacturing system, the 3D manufacturing and verification research and development have been issued. So, unlike in the past, moving 3D facilities are very various like JIGs, turn table, AS/RS worked in the automated manufacturing industry. Because 3D mesh models are used in these kinds of 3D simulation, users have to define the kinematic information manually. This 3D mesh data doesn't have parametric information and design history of the 3D model unlike the design level data. So, it is lighter than 3D design level data and more efficient to render on the 3D virtual manufacturing environment. But, when user wants to find a common axis located between the links, the parameter information of the model has to reconstruct for defining kinematic construction. It takes a long time and very repetitive to define an axis and makes a joint using 3D mesh data and it is non-intuitive task for user. This paper proposed template model that provides kinematic information of the JIG. This model is kinds of a state diagram to describe a relation between links. So, this model can be used for a kinematic template to the JIG which has a same mechanism. The template model has to be registered in the template library to use in the future, after user made the model of the specific type of the 3D JIG model.

• The Korean Journal of Physiology and Pharmacology
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• v.8 no.2
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• pp.69-76
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• 2004

A variety of G protein coupled receptors (GPCRs) are expressed in the presynaptic terminals of central and peripheral synapses and play regulatory roles in transmitter release. The patch-clamp whole-cell recording technique, applied to the calyx of Held presynaptic terminal in brainstem slices of rodents, has made it possible to directly examine intracellular mechanisms underlying the GPCR-mediated presynaptic inhibition. At the calyx of Held, bath-application of agonists for GPCRs such as $GABA_B$ receptors, group III metabotropic glutamate receptors (mGluRs), adenosine $A_1$ receptors, or adrenaline ${\alpha}2$ receptors, attenuate evoked transmitter release via inhibiting voltage-activated $Ca^{2+}$ currents without affecting voltage-activated $K^+$ currents or inwardly rectifying $K^+$ currents. Furthermore, inhibition of voltage-activated $Ca^{2+}$ currents fully explains the magnitude of GPCR-mediated presynaptic inhibition, indicating no essential involvement of exocytotic mechanisms in the downstream of $Ca^{2+}$ influx. Direct loadings of G protein ${\beta}{\gamma}$ subunit $(G{\beta}{\gamma})$ into the calyceal terminal mimic and occlude the inhibitory effect of a GPCR agonist on presynaptic $Ca^{2+}$ currents $(Ip_{Ca})$, suggesting that $G{\beta}{\gamma}$ mediates presynaptic inhibition by GPCRs. Among presynaptic GPCRs glutamate and adenosine autoreceptors play regulatory roles in transmitter release during early postnatal period when the release probability (p) is high, but these functions are lost concomitantly with a decrease in p during postnatal development.

• Journal of the Institute of Electronics Engineers of Korea CI
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• v.43 no.6 s.312
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• pp.52-59
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• 2006

Recently, the internet has seen tremendous growth with plenty of enriched information due to an increasing number of specialized personal interests and popularizations of private cyber space called, blog. Many of today's blog provide internet users, RSS, which is also hewn as the syndication technology. It enables blog users to receive update automatically by registering their RSS channel address with RSS aggregator. In other words, it keeps internet users wasting their time checking back the web site for update. This paper propose the ways to manage RSS Channel Searching Crawler and collected RSS Channels for internet users to search for a specific RSS channel of their want without any obstacles. At the same time. This paper proposes RSS channel ranking based on user popularity. So, we focus on an idea of adding index to information and web update for users to receive appropriate information according to user property.

• The Journal of Korean Academy of Prosthodontics
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• v.40 no.3
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• pp.236-245
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• 2002

The acrylic resin was first introduced as denture base materials in 1937 and it is commonly used for denture base fabrication nowadays. Three different curing cycles (Conventional curing cycle, short curing cycle and long curing cycle) and three commercially available heat-activated acrylic resins (Vertex RS, Lucitone 199 and ProBase Hot) were investigated to find the curing cycle and material that showed the minimum shrinkage of the resin during polymerization process. A brass master mold was fabricated and duplicated by additional silicone impression material. Stone molds were made by pouring of type III dental stone (SILKY-ROCK YELLOW, Whip-Mix, Louisville, Kentucky). It was embedded in the flask. Strain gauge and thermocouple were embedded in the specimen. Strain gauge and thermocouple were connected to signal conditioning amplifier and data was recorded by pre-programmed software. The parameters ESmax (Maximum expansion strain), Sb (Strain measured just before deflasking procedure), Sa (Strain measured just after deflasking procedure) and Sf (Strain measured at the end of the experiment) were measured. ${\Delta}$S was calculated from Sb and Sa (${\Delta}$S=Sb-Sa). In the experiment concerned about materials, the parameters 90-ESmax (Maximum expansion strain measured during early 90 minutes of curing procedure), 180-ESmax (Maximum expansion strain measured from 90 minutes to 180 minutes), Sb, Sa, ${\Delta}$S and Sf were measured and the following conclusions were made. 1. The ESmax value of conventional curing cycle showed the largest value and the 180-ESmax value of Lucitone 199 showed the smallest value. 90-ESmax values showed no significant difference (p<0.05). 2. ${\Delta}$S values of conventional curing cycle showed the positive values. ${\Delta}$S values of short curing cycle and long curing cycle showed the negative values. All three materials cured by conventional curing cycle showed the positive values. 3. The Sf values of long curing cycle and ProBase Hot (cured by conventional curing cycle) showed the smallest values.

• KSBB Journal
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• v.27 no.4
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• pp.257-262
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• 2012

The gene encoding Thermus thermophilus HJ6 laccase (Tt-laccase) was cloned, sequenced, and comprised of 1,389 nucleotides encoding a protein (462 amino acids) with a predicted molecular mass of 51,049 Da. The deduced amino acid sequence of Tt-laccase showed 99.7% and 44.3% identities to the Thermus thermophilus HB27 laccase and Synechococcus sp. RS9917 laccase, respectively. Tt-laccase gene was expressed as a fusion protein with six histidine residues in E. coli Rosetta-gami (DE3) cells, and the recombinant protein was purified to homogeneity. UV-Vis spectrum analysis revealed that the enzyme has copper atoms, a type I Cu(II) and a type III binuclear Cu(II). The optimum pH for the oxidation of guaiacol was 5.0 and the optimum temperature was $90^{\circ}C$ The half-life of heat inactivation was about 120 min at $90^{\circ}C$ The enzyme reaction was inhibited by sodium azide, L-cystein, EDTA, dithiothreitol, tropolone, and kojic acid. The enzyme oxidized various known laccase substrates, its lowest $K_m$ value being for 4-hydroxyindole, highest $k_{cat}$ value for syringaldazine, and highest $k_{cat}/K_m$ for guaiacol.

• Journal of Chest Surgery
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• v.26 no.8
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• pp.591-594
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• 1993

To clarify the apparent hypoplasia of the descending aorta in infants with atrioventricular septal defect[AVSD] patients, we reviewed the catheterization data and angiograms of 34 consecutive patients with AVSD less than 1 year of age who underwent repair at our institution since 1985. We compared them to 10 patients with Atrial Septal Defect[ASD] and 10 patients with Ventricular Septal Defect[VSD] who were matched for age, size and Qp/Qs. The Descending Aorta Index [DAI] of the AVSD group was not different from the VSD or ASD groups, [147.9$\pm$ 34.8 mm2/m2 versus 158.6$\pm$ 31.5 mm2/m2 and 153.2$\pm$ 43.1 mm2/m2].However, the Pulmonary Artery Index [PAI] of the AVSD group was significantly larger than the other groups [684.3$\pm$ 170.7 mm2/m2 versus 454.1$\pm$ 109.1 mm2/m2 and 534.9$\pm$ 148.4 mm2/m2][p<0.05], as was the ratio of PAI/DAI in the AVSD group [4.99$\pm$ 1.77 versus 2.89$\pm$ 0.81 and 3.6$\pm$ 0.92][p<0.05]. Despite similar Qp/Qs ratios, both the mean PA pressure and the Rp/Rs in the AVSD group was higher than the VSD and ASD groups: 43.1$\pm$ 15.6 mmHg versus 29$\pm$ 11.6 mmHg and 24$\pm$ 18.1 mmHg [p<0.05], and 0.27$\pm$ 0.22 versus 0.14$\pm$ 0.03 and 0.11$\pm$ 0.05 [p<0.05] respectively. The apparent hypoplasia of the descending aorta in infants with AVSD is an illusion created by the abnormally large pulmonary arteries, which are significantly larger than in patients with ASDs or VSDs.