• Journal of Embryo Transfer
• /
• v.30 no.2
• /
• pp.91-97
• /
• 2015

Amphiregulin (AREG), a glycoprotein that is a member of the epidermal growth factor (EGF) family, is expressed by the porcine conceptus and endometrium. AREG genotypes were determined based on an SNP in the intron 3 of the gene. Contradictory effects of AREG genotypes on reproductive traits in different pig breeds were reported previously. G allele had undesirable effect on reproductive trait in Meishan breed, while it had favorable effects in Polish Landrace and Large White. We determined AREG genotypes of 179 pigs including the Duroc, Landrace, Yorkshire, Korean native pig (KNP), and Meishan breeds. Two new SNPs were identified near the previously reported SNP in the intron 3 of AREG. Frequencies of AREG alleles among the Duroc, Landrace, Yorkshire, and KNP sows were significantly different (p<0.001), indicating association between AREG genotypes and pig breeds. The first parity litter size was significantly affected by the breeds (p=0.014), but not by AREG genotypes (p=0.148). However, there were breed and AREG genotype associated trends in the first parity litter size. The first parity litter size appeared to be higher in Duroc and KNP sows with G allele, while it appeared to be lower in Landrace sows with G allele. Significant variability of AREG alleles among pig breeds, for the first time in Duroc and KNP sows, was identified. AREG genotypes may influence reproductive traits differentially for each breed and thus, AREG genotypes may need to be considered when sows are bred to increase litter size.

• Journal of the Korea Institute of Military Science and Technology
• /
• v.24 no.5
• /
• pp.492-502
• /
• 2021

In electronic warfare, source enumeration and direction-of-arrival estimation are important. The source enumeration method based on eigenvalues of covariance matrix from received is one of the most used methods. However, there are some drawbacks such as accuracy less than 100 % at high SNR, poor performance at low SNR and reduction of maximum number of estimating sources. We suggested new method based on eigenvalues gaps, which is named AREG(Accumulated Ratio of Eigenvalues Gaps). Meanwhile, FGML(Fast Gridless Maximum Likelihood) which reconstructs the covariance matrix was suggested by Wu et al., and it improves performance of the existing source enumeration methods without modification of algorithms. In this paper, first, we combine AREG with FGML to improve the performance. Second, we compare the performance of source enumeration and direction-of-arrival estimation methods in Rayleigh fading. Third, we suggest new method named REG(Ratio of Eigenvalues Gaps) to reduce performance degradation in Rayleigh Fading environment of AREG.

• Journal of the Korea Convergence Society
• /
• v.8 no.7
• /
• pp.349-356
• /
• 2017

The purpose of this study is to provide guidelines for effective osteoarthritis passive aquatic rehabilitation program and form of exercise prescription through passive aquatic rehabilitation exercise for 24 weeks for women with osteoarthritis. The subjects of this study were the passive aquatic rehabilitation group (CG, n = 10) and the control group (AREG, n = 10) among the subjects who had been diagnosed with osteoarthritis by the K orthopedic surgeon and visited the hospital more than 3 times were selected. The results of this study showed that the change of shoulder height in the group was significantly different in passive aquatic rehabilitation exercise group (p <.001). There were significant differences in passive aquatic rehabilitation exercise group (p <.001) between the groups with inhaled sacpula patterns. Changes in the pelvis patterns inferior pattern of the left and right pelvis patterns in the group were significantly different in passive aquatic rehabilitation exercise group (p <.001).

• Journal of Trauma and Injury
• /
• v.34 no.1
• /
• pp.31-38
• /
• 2021

Purpose: Traumatic vertebral injuries have a prevalence of 4-5% at level I centers. Studies have demonstrated that isolated thoracolumbar transverse process fractures (iTPF) rarely require brace or surgical interventions. We hypothesized that similarly isolated thoracolumbar spinous process fractures (iSPF) would have less need for bracing and operative interventions than SPFs with associated vertebral body (VB) fractures (SPF+VB). We performed a similar analysis for iTPF compared to transverse process fractures associated with VB injury (TPF+VB). Methods: In this single-center, retrospective study from 2012 to 2016, patients were classified into iSPF, SPF+VB, iTPF, and TPF+VB groups. Data including the fracture pattern, neurologic deficits, and operative intervention were obtained. The primary outcome studied was the need for bracing and/or surgery. A statistical analysis was conducted. Results: Of 98 patients with spinous process fractures, 21 had iSPF and 77 had SPF+VB. No iSPF patients underwent surgery, whereas 24 (31.17%) SPF+VB patients did undergo surgery (p=0.012). In the iSPF group, three patients (15%) received braces only for comfort, whereas 37 (48.68%) of the SPF+VB group required bracing (p=0.058). Of 474 patients with transverse process fractures, 335 had iTPF and 139 had TPF+VB. No iTPF patients underwent surgery, whereas 28 (20.14%) TPF+VB patients did (p≤0.001). Of the iTPF patients, six (1.86%) were recommended to receive braces only for comfort, while 68 (50.75%) of the TPF+VB patients required bracing (p<0.001). Conclusions: No patients with iSPF or iTPF required surgical intervention, and bracing was recommended to patients in these groups for comfort only. It appears that these injures may be safely managed without interventions, calling into question the need for spine consultation.

• Fisheries and Aquatic Sciences
• /
• v.26 no.6
• /
• pp.406-422
• /
• 2023

Sarcopenia is an age-related, progressive skeletal muscle disorder involving the loss of muscle mass and strength. Previous studies have shown that γ-aminobutyric acid (GABA) from fermented oysters aids in regulatory T cells (Tregs) cell expansion and function by enhancing autophagy, and concomitantly mediate muscle regeneration by modulating muscle inflammation and satellite cell function. The fermentation process of oysters not only increases the GABA content but also enhances the content of branched amino acids and free amino acids that aid the level of protein absorption and muscle strength, mass, and repair. In this study, the effect of GABA-enriched fermented sarco oyster extract (FSO) on reduced muscle mass and functions via Treg modulation and enhanced autophagy in aged mice was investigated. Results showed that FSO enhanced the expression of autophagy markers (autophagy-related gene 5 [ATG5] and GABA receptor-associated protein [GABARAP]), forkhead box protein 3 (FoxP3) expression, and levels of anti-inflammatory cytokines (interleukin [IL]-10 and transforming growth factor [TGF]-β) secreted by Tregs while reducing pro-inflammatory cytokine levels (IL-17A and interferon [IFN]-γ). Furthermore, FSO increased the expression of IL-33 and its receptor IL-1 receptor-like 1 (ST2); well-known signaling pathways that increase amphiregulin (Areg) secretion and expression of myogenesis markers (myogenic factor 5, myoblast determination protein 1, and myogenin). Muscle mass and function were also enhanced via FSO. Overall, the current study suggests that FSO increased autophagy, which enhanced Treg accumulation and function, decreased muscle inflammation, and increased satellite cell function for muscle regeneration and therefore could decrease the loss of muscle mass and function with aging.