• Journal of the Korean Statistical Society
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• 제32권4호
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• pp.313-335
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• 2003

Hourly ozone data are available for 73 stations in South Korea from January, 1988 to August, 1998. We are interested in detecting trends in both the mean levels and the extremes of ozone, and in determining how these trends vary over the country. The latter aspect means that we also have to understand the spatial dependence of ozone. In this connection, therefore, we examine in this paper the following features: determining trends in mean ozone levels at individual stations and combination across stations; determining trends in extreme ozone levels at individual stations and combination across stations; spatial modeling of trends in mean and extreme ozone levels.

• 한국표면공학회지
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• 제42권3호
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• pp.116-121
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• 2009

The 2-step low temperature plasma processes (the combined carburizing and post-nitriding) offer the increase of both surface hardness and thickness of hardened layer and corrosion resistance than the individually processed low temperature nitriding and low temperature carburizing techniques. The 2-step low temperature plasma processes were carried out for improving both the surface hardness and corrosion resistance of AISI 316L stainless steel. The influence of gas compositions on the surface properties during nitriding step were investigated. The expanded austenite (${\gamma}_N$) was formed on all of the treated surface. The thickness of ${\gamma}_N$ and concentration of N on the surface increased with increasing both nitrogen gas and Ar gas levels in the atmosphere. The thickness of ${\gamma}_N$ increased up to about $20{\mu}m$ and the thickness of entire hardened layer was determined to be about $40{\mu}m$. The surface hardness was independent of nitrogen and Ar gas contents and reached up to about 1200 $HV_{0.1}$ which is about 5 times higher than that of untreated sample (250 $HV_{0.1}$). The corrosion resistance in 2-step low temperature plasma processed austenitic stainless steels was also much enhanced than that in the untreated austenitic stainless steels due to a high concentration of N on the surface.

• 대한한의학방제학회지
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• 제31권4호
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• pp.295-313
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• 2023

Objectives : While treatments for cancer are advancing, the development of effective treatments for cancer metastasis, the main cause of cancer patient death, remains insufficient. Recent studies on Dichroae Radix have revealed that its active ingredients have the potential to inhibit cancer metastasis. This study aimed to investigate the cancer metastasis inhibitory effect of Dichroae Radix using network pharmacological analysis. Methods : The active compounds of Dichroae Radix have been identified using Traditional Chinese Medicine System Pharmacology Database and Analysis Platform. The UniProt database was used to collect each of information of all target proteins associated with the active compounds. To find the bio-metabolic processes associated with each target, the DAVID6.8 Gene Functional classifier tool was used. Compound-Target and Target-Pathway networks were analyzed via Cytoscape 3.40. Results : In total, 25 active compounds and their 62 non-redundant targets were selected through the TCMSP database and analysis platform. The target genes underwent gene ontology and pathway enrichment analysis. The gene list applied to the gene ontology analysis revealed associations with various biological processes, including signal transduction, chemical synaptic transmission, G-protein-coupled receptor signaling pathways, response to xenobiotic stimulus, and response to drugs, among others. A total of eleven genes, including HSP90AB1, CALM1, F2, AR, PAKACA, PTGS2, NOS2, RXRA, ESR1, ESR2, and NCOA1, were found to be associated with biological pathways related to cancer metastasis. Furthermore, nineteen of the active compounds from Dichroae Radix were confirmed to interact with these genes. Conclusions : The results provide valuable insights into the mechanism of action and molecular targets of Dichroae Radix. Notably, Berberine, the main active ingredient of Dichroae Radix, plays a significant role in degrading AR proteins in advanced prostate cancer. Further studies and validations can provide crucial data to advance cancer metastasis prevention and treatment strategies.

• Parasites, Hosts and Diseases
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• 제58권4호
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• pp.393-402
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• 2020

Toxoplasma gondii is an intracellular parasite that causes severe disease when the infection occurs during pregnancy. Adenosine is a purine nucleoside involved in numerous physiological processes; however, the role of adenosine receptors in T. gondii-induced trophoblast cell function has not been investigated until now. The goal of the present study was to evaluate the intracellular signaling pathways regulated by adenosine receptors using a HTR-8/SVneo trophoblast cell model of T. gondii infection. HTR8/SVneo human extravillous trophoblast cells were infected with or without T. gondii and then evaluated for cell morphology, intracellular proliferation of the parasite, adenosine receptor expression, TNF-α production and mitogen-activated protein (MAP) kinase signaling pathways triggered by adenosine A₃ receptor (A₃AR). HTR8/SVneo cells infected with T. gondii exhibited an altered cytoskeletal changes, an increased infection rate and reduced viability in an infection time-dependent manner. T. gondii significantly promoted increased TNF-α production, A₃AR protein levels and p38, ERK1/2 and JNK phosphorylation compared to those observed in uninfected control cells. Moreover, the inhibition of A₃AR by A₃AR siRNA transfection apparently suppressed the T. gondii infection-mediated upregulation of TNF-α, A₃AR production and MAPK activation. In addition, T. gondii-promoted TNF-α secretion was dramatically attenuated by pretreatment with PD098059 or SP600125. These results indicate that A₃AR-mediated activation of ERK1/2 and JNK positively regulates TNF-α secretion in T. gondii-infected HTR8/SVneo cells.

• 한국해양공학회:학술대회논문집
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• 한국해양공학회 2004년도 학술대회지
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• pp.365-369
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• 2004

Recently, Inconel 625 is used widely in offshore processing piping in order to extend the maintenance tenn and improve the quality of anti-corrosion. According to the resistance to attack in various corrosive media at temperatures from $200^{\circ}C$ to aver $1090^{\circ}C$, in combination with good low- and high-temperature mechanical strength. In general, High quality weldments for this material are readily produced by commonly used processes. in recent years, the flux cored arc welding(FCAW) process is becoming more popular due to higher deposition rate and a better weld quality as compared to the shielded metal arc welding (SMAW) process, at the same time, exhibiting equally good weld metal toughness similar to the SAW process. In this study, the weldability and weldment characteristics(mechanical properties and corrosive environment) of Inconel 625 are considered in FCAW weld associated with the several weld shielding gases($80\%Ar\;+\;20\%\;CO_2,\;50\%Ar\;+\;50\%\;CO_2,\;100\%\;CO_2$) in viewpoint of welding productivity.

• 한국결정성장학회지
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• 제20권3호
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• pp.117-124
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• 2010

For Ar=5, Pr=1.18, Le=0.15, Pe=2.89, Cv=1.06, $P_B$=20 Torr, the effects of impurity $(N_2)$ on thermally and solutally buoyancy-driven convection ($Gr_t=3.46{\times}10^4$ and $Gr_s=6.02{\times}10^5$, respectively) are theoretically investigated for further understanding and insight into an essence of thermo-solutal convection occurring in the vapor phase during the physical vapor transport. For $10K{\leq}{\Delta}T{\leq}50K$, the crystal growth rates are intimately related and linearly proportional to a temperature difference between the source and crystal region which is a driving force for thermally buoyancy-driven convection. Moreover, both the dimensionless Peclet number (Pe) and dimensional maximum velocity magnitudes are directly and linearly proportional to ${\Delta}T$. The growth rate is second order-exponentially decayed for $2{\leq}Ar{\leq}5$. This is related to a finding that the effects of side walls tend to stabilize the thermo-solutal convection in the growth reactor. Finally, the growth rate is found to be first order exponentially decayed for $10{\leq}P_B{\leq}200$ Torr.

• 한국소음진동공학회:학술대회논문집
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• 한국소음진동공학회 2008년도 추계학술대회논문집
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• pp.561-562
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• 2008

The numerical analysis of sound radiation by vibrating structure is a well known and mature technology used in many industries. Accurate methods based on the boundary or finite element method have been successfully developed over the last two decades and are now available in standard CAE tools. These methods are however known to require significant computational resources which, furthermore, very quickly increase with the frequency of interest. The low speed of most current methods is a main obstacle for a systematic use of acoustic CAE in industrial design processes. In this paper we are going to present a set of innovative techniques that significantly speed-up the calculation of acoustic radiation indicators (acoustic pressure, velocity, intensity and power; contribution vectors). The modeling is based on the well known combination of finite elements and infinite elements but also combines the following ingredients to obtain a very high performance: o a multi-frontal massively parallel sparse direct solver; o a multi-frequency solver based on the Krylov method; o the use of pellicular acoustic modes as a vector basis for representing acoustic excitations; o the numerical evaluation of Green functions related to the specific geometry of the problem under investigation. All these ingredients are embedded in the ACTRAN/AR CAE tool which provides unprecedented performance for acoustic radiation analysis. The method will be demonstrated on several applications taken from various industries.

• 한국정보과학회:학술대회논문집
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• 한국정보과학회 2007년도 한국컴퓨터종합학술대회논문집 Vol.34 No.1 (C)
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• pp.217-222
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• 2007

본 논문은 두 대의 카메라로부터 들어온 영상을 보여주는 see-through 장치의 사용 환경하에서 일반적인 사용자도 쉽고 편리하게 컴퓨터 시스템 또는 여러 프로세스들을 제어할 수 있는 사용자 인터페이스를 제안한다. 이를 위해 AR기술을 접목하여 영상이 보이는 화면에 가상의 버튼들을 합성하였으며, 화면상에 보이는 손의 위치를 추적하여 손가락에 의한 버튼의 선택 유무를 판단하고 각 상황에 따른 버튼의 색상 변경을 통해 결과를 나타내었다. 사용자는 단순히 화면을 보며 공중에서 손가락을 움직여 버튼을 선택함으로써 관련 작업을 수행 할 수 있다.

• 대기
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• 제17권4호
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• pp.483-492
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• 2007

The objective of this study is to describe scientific progresses in understanding of climate change in the Intergovernmental Panel on Climate Change (IPCC) assessment reports, contributed by Working group I. Since 1988, IPCC's four assessment reports showed significant improvements in understanding of observed climate change, drivers of climate change, detection and attribution of climate change, climate models, and future projection. The results are based on large amounts of observation data, sophisticated analyses of data, improvements of climate models and the simulations. While the First Assessment Report (FAR) in 1990 reported that a detectable anthropogenic influence on climate has little observational evidence, the Fourth Assessment Report (AR4) reported that warming of the climate system is unequivocal and is very likely due to human influences. It is also noted that anthropogenic warming and sea level rise would continue for centuries due to the time scales associated with climate processes and feedbacks, even if greenhouse gas were to be stabilized.

• 한국진공학회:학술대회논문집
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• 한국진공학회 1994년도 제6회 학술발표회 논문개요집
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• pp.35-35
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• 1994

The surface segragation of NiZr, CuZr alloy has been studied wi th X-ray Imotoelectron spectroscopy(XPS), Auger electron spectroscopy(AES) and low energy ion scattering(LEIS). The composition of outmost atomic layer has been determinded by the use of LEIS at several incident energies using Ar+ ion. In the LEIS analysis, the effect of charge exchange has been estimated by a novel measurment of the charge exchange parameters while simul taneous determining the relative concentrations of Ni and Zr and the complementary information obtained will be described. The composition of the clean annealed surface, measured with AES only, will be contrasted wi th the surface concentration of the preferentially sputtered surface. The experimental results has been clearly demonstrated that when the NiZr ruld CuZr alloys are exposed to continuous Ar+ ion bombardment the outermost atomic layer is Zr rich due to preferential sputtering of Ni atoms. where Ni is preferentially sputtered, but the difference in sputtering yields is not sufficient to explain the observed composition. Therefore, it is necessary to consider other processes such as Radiation Induced Segregation(RIS). The surface composition of the heated sample surface predicts that Zr should surface segregate which futher supports the view that part of the Zr enrichment is due to RIS.to RIS.