• 대한치과교정학회지
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• 제37권3호
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• pp.182-191
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• 2007

본 연구는 두개악안면 3차원 입체영상을 이용한 진단 시 유용한 정중시상기준평면 설정에 도움이 되고자 시행되었다. 임상검사를 통하여 안면이 좌우 대칭으로 보이는 성인 정상교합자를 대상으로 두경부 전산화단층사진을 촬영하고 컴퓨터 프로그램을 이용하여 3차원 입체영상으로 재구성하였다. 두개의 정중시상부에 위치하는 Cg, ANS, PNS, Ba, Op 등의 계측점과 Po, Or로 구성된 FH plane을 이용하여 6개의 정중시상기준평면(Cg-ANS-Ba, Cg-ANS-Op, Cg-PNS-Ba, Cg-PNS-Op, FH${\perp}$(Cg, Ba), FH${\perp}$(Cg, Op))을 설정하고, 좌우 대칭성 의 Z, Fr, Fs, Zy, Mx, Ms등 6쌍의 계측점을 선정한 후, 설정된 정중시상기준평면에서부터 각 계측점까지의 좌측 및 우측 거리를 계측하고 t-검정을 통하여 유의차를 검정하는 한편, 좌우 차이값의 정도를 설정된 기준평면간에 비교하였다. 또한 정중시상 기준평면 설정의 재현도를 알아보기 위하여 정중시상기준평면의 설정에 사용된 계측점을 2주 간격으로 재계측하고 비교 분석한 결과, 본 연구에서 사용된 모든 정중시상기준평면이 두개악안면의 3차원적 분석 시 기준평면으로 사용될 수 있으며 특히, Cg와 ANS를 포함한 정중시상기준평면이 보다 타당함을 시사하였다.

• 생물환경조절학회지
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• 제12권2호
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• pp.89-94
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• 2003

본 실험은 토마토의 순환식 시스템 양액재배에서 배액의 재순환 시 안정된 pH와 균형적인 양분 공급 방법을 구명하고자 수행되었다. 배액의 pH나 무기성분을 교정하지 않는 구(대조구), EC측정 및 양분 분석 교정구를 처리내용으로 두었다. 초기생육인 초장은 처리간에 차이가 없었으나 생체중 및 건물중은 양분분석구가 대조구에 비해 무거웠다. 후기생육에서는 양분분석구가 대조구에 비해 과중이 무겁고, 착과수가 많아 수량이 증가하였다 배액 EC는 대조구에 비해 EC측정구와 양분분석구가 전반적으로 낮았다. 배액의 pH는 전 생육기간에서 양분 분석구 및 EC측정구는 6.2∼6.5를 유지하였으나 대조구는 지속적으로 높아져 후기에는 7.2정도 되었다. 배액의 무기성분에서 N, P 및 K의 함량은 모든 처리구에서 셍육이 경과함에 따라 적어졌으며, 대조구에 비해 양분분석구가 적었다 Ca 및 Mg의 함량은 모든 처리구에서 생육초기에는 급격히 감소하였으며 생육후기에는 앙분 분석구와 EC측정구는 적은 상태로 유지되었으나 대조구는 급격히 증가하는 경향이었다. 이상의 결과에서 순환식 시스템을 이용한 토마토의 양액재배시 배액의 양분을 분석한 후 교정하는 것이 생육에 효과적이었다.

• 한국방사성폐기물학회:학술대회논문집
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• 한국방사성폐기물학회 2003년도 가을 학술논문집
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• pp.21-31
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• 2003

IAEA, FT-04-020, ANS 16.1의 침출시험법을 각각 수행하여 얻은 시험결과를 이용하여 상호비교 평가하였다. 붕산을 함유한 파라핀 및 시멘트 고화체에서의 Co-60과 Cs-137의 침출지수는 6이상이었으나 고화매질과 탈염수의 종류에 따라 상반되는 침출거동을 보였다. 침출수로 합성해수와 탈염수를 사용하였을 경우 Co는 시멘트 고화체에서는 합성해수, 파라핀 고화체에서는 탈염수에서 침출이 높았다. 반면에 Cs의 침출정도는 시멘트에서는 탈염수, 파라핀에서는 합성해수에서 높았다. Co의 침출분율은 시멘트 고화체에서 IAEA > ANS > FT의 순으로 높았으며, 반대로 파라핀 고화체에서는 이의 역순이었다.

• 한국식품영양과학회지
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• 제24권3호
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• pp.446-453
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• 1995

The improtant components of extracellular matrix(ECM) are collagen and chondroitin sulfate. The hydrophobic surface of collagen is one of the determining factors of diameter of collagen fiber and also is closely related to the aging phenomena. The controlling mechanism of the diameter of collagen fiber influenced by the interaction with chondroitin sulfate was evaluated using bis-ANS as a hydrophobic probe. Hydrophobic surface area of collagen molecule shielded by chondroitin sulfate was evaluated. Relative fluorescence intensity of collagen in thepresence of chondroitin sulfate was measured using bis-ANS as a hydrophobic probe. The fluorescence intensity decreased with the increase in chondroitin sulfate up to 3.8 chondroitin sulfate/collagen(mole/mole). Further increase in the ratio of chondroitin sulfate to collagen did not change the fluorescence intensity. Similar changes in the relative fluorescence intensity were observed for both rat tail and lathyrific rat skin collagen. The fluorescence intensity indicated by the binding between bis-ANS and hydrophobic sites of collagen was pH dependent, and the shielding effect of collagen-chondroitin sulfate interaction could not be detected at pH above 6.0. This is probably due to the charge repulsions caused by negative charged collagen molecules at higher pH.

• 대한구순구개열학회지
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• 제2권1_2호
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• pp.15-22
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• 1999

It is well known that the postoperative skeletal instability after Le Fort I osteotomy for advancement of maxilla in the cleft patients is one of the major surgical problems. So we had tried to compare the amount of relapse after Le Fort I advancement surgery in the horizontal and vertical positional change, angular change of reference points between cleft patients and non-cleft patients. Longitudinal records of 10 consecutive cleft patients (test group) and 20 non-cleft patients (control group) were analyzed. Lateral cephalograms were taken preoperatively, immediately postoperatively, and 2, 6, 12 months postoperatively. We measured horizontal and vertical changes (ANS, PNS, AI) and angular change (SNA) of the reference points and lines. In the test group, horizontal relapse of ANS, PNS, AI point are 36.4%, 37.5%, 32.0% respectively at 12 months postoperatively. The vertical relapse of ANS, PNS, AI are 25.3%, 32.3%, 39.1% respectively at 12 months postoperatively. The angular change of SNA is 33.6% at 12 months postoperatively. In the control group, horizontal relapse of ANS, PNS, AI point are 23.8%, 30.2%, 21.7% respectively at 12 months postoperatively. The vertical relapse of ANS, PNS, AI are 22.7%, 27.3%, 25.1% respectively at 12 months postoperatively. The angular change of SNA is 22.2% at 12 months postoperatively. The cleft patients have a larger tendency of skeletal and dental relapse compared with non-cleft patients after Le Fort I surgery. So the oral and maxillofacial surgeons must keep in mind these facts in order to minimize the relapse phenomenon from the beginning of surgical planning to postoperative care.

• BMB Reports
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• 제29권3호
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• pp.230-235
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• 1996

The interaction of ${\alpha}-ketoglutarate$ dehydrogenase complex (${\alpha}-KGDC$) with a hydrophobic fluorescent probe [1,1'-bi(4-aniline)naphthalene-5,5'-disulfonic acid] (bis-ANS) was studied. The punfied ${\alpha}-KGDC$ was potently inhibited by bis-ANS with an apparent half maximal inhibitory concentration ($IC_{50}$) of 9.8 ${\mu}m$ at pH 8.0. The catalytic activities of both the E1o and E2o subunits were predominantly inhibited while that of the E3 component was hardly affected. The binding of bis-ANS to the enzyme caused a marked enhancement and blue shift from 523 nm to 482 nm in the fluorescence emission spectrum. The dissociation constant ($K_d$) and the number of binding sites (n) were calculated to be 0.87 mM and 158, respectively. Allosteric regulators such as purine nucleotides and divalent cations further increased the fluorescence intensity of the $bis-ANS-{\alpha}-KGDC$ binary complex. These data suggest that the binding of these allosteric regulators to ${\alpha}-KGDC$ may cause the conformational changes in the enzyme and that bis-ANS could be used as a valuable probe to study the interaction of the multi-enzyme complex and its allosteric regulators.

• Journal of Pharmaceutical Investigation
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• 제22권4호
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• pp.289-300
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• 1992

The counter-transport phenomena in the hepatic transport of 1-anilino-8-naphthalene sulfonate (ANS) were kinetically investigated by analyzing the plasma disappearance-time profiles and the transport into the isolated hepatocytes. In vivo "counter transport phenomena" were simulated based on the perfusion model which incorporated the carrier-mediated transport and the saturable intracellular binding. The condition that the mobility of carrier-ligand complex is greater than that of free carrier is not essential for the occurrence of counter-transport phenomenon. To examine the inhibitory effects on the initial uptake of a ligand by the liver, it is necessary to judge whether the true counter-transport mechanism (trans-stimulation) is working or not. The initial plasma disappearance curves of ANS were then kinetically analyzed based on a two-compartment model, in which the ligand is eliminated only from the peripheral compartment (liver compartment). No effects on the initial plasma disappearance rates of ANS were observed after preloading of bromophenol blue (BPB) or rose bengal (RB) in the liver. Inhibitory effect of BPB or RB on the initial uptake (or efflux) rates of ANS by the isolated hepatocytes were not observed, suggesting that the true counter transport mechanism is not working. In conclusion, checking the preloading effects of transstimulation on the initial uptake of a ligand by the liver could be a useful criterion for carrier cycling and common use of the same carrier between two ligands. However, one cannot exclude those possibilities even if the preloading effects cannot be observed.

• 한국식품과학회지
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• 제25권5호
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• pp.571-575
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• 1993

대두 펩타이드의 표면소수도가 혈청 콜레스테롤의 농도에 미치는 영향을 조사하기 위하여, 대두 단백질(ISP), 카세인(CNP), 이들 단백질을 펩신으로 가수분해하여 pH에 따른 펩타이드 침전 획분들(SHT, SH8, SH6, SH4, CHT, CH6, CH5, CH4)을 흰쥐에 섭취시키고 혈청 콜레스테롤 농도 및 분변 스테로이드이 배설량을 측정하였다. 그리고 각 펩타이드의 표면소수도를 ANS 형광법 및 SDS 결합법으로 측정하여, 이들의 상관관계를 분석한 결과, 펩타이드의 ANS 표면소수도가 높아질수록 분변으로 배설된 스테로이드량은 증가하였으며(r=0.81), 혈청 콜레스테롤 농도는 낮아졌다.(r=-0.868). 그러나 SDS 표면소수도는 그들과 상관관계가 없었다. 또한 대두 단백질은 가수분해에 의하여 ANS 표면소수도가 증가하였다. 이상의 결과는 흰쥐의 담즙염이, 소화중 생성된 높은 표면소수도의 펩타이드와 결합하여 체외로 배출되므로서 대두단백질의 섭취에 의한 혈청 콜레스테롤 농도가 낮아짐을 시사하였다.

• 한국원자력학회:학술대회논문집
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• 한국원자력학회 1996년도 춘계학술발표회논문집(2)
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• pp.467-472
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• 1996

This study discusses special aspects of severe accident related recriticality modeling and analysis in the Advanced Neutron Source (ANS) reactor.$^{1, 2)}$ The analytical comparison of three elements core to former two elements case is conducted including evaluation of suitable nuclear cross-section sets to account for the effects of system configulation, fuel and moderator mixture temperature, material dispersion and the other thermal-hydraulics. Three elements core ANS reactor is the alternative core design which was proposed as a modified core design, with three fuel elements instead of two, that would allow operation with only 50% enriched uranium (former uranium fuel is the baseline design value of 93%) A comprehensive test matrix of calculations to evaluate the threat of a criticality event in the ANS is described. Strong dependencies still on geometry, material constituents, and thermal-hydraulic conditions are verified. Therefore, the concepts of mitigative design features are qualified.d.

• 한국압력기기공학회 논문집
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• 제14권1호
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• pp.48-57
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• 2018

Configuration management (CM) is the process of identifying and documenting characteristics of plant structures, systems and components (SSCs), and of ensuring that changes to these characteristics are properly assessed, approved, implemented, verified and recorded. The purpose of this study is to examine regulation and technical standards developed under different concepts and level of depth for classification of nuclear SSCs as an essential prerequisite of the CM. In this context, main contents of currently adopted NSSC Notice 2016-10 are reviewed and compared with those in recently published ANSI/ANS 58.14 and IAEA SSG-30. The technical standards were prototypically used for classification of O-rings in two nuclear systems. It is found that ANSI/ANS 58.14 results in different categories taking into account specific features while IAEA SSG-30 leads to same categorization of the O-rings. Key findings will be summarized for Korean regulatory amendment in the future.