• Title/Summary/Keyword: ANG-2

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Inhibition of C2-ceramide induced contraction in cat esophageal smooth muscle cell by newly synthesized Ceramide analogues

  • Lee, Doo-Won;Yang, Sung-Jun;Lee, Yul-Pyo;Lee, Tai-Sang;Park, Jun-Hong;Choi, Su-Hang;Yim, Chul-Bu;Sohn, Uy-Dong;Choi, Tae-Sik
    • Proceedings of the PSK Conference
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    • 2002.10a
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    • pp.248.1-248.1
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    • 2002

  • It has been shown that C2-ceramide (C2), short chain ceramide, plays a role in mediating contraction of cat esophageal smooth muscle cells. We examined the effect of newly synthesized ceramide analogues on the C2-ceramide induced contraction in esophageal smooth muscle cells isolated with collagenase. C2-ceramide produced contraction of smooth muscle cells in a dose dependent manner. (omitted)

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Identification of a novel $Ca^{2+}$-independent Phospholipase $A_2$ in Bovine Brain

  • Jeong, Eui-Man;Jun, Hyung-Jin;Kim, Ha-Dong;Lee, Ho-Sup;Min, Pil-Gi;Jo, Dong-Hwan;Jung, Sung-Yun;Kim, Dea-Kyong
    • Proceedings of the PSK Conference
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    • 2003.10b
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    • pp.102.1-102.1
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    • 2003

  • Phospholipase A$_2$(PLA$_2$) catalyzes the hydrolysis of the sn-2 position of membrane glycerophospholipids to liberate arachidonic acid(AA), a precursor of eicosanoids including prostaglandins(PGs) and leukotrienes (LTs). The same reaction also produces lyso-phospholipids. So far, at least 19 enzymes that possess PLA2 activity have been identified, consists of low-molecular-weight, Ca$\^$2+/-requiring, secretory enzymes that have been implicated in a number of biological processes, such as modification of eicosanoid generation, inflammation, host defense, and atherosclerosis. (omitted)

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