• Health Policy and Management
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• v.15 no.1
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• pp.57-77
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• 2005

The purpose of this study was to assess medical professionals' knowledge and attitude about AIDS. The subjects of study were medical doctors and dentists, belonging to Korea Association of Public Health Doctors. We sent a e-mailed questionnaire to 3,059 members and received 407 replies. Questionnaire was made on the basis of former studies' results and interviews with infected people. Major findings of this study were as follow. A lot of medical professionals had incorrect and biased knowledge about AIDS. More than half of them overestimated infection probability in case of being prickled with a contaminated needle. And many has negative attitude. The more they had correct informations about AIDS, the more they had possibilities to have friendly attitude to infected people. Incorrect knowledge cause excessive fears about AIDS, which amplify the stigma and discrimination. They contribute to people's vulnerability not only to HIV infection but also to other threats to health and well-being. It is in need of medical professionals' effort to increase their knowledge and improve attitude about AIDS.

• Journal of Korean Academy of Nursing
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• v.31 no.2
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• pp.292-303
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• 2001

The purpose of the study was to find out the level of knowledge, attitude, subjective norm, social interaction, and behavioral intention of nursing students regarding AIDS. It also identified factors that predict behavioral intentions and to provide care for patients with AIDS using Theory of Reasoned Action. The subjects consisted of 117 nursing students at three universities. Data was collected with self reporting in a questionnaire of with 67 items. Data was analyzed by an SPSS pc+ program. The results were as follows; 1. The mean age of the subjects was 20.98 years. The mean score for HIV/AIDS knowledge was 24.444 out of 32. Mostly Korean students were quite knowledgeable about the basic facts and symptoms of AIDS but confused about the made of transmission such as public toilets, prevention methods, and especially infection control. 2. This study found that social interaction, attitudes and subjective norms of Korean nursing students explained the intention to care for AIDS patients. The students who had a more positive attitude toward caring for AIDS patients and those who perceived more support from their significant others for caring the AIDS patients reported a more positive intention to care for AIDS patients. 3. In stepwise multiple regression analysis, 47.58% of the variance in AIDS patient care intention was accounted for by social interaction (33.41%), attitude (9.1%), and subjective norm (5.0 %). According to the finding of this study, and social interaction are the most significant predictors of intentions. Therefore it can be suggested that a HIV/AIDS prevention program should focus on transmission modes and prevention methods, especially in infection control. AIDS education efforts aimed at nursing students should place greater emphasis on correcting these kinds of misconceptions. Nursing intenvention for reducing fear of contagion, improving perception of social interaction, fostering positive attitudes and increasing intention to care for AIDS patients should be provided for nursing students. They also recommended that nursing students be adequately prepared to care for AIDS patients because of the increasing probability that they will encounter AIDS patients. Therefore it is important that education about HIV/AIDS should be incorporated within current undergraduate curriculum.

• Journal of Korean Academy of Nursing
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• v.27 no.1
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• pp.201-211
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• 1997

This study was an evaluation study of AIDS education program. The purpose of this study was to clarify the education effects on AIDS for health care workers to develop a better next education program. This study was done by self reporting with a 67 items of structured questionnaire by 431 health care workers included doctors, nurses, laboratory technicians, and health educators. Data were collected at the time of completion of each AIDS education with the help of education program manager. Both the AIDS related knowledge score and the acceptance attitudes score were significantly higher in the male group, in the medical institution employer group, in the group who have met the HIV infected person, who has known the HIV positive person, and the group of laboratory technician, but the AIDS prevention intention score was statistically higher in the group of female and laboratory technician group. The post education scores of AIDS related knowledge. acceptance attitudes, and preventive intention were statistically higher than those of the preeducation. The most increased item among AIDS prevention intention list was 'I will provide the meeting between the HIV infected persons and the public (+21.9%)'. But even the decreased item among AIDS prevention intention list was 'I will advice to female not to have extra marital sexual contact to avoid AIDS(-3.1%)'. It could be concluded that the health care workers were ignorant of vertical transmission of AIDS, they were afraid of disclosing the infection status, and have less AIDS prevention intention. Therefore it is needed to take an assessment process before each new education trategy to increase AIDS related the effect of the education on AIDS.

• Proceedings of the Korean Society of Applied Pharmacology
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• 1993.04a
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• pp.80-80
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• 1993

(목적) 본 연구에서 사용된 바이러스는 HIV-1 nef유전자가 일부 삭제되고 대신 Chloramphenicol acetyltransferase(CAT)가 pSVCAT recombinant 바이러스다. 이러한 recombinant 바이러스를 사용하는 이유는 첫째, CAT activity가 매우 민감하므로 바이러스의 복제억제 정도를 정확하게 측정 할 수 있고 둘째, simian immunodeficiency virus(SIV)의 경우 nef 유전가 in vivo에서는 바이러스의 복제에 필수적이므로 HIV가 SIV와 유사한 것으로 미루어 본 연구에서 사용되는 recombinant SVCAT 바이러스가 안전한 것으로 고려되기 때문이다. (방법) 특히 화합물이 HIV-1의 복제에 얼마나 영향이 있는가는 1) 어느정 도의 virus inoculm을 넣었는지 2) 사용하는 cell line 3) 사용한 cell line의 infection kinetics 4) 실험의 지속기간 5) 테스트하는 assay의 sensitivity에 의존한다. 따라서 $10^{5}$ cell의 H9과 sup T1을 24 well plate에 넣고 sup T1 cell line의 경우 3일 후 항 화합물에 의한 syncytia 형성 및 CAT activity의 억제정도를 현재 AIDS drug으로 쓰이고 있는 Zidovudine을 control로 비교 관찰하였다. H9 cell line의 경우 3일 간격으로 media의 3/4을 fresh media로 바꾸어 주고 9일 후 CAT assay를 하였다. 이러한 assay에서 activity를 보이는 화합물을 reverse transcriptase와 P24 ELISA assay를 재확인하였다.다.

• Journal of Convergence for Information Technology
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• v.10 no.8
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• pp.108-119
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• 2020

This describes the level of knowledge and attitudes about HIV and their related factors among Cambodian adolescents. A cross-sectional design was used to examine the knowledge and attitude of 463 Cambodian high school students using HIV-KQ-18 (HIV-Knowledge Questionnaire-18) and HIV/AIDS Behavior Surveillance Survey Index (measuring attitude about HIV). The majority of the adolescents had a relatively low level of overall HIV knowledge (6.70 ± 3.66 (range: 0-16)) and held a very negative attitude (1.92 ± 0.87 points (range: 0-4)) toward the disease. Using multiple regression analysis, being male (β = 0.28, p < 0.001) and using YouTube as a social network service (β = 0.33, p = 0.035) were found to be independent factors associated with higher level of HIV knowledge. Study findings suggest the importance of informing policymakers and school nurses about the need to develop a and require a culturally sensitive specific health education program on HIV for Cambodian adolescents.

• RED RIBBON
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• s.28
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• pp.10-11
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• 1999

• Proceedings of the PSK Conference
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• 2002.10a
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• pp.155-160
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• 2002

A series of modified oligonucleotides containing a phosphorothioate (P=S) backbone and a six-membered azasugar (6-AZS) as a sugar substitute in a nucleotide were synthesized and tested for their ability to inhibit the human immunodeficiency virus type I(HIV-l) in vitro without the aid of any transfecting agents. While P=S oligonucleotides with natural nucleotides had little anti-HIV-l activity, the six-membered azasugar nucleotide (6-AZN)-containing P=S oligonucleotides (AZPSONs) potently inhibited the HIV-l/SHIV replication and syncytium formation (ECso = 0.02-0.2 /lM) without cytotoxicity up to 100 /lM. DBM-2198, the most effective in anti-HIV-l activity among the AZPSONs, consists of random sequence and five 6¬AZNs evenly distributed in 18 nucleotides. DBM-2198 showed strong antiviral activity against, not only laboratory strains, but also primary isolates and even drug-resistant strains of HIV-I. DBM-2198 was much more effective than ddI or ddC in its anti-HIV-l activity in vitro. Particularly noteworthy is that the anti-HIV-l activity of DBM-2198 was better than that of AZT with respect to its long-lasting efficacy after a single treatment. Nevertheless, the antiviral activity of the AZPSONs was very specific to HIV-I. Poliovirus, or even simian immunodeficiency virus (SIV), was not inhibited by the AZPSONs. Taken together, our results strongly suggest that AZPSON can be used as a safe and effective AIDS-therapeutic drug against a broad spectrum of HIV -1 strains.

• Proceedings of the Microbiological Society of Korea Conference
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• 2006.05a
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• pp.17-19
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• 2006

• The Journal of the Korean life insurance medical association
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• v.29 no.1
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• pp.4-6
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• 2010

The life expectancy of HIV-infected subjects has improved dramatically since the introduction of highly-active antiretroviral therapy (HAART). Considering that patients with HIV infection are living longer, treatment plans should include those for the accompanying co-morbidities such as cardiovascular diseases, metabolic syndrome, malignancy, etc. This review discusses the impact of HAART on the epidemiology of survival and co-morbidities (malignancy and cardiovascular diseases) among HIV-infected subjects.

• Journal of Preventive Medicine and Public Health
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• v.26 no.4 s.44
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• pp.541-550
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• 1993

In order to investigate psychological and behavioral characteristics of homosexuals and to present evidence that homosexuals are in danger of HIV infection in Korea, this study was done by self-administered questionnaire and then direct interview with the 28 (35%) HIV infected homosexual/bisexuals of 79 HIV infected persons reported in 1992. Homosexuals without heterosexual activity were 9 and the others were bisexuals. Sixty-five percent of respondents had a guilty conscience for their homosexual activty. Twenty (71%) were in twenties and 5 (18%) in thirties. Twelve(43%) were detected via health card checking by health office, 21% by blood donation, 18% by hospital visit, and 7% by partner notification. Motivations for homosexual activity were curiosity (36%), temptation or recommendation (14%) and compulsion (11%). Eighteen (72%) never used condom on anal sex. Nine of 26 respondents had experience for anal sex with foreigners. Fourteen (54%) of 26 respondents had history for sexually transmitted diseases. Fighty percent did not have sexual contact after HIV infection and the others usually used condom. It was confirmed that over 57% of the respondents were infected within 1 year before HIV diagnosis and over 82% within 2 years. These data suggest that HTV infection among homosexual group is rapidly spreading.