• Biomedical Science Letters
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• v.25 no.3
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• pp.256-266
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• 2019

In this study, obese adults were compared for their ability to predict obesity and lipid related variables and their optimal cutoff values to predict metabolic syndrome and insulin resistance. In this study, 9,256 adults aged 20 years or older and less than 80 years old, who were in the Gyeonggi region from January 2014 to December 2016 and who were examined at a general hospital, were enrolled. The diagnostic criteria for obesity were WHO (World Health Organization), and BMI $25kg/m^2$ or more presented in the Asia-Pacific region. Metabolic syndrome was diagnosed based on the criteria of American Heart Association / National Heart, Lung, and Blood Institute (AHA / NHLBI). According to the results of receiver operating characteristic curve (ROC) analysis, Triglyceride / HDL-cholesterol (TG / HDL-C), Triglyceride and Glucose (TyG) index, lipid accumulation product (LAP) and visceral adiposity index (VAI) showed high predictive power for diagnosing metabolic syndrome. The diagnostic accuracy of LAP (AUC: 0.854) for males and VAI (0.888) for females was the highest. The optimal cutoff value of LAP was 42.71 for male and 35.44 for female, and the cutoff value of VAI was 1.92 for male and 2.15 for female. In addition, WHtR (waist to height ratio), TyG index, and LAP were used as predictors of insulin resistance in obese adults. Therefore, LAP and VAI were superior to other indicators in predicting metabolic syndrome in obese adults.

• Steel and Composite Structures
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• v.50 no.4
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• pp.443-458
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• 2024

The construction industry, one of the biggest producers of greenhouse emissions, is under a lot of pressure as a result of growing worries about how climate change may affect local communities. Geopolymer concrete (GPC) has emerged as a feasible choice for construction materials as a result of the environmental issues connected to the manufacture of cement. The findings of this study contribute to the development of machine learning methods for estimating the properties of eco-friendly concrete, which might be used in lieu of traditional concrete to reduce CO₂ emissions in the building industry. In the present work, the compressive strength (f_c) of GPC is calculated using random forests regression (RFR) methodology where natural zeolite (NZ) and silica fume (SF) replace ground granulated blast-furnace slag (GGBFS). From the literature, a thorough set of experimental experiments on GPC samples were compiled, totaling 254 data rows. The considered RFR integrated with artificial hummingbird optimization (AHA), black widow optimization algorithm (BWOA), and chimp optimization algorithm (ChOA), abbreviated as ARFR, BRFR, and CRFR. The outcomes obtained for RFR models demonstrated satisfactory performance across all evaluation metrics in the prediction procedure. For R² metric, the CRFR model gained 0.9988 and 0.9981 in the train and test data set higher than those for BRFR (0.9982 and 0.9969), followed by ARFR (0.9971 and 0.9956). Some other error and distribution metrics depicted a roughly 50% improvement for CRFR respect to ARFR.

• Journal of Korean Academy of Fundamentals of Nursing
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• v.10 no.2
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• pp.163-170
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• 2003

Purpose: This study was done to identify stress, fatigue, and self efficacy in patients on dialysis and identify their effect on quality of life. Method: The participants (n=149) who agreed to participate in the research were selected from among those who were on dialysis treatment at C University Medical Centers in Seoul and Inchon, and at C University Medical Center in Jeju. The data were collected from July, 2001 to March, 2002 using interviews. Data analysis was done with t-test, ANOVA, and multiple stepwise regression using the SAS program. Result: Quality of life was significantly different according to economic status, and type of dialysis. Quality of life for the group with higher economic status was better than for the group with lower economic status, and the group on peritoneal dialysis had higher quality of lift scores than the group on hemodialysis. As for self-efficacy, there were significant difference according to duration of disease, type of dialysis, and duration of dialysis. Stress was significantly different according to marital status. Quality of life was significantly predicted by stress (40.02%) and fatigue (3.85%). Conclusion: To improve quality of life for people on dialysis, their stress should be treated positively, also multi-dimensional nursing interventions to provide emotional support and nursing interventions to diminish fatigue are required.

• Korean Journal of Clinical Pharmacy
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• v.22 no.2
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• pp.113-122
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• 2012

ACC/AHA/SCAI Guideline recommends for administration dual antiplatelet therapy after drug-eluting stent (DES) to prevent restenosis and stent thrombosis in patients with percutaneous coronary intervention (PCI). Recently triple antiplatelet therapy including cilostazol is known to reduce restenosis and stent thrombosis significantly after DES implantation. However, there is lack of data providing the efficacy of triple antiplatelet therapy. The purpose of this study is to evaluate the clinical effects of the triple therapy after DES implantation compared with the dual therapy. This retrospective study collected data from medical charts of 251 patients who received DES implantation between Jul 2006 and Jun 2008. They received either dual antiplatelet therapy (N = 154 clopidogrel and aspirin; Dual group) or triple antiplatelet therapy (N = 97 cliostazol, clopidogrel and aspirin; Triple group). Major adverse cardiac event rates (MACE, included total death, myocardial infarction, target lesion revascularization) at 12 months, 24 months, stent thrombosis, rates of bleeding complications and adverse drug reactions were compared between these two groups. Compared with the dual group, the triple group had a similar incidence of the MACE rates at 24months (12.3% vs. 12.4%, p = 0.99). There is no difference in overall stent thrombosis between two groups (Dual group 2.6% vs. Triple group 4.1%, p = 0.5). Subgroup analysis showed that diabetic patients got more benefit in reducing MACE rates but, there is no statistical difference. Bleeding complications and adverse drug effects were not different significantly. As compared with dual antiplatelet therapy, triple antiplatelet therapy did not reduce the 12-months, 24-months MACE rates and stent thrombosis. Bleeding complications and adverse drug effects were not different.

• YAKHAK HOEJI
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• v.40 no.2
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• pp.155-162
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• 1996

Hyperkeratinization is a dermatologic disorder, which is due to the increase of corneocyte cohesion force. Glycolic acid, an alpha hydroxy acid(AHA), has been used to breakdown the hyperkeratinization processes. However, it has a problem of skin irritation when applied topically, due to the strong acidity especially in high concentration. A molecular optimization of glycolic acid has been tried to reduce the skin irritation by the way of prodrug formation. Ethyl glycolate was synthesized by the esterification of glycolic acid with ethanol in acidic conditions in the presence of sulfuric acid, and examined under the spectroscopic trials, such as UV, IR, $^1H$-NMR, and GC-MS. The physicochemical and biopharmaceutical properties of the prodrug were also evaluated. Through the toxicological tests of both skin irritation and eye mucous irritation, it has been proved that ethyl glycolate was less irritant than glycolic acid, since the pH value of synthetic prodrug was higher than that of glycolic acid. In the penetration test through nude mouse skin by diffusion cell, ethyl glycolate was continuously hydrolyzed to glycolic acid, which was assayed form the receptor compartment. It was obtained that the penetrated amount of ethyl glycolate was five times higher than that of glycolic acid. These results suggest that ethyl glycolate might be a successful prodrug of glycolic acid to reduce the skin irritation and to increase the skin penetration as well.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.16 no.1
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• pp.480-489
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• 2015

This study aimed to compare the education effect of easily accessible cardiopulmonary resuscitation (CPR) applications on smart-phones. The differences of performance and accuracy of CPR between animation CPR group and modified Pocket CPR group in Reserve Officers' Training Corps students of K university were evaluated by 2010 AHA guidelines. Data were collected from May 19, 2012 to May 20, 2012. There was no statistically significant difference between both of group in the performance and accuracy of CPR. However, the modified Pocket CPR group showed significant increase in the accuracy of chest compression depth (26.4%, p<.05), while the animation CPR group showed significant increase in the accuracy of chest compression location after the education (25.2%, p<.01). In conclusion, the methods using advantage and complementing disadvantage of animation CPR application and Pocket CPR application could help that people could easily access and perform to CPR.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.11 no.2
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• pp.733-740
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• 2010

This study was carried out examine the difference in the quality of CPR between knee protection and no knee protection when CPR is performed with mannequin on the floor covered with laminated paper. Subjects of the research were 48 experimental group and 56 control group who were college students in G province and U metropolitan city and completed AHA BLS Provider Course from Apr. 20 to Nov. 15, 2009. This study made knee pad(material: polyester 100%, thickness: 2.5cm, width 16cm${\times}$length 17cm) to protect knee for experimental treatment and measurement of CPR quality was connected with Resusci Anne(Leardal, Norway) mannequin and the results of CPR were recorded with Resusci Anne $Skillreporter^{TM}$(Leardal, Norway). Collected data were analyzed by SPSS/PC+(version 14.0). In conclusion, knee protection in CPR on the floor covered with laminated paper showed higher quality of CPR than that of no knee protection regardless of sex, height and weight.

• Research in Community and Public Health Nursing
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• v.23 no.1
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• pp.13-21
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• 2012

Purpose: The purpose of this study was to estimate the effects of lifestyle factors on metabolic syndrome (MS) among Korean adults ($age{\geq}20$). Methods: A total of 7,798 subjects (weighted subjects=37,215,961) were recruited from the 2009 Fourth Korea National Health and Nutrition Examination Survey (KNHANES IV-3). Data were analyzed by t-test, ${\chi}^2$-test, and logistic regression in consideration of strata, cluster and weight as national data using the SAS 9.1 program. Results: The prevalence of MS by definition of AHA/NHLBI and waist circumference cutoff points for Koreans was 22.4%. The mean clinical MS score for MS patients was 3.4, but the mean score for the non-MS group was 1.2 out of 5.0. Among the lifestyle factors, smoking (OR=1.024), stress ($0.546{\leq}OR{\leq}0.587$) and drinking (OR=1.005) had significant influence on the MS risk and MS scores, but exercise did not. Conclusion: The results of this study indicate that further research is necessary on the effect of lifestyle factors on MS risk and nurses should focus on effective programs about smoking, stress and drinking for the prevention and reduction of MS risk.

• BMB Reports
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• v.38 no.5
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• pp.602-608
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• 2005

As a crucial transcription factor family, heat-shock factors were mainly analyzed and characterized in tomato and Arabidopsis. In this study, we isolated two putative heat shock factors OsHSF6 and OsHSF12 that interact specifically with heat-shock element (HSE) from Oryza sativa L by yeast one-hybrid method. The full-length cDNA of OsHSF6 and OsHSF12 have 1074bp and 920bp open reading frame (ORF), respectively. Analysis of the deduced amino acid sequences revealed that OsHSF6 was a class A heat shock factor (HSF) with all the conserved sequence elements characteristic of heat stress transcription factor, while OsHSF12 was a class B HSF with C-terminal domain (CTD) lacking of AHA motif. Bioinformatic analysis showed that the sequences and structures of two HSFs' DNA binding domain (DBD) had a high similarity with LpHSF24. The results of RT-PCR indicated OsHSF6 gene was expressed immediately after rice plants exposure to heat stress, and the transcription of OsHSF6 gene accumulated primarily in immature seeds, roots and leaves. However, we did not find the transcription of OsHSF12 gene in different organs and growth periods. Our results implied that OsHSF6 might be function as a HSF regulating early expression of stress genes in response to heat shock, and OsHSF12 might be act as a synergistic factor to regulate the expression of down-stream genes.

• The Journal of Internal Korean Medicine
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• v.34 no.2
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• pp.215-229
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• 2013

Objectives : Basic life support (BLS) is considered one of the essential clinical skills medical students should master. Nevertheless, neither the current state of education nor the educative effect of and attitudes toward BLS in Korean medical students have yet been reported. The aim of this study was to examine the educative effect of BLS training for Korean medical students in terms of attitudes, knowledge, and skills. Methods : Surveys concerning attitudes toward BLS and its education, and tests for knowledge and scheme performance were conducted with 85 students in a college of Korean medicine under training for American Heart Association (AHA) BLS course for healthcare providers. Results : Before training, 70.6% of students answered they felt the necessity to be trained in the BLS course. The levels of confidence to perform and self-presumed knowledge on BLS were low at first. After training, however, the level of confidence and knowledge increased significantly. In the final test, the mean scores of written test and scheme performance significantly decreased, while the level of confidence didn't. Most of the participants answered they wanted to be re-trained under regular re-education system. Conclusions : To evaluate the current state of BLS education and its educative effect in Korean medical schools, it's required to expand the target of research to larger number of colleges and students over the country.