• Asian Pacific Journal of Cancer Prevention
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• v.15 no.14
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• pp.5587-5592
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• 2014

Aloe-emodin (AE), a natural anthraquinone compound, has been reported to exhibit anticancer activity in various cancer cell lines and anti-inflammatory effects in murine macrophages. In the present study, we investigated the cancer chemopreventive effects of AE in an Apc-deficient Min mouse model. In the first experiment, male Min mice were fed a basal diet or diets containing 5 ppm AE and 10 ppm AE for 12 weeks. The dietary administration of 5 ppm AE significantly reduced the number of colorectal tumors. In a second experiment, we investigated the effects of AE on colitis-related colon carcinogenesis in Min mouse treated with dextran sodium sulfate (DSS). Female Min mice were administered 1% DSS in their drinking water for 7 days. AE was given to mice in their diet at a dose of 5 or 50 ppm for 5 weeks. Feeding with AE significantly reduced the number of colorectal tumors. When proliferation of cells in normal-appearing colonic mucosa was assessed by monoclonal anti-rat Ki-67 antibody (MIB-5) immunohistochemistry in experiments 1 and 2, the AE treatment significantly decreased the mean MIB-5-labeling index. These results suggest that the dietary administration of low-dose AE may have chemopreventive effects against development of colorectal tumors in Min mice, possibly in part by reducing cell proliferation in colorectal mucosa.

• Journal of the Korean Society of Safety
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• v.38 no.2
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• pp.36-43
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• 2023

In this study, a four-point bending test was conducted to assess and detect the damage to reinforced concrete structures using the acoustic emission (AE) technique. Based on the crack investigation results, flexural failure was classified into four stages and compared with the characteristic analysis results of AE parameters. The parametric characterization indicated that the activity of the primary AE signal was high in the early stage, and that of the second signal increased after the flexural cracks stabilized. Because the secondary AE signal included noise generated by friction, parameter-based analysis for damage assessment was performed using the primary signal; the secondary signal was used as complement. The activity analyses of the primary and secondary signals effectively classified crack propagation; however, determining the macrocracks and yielding of reinforcing bars had certain limitations. Nevertheless, applying the damage index with cumulative AE energy is a complementary technique for detecting and assessing structure damage that well detects the occurrence of macrocracks.

• Journal of Korean society of Dental Hygiene
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• v.13 no.1
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• pp.13-20
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• 2013

Objectives : This research is performed to arrange oral health improvement program and improve the quality of life by raising total health index of male workers. The relationship between the oral health, oral health index and total health index of workers are investigated through the direct or indirect effects based on structural equational modeling. Methods : Total 272 people who work in Gyeong-Nam province participated in this survey. Results : Oral health knowledge has an meaningful direct effects on the oral health practice with ${\gamma}$=.259 and dietary pattern with ${\gamma}$=.224. Total health index has indirect relationship with the oral health index with ${\beta}$=.141 and dietary pattern has direct relationship with the oral health index with ${\beta}$=.315. The oral health index has direct relationship with total health index with ${\beta}$=.454. Conclusions : Our research shows that there is meaningful relationship between the oral health, oral health index and total health index of workers. The systematic and continuous programs for oral health should be transferred to workers for the raise of oral health and the quality of the life.

• Journal of Korean Medicine for Obesity Research
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• v.23 no.1
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• pp.28-41
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• 2023

Objectives: This study was aimed to evaluate the hemodynamic feasibility using pulse parameters as a way to establish safe dose guidelines for herbal prescription containing Ephedra herb (Ephedra intermedia Schrenk & C.A.Mey) on weight loss, and to provide a foundation for developing evidence-based guidelines for clinical use. Methods: Forty-two volunteers were recruited to participate in a study examining the changes in pulse wave characteristics following the ingestion of Gambi-hwan, a herbal prescription containing ephedra, over a period of 4 weeks, and pulse wave measurements were taken before and after the administration. Pulse wave parameters were measured in this study using a 3-dimensional radial pulse tonometry device (DMP-Lifeplus). In addition, questionnaire, blood pressure, temperature, and body composition were also measured as secondary measures. Results: Fifteen minutes after administration of Gambi-hwan, the non-adverse event group (non-AE) exhibited a statistically significant increase in several power and pressure-related parameters, including h1, h5, systolic area, pulse area, and pulse width, while the AE group showed a trend of decreasing stroke volume and increasing Radial Augmentation Index (RAI), w, and w/t. After 4 weeks of administration, both groups exhibited significant changes in pulse rate, w/t, RAI, t3/t, stroke volume (SV), and stroke volume Index (SVI). Notably, there are significant differences between AE group and non-AE group in w/t, SV, and SVI. Conclusions: These findings suggest that pulse parameters may be a useful way to establish safe dosing guidelines for weight loss herbal prescription containing ephedra. Further research is needed to confirm these results and to develop evidence-based guidelines for clinical use.

• Journal of Astronomy and Space Sciences
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• v.31 no.1
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• pp.7-13
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• 2014

Variabilities in the solar wind cause disturbances throughout the heliosphere on all temporal and spatial scales, which leads to changeable space weather. As a view of space weather forecasting, in particular, it is important to know direct and indirect causes modulating the space environment near the Earth in advance. Recently, there are discussions on a role of the interaction of the solar wind with Mercury in affecting the solar wind velocity in the Earth's neighborhood during its inferior conjunctions. In this study we investigate a question of whether other parameters describing the space environment near the Earth are modulated by the inner planets' wake, by examining whether the interplanetary magnetic field and the proton density in the solar wind observed by the Advanced Composition Explorer (ACE) spacecraft, and the geomagnetic field via the Dst index and Auroral Electrojet index (AE index) are dependent upon the relative position of the inner planets. We find there are indeed apparent variations. For example, the mean variations of the geomagnetic fields measured in the Earth's neighborhood apparently have varied with a timescale of about 10 to 25 days. Those variations in the parameters we have studied, however, turn out to be a part of random fluctuations and have nothing to do with the relative position of inner planets. Moreover, it is found that variations of the proton density in the solar wind, the Dst index, and the AE index are distributed with the Gaussian distribution. Finally, we point out that some of properties in the behavior of the random fluctuation are to be studied.

• Proceedings of the Materials Research Society of Korea Conference
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• 2006.05a
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• pp.28.1-28.1
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• 2006

• Journal of the Korean Society for Nondestructive Testing
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• v.21 no.4
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• pp.425-433
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• 2001

A correlation between fatigue damage and acousto-ultrasonic (AU) parameters has been obtained from signals acquired during fatigue loading of the single-lap joints of a carbon-fiber reinforced plastic (CFRP) laminates and A16061 plate. The correlation showed an analogy to those representing the stiffness reduction $(E/E_0)$ of polymer matrix composites by the accumulation of fatigue damage. This has been attributed to the transmission characteristics of acoustic wave energy through bonded joints with delamination-type defects and their influence on the change of spectral content of AU signals. Another correlation between fatigue cycles and the spectral magnitude of acoustic emission (AE) signals has also been found during the final stage of fatigue loading. Both AU and AE can be applied almost in real-time to monitor the evolution of damage during fatigue loading.

• Journal of Korean society of Dental Hygiene
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• v.17 no.5
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• pp.931-942
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• 2017

Objectives: The purpose of this study was to provide a counseling program basis for the department satisfaction in dental hygiene department according to the subjective factors of happiness in dental hygiene students. Methods: A self-reported questionnaire was completed by 197 dental hygiene students in Gwangju from April 10 to 30, 2017. From collected data, general characteristics, happiness index and department satisfaction of the subjects were investigated. Data were analyzed using the IBM SPSS 18.0 program. Results: The happiness index according to general characteristics showed a significant difference in grade, character, friendship, academic achievement, pocket money satisfaction and health condition. The department satisfaction according to general characteristics showed a significant difference in grade, age, character, motivation for further study, friendship, academic achievement, pocket money satisfaction, health condition, sleep time. Happiness index showed a significant correlation with department satisfaction. The happiness index was higher as the department satisfaction was higher. Factors that affect happiness index are friendship, health condition, relationship satisfaction, perception satisfaction, school satisfaction, curriculum satisfaction and department satisfaction. Conclusions: The happiness index was higher as the department satisfaction was higher. Therefore, it is necessary to develop various programs to increase the happiness.

• Journal of Oriental Neuropsychiatry
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• v.27 no.2
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• pp.89-101
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• 2016

Objectives In human, there is a diversity in the breathing pattern, for instance inspiratory and expiratory time, volume, breathing frequency, and breath-to-breath variation. Expecially, respiratory variability can provide important information about breathing regulation and physiological flexibility. it is significant to not only breathing index but also physiological index.Methods Thus this paper reviews the literature on respiratory variability with the aim of clinical application.Results We could find the interrelationships and respiratory variability between emotions, psychopathy, sighing, mental and physical activity.Conclusions As a result, respiratory variability can serve an important physiological index in the clinical area and reflects how our bodies act in diverse environments under various condition.

• Archives of Plastic Surgery
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• v.39 no.4
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• pp.397-403
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• 2012

Background Nonabsorbable sutures are favorable for repairing flexor tendons. However, absorbable sutures have performed favorably in an animal model. Methods Two-strand sutures using the interlocking modified Kessler method with polydioxanone absorbable sutures 4-0 were used to repair completely ruptured flexor tendons in 55 fingers from 41 consecutive patients. The medical records of average 42 follow up weeks were analyzed retrospectively. The data analyzed using the chi-squared test, and Fisher's exact test was used for postoperative complications. The results were compared with those of other studies. Results Among the index, middle, ring, and little fingers were injured in 9, 17, 16, and 13 fingers, respectively. The injury levels varied from zone 1 to 5. Of the 55 digits in our study, there were 26 (47%) isolated flexor digitorum profundus (FDP) injuries and 29 (53%) combined FDP and with flexor digitorum superficialis injuries. Pulley repair was also conducted. Concomitant injuries of blood vessels and nerves were found in 17 patients (23 fingers); nerve injuries occurred in 5 patients (10 fingers). Two patients had ruptures (3.6%), and one patient had two adhesions (3.6%). Using the original Strickland criteria, all the patients were assessed to be excellent or good. Also, fibrosis and long-term foreign body tissue reactions such as stitch granuloma were less likely occurred in our study. Compared to the Cullen's report that used nonabsorbable sutures, there was no significant difference in the rupture or adhesion rates. Conclusions Therefore, this study suggests that appropriate absorbable core sutures can be used safely for flexor tendon repairs.