• 비파괴검사학회지
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• 제4권1호
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• pp.5-10
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• 1984

One of the cylindrical reactor vessels in petrochemical plants was examined by acoustic emission method. The vessel was quiet in view of A.E. activity throughout the pressure range $12-44kg.f/cm^{2}.G$. Above the pressure of $44kg.f/cm^2$, some events were appeared lower than 30 counts. In order to verify the events, other Nondestructive testing methods were performed and a surface crack, 10mm in length and 0.8mm in depth, was found on the outside surface of circumferential weld.

• Korean Journal of Acupuncture
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• 제25권2호
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• pp.95-105
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• 2008

Objectives : This study is to establish the appropriate assessment of causalities from adverse events (AEs) which are related to acupuncture treatment. Methods : We assessed thirty AEs which were caused in the early phase trial on concomitant use of acupuncture and herbal medicines. We scored each AE on the questionnaire in Naranjo and SNU algorithm scale which are for drug causality assessment in pharmacoepidemiology. Results : In Naranjo scale, there were consistencies among the evaluators qualitatively with "Probable", "Possible" degree. In reliability test, parameters, such as, gamma and kendall's tau-b revealed the degrees of 73%, and 32%, respectively. There were disaccordant tendency in SNU algorithm scale. Conclusion : A new algorithm which reflects acupuncture properties should be developed and elucidated.

• Infection and chemotherapy
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• 제50권4호
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• pp.301-310
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• 2018

Backgroud: Influenza vaccination is recommended for adults aged ${\geq}65$ years as they are at high risk of significant morbidity and mortality. This open-label, multicenter, post-marketing surveillance study assessed the safety of the MF59-adjuvanted trivalent inactivated subunit influenza vaccine, which is marketed as $FLUAD^{(R)}$ and $VANTAFLU^{(R)}$, in South Korean subjects aged ${\geq}65$ years. Materials and Methods: Solicited local and systemic adverse events (AEs) were collected from day 1 to 4 of the study. All unsolicited AEs and serious AEs (SAEs) were recorded from day 1 until study termination (day 29). Results: Of the 770 subjects enrolled ($FLUAD^{(R)}$, n = 389; $VANTAFLU^{(R)}$, n = 381), 39% overall experienced any solicited AE. Local AEs were reported by 33% of subjects overall; with the most common events being injection-site pain (30%) and tenderness (27%). Systemic AEs were reported by 19% of subjects overall with the most common events being myalgia (11%) and fatigue (8%). Conclusion: These results show that the MF59-adjuvanted influenza vaccine known as $FLUAD^{(R)}$ or $VANTAFLU^{(R)}$ had acceptable safety profiles in older adults (aged ${\geq}65$ years) in South Korea.

• 비파괴검사학회지
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• 제3권1호
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• pp.12-18
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• 1983

This paper describes the procedures and results of an acoustic emission testing performed during hydrotest of spherical pressure vessel for propane storage. A computer based multi-channel real time monitoring and source location analysis AET-4900 system was used for AE testing. The vessel was extremely quiet throughout the entire test run and especially 6 to $14.5kg/cm^{2}$, it is normal operating pressure range. After exceeding $14.5kg/cm^{2}$, one of the 20 sections showed the most event in any one section 11 total but there were scattered at different locations. In order to confirm the events seen in horizontal weld line of that section, proof testing was performed with ultrasonics and radiography.

• Geomechanics and Engineering
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• 제12권6호
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• pp.919-933
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• 2017

A series of Brazilian tests under diameter compression for disc specimens was carried out to investigate the strength and failure behavior by using acoustic emission (AE) and photography monitoring technique. On the basis of experimental results, load-displacement curves, AE counts, real-time crack evolution process, failure modes and strength property of granite specimens containing two pre-existing holes were analyzed in detail. Two typical types of load-displacement curves are identified, i.e., sudden instability (type I) and progressive failure (type II). In accordance with the two types of load-displacement curves, the AE events also have different responses. The present experiments on disc specimens containing two pre-existing holes under Brazilian test reveal four distinct failure modes, including diametrical splitting failure mode (mode I), one crack coalescence failure mode (mode II), two crack coalescences failure mode (mode III) and no crack coalescence failure mode (mode IV). Compared with intact granite specimen, the disc specimen containing two holes fails with lower strength, which is closely related to the bridge angle. The failure strength of pre-holed specimen first decreases and then increases with the bridge angle. Finally, a preliminary interpretation was proposed to explain the strength evolution law of granite specimen containing two holes based on the microscopic observation of fracture plane.

• 한국지반공학회:학술대회논문집
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• 한국지반공학회 2008년도 추계 학술발표회
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• pp.946-956
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• 2008

Acoustic emission(AE) is low-energy seismic event associated with a sudden inelastic deformation such as the sudden movement of existing fractures, the generation of new fractures or the propagation of fractures. These events rapidly increase before major failure and happen within a given rock volume and radiate detectable seismic waves. Rock slopes are usually large in scale and there are many discontinuities in rock mass. AE waves are strongly attenuated when they propagate through joints. Thus we should resolve the attenuation problem to monitor large volume. In this study, we developed waveguide which is composed of two different materials, cement mortar and stainless steel rod. And several laboratory tests on developed waveguide are performed to obtain generalized AE parameters to predict the failure stage in rock slope. Comparing field data with experimental data in laboratory tests, failure stage of rock slope can be evaluated. To verify and optimize the developed monitoring method, we are now carrying out the field application at a rock slope.

• 한국해양공학회지
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• 제26권5호
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• pp.5-10
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• 2012

In this study, carbon steel (A53) is used as the material for the pipes in a marine plant and ship industry. Welds are necessary to join the carbon steel, and the effect of this welding on the properties of the carbon steel has been studied by many researchers. In this study, the dynamic behavior of welded carbon steel was studied using an acoustic emission (AE) technique, which is a nondestructive test. There are numerous AE parameters that can be used to analyze the damage behavior of carbon steel by external loading. The AE parameters of energy, cumulative count, amplitude, and AE event were used, and each parameter was differentiated according to the degree of damage to the carbon steel. The energy showed a high level at the elastic range of the load curve, while the amplitude had the highest value at the hardening region. The cumulative count showed a growth tendency similar to the loading curve. In addition, an ultrasonic technique and hardness test were applied to evaluate the mechanical properties according to the base zone, HAZ region, and weld zone of the weld specimen. The velocity and attenuation ratio showed little change between zones, and an evaluation of the ultrasonic waves on each zone of the specimen was found to be a useful method to clarify the mechanical properties of the carbon steel.

• 천문학회보
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• 제32권2호
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• pp.65.2-65.2
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• 2007

• Geomechanics and Engineering
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• 제22권5호
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• pp.385-396
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• 2020

A uniaxial compression test was performed to analyse the mechanical properties and macroscale and mesoscale failure mechanisms of sandstone with pyrite concretions. The effect of the pyrite concretions on the evolution of macroscale cracks in the sandstone was further investigated through numerical simulations with Particle Flow Code in 2D (PFC2D). The results revealed that pyrite concretions substantially influence the mechanical properties and macroscale and mesoscale failure characteristics of sandstone. During the initial loading stage, significant stress concentrations occurred around the edges of the pyrite concretion accompanied by the preferential generation of cracks. Meanwhile, the events and cumulative energy counts of the acoustic emission (AE) signal increased rapidly because of friction sliding between the concretion and sandstone matrix. As the axial stress increased, the degree of the stress concentration remained relatively unchanged around the edges of the concretions. The cracks continued growing rapidly around the edges of the concretions and gradually expanded toward the centre of the sample. During this stage, the AE events and cumulative energy counts increased quite slowly. As the axial stress approached the peak strength of the sandstone, the cracks that developed around the edges of the concretion started to merge with cracks that propagated at the top-left and bottom-right corners of the sample. This crack evolution ultimately resulted in the shear failure of the sandstone sample around the edges of the pyrite concretions.

• 한국임상약학회지
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• 제31권3호
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• pp.237-246
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• 2021

Background: Pembrolizumab, an anti-cancer drug, is known to increase the activity of the immune system, leading to side effects called immune-related adverse events (irAE), including type 1 diabetes. This study analyzed the correlation between blood glucose level and pembrolizumab administration and investigated the covariates that affect those changes in cancer treatment. Methods: The information of 133 adult cancer patients was obtained from the electronic medical record (EMR) to identify the changes in random blood glucose (RBG) levels during the pembrolizumab treatment. Subjects were classified into subgroups according to their baseline RBG level, history of diabetes, and the use of steroids, and linear regression analysis was conducted. In addition, a secondary analysis was performed within the group of subjects having a strong correlation to glycemic change, which was based on the Pearson correlation coefficient being less than -0.7 or greater than +0.7. Univariate and multivariate logistic regressions were conducted to identify the risk factors to glycemic increase. Results: The RBG level tended to descend without significant differences in total patients during the administration period of pembrolizumab. Despite the insignificance, the logistic regression analysis presents that the odds ratios of baseline RBG less than 130 mg/dL, prophylactic steroid use, and higher dose of pembrolizumab per cycle (mg/kg/cycle) were greater than 1. Conclusions: Prophylactic administration of steroids and a higher dose of pembrolizumab per cycle may increase the blood glucose level as irAE in cancer patients with a strong tendency to glycemic change.