• BMB Reports
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• v.49 no.5
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• pp.282-287
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• 2016

Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a homo-trimeric cytotoxic ligand. Several studies have demonstrated that incorporation of artificial trimerization motifs into the TRAIL protein leads to the enhancement of biological activity. Here, we show that linkage of the isoleucine zipper hexamerization motif to the N-terminus of TRAIL, referred as ILz(6):TRAIL, leads to multimerization of its trimeric form, which has higher cytotoxic activity compared to its native state. Size exclusion chromatography of ILz(6):TRAIL revealed possible existence of various forms such as trimeric, hexameric, and multimeric (possibly containing one-, two-, and multi-units of trimeric TRAIL, respectively). Increased number of multimerized ILz(6):TRAIL units corresponded with enhanced cytotoxic activity. Further, a high degree of ILz(6):TRAIL multimerization triggered rapid signaling events such as activation of caspases, tBid generation, and chromatin condensation. Taken together, these results indicate that multimerization of TRAIL significantly enhances its cytotoxic activity.

• The Korean Journal of Community Living Science
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• v.25 no.1
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• pp.75-87
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• 2014

This study examines the relationships between elementary school students' multiple intelligences, prosocial behaviors, and school adjustments. The sample included 367 students from two elementary schools, and data were collected using the multiple-intelligence index, the prosocial behavior inventory, and the school adjustment index. A statistical analysis was conducted using t-test, a one-way ANOVA (Duncan's test), and a multiple regression analysis. According to the results, there were significant differences in the students' prosocial behaviors according to their multiple intelligences in terms of their sharing, kindness, cooperation, help, sympathy, and protection. In addition, there were significant differences in their school adjustments according to their multiple intelligence in terms of their adjustments to their teachers, friends, studies, and rules and events. The students' multiple intelligence was a significant predictors of their prosocial behaviors and school adjustments. In particular, their interpersonal intelligences, intrapersonal intelligences, and linguistic intelligences were significant predictors of their prosocial behaviors and school adjustments. These results suggest that elementary school students should be encouraged to develop their multiple intelligence to facilitate their prosocial behaviors and school adjustments.

• Animal cells and systems
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• v.1 no.4
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• pp.637-640
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• 1997

Raf-1, a cytoplasmic serine/threonine protein kinase, serves as a central intermediate in many signaling pathways in cell proliferation, differentiation, and development. In this study, we investigated that B-raf, Drosophila homolog of the human c-raf-1, is involved in ultraviolet (UV) responsive events by using hypomorphic mutant $D-raf^{c110}$ and Draf-lacZ transgenic fly. At first, effect of UV damage on the survival of wild-type and $D-raf^{C110}$ strains was examined. In terms of $1/LD_{50}$ value, the relative ratio of UV sensitivities of wild-type versus $D-raf^{C110}$ strain was 1 : 2.2. By using quantitative $\beta$-galactosidase activity analysis, transcriptional activity of the D-raf gene promoter was also examined in UV-irradiated Draf-lacZ transgenic larvae. UV irradiation increased the expression of lacZ reporter gene in Draf-lacZ transgenic fly. However, in $D-raf^{C110}$ strain the transcriptional activity of D-raf gene promoter by UV irradiation was extensively reduced. Results obtained in this study suggest that D-raf plays a role in UV response, leading to better survival of Drosophila to UV damage.

• Research in Community and Public Health Nursing
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• v.20 no.1
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• pp.105-111
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• 2009

Purpose: The purpose of this study was to identify minimum datasets for ulcer assessment and to map the minimum datasets to paper-based nursing records for pressure ulcer care in homecare setting. Methods: To identify minimum datasets for pressure ulcer assessment, the authors reviewed four guidelines for pressure ulcer care. The content validity of the minimum datasets was assessed by three homecare nurse specialists. To map the minimum datasets to nursing records, the authors examined 107 pressure ulcer events derived from 45 pressure ulcer patients who received home nursing from two hospitals in Gyeonggi Province. Results: The minimum datasets for initial assessment were anatomical location, stage, size, tissue, exudate, condition of periwound skin, undermining, odor, and pain. 'Location' was recorded best, accounting for a complete recording rate of 98.1%. 'Exudate' and 'pain' showed the poorest record, accounting for 2.8% and 0%, respectively. The minimum datasets for progress assessment were wound size, tissue, and exudate, each accounted for 31.8%, 2.8%, and 4.7%, respectively. Conclusion: This study concluded that data on pressure ulcer assessment was not sufficient homecare and it can be improved by adopting minimum datasets as identified in this study.

• Journal of Korean Society of Rural Planning
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• v.11 no.1 s.26
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• pp.17-24
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• 2005

The purpose of this study is to evaluate the hydrological impact due to temporal land cover change by gradual urbanization of Anseong-cheon Gongdo watershed ($371.8km^2$). Land covers of 1981, 1990, 2000 Landsat TM images were classified by maximum likelihood method. The watershed showed a trend that forest & paddy areas decreased about $33km^2$ and $27km^2$, respectively and urban area increased about $11km^2$ during the periods. To identify the impact of streamflow due to urbanization, WMS HEC-1 was used. According to apply Huffs quartile storm events by changing land cover data, peak runoff discharge of each frequency rainfall (50, 100, 500 years) increased about 56, 36, $192m^3/sec$, respectively.

• Korean Journal of Remote Sensing
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• v.22 no.5
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• pp.407-413
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• 2006

To investigate the streamflow impact of land cover changes by a typhoon, HEC-l storm runoff model was applied by using land cover information before and after the typhoon. The model was calibrated with three storm events of 1985 to 1988 based on 1985 land cover condition for a $192.7km^{2}$ watershed in northeast coast of South Korea. After the model was tested, it was run to estimate impacts of land cover change by the typhoon RUSA occurred in 2002 (31 August-1 September) with 897.5 mm rainfall. The land covers before and after the typhoon were prepared using Landsat 7 ETM+ of September 11 of 2000 and Landsat 5 TM of September 29 of 2002 respectively. For the $6.9km^{2}$ damaged area (3.6 % of the watershed), the peak runoff and total runoff by the changed land cover condition increased 12.5 % and 12.7 % for 50 years rainfall frequency and 1.4 % and 1.8 % for 500 years rainfall frequency respectively based on AMC (Antecedent Moisture Condition)-I condition.

• Korean Journal of Remote Sensing
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• v.24 no.1
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• pp.35-43
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• 2008

The purpose of this study is to evaluate the hydrological impact due to temporal land cover change by gradual urbanization of upstream watershed of Pyeongtaek gauging station of Anseong-cheon. WMS HEC-1 was adopted, and OEM with 200 m resolution and hydrologic soil group from 1:50,000 scale soil map were prepared. Land covers of 1986, 1990, 1994 and 1999 Landsat TM images were classified by maximum likelihood method. The watershed showed a trend that forest & paddy areas decreased and urban/residential area gradually increased during the four selected years. The model was calibrated at 2 locations (Pyeonglaek and Gongdo) by comparing observed with simulated discharge results for 5 summer storm events from 1998 to 2001. The watershed average CN values varied from 61.7 to 62.3 for the 4 selected years. To identify the impact of streamflow by temporal area change of a target land use, a simple evaluation method that the CN values of areas except the target land use are unified as one representative CN value was suggested. By applying the method, watershed average CN value was affected in the order of paddy, forest and urban/residential, respectively.

• Proceedings of the Korean Society of Propulsion Engineers Conference
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• 2012.05a
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• pp.411-413
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• 2012

This study has been investigated about hygrothermal environmental effects on the pin-joined carbon/epoxy composites through acoustic emission technique. The specimens were classified as three types for pin loading test : Base (before immersion), RT (room temperature immersion), HT ($75^{\circ}C$ immersion). As a results, the bearing strength of RT specimens was weakly decreased than that of base specimens. The bearing strength of HT specimens was greatly decreased than that of Base and RT specimens due to effects of simultaneous moisture and higher temperature. Also, the results from cumulative hit of acoustic emission indicated that AE events induced by matrix cracks of HT specimens was lower than that of base specimens.

• The Korean Journal of Pain
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• v.18 no.2
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• pp.165-170
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• 2005

Background: It is difficult to treat tourniquet-induced hypertension despite adequate anesthesia, and the mechanism of that is not known. And it may be possible that intraoperative continuous infusion of opioid induces preemptive analgesia postoperatively. We investigated the effect of intraoperative continuous i.v. fentanyl on tourniquet induced cardiovascular changes and postoperative preemptive analgesia in total knee replacements. Methods: Sixty patients were randomly assigned to two groups; In study group ($1.5{\mu}g/kg$ loading and $0.5{\mu}g/kg/hr$ continuous infusion of fentanyl before skin incision and tourniquet inflation) and control group (no treatment). Anesthesia was maintained with enflurane (1-2 MAC) and 50% nitrous oxide in oxygen. Arterial pressure and heart rate were compared between two groups. They received postoperative pain treatment with patient-controlled analgesia (PCA) with fentanyl during the postoperative 48 hours after total knee replacement. Visual analog scale (VAS) scores at either rest or movement were used to assess pain. Total fentanyl dose delivered, number of PCA requests, supplemental analgesics, overall satisfaction score and adverse events were evaluated. Results: There were no significant differences between the two groups on cardiovascular changes by tourniquet induced pain effect. VAS, PCA delivered dose and PCA demands at movement in the 24-48 hour decreased in study group compared with control group (P < 0.05). But there were no significant differences between the two groups on the other time periods except 24-48 hour's patient satisfaction and adverse events. Conclusions: We suggest that intraoperative continuous i.v. fentanyl infusion dose not affect cardiovascular change by tourniquet induced pain. But it may induce preemptive analgesia postoperatively.

• Dementia and Neurocognitive Disorders
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• v.22 no.3
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• pp.100-108
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• 2023

Background and Purpose: The efficacy and safety of GV1001 have been demonstrated in patients with moderate-to-severe Alzheimer's disease (AD). In this study, we aimed to further demonstrate the effectiveness of GV1001 using subscales of the Severe Impairment Battery (SIB), which is a validated measure to assess cognitive function in patients with moderate-to-severe AD. Methods: We performed a post hoc analysis of data from a 6 month, multicenter, phase 2, randomized, double-blind, placebo-controlled trial with GV1001 (ClinicalTrials.gov, NCT03184467). Patients were randomized to receive either GV1001 or a placebo for 24 weeks. In the current study, nine subscales of SIB-social interaction, memory, orientation, language, attention, praxis, visuospatial ability, construction, and orientation to name-were compared between the treatment (GV1001 1.12 mg) and placebo groups at weeks 12 and 24. The safety endpoints for these patients were also determined based on adverse events. Results: In addition to the considerable beneficial effect of GV1001 on the SIB total score, GV1001 1.12 mg showed the most significant effect on language function at 24 weeks compared to placebo in both the full analysis set (FAS) and per-protocol set (PPS) (p=0.017 and p=0.011, respectively). The rate of adverse events did not differ significantly between the 2 groups. Conclusions: Patients with moderate-to-severe AD receiving GV1001 had greater language benefits than those receiving placebo, as measured using the SIB language subscale.