• Dementia and Neurocognitive Disorders
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• v.22 no.3
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• pp.87-99
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• 2023

Background and Purpose: According to the amyloid cascade hypothesis, fibrillary amyloid-beta load in the brain causes Alzheimer's disease (AD) with toxic effects. Recently, perivascular spaces (PVSs), fluid-filled cavities around small penetrating arterioles and venules in the brain, and the glymphatic system relationship with type 2 diabetes mellitus (DM2) and AD has been an important research topic from a physiopathological point of view. There are two types of PVSs that are associated with sporadic atherosclerosis and cerebral amyloid angiopathy. In this study, we evaluated the relationship between the number and localization of enlarged PVSs in AD. Methods: A total of 254 patients with AD and 125 healthy controls were included in this study All the patients were evaluated with neurological and cognitive examinations and magnetic resonance imaging (MRI). PVSs on MRI were graded by recording their number and location. The study was a retrospective study. Results: In our study, the number of white matter convexity-central semiovale localized PVSs was higher in patients than in the control group. In addition, the number of PVSs in this localization score was higher in patients with DM2. Cerebral PVS counts were higher in patients with AD than in the control group. Conclusions: These results suggest the important role of cerebral amyloid angiopathy, one of the vascular risk factors, and the glymphatic system in the pathogenesis of AD. In addition, the results of our study suggest that the evaluation of PVSs levels, especially at the (centrum semiovale), using imaging studies in AD is a potential diagnostic option.

• Biomolecules & Therapeutics
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• v.30 no.6
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• pp.501-509
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• 2022

Atopic dermatitis (AD) is a chronic inflammatory skin disorder. Suppression of MAPKs and NF-κB is implicated as a vital mechanism of action of several traditional Chinese medicines for AD therapy. Although overexpression of MAPK mRNA in the skin tissue has been shown in the AD model, the roles of each MAPK in AD pathogenesis have rarely been studied. This study examined the effect of NJK14047, an inhibitor of p38 MAPKs, on AD-like skin lesions induced in BALB/c mice by sensitization and challenges with 1-chloro-2,4-dinitrobenzene (CDNB) on dorsal skin and ears, respectively. After induction of AD, NJK14047 (2.5 mg/kg) or dexamethasone (10 mg/kg) was administrated for 3 weeks via intraperitoneal injection. Following its administration, NJK14047 suppressed CDNB-induced AD-like symptoms such as skin hypertrophy and suppressed mast cell infiltration into the skin lesions. It also reduced CDNB-induced increase in T_H2 cytokine (IL-13) and T_H1 cytokines (interferon-γ and IL-12A) levels but did not decrease serum IgE level. Furthermore, NJK14047 blocked CDNB-induced lymph node enlargement. These results suggest that NJK14047, a p38 MAPK inhibitor, might be an optimal therapeutic option with unique modes of action for AD treatment.

• Asian Journal of Atmospheric Environment
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• v.7 no.2
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• pp.114-119
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• 2013

The characteristics of Asian dust (AD) in Korea between 1997 and 2005 were investigated, focusing on peak 1-hour $PM_{10}$ concentrations during AD events at seven cities over the Korean Peninsula. The frequency of AD events decreased from Seoul to Busan, indicating the major pathway of AD in Korea was from northwest to southeast. AD events were most frequent in 2001 while peak concentrations during AD events were much higher in 2002. Recent works show that the trajectories from northerly directions increased during the 2000s and later (Chun, 2009; Kim, 2008). In this work, the fraction of trajectories from the northwest was the largest on the whole, although trajectories from each direction varied by city and year. It is presumed that high concentrations of $PM_{10}$ during AD events are generally associated with trajectories from the northwest rather than from the source region.

• Journal of Korean Society for Atmospheric Environment
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• v.18 no.5
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• pp.419-426
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• 2002

The concentrations of three different fractions of particulate matters including PM2.5, PM10, and TSP were compared between the Asian Dust (AD) and non-AD (NAD) periods during the spring season of 2001. For the purpose of this comparative analysis, the data sets were obtained from four different observatory sites located within the city boundary of Seoul that concurrently measure those three fractions of PM at hourly intervals. According to our study, several conclusions can be drawn to describe relationships between the AD event and PM distribution characteristics. First of all, it is apparent that the concentrations of PM are distinctively distinguished between AD and NAD. If the extent of contribution to the AD events are assessed on the quantitative basis, it appears that their magnitude increases on the order of PM2.5, PM10, and TSP. As a result, the increase of PM observed during AD event is dominated by the coarse rather than fine fraction of PM. Moreover, when their relationships were assessed in terms of fractional ratios, it was found that TSP/PM10 ratios were almost constant, regardless of the occurrences of AD. On the other hand, the coarse/fine or TSP/PM2.5 ratios changed dramatically between AD and NAD periods. The results of our analysis cleary distinguishes quantitative role of each PM fraction between AD and NAD period, while suggesting indirectly the possible control of source processes on such relationships.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.10 no.9
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• pp.1654-1662
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• 2006

An ad hoc network is multi-hop network composed of radio links. and the transmission quality of a radio link is more unstable than that of a wired circuit. Packet loss thus occurs frequently in an ad hoc network, and the consequent connection failure results in a severe deterioration of TCP performance. TCP performance also deteriorates because of the collision of data packets and ACK packets in the radio channel. In this paper we study to improve the performance of the Mobile Ad-hoc network by using Delayed ACK algorithm with our proposed ODA(Ordering-Delayed ACK) method. The proposed ODA algorithm increases the number of the data packets orderly at the receiver side which is going to be applied for the Mobile Ad-hoc network. We accomplished a computer simulation using NS-2. From the simulation results, we find the proposed ODA algorithm obviously enlarge the channel capacity and improve the network performance at the situation of multi-hop of ad-hoc network than the existing Delayed ACK algorithm.

• Proceedings of the Korea Information Processing Society Conference
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• 2002.11b
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• pp.1367-1370
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• 2002

본 논문에서는 안정적인 단방향 링크 환경을 갖는 Ad Hoc 네트워크에 적용할 수 있는 라우팅 프로토콜을 제안한다. 이동 Ad Hoc 네트워크에서 자주 발생하는 단방향 링크는 그 불안정성 때문에 프로토콜의 복잡성을 증가시키고, 성능을 저하시키는 원인이 될 수 있기 때문에 대부분의 현재 제안되고 있는 라우팅 프로토콜에서 고려되지 않고 있다. 그러나, 단방향 링크는 항상 양방향 링크보다 짧은 경로를 제공하여, 효율적 활용되면 오히려 망의 성능을 향상시킬 수 있는 중요한 망 자원이다. 본 논문에서는 반영구적으로 고정된 노드들을 망 하부구조로 갖으며 단방향 링크를 활용한 Ad Hoc 네트워크 구조(HANIC)를 소개하고, HANIC구조에 활용할 Ad Hoc 라우팅 프로토콜인 $H^2$DVRP를 제안한다. $H^2$DVRP는 AODV 라우팅 프로토콜에 단방향 링크 환경 지원을 위한 기능을 추가하여 구성된 라우팅 프로토콜이다.

• Convergence Security Journal
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• v.12 no.4
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• pp.49-55
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• 2012

In this paper, we consider the limit of the previous works for ad-hoc network, then propose a dynamic routing scheme which employs a 2-tier hierarchical structure. We adopt the advantages of proactive and reactive routing scheme for efficient network management. We define this method as NSDR(New Secure Dynamic Routing) scheme. We also propose a trustworthy authentication and key management for the proposed ad-hoc network. We currently study the possibility that ad-hoc networks can provide a service such as key management and authentication for the next generation mobile network.

• Asian Journal of Atmospheric Environment
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• v.8 no.3
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• pp.154-161
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• 2014

The present study was undertaken to evaluate the chemical characteristics of Asian dust (hereafter called "AD") particles with the aid of the most advanced micro-PIXE (Particle-induced X-ray emission) analytical technique. To this end, size-selected particles were sampled on a rural peninsula of Korea (Byunsan, 35.37N; 126.27E) during AD and non-AD periods in 2004. The coarse particle (> $2{\mu}m$) number density during an AD event were 170 times higher than those of the non-AD counterpart. The average net-count of silica in individual particles collected on AD event was roughly 11 times higher than that of non-AD counterpart. The X-ray net-counts of trace elements (Zn, Co, Mn, and V) were also considerably high in AD relative to the non-AD day. Particle classification based on the inter ratio analysis of elemental net-count suggests that a large portion of the coarse particles collected during AD event underwent chemical transformation to a certain degree. The visual interpretation of micro-PIXE elemental maps and elemental localization data in and/or on individual AD particles clarified the internal mixture of AD particles with sea-salt and artificial metallic particles.

• Asian Journal of Atmospheric Environment
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• v.4 no.2
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• pp.106-114
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• 2010

By the application of novel double detector system of micro-PIXE that can detect light elements (Z<14), we made an attempt to provide a thorough discussion on the aging processes of Asian dust (hereafter called "AD") particle by reaction with sea-slat. The elemental spectra and maps obtained from the microbeam radiation of micro-PIXE to individual AD particles were useful for fractionating AD particles into both internally and externally mixed particles. A spatial distribution of elements in a minute domain of single particle obtained by scanning the microbeam irradiation enabled us not only to estimate the chemical mixing state of individual AD particles but also to presume their aging processes in both ambient air and cloud. By calculating the normalized micro-PIXE net count of elements, it was possible to classify individual AD particles into three distinct groups (i.e., (1) Aging type 1: AD particle coated by the gaseous Cl evaporated by the reaction between artificial acids and sea salt; (2) Aging type 2: AD particle mixed with sea salt but no additional reaction with artificial acids; and (3) Non-aged type) A relatively high transformation rate (63.3-75.9%) was shown in large particles (greater than $5.1\;{\mu}m$ in diameter).

• Journal of Korean Public Health Nursing
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• v.34 no.2
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• pp.251-262
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• 2020

Purpose: This study attempts to provide basic data for establishing and implementing an advanced directive (AD) system that helps identify dignified death attitudes and reduces death anxiety of the preliminary, through preparation of an AD. Methods: Data were collected from 135 preliminary elderly aged 55 to 64 years, recruited from health centers and welfare facilities. All data were analyzed using SPSS 22.0. Results: Overall scores of the participants were 2.26±0.64 for death anxiety scale, and 3.16±0.44 for dignified death attitude. Scores of individuals who prepared an AD were determined to be 2.19±0.64 for death anxiety, and 3.34±0.44 for dignity of death. The difference in scores obtained for dignified death attitude was significantly higher for the group that signed an AD, as compared to the group with no AD (F=14.81, p<0.001). Conclusions: Results of this study reveal that preliminary elderly who sign an AD have a higher dignified death attitude score as compared to subjects who do not sign an AD. Additionally, the former group of participants desire a dignified end to their life. This indicates a necessity to promote public campaigns for ADs, and to develop educational programs that assist the elderly to prepare for a dignified death and make autonomous decisions.