• Magazine of the Korea Concrete Institute
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• v.20 no.6
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• pp.28-35
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• 2008

The Burj Dubai Project will be the tallest structure ever built by man; when completed the tower will be more than 700 meter tall and more than 160 floors. While the early integration of aerodynamic shaping and wind engineering considerations played a major role in the architectural massing and design of this multi-use/residential tower, where mitigating and taming the dynamic wind effects was one of the most important design criteria, the material selection for the structural systems of the tower was also a major consideration and required detailed evaluation of the material technologies and skilled labor available in the market at the time Concrete was selected for its strength, stiffness, damping, redundancy, moldability, free fireproofing, speed of construction, and cost effectiveness. In addition, the design challenges of using concrete for the design of the structural system components will be addressed. The focus on this paper will also be on the early planning of the concrete works of the Burj Dubai Project.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.43 no.6
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• pp.373-387
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• 2017

Objectives: The purpose of this study was to introduce our three experiments on bone morphogenetic protein (BMP) and its carriers performed using the critical sized segmental defect (CSD) model in rat fibula and to investigate development of animal models and carriers for more effective bone regeneration. Materials and Methods: For the experiments, 14, 16, and 24 rats with CSDs on both fibulae were used in Experiments 1, 2, and 3, respectively. BMP-2 with absorbable collagen sponge (ACS) (Experiments 1 and 2), autoclaved autogenous bone (AAB) and fibrin glue (FG) (Experiment 3), and xenogenic bone (Experiment 2) were used in the experimental groups. Radiographic and histomorphological evaluations were performed during the follow-up period of each experiment. Results: Significant new bone formation was commonly observed in all experimental groups using BMP-2 compared to control and xenograft (porcine bone) groups. Although there was some difference based on BMP carrier, regenerated bone volume was typically reduced by remodeling after initially forming excessive bone. Conclusion: BMP-2 demonstrates excellent ability for bone regeneration because of its osteoinductivity, but efficacy can be significantly different depending on its delivery system. ACS and FG showed relatively good bone regeneration capacity, satisfying the essential conditions of localization and release-control when used as BMP carriers. AAB could not provide release-control as a BMP carrier, but its space-maintenance role was remarkable. Carriers and scaffolds that can provide sufficient support to the BMP/carrier complex are necessary for large bone defects, and AAB is thought to be able to act as an effective scaffold. The CSD model of rat fibula is simple and useful for initial estimate of bone regeneration by agents including BMPs.