• The Korean Journal of Physiology and Pharmacology
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• 제26권6호
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• pp.541-556
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• 2022

Myocardial fibrosis is a key link in the occurrence and development of diabetic cardiomyopathy. Its etiology is complex, and the effect of drugs is not good. Cardiomyocyte apoptosis is an important cause of myocardial fibrosis. The purpose of this study was to investigate the effect of gaseous signal molecule sulfur dioxide (SO₂) on diabetic myocardial fibrosis and its internal regulatory mechanism. Masson and TUNEL staining, Western-blot, transmission electron microscopy, RT-qPCR, immunofluorescence staining, and flow cytometry were used in the study, and the interstitial collagen deposition, autophagy, apoptosis, and changes in phosphatidylinositol 3-kinase (PI3K)/AKT pathways were evaluated from in vivo and in vitro experiments. The results showed that diabetic myocardial fibrosis was accompanied by cardiomyocyte apoptosis and down-regulation of endogenous SO₂-producing enzyme aspartate aminotransferase (AAT)_1/2. However, exogenous SO₂ donors could up-regulate AAT_1/2, reduce apoptosis of cardiomyocytes induced by diabetic rats or high glucose, inhibit phosphorylation of PI3K/AKT protein, up-regulate autophagy, and reduce interstitial collagen deposition. In conclusion, the results of this study suggest that the gaseous signal molecule SO₂ can inhibit the PI3K/AKT pathway to promote cytoprotective autophagy and inhibit cardiomyocyte apoptosis to improve myocardial fibrosis in diabetic rats. The results of this study are expected to provide new targets and intervention strategies for the prevention and treatment of diabetic cardiomyopathy.

• 생명과학회지
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• 제32권9호
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• pp.690-697
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• 2022

본 연구는 홍해삼의 유전체를 분석하여 홍해삼의 유전자 마커 개발을 위한 기초 자료로 활용하기 위해 수행되었다. 울릉도_일반과 울릉도_토착으로 microsatellite marker 분석을 실시하였다. 그 결과 dinucleotide repeat 서열이 81.3~81.4%로 가장 많이 차지 되었으며, 반복서열 개수가 증가될수록 감소되는 경향을 보였다. 일반적으로 microsatellite는 5~10 반복수 사이에 집중적으로 존재하였으며, 반복 서열의 크기가 클수록 반복수가 적어지는 양상을 보였다. Di, tri, tetra-nucleotides 반복에서 각각 (AT)₅, (AAT)₅, (AAAT)₅ 등이 가장 높은 것들로 나타났다. (CG), (CCG) 등은 동일 반복 단위의 다른 반복 단위에 비교하여 매우 낮게 관찰되었다. Di-와 tri-nucleotide는 반복수가 각각 35와 32까지 지속적으로 나타난 다음에 비연속적으로 44와 43 반복까지 계수 되었다. Tetra-, penta- 및 hexa-nucleotide는 각각 25, 21 및 14까지 연속적으로 나타났다. 본 분석결과에 따르면 microsatellite는 특이서열반복에 대해 편중되는 경향성을 보이는 것으로 나타났다. 따라서 홍해삼의 microsatellite 분석에서 고유의 반복 서열과 반복수를 유지하는 것으로 추정되므로 향후 연구를 위한 기초 자료로 활용하는 것이 가능할 것으로 판단된다.

• 한국통신학회논문지
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• 제29권1B호
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• pp.109-116
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• 2004

광 버스트 스위칭 (Optical Burst Switching) 기술은 IP/WDM 네트워크를 효율적으로 지원하기 위한 솔루션으로서 활발한 연구가 수행되고 있다. 광 버스트 스위칭 기술의 특징은 광 도메인 내에서의 투명한 광 데이터의 전송을 위하여 자기 유사성을 가지는 IP 트래픽을 데이터 버스트 단위로 어셈블하고 Offset Time과 Delayed Reservation을 이용한다는 것이다. 특히, IP 트래픽을 데이터 버스트로 어셈블 하는 버스트 어셈블리는 광 버스트스위칭 네트워크의 성능에 지대한 영향을 준다. 본 논문에서는 세 가지 방식의 버스트 어셈블리에 대한 성능 평가를 수행하고 각 방식이 광 버스트 스위칭 네트워크 성능에 미치는 영향을 비교 분석한다.

• Journal of Microbiology and Biotechnology
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• 제11권6호
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• pp.934-939
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• 2001

The growth inhibition of Campylobacter jejuni ATCC 33291 in the presence of $1\%$ acetic acid at 4, 25, and $42^{\circ}C$, followed by $25^{\circ}C$ and $4^{\circ}C$, at pH 5.5 and pH 6.5, and by the addition of $1\%$ acetic acid aat 4, 25, and $42^{\circ}C$ were determined to be 22, 8.5, and 1.4 min, respectively, in an FBP-SBB medium. The D values of C. jejuni were increased by the addition of chicken and did not follow the linear relationship observed in the FBP-SBB media without chicken. When using distilled water instead of FBP-SBB in the model system, the death rate of C. jejuni was dramatically accelerated. The injured or low cell numbers that were impossible to enumerate using the plate count method, were detected by a polymerase chain reaction and enrichment culture procedure. These results suggested that acetic acid is reliable and effective as a disinfectant, however, it is necessary to take additional care at refrigeration temperatures due to the potential of injred cells during poultry processing.

• 천문학논총
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• 제15권spc1호
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• pp.1-13
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• 2000

We review the early historical developement of astronomical spectrographs, properties of emission line spectra of HII regions in spiral galaxies, and absorption line features of galactic globular clusters. Emission line spectra of HII regions within three spiral galaxies NGC 300, NGC 1365, and NGC 7793, which were observed from AAT/IPCS, had been analysed, and we discuss the abundances of elements in HII regions and the radial abundace gradients through the galaxies. The radial UBV color variations of two globular clusters, NGC 1851 and NGC 2808, were examined for correlations with radial variations of several absorption lines in the integrated spectra, which were obtained from SAAO 74 inch telescope and image tube spectrograph. Nine giant star's spectra in NGC 3201 were also obtained and analysed for the radial abundance gradients in the globular cluster. The results show that the presence of a radial color gradient in a globular cluster is correlated with the presence of abundance gradients. Finally, we suggest some scientific programs for the new high dispersion spectrograph, which will be installed to the BOAO 1.8m telescope.

• 천문학회보
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• 제37권1호
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• pp.63.2-63.2
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• 2012

한국천문연구원의 대형광학망원경 개발사업(K-GMT)의 세 가지 세부 목표 중 GMT 망원경 건설 후 GMT 망원경 활용 극대화가 그 하나이며 이 목표를 달성하기 위한 두 부류의 큰 활동이 이루어지고 있다. 첫째, 국내 전문가로 구성된 과학.기기 워킹그룹(Science Instrument Working Group)은 한국천문학계 연구역량강화 프로그램을 준비하고 시행하고 있으며 2012년 K-GMT 여름학교를 개최할 예정이다. 둘째, 천문연은 2개의 핵심연구주제를 선정하고 2011년부터 학계와 공동으로 pilot 연구를 수행하고 있다. 이 학연공동연구에서는 AAT를 이용한 남반구 별탄생영역 관측, CFHT를 이용한 은하단/은하군 관측을 수행하였고 2012년엔 UKIRT 망원경을 이용하여 우리은하평면의 [FeII] 서베이 관측 등을 수행할 계획이다.

• 대한기계학회논문집
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• 제4권4호
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• pp.152-159
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• 1980

The temperature and the grain boundary precipitation have the great influence on the low-cycle fatigue behavior of austenite stainless steel at elevated temperature. For the purpose of investigating the mechanism concerning the change of fatigue micro crack mode in SUS 316 under various conditions low-cycle fatigue test was carried out at the elevated temperature 600.deg.C, plastic strain range 2% and constant strain rate .5c.p.m. A special attention is given to the observation of intergranular crack initiation. The results obtained are summarized as follows. The low-cycle fatigue behavior of SUS 316 at 600.deg.C is affected by transition of crack initiation mode from intergranular to transgranular. The transition is due to the aging effect, which is caused by grain boundary precipitations of Cr$\_$23/C$\_$6/. Since the intergranular crack initiation is brought about by the grain boundary sliding, the transgranular crack initiates in case that the strengthening of grain boundary due to the precipitation of Cr$\_$23/C$\_$6/ carbides takes place ahead of the intergranular crack initiation.

• Asian-Australasian Journal of Animal Sciences
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• 제8권4호
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• pp.357-364
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• 1995

A biochemical genetic study on blood enzyme/protein systems in some breeds/crosses of sheep in Malaysia was carried out using horizontal starch gel electrophoresis. Blood samples were collected from 435 sheep, representing 8 breeds/crosses. These included 5 wool sheep breeds (Thai Longtail, wiltshire, Suffolk, Dorsimal and cMBLx), 1 hair sheep breed (Barbados Blackbelly) and 2 hybrids between wool sheep and hair sheep (Cameroon ${\times}$ Thai Longtail and Bali Bali ${\times}$ Malin). Twenty loci systems were examined. Of these, ten ($HB{\beta}$, ALB, TF, XP, CAT, DIA1, EsA, GPI, ME and NP) exhibited genetic variation whereas the other ten (AAT, CA, DIA2, ${\alpha}GLO$, ${\alpha}GLU$, LDH, MDH, PEP[leu-gly-gly], 6PGD and SOD) were monomorphic. The allelic frequencies which were obtained in 10 polymorphic markers are assessed and compared with the results obtained by previous workers. The estimations of inbreeding coefficient, intrabreed variation and breed relationships have been critically discussed and are used to reveal some important recommendations.

• 한국자원식물학회지
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• 제5권1호
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• pp.37-47
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• 1992

1990년 5월부터 10월까지 내장산 국립공원, 선운산 도립공원 및 만덕산 일대에서 외대버섯들을 다수 채집하였다. 이 외대버섯들을 동정한 결과, 한국미기록종으로 확인된 것은 다음과 같으며 이들에 대하여 한국보통명과 한국어 설명을 첨가하였다. Entoloma subfarinaceum(가루외대버섯아재비) : 균모(갓)는 소형, 배꼽형, 회갈색, 가루비늘, 가장 자리에 줄무늬가 있다. 주름살은 올린주름살 또는 바른주름살, 가장자리는 물결형이다. 자루(대)는 가늘과 비틀리면, 회갈색, 윗쪽은 가루비늘이 분포 하나 아래는 밋밋하다. 포자는 중형, 5각형, 연낭 상체와 측낭상체는 없다. 여름에 혼효림의 낙엽속의 흙에 산생 또는 군생한다. E. viriginicum(처녀의대버섯) : 균모는 소형, 배꼽형, 회갈색, 가장자리에 줄무늬가 있다. 주름살은 배불뚝형, 간격은 좁고, 끝블은 주름살이다. 자루는 원통형, 거의 청색이다. 포자는 중형, 대부분 7각형으로 결절형, 연낭상체와 측낭상체는 없다. 여름에 고목의 이끼속에 군생한다. (중략)

• 한국표면공학회지
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• 제23권1호
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• pp.34-43
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• 1990

Al-Si piston alloys such as AlS10CuMg have been anodized to examine apossibility of forming a hard film aat relatively higher temperatures compard with those in conventional sulfuric acid processes. Three types of electrolytes have been employed in this study ; electrolyte A(15% H2SO4, $0^{\circ}C$), electrolyte B(12% H2SO4, 1% oxalic, $10^{\circ}C$), electrolyte C(tartaric acid 125g/L+oxalic 75g/L+aluminum sulfate 225g/L, $25^{\circ}C$). Hard anodisine process in electrolyte B at a current density of 1.54A/dm2 produced a harder film of VHN 396 at a relatibely low film forming voltage compared with those obtained in other electrolyte at equivalent current density. A liner relationship between hardness and abrasion resistance exists for Al-Si piston alloys. The hardness of anodized film decreasees with increasing silicon content in Al-Si alloys and also with bath temperature. The film hardeness of Na-modified alloy os higher than that of P-modified alloy due to its finer microstructre. The film on the silicon phase in Al-Si alloys is observed to be formed by lateral growth of oxide film nucleated at surroundings.