• Journal of Korean Society of Transportation
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• v.22 no.2 s.73
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• pp.145-154
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• 2004

The growing demand for customer-responsive, made-to-order manufacturing is stimulating the need for improved dynamic decision-making processes in commercial fleet operations. Moreover, the rapid growth of electronic commerce through the internet is also requiring advanced and precise real-time operation of vehicle fleets. Accompanying these demand side developments/pressures, the growing availability of technologies such as AVL(Automatic Vehicle Location) systems and continuous two-way communication devices is driving developments on the supply side. These technologies enable the dispatcher to identify the current location of trucks and to communicate with drivers in real time affording the carrier fleet dispatcher the opportunity to dynamically respond to changes in demand, driver and vehicle availability, as well as traffic network conditions. This research investigates key aspects of real time dynamic routing and scheduling problems in fleet operation particularly in a truckload pickup-and-delivery problem under various settings, in which information of stochastic demands is revealed on a continuous basis, i.e., as the scheduled routes are executed. The most promising solution strategies for dealing with this real-time problem are analyzed and integrated. Furthermore, this research develops. analyzes, and implements hybrid algorithms for solving them, which combine fast local heuristic approach with an optimization-based approach. In addition, various partitioning algorithms being able to deal with large fleet of vehicles are developed based on 'divided & conquer' technique. Simulation experiments are developed and conducted to evaluate the performance of these algorithms.

• Asian-Australasian Journal of Animal Sciences
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• v.23 no.9
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• pp.1145-1151
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• 2010

The objective of this work was to analyze the relationship between ovine major histocompatibility complex (MHC) DRB1 gene polymorphism and genetic resistance to hydatidosis in Kazakh sheep. The Ovar (ovine MHC) class II DRB1 second exon was amplified by polymerase chain reaction (PCR) from DNA samples of 702 Kazakh sheep, including 302 sheep with hydatidosis and 400 health controls. PCR products were characterized by the restriction fragment length polymorphism (RFLP) technique using five restriction enzymes, i.e., MvaI, HaeIII, SacI, SacII and Hin1I, yielding 14 alleles and 28 genotypes. Comparing the frequency of genotypes in hydatidosis sheep with the control group, it was found that the genotype frequencies of MvaIbc, Hin1Iab, SacIIab, HaeIIIde, HaeIIIdf and HaeIIIdd in control sheep were significantly (p<0.01) higher than in hydatidosis sheep, indicating that a significant correlation existed between these genotypes and resistance to hydatidosis. Genotype frequencies of MvaIbb, SacIIaa, Hin1Ibb and HaeIIIef in sheep with hydatidosis were extremely significantly (p<0.01) higher than in the control group, and the genotype frequency of HaeIIIab was significantly higher (p<0.05), indicating that a marked correlation existed between these genotypes and susceptibility to hydatidosis. By way of analyzing haplotype with these resistant genotypes, the hydatidosis resistant haplotype MvaIbc-SacIIab-Hin1Iab of Kazakh sheep was screened out, and then verified through artificial hydatid infection in sheep. The results indicated that the infection rate of sheep with the resistant haplotype of hydatidosis was significantly lower (p<0.01) than without this resistant haplotype. It showed that the genic haplotype MvaIbc-SacIIab-Hin1Iab of Ovar-DRB1 exon 2 was the resistant haplotype of hydatidosis in Kazakh sheep.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.23 no.2
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• pp.23-32
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• 1997

Melanin pigmentation in human skin is a major defense mechanism against ultraviolet light of the sun. Tyrosinase(EC 1.14.18.1) plays a key role in the biosynthesis of ultraviolet of melanin. This is why much researches have been focused on its regulation in controlling the epidermal melanization. We have found that the water-extract of Banha(Pinelliae ternate B.), an oriental medicinal plant, has no tyrosinase inhibitory activity, but does inhibit the melanin biolsynthesis in B16 mouse melanin cells. We also found that Banha extract lowers the tyrosinase activity in cultured cells. To elucidate the action mechanism of Banha extract we have investigated its effect on the tyrosinase mRNA level using reverse transcription-polymerase chain reaction technique. It was revealed that Banha extract reduced the tyrosinase mRNA level in dose dependent manner; when B16 mouse melanoma cells were cultured with 2mg/ml and 5mg/ml of Banha extract, there were 20% and 44% decrease in tyrosinase mRNA level, respectively. These data suggest that the Banha extract exerts its melanogenic inhibitory effect through the transcriptional regulation of tyrosinase mRNA.

• BMB Reports
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• v.45 no.4
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• pp.253-258
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• 2012

The dermal papilla cells (DPCs) of hair follicles are known to secrete paracrine factors for follicular cells. Shotgun proteomic analysis was performed to compare the expression profiles of the secretomes of human DPCs and dermal fibroblasts (DFs). In this study, the proteins secreted by DPCs and matched DFs were analyzed by 1DE/LTQ FTICR MS/MS, semi-quantitatively determined using emPAI mole percent values and then characterized using protein interaction network analysis. Among the 1,271 and 1,188 proteins identified in DFs and DPCs, respectively, 1,529 were further analyzed using the Ingenuity Pathway Analysis tool. We identified 28 DPC-specific extracellular matrix proteins including transporters (ECM1, A2M), enzymes (LOX, PON2), and peptidases (C3, C1R). The biochemically-validated DPC-specific proteins included thrombospondin 1 (THBS1), an insulin-like growth factor binding protein3 (IGFBP3), and, of particular interest, an integrin beta1 subunit (ITGB1) as a key network core protein. Using the shotgun proteomic technique and network analysis, we selected ITGB1, IGFBP3, and THBS1 as being possible hair-growth modulating protein biomarkers.

• Journal of the Korean GEO-environmental Society
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• v.8 no.5
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• pp.5-14
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• 2007

The quantity of noxious wastes generated by the growth in industrialization and population in all over the world and its potential hazards in subsurface environments are becoming increasingly significant. The extraction of the contaminant from the soil and movement of the water are restricted due to the low permeability and adsorption characteristics of the reclaimed soils. Incorporated technique with PVDs have been used for dewatering from fine-grained soils for the purpose of ground improvement by means of soil flushing and soil vapor extraction systems. This paper is to evaluate several key parameters that affected to the performance of the PVDs specifically with regard to: well resistance of PVD, zone of influence, and smear effects. In the feasibility of contaminant remediation was evaluated in pilot-scale laboratory experiments. Well resistance is affected on the vertical discharge capacity of the PVDs under the various vacuum pressures. The discharge capacity increases consistently in areal extents with higher applied vacuum up to a limiting vacuum pressure. The head values for each piezometer at different vacuum pressures show that the largest head loss occurs within 14 cm of the PVD. Air flow rates and head losses were measured for the PVD placed in the model test box and the gas permeability of the silty soils was calculated. Increasing the equivalent diameter results in a decrease in the calculated gas permeability. It is concluded that the gas permeability determined over the 1,500 to 2,000 $cm^3/s$ flow rates are the most accurate values which yields gas permeability of about 3.152 Darcy.

• The Journal of the Korea Contents Association
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• v.10 no.4
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• pp.282-291
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• 2010

This study is carried out in order to suggest the effective method to enhance the resettlement of natives for re-maintenance promotion district of Asansi. This study is carried out through current status survey, native survey, and examining related laws, and the result of study is as follows. First, as a result of examining the intention of resettlement for the residents and merchants who live in the project district, 84% of residents and 80% of merchants wish to resettle. Second, in order to enhance the rate of resettlement, driving project to satisfy the demands of residents and merchants is needed. For this, house supplying policy and complex design technique for corresponding this tendency is needed because they prefer to live a single houses or housing attached to shopping street of 100 million won valued below as well as apartments,. And new types of business which can activate the function of the old city are needed, but making commercial space where current merchants can constantly do business activities is demanded. Third, the expansion of urban regeneration concept which have economics, society, culture, welfare and community as well as physical environment improvement are emphasized is needed. Fourth, the role of government for urban regeneration should be strengthened, and institutional improvement should be supported. Government needs to constantly support including financial supporting in order for the regeneration of regional city, and especially should scout for the policies which community can be maintained and should support first. For this, utilizing public lands inside project district into leading project, government should utilize into "constructing rental houses for natives", inducing the leading key facilities. Fifth, various plan techniques for the resettlement of natives of other advanced countries should be examined and be achieved.

• Korean Journal of Animal Reproduction
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• v.24 no.4
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• pp.451-455
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• 2000

Gene targeting are very useful tools for the research on the gene function in vivo, mass production of foreign materials and biomedical approach of therapeutic process. But this process is very complicated and necessary highly skilled technique, because it is very different from ES cell origin, genetic background of embryo, and experimental conditions. We investigated the productivity ability of chimeric mouse after aggregation with TT2 ES cells. Increse of ES cell density caused gradual decrease in embryo development in vitro and in th $\varepsilon$ production of chimeric mice in vivo. One million ES cell density for the aggregation was very efficient to produce high percentage chimeric mice in their coat color. These results suggested that appropriate cell density plays a key role in the development and production of chimeric mice by a 8-cell aggregation method.

• The Korean Journal of Nuclear Medicine
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• v.29 no.1
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• pp.48-53
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• 1995

This study investigates a simple mathematical model for the quantitative estimation of regional myocardial blood flow in experimental canine coronary artery thrombosis using Rb-82 dynamic myocardial positron emission tomography. The coronary thrombosis was induced using the new catheter technique by narrowing the lumen of coronary vessel gradually, which finally led to partial obstruction of coronary artery. Ten Rb-82 dynamic myocardial PET scans were performed sequentially for each experiment using our 5, 10 and 20 second acquisition protocol, respectively, and three regions of interest were drawn on the transaxial slices, one on left ventricular chamber for input function and the other two on normal and decreased perfusion segments for the flow estimation in those regions. Single compartment model has been applied to the measured sets of regional PET data, and the rate constants of influx to myocardial tissue were calculated for regional myocardial flow estimates with the three parameter fits of raw data by the Levenberg-Marquardt method. The results showed that, (1) single compartment model suggested by Kety-Schmidt could be used for the simple estimation of regional myocardial blood flow, (2) the calculated regional myocardial blood flow estimates were dependent on the selection of input function, which reflected partial volume effect and left ventricular wall motion, and (3) mathematically fitted input and tissue time activity curves were more suitable than the direct application of the measured data in terms of convergence.

• Journal of KIISE:Software and Applications
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• v.28 no.10
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• pp.720-731
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• 2001

Complexity metrics have been developed for the structured paradigm of software development are not suitable for use with the object-oriented(OO) paradigm, because they do not support key object-oriented concepts such as inheritance, polymorphism. message passing and encapsulation. There are many researches on OO software metrics such as program complexity or design metrics. But metrics measuring the complexity of classes at the OO analysis phase are needed because they provide earlier feedback to the development project. and earlier feedback means more effective developing and less costly maintenance. In this paper, we propose the new metrics to measure the complexity of analysis classes which draw out in the analysis based on RUP(Rational Unified Process). By the collaboration complexity, is denoted by CC, we mean the maximum number of the collaborations can be achieved with each of the collaborator and determine the potential complexity. And the interface complexity, is denoted by IC, shows the difficulty related to understand the interface of collaborators each other. We verify theoretically the suggested metrics for Weyuker's nine properties. Moreover, we show the computation results for analysis classes of the system which automatically respond to questions of the user using the text mining technique. As a result of the comparison of CC and CBO and WMC suggested by Chidamber and Kemerer, the class that have highly the proposed metric value maintain the high complexity at the design phase too. And the complexity can be represented by CC and IC more than CBO and WMC. We can expect that our metrics may provide us the earlier feedback and hence possible to predict the efforts, costs and time required to remainder processes. As a result, we expect to develop the cost-effective OO software by reviewing the complexity of analysis classes in the first stage of SDLC(Software Development Life Cycle).

• Journal of Service Research and Studies
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• v.7 no.4
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• pp.51-68
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• 2017

Financial technology (FinTech) is an emerging financial service sector include innovations in financial literacy and investment, retail banking, education, and crypto-currencies like bitcoin. One of the crucial branch of financial technology-third-party payment (TPP) is undergoing rapid growth, with online/mobile systems replacing offline financial systems. System quality and user attitudes are key perceptions driving third-party payment usage, the importance of these perceptions, however, may be different with countries as users' thinking varies from country to country. Thus, the purpose of this study is to elaborate how factors differ from China to Korea by drawing on the unified theory of acceptance and use of technology (UTAUT2). Additionally, this study also aims to propose a multi-attribute evaluation of the third-party online payment system based on analytic hierarchy process (AHP), fuzzy sets and technique for order performance by similarity to ideal solution (TOPSIS), to examine the relative importance of the perceptions influencing new technology adoption intention. The results showed that the price value has the most significant influence on Chinese perceptions, while the perceived credibility has the most significant effect on Korean perceptions. Sub-criteria also performs different results to Chinese and Korean third-party online payment system.