• 한국지하수토양환경학회지:지하수토양환경
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• 제25권4호
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• pp.87-97
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• 2020

In this study, the applicability of the geostatistical evolution strategy as an inverse analysis method of estimating hydraulic properties of small-scale basin was tested. The geostatistical evolution strategy is a type of data assimilation method that can effectively estimate aquifer hydraulic conductivity by combining a global optimization model of the evolution strategy and a local optimization model of the ensemble Kalman filtering. In the applicability test, the geometry, hydraulic boundary conditions, and the distribution of groundwater monitoring wells of Hanlim-Eup were employed. On the other hand, a synthetic hydraulic conductivity distribution was generated and used as the reference property for ease of estimation quality assessment. In the estimations, two different cases were tested where, in Case I, both groundwater levels and hydraulic conductivity measurements were assumed to be available, and only the groundwater levels were available, in Case II. In both cases, the reference and estimated hydraulic conductivity fields were found to show reasonable similarity, even though the prior information for estimation was not accurate. The ability to estimate hydraulic conductivity without accurate prior information suggests that this method can be used effectively to estimate mathematical properties in real-world cases, many of which little prior information is available for the aquifer conditions.

• 한국건설관리학회:학술대회논문집
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• 한국건설관리학회 2004년도 제5회 정기학술발표대회 논문집
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• pp.442-446
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• 2004

현재 정부의 주요 국정과제는 국토의 균형 있는 발전과 지방분권화 정책이다. 건교부를 포함한 타 부처에서는 이를 위해 많은 전략들을 수립하고 있다. 그러나 현재 국내 건설기술의 경우는 수도권에 집중되어있어 지역특성화가 이루어지고 있지 못한 실정이다. 건설 기술의 지역특성화가 이루어지지 못하면 지방산업경제의 경쟁력이 떨어지고 지방산업 경제의 낙후는 국가 경쟁력을 상실시켜 결국은 국가 경제력도 상실될 것이다. 따라서 건설기술의 지역특성을 맞추어 발전시키는 전략수립이 필요하고 전략을 수립하기에 앞서 지역 특성을 나타내는 건설기술의 도출이 필요하다. 본 연구의 의의는 지역특성화의 의미와 국내외 지역특성화 현황을 통해 알아보고 국가 정책방향과 설문을 통한 기술 수요조사, 기술역량을 조사하여 지역별 특성을 내포하는 건설기술을 도출함으로써 지역별 건설기술 발전을 위한 기초 자료를 확보했다는데 있다.

• 농촌계획
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• 제20권1호
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• pp.161-173
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• 2014

This study aimed to adaptive reuse plan a take advantage of Suncheon Bay Garden Expo 2013. Detailed objectives included: to identify and foster cultural and ecological resources in Suncheon Bay and Garden Expo Site; and to search and propose characterized program in the site for efficient utilization; and to revitalize a site for the vitalizations of the region where garden culture and garden industries for strengthening local competitiveness. The study was multi-phased. The first stage included basic surveys such as site status and environmental context analysis, and questionnaires and similar case studies, and the second stage was to review the direction of preliminary planning, develop associated industries and strategies for regional revitalization and review and incorporate project details. And the third stage aimed to develop a comprehensive plan from spatial plans and program plans and suggest plans to vitalize the operation of the site. The results of the study are as follows: First, the characterization strategy is 'healing experience tourism', 'healing garden', 'healing herbal care' are suitable for the site and regional revitalization. Second, the dimension of 2013 Suncheon Bay Garden Expo which was distinguished into four areas, in consideration of the characteristics and contents of the garden expo site for efficient operation and maintenance. Four area are as follows: the park oriented area, the experiential tourism oriented area, the existing conservation oriented area, and the area for associated industries. Third, the practice of private and public partnerships is needed in order to efficiently manage and operations. The significance of this study is that it is seeking to take advantage of the Garden Expo site and set the plan by existing resources and in consideration of local characteristics, in conjunction with area to envision and proposed management plan. Some problems are remained which have not been able to deal with details program and organization and financial planning programs for the operation of the site. This is for further study.

• 한국경제지리학회지
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• 제25권3호
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• pp.339-356
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• 2022

본 연구는 창업과 기업 성장 기반이 취약한 비수도권 지역에서 지역대학의 우수한 연구·산학협력 역량을 기반으로 캠퍼스에 지역혁신생태계를 구축한 사례로서 일본의 홋카이도대학 리서치&비즈니스파크에 주목한다. 홋카이도대학 리서치&비즈니스파크는 캠퍼스 유휴부지를 활용하여 지역 주도로 중장기계획을 수립하고, 그에 따라 2003년부터 지금까지 점진적인 개발과정을 거쳐서 조성되고 있으며, 지역대학 특성화와 지역산업 기반을 고려한 바이오산업클러스터 구축이라는 산업적 접근 방식을 통해 산학협력 활성화를 추구하였다. 또한 지역 산학연관 협력적 거버넌스에 의해 다양한 기업지원 서비스를 제공한다. 이러한 홋카이도대학 리서치&비즈니스파크 조성전략은 최근 캠퍼스 혁신파크 등 대학 캠퍼스를 활용하여 지역의 발전을 도모하는 각종 정책 및 사업에 중요한 정책적 시사점을 제공한다.

• 한국주거학회논문집
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• 제26권5호
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• pp.89-96
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• 2015

This project was conducted as part of the Building America program that proposed the overall mission to achieve 30-50% reduction in existing building energy use. The purposes of this project were to analyze architectural styles and features named as archetypes of existing homes within the Great Lakes regions that include Michigan and identify the dominant type that would offer significant potential for energy-efficient retrofit. Housing archetypes were analyzed according to vintage, style, and construction characteristics in two target cities within the region. The findings from an intensive case study targeting the City of Ann Arbor established a fundamental framework for characterizing local housing archetypes and determined the dominant housing archetype that needed energy-efficient retrofit. An extended case study then conducted in Grand Rapids additionally refined this framework for the future application. This paper explained the process and data collection method to develop the framework that can be utilized by other researchers to determine the target housing types for energy-retrofit research.

• International Journal of Oral Biology
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• 제46권4호
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• pp.176-183
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• 2021

Oral squamous cell carcinoma (OSCC) metastasis is characterized by distant metastasis and local recurrence. Combined chemotherapy with cisplatin and 5-fluorouracil is routinely used to treat patients with OSCC, and the combined use of gefitinib with cytotoxic drugs has been reported to enhance the sensitivity of cancer cells in vitro. However, the development of drug resistance because of prolonged chemotherapy is inevitable, leading to a poor prognosis. Therefore, understanding alterations in signaling pathways and gene expression is crucial for overcoming the development of drug resistance. However, the altered characterization of Ca²⁺ signaling in drug-resistant OSCC cells remains unclear. In this study, we investigated alterations in intracellular Ca²⁺ ([Ca²⁺]_i) mobilization upon the development of gefitinib resistance in human tongue squamous carcinoma cell line (HSC)-3 and HSC-4 using ratiometric analysis. This study demonstrated the presence of altered epidermal growth factor- and purinergic agonist-mediated [Ca²⁺]_i mobilization in gefitinib-resistant OSCC cells. Moreover, Ca²⁺ content in the endoplasmic reticulum, store-operated calcium entry, and lysosomal Ca²⁺ release through the transient receptor potential mucolipin 1, were confirmed to be significantly reduced upon the development of apoptosis resistance. Consistent with [Ca²⁺]_i mobilization, we identified modified expression levels of Ca²⁺ signaling-related genes in gefitinib-resistant cells. Taken together, we propose that the regulation of [Ca²⁺]_i mobilization and related gene expression can be a new strategy to overcome drug resistance in patients with cancer.

• 한국물환경학회지
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• 제26권4호
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• pp.654-663
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• 2010

Attention has increasingly focused on the pollutant load discharged from rural area since the enforcement of total maximum daily loads (TMDLs) in korea. As one of the methods to control the inflow of pollutant load during wet weather events, local governments are attempting to apply non-point source control facility. To design those facilities appropriately, it is essential to understand the runoff characteristics of pollutants such as TSS, $BOD_5$, $COD_{Cr}$, TP and TN. In the paper, the quantitative analyses for pollutant runoff characteristics were examined in a small rural watershed with the area of about 53 hectares. For a dry weather day and wet weather events, variation patterns of dry weather flow and runoff characteristics of wet weather flows were monitored and investigated. The runoff model using XP-SWMM reflecting the landuse types of the watershed in detail was simulated to perform the sensitivity analyses for several factors influencing on their hydrograph and pollutographs. As a result, for the case of medium and small rainfall events (i. e. total rainfall of 35.8 and 17.5 mm), the impervious area including green house, roof and road which covers relatively low portion of total area (i. e. 16%) caused substantial first flush and the majority of total runoff load. Therefore, it has been concluded that the runoff characteristics of each pollutant and distribution of impervious area should be considered for the establishment of the control strategy of non-point pollutant runoff at a rural area.

• 한국태양에너지학회 논문집
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• 제32권3호
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• pp.162-169
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• 2012

Our country set the mid-term reduction goal of greenhouse gases up to 2020 in accordance with Bali roadmap agreed in 2007 through the negotiation with UNFCCC in 2009 and specified the proper goal as by the Basic Act on Green Growth that went into effect at April, 2010. First of all the enlargement of green building construction has been suggested as a worldwide strategy to achieve the green house gas reduction. Building area is one of most important sectors for the countermeasure of climate change agreement and the achievement of national green house gas reduction goal and the need to reduce its green house gases has been increased accordingly. The objective of the study is to examine the status and characterization of mass energy consumption local governmental buildings' green house gas emissions depending on usage (hotel, school, apartment, hospital) through the green house gas emission source unit analysis. The result indicated that the energy source unit was proportional to green house gas source unit and hotel showed the highest green house gas emission source unit per open area of construction unit, followed by hospital, apartment, and then school. In case of apartment, green house gas emission source unit per open area of construction unit decreased as year went on. Meanwhile school building showed a striking increase in the annual energy source unit.