• The Journal of Korean Medicine
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• v.24 no.4
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• pp.1-5
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• 2003

Leptin has a close correlation with obesity, which is known to be a major factor for stroke. This study was performed to determine whether serum leptin level would be an independent risk factor for stroke and whether it would change significantly early after stroke. Subjects were selected from those within I month after onset and non-stroke referents at Kyung Hee Oriental Medical Center in Seoul, Korea. We compared leptin and the other characteristics between stroke subjects and referents. Body mass index, hypertension history, presence of drinking and smoking, waist/hip ratio, total cholesterol and triglyceride were recorded. To assess odds ratio of leptin for stroke, we used logistic regression analysis. Leptin was rechecked 2 weeks later and compared with the former value in acute stroke subjects. In this study, serum leptin did not differ significantly between stroke subjects and referents, and its odds ratio was not significant in male (OR=0.52, 95％ Cl; 0.13-2.08) and female (OR=1.57, 95％ Cl; 0.53-4.67). In acute stroke subjects, leptin did not change significantly 2 weeks later. Hypertension had a significant odds ratio in male (OR=3.39, 95％ Cl; 1.02-11.24) and female (OR=12.37, 95％ Cl; 3.67-41.65). High waist/hip ratio was only in female (OR=6.70, 95％ Cl; 1.73-26.02). In conclusion, leptin was not an independent risk factor for stroke and its serum level did not change significantly early after stroke. Hypertension and waist/hip ratio had significant relative risks.

• Journal of Ginseng Research
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• v.19 no.2
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• pp.87-92
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• 1995

We conducted a prospective cohort study to evaluate the preventive effect of ginseng on the development of cancer in the population over 40 years old residing in Kangwha-eup from August 1987 to December 1992. Alnong 4, 634 persons (2, 362 men, 2, 272 women), 335 (7.6%) persons had died. Cancer accounted for 79 (22.8%) of the total death. Of 4, 634 persons eligible for analysis, 70.475 (3, 263) were ginseng intakes. Ginseng intakes had a decreased risk (RR=0.48, 95% Cl : 0.34~0.67) compared with non-intakes. The relative risk of cancer according to the kind of ginseng was 0.23 (95% Cl : 0.08~ 0.63) for fresh ginseng extract intakes. There was a decrease in risk with rising the frequency of ginseng intake, showing statistically significant dose-response relationship. The longer the duration of ginseng intake or the greater the total number of ginseng consumed, the lower the risk. Newly diagnosed cancer cases have been identified: 42 stomach, 24 lung, 14 liver and 57 at other sites. The relative risks of ginseng intakes were 0.34 (95% Cl 0.19~0.60) in gastric cancer and 0.27 (95% Cl : 0.12-0.60) in lung cancer. Among ginseng preparations, fresh ginseng intakes were significantly associated with the decreased risk of gastric cancer (RR: 0.19, 95% Cl : 0.04~0.98). These results strongly revealed that Panax Ginseng C.A. Meyer (Korean ginseng) has preventive effect against cancer.

• Journal of Korean Neurosurgical Society
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• v.66 no.2
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• pp.190-198
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• 2023

Objective : Low back pain (LBP) is a global health problem that affects the productivity of the patients. Several factors such as individual, occupational, and psychosocial factors increase the risk of LBP. However, only a few studies investigated those factors, especially in middle adulthood in Indonesia. Indonesia is a country with a young population that has been rapidly developing in recent years. This study was conducted to find out the factors associated with LBP in middle adulthood. Methods : This study is a cross-sectional observational analytic study using a convenience sampling method with a total sample of 3005 respondents. Data were collected using a questionnaire which was then analyzed using the chi-square test, Kolmogorov-smirnov, Spearman's Rank, and logistic regression test. Results : From the result of this study, it was found that the 12-month prevalence of LBP in middle-aged adults was 44,29%. Female (odds ratio [OR], 1.3; 95% confidence interval [Cl], 1.098-1.545; p=0.002), lack of physical exercises (OR, 0.87; 95% Cl, 0.794-0.959; p=0.005), high body mass index (OR, 1.09; 95% Cl, 1.009-1.187; p=0.002), stress level (OR, 1.26; 95% Cl, 1.088-1.458; p=0.002), and years of work experience (OR, 1.1; 95% Cl, 1.001-1.225; p=0.047) were determined as risk factors that significantly associated with LBP. Conclusion : LBP is quite common among middle-aged adults in Indonesia. Female gender, higher body mass index, lack of physical activity, stress level, and years of work experience were all potential risk factors for LBP in middle-aged adults. Middle-aged adults in Indonesia should be aware of LBP and avoid disabilities by identifying risk factors that may worsen LBP in the future.

• Korean Journal of Clinical Pharmacy
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• v.31 no.2
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• pp.136-144
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• 2021

Background: Zinc is known for modulating antiviral and antibacterial immunity and regulating inflammatory response. This study aimed to examine the effect of zinc supplementation on clinical outcomes of hospitalized COVID-19 patients through systematic literature review and meta-analysis. Methods: PubMed/Medline, Embase, and Cochrane library databases were searched for studies comparing zinc supplement group versus control group for clinical outcomes of COVID-19 up to November 3, 2020. The search results were updated on February 9, 2021. The meta-analysis was performed by RevMan 5.4 software. Results: Total 4 studies were included in this systematic review. The zinc administered group had a significantly lower mortality rate compared with the control group (odds ratio [OR] 0.63, 95% confidence interval [95% CI] 0.53-0.75, p<0.001), with significantly higher discharge rate (OR 1.32, 95% Cl 1.15-1.52, p<0.001). However, there were no significant differences in the intensive care unit admission rate (OR 1.07, 95% Cl 0.26-4.48, p=0.92), mechanical ventilation rate (OR 0.80, 95% Cl 0.45-1.41, p=0.44), and length of hospital stay (mean difference 0.75, 95% Cl -0.64 to 2.13, p=0.29) between the two groups. Conclusion: The meta-analysis of zinc administration showed positive clinical effects on the discharge rate and mortality of COVID-19 hospitalized patients. However, large-scale randomized controlled trial should be conducted for zinc to be considered as one of the adjuvant treatments.

• Journal of the Korean Chemical Society
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• v.41 no.12
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• pp.653-660
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• 1997

Silicone rubber-matrix membranes doped with tetradecyltrimethylammonium chloride (TDTMACl) are used to enhance electrode performance for chloride measurements in physiological samples. The optimized membrane formulation incorporates 95.4 wt% silicone rubber and 4.6 wt% TDTMACl, and its pH response is negligible in the range of pH 6-10. The TDTMACl-doped silicone rubber membrane exhibits sub-Nernstian response to chloride from 10 to 300 mM (-37.5 mV/decade), but its selectivities for chloride over other anions are remarkably enhanced: KpotCl,NO3=1.3, KpotCl,I=2.0, KpotCl,Sal=0.8, KpotCl,SCN=2.0 and KpotCl,ClO4=0.8. Furthermore, since the silicone rubber-matrix membrane exhibits better adhesion to the solid surface than do PVC membranes, the lifetime of the coated-wire type membrane electrode is greatly improved. The response properties toward chloride and salicylate for solid-state sensor are not significantly changed after at least 35 days of use.

• The Journal of Korean Physical Therapy
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• v.12 no.3
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• pp.331-338
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• 2000

Objectives: The objective of this study was to investigate the experience and point prevalence rate and factors related with Low Back Pain (LBP) in bin drivers. Methods: Questionnaires were completed by 200 drivers at 2 bus companies in Andong city in October.2000. The information was used to estimate odds ratio (OR) and $99\%$ confidence intervals (CI) for factors relation to LBP. A cross-section study design was used. Results: The experience rate for LBP was $53.5\%$, point prevalence rate was $31.5\%$. Variables significantly associated with LBP experience were employ duration and stress related occupation. The higher subjects had experienced stress. the higher experience for LBP was (OR=2.9, $95\%$ Cl 1.2-7.2). The longer subjects had employ duration in bus company, the higher experience far LBP was (OR=1.3, $95\%$ Cl 1.2-7.2). Significant factors relation to a week point prevalence far LBP were obesity and employ duration. LBP increased as weight increased (OR=4.1, Cl 1.6-10.7). The longer subjects has employ duration at bus company, the higher LBP is (OR=1.4. $95\%$ Cl 1.6-2.9). Conclusions: Results from this study indicated that a statistically significant factor relation to LBP was stress related occupation. employ duration, and obesity.

• Proceedings of the KAIS Fall Conference
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• 2009.05a
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• pp.123-127
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• 2009

본 논문은 국내 일부지역 주민의 건강행태가 위암발생에 영향을 미치는 요인들을 규명하기 위해 시행하였다. 이를 위해 서울에 소재한 한 종합병원에 위암관련 검진을 받기 위해 내원한 환자로 조직병리검사상 위암으로 확진받은 91명을 환자군으로 선정하였다. 대조군도 환자군과 동일한 기간, 동일한 병원 내과에 내원하여 동일한 방법으로 검진한 결과 위암에 속하지 않는 것으로 진단된 환자군과 연령, 성별에 대해 짝짓기하여 선정된 91명이었다. 자료수집은 2008년 12월 20일부터 2009년 1월 30일까지 설문과 면접조사의 방법을 병행하여 진행하였다. 연구결과 첫째, 취미활동량은 취미활동을 전혀 하지 않는 군에 비해 일일 평균 300kcal 미만 또는 그 이상의 열량을 소모하는 군에서 교차비가 각각 0.27과 0.33으로 위암발생 위험을 유의하게 감소시켰다(P<0.05). 둘째, 음주경험이 없는 군에 비해 있는 군(OR=1.85, 95% Cl=1.02-3.36), 총 음주기간이 30년 이상인 경우(OR=5.91, 95% Cl=1.78-19.95)에서 유의하게 높았다. 셋째, 탄음식을 주 3회 이상 섭취할 경우(OR=4.85 95% Cl=1.61-9.84), 짠음식의 섭취빈도가 주 3회 이상인 경우(OR=1.49 95% Cl=0.26-0.91) 위암발생과 유의하게 관련되었다. 넷째, 다중 로지스틱 회귀분석결과 위암발생에 영향을 미치는 요인은 월평균소득, 10년 전 BMI, 취미활동량, 알코올 섭취량, 탄류 및 짠류 섭취였다. 이러한 연구결과를 토대로 적당한 취미활동이 육체적 활동량의 증가뿐만 아니라 건강행동변화를 유도하여 결과적으로 위암예방 효과를 높일 수 있을 것이라 본다.

• 한국포장학회:학술대회논문집
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• 2006.11a
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• pp.95-101
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• 2006

거창사과원예협동조합에서 구입한 사과 600상자를 5% $CaCl_2$ 용액에 각각 15분간 침지하는 방법으로 전처리 후 24시간 건조시키고 무포장구, $25{\mu}m$ 두께의 기능성 MA 필름으로 포장한 포장구와 무처리 무포장구인 대조구로 나누어 $0^{\circ}C$의 저온저장고로 옮겨 7개월 동안 저장하면서 3주 간격으로 품질을 분석하였다. 저장 기간이 증가할수록 중량 감소율은 Control 구보다 $CaCl_2$구와 $CaCl_2+MA$구의 중량 감소율이 월등히 낮았다. 경도변화는 저장 기간이 증가할수록 감소하는 경향을 보였으며, 그 중 $CaCl_2$구는 초기치 0.97 $kg_f$에서 저장 18주에는 0.95 $kg_f$로 초기치에 비해 2%의 가장 적은 변화를 보였다. 산도는 대조구보다 처리구의 산도가 높게 나타났으나 큰 차이는 나타나지 않았다. 가용성 고형분 함량은 저장 기간 모든 실험구에 따른 큰 차이가 없었다. 비타민 C 함량은 저장기간이 지날수록 모든 실험구에서 감소하는 경향을 보였으며, 기호도 조사에서 $CaCl_2$구와 $CaCl_2+MA$구가 대조구보다 유의적으로 높게 나타났다.

• Journal of the Korean Chemical Society
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• v.30 no.6
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• pp.526-531
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• 1986

The stability constants of 1,15-diaza-3,4:12,13-dibenzo-5,8,11-trioxacycloheptadecane (NenOdien H$_4$, L) with transition metal ions such as $Co^{2+},\;Ni^{2+},\;Cu^{2+},\;and\;Zn^{2+}$ have been determined by potentiometry in 95% methanol solution at 25$^{\circ}$C. The complex formation of the NenOdien $_4$ with the transition metal ions depends on the basicity of the donor atoms. The order of complex stability was Co(II) < Ni(II) < Cu(II) > Zn(II). The geometries of the complexes in solid state were discussed by visible-near infrared and infrared spectrophotometry, elemental analysis and electro-conductivity. The results suggest that the geometries of the solid complexes are octahedral for $[CoL_2(OH_2)Cl]Cl{\cdot}2H_2O$, $[NiL_2(OH_2)Cl]Cl{\cdot}2H_2O$, and $[ZnLCl_2]{\cdot}\frac{1}{2}H_2O$ and square pyramidal for [CuLCl]Cl, respectively.

• Journal of the Korean Chemical Society
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• v.41 no.9
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• pp.488-494
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• 1997

Lithium and sodium ions have been intercalated into two dimensional structure of $FeMoO_4Cl$. The electronic localization and the large difference in unit cell parameter between the pristine material and the intercalates lead to the existence of large biphased domains. In the case of the lithium system, a narrow range of $Li_xFeMoO_4Cl$ ($0.95{\leq}x{\leq}1.06$) solid solution has been found around the $LiFeMoO_4Cl$ composition. The OCV curve fitting has been performed using Armand's model. The occurrence of several parts in the charge-discharge curve is related to the electronic and structural modifications of the material during the intercalation process.