• Title/Summary/Keyword: 7$\beta$-[trans-3-(p-chlorophenyl)-5-oxo-pyrrolidin-2-yl]acetamidopenicillanic acid

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Synthesis of $\beta$-Lactam Antibiotics and Their Antibacterial Activity (베타 락탐계 항생제의 합성 및 항균력)

  • 홍석기;남재우;이경태;신관석
    • YAKHAK HOEJI
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    • v.37 no.2
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    • pp.158-162
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    • 1993

  • 6$\beta$-(trans-3-Aryl-5-oxo-pyrrolidin-2-yl)acetamidopenicillanic acid(7a~7c) and 7$\beta$-(trans-3-Aryl-5-oxo-pyrrolidin-2-yl) acetamidocephalosporanic acid(8a~8c) were synthesized and tested in vitro antibacterial activity. Of these new penicillins exhibited good antibacterial activity against Gram-positive bacteria whereas none of the compounds possessed the activity against Gram-negative bacteria at the concentration tested.

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