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Characterization of Single Nucleotide Polymorphisms in 55 Disease-Associated Genes in a Korean Population

  • Lee, Seung-Ku;Kim, Hyoun-Geun;Kang, Jason-J.;Oh, Won-Il;Oh, Berm-Seok;Kwack, Kyu-Bum
    • Genomics & Informatics
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    • 제5권4호
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    • pp.152-160
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    • 2007
  • Most common diseases are caused by multiple genetic and environmental factors. Among the genetic factors, single nucleotide polymorphisms (SNPs) are common DNA sequence variations in individuals and can serve as important genetic markers. Recently, investigations of gene-based and whole genome-based SNPs have been applied to association studies for marker discovery. However, SNPs are so population-specific that the association needs to be verified. Fifty-five genes and 384 SNPs were selected based on association with disease. Genotypes of 337 SNPs in candidate genes were determined using Illumina Sentrix Array Matrix (SAM) chips by an allele-specific extension method in 364 unrelated Korean individuals. Allelic frequencies of SNPs were compared with those of other populations obtained from the International HapMap database. Minor allele frequencies, linkage disequilibrium blocks, tagSNPs, and haplotypes of functional candidate SNPs in 55 genetic disease-associated genes were provided. Our data may provide useful information for the selection of genetic markers for gene-based genetic disease-association studies of the Korean population.

전류파형을 변조한 단상유도전동기구의 특성에 관한 연구 (Performances of Current-Waveform Modulated Single-Phase Induction Machine)

  • 황영문;김철우;박용규
    • 전기의세계
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    • 제24권1호
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    • pp.55-62
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    • 1975
  • A single-phase induction motor with it's stator winding splitted into two series windings, of which the terminals of one winding is switched pulsationally by a thyristor type ON-OFF device so that the motor may operate as a pulsational shaded-pole motor, can modulate current waveforms of it's two series windings. In view of current waveform modulation method, a single-phase single-winding motor operates as a two-phase induction motor with asymmetrical axis windings where the starting torque can be obtained effectively without an auxiliary capacitor attached and it's running speed controlled by shifting phase between current waveforms differently. Equivalent circuit for analysis is modified from a double revolving field equivalent circuit of a single-phase induction motor with asymmetrical windings whose angle is 45.deg.C elet. degrees. Analysis and test results show that ON-OFF action of the pulsational shaded-pole winding has the same effect of a series capacitor, and then at heavy loads this motor operates with a small amonut of the input current than that having the fixed shaded-pole winding.

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베르누이법 의한 장잔광성 $SrAl_2O_4:Eu^{2+},\;Dy^{3+}$ 단결정 성장 (Growth of long persistent $SrAl_2O_4:Eu^{2+},\;Dy^{3+}$ phosphor single crystals by the Verneuil method)

  • 남경주;최종건
    • 한국결정성장학회지
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    • 제15권6호
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    • pp.225-228
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    • 2005
  • 본 연구에서는 장잔광성 $SrAl_2O_4:Eu^{2+},\;Dy^{3+}$ 단결정을 베르누이법으로 성장시켰다. 성장된 $SrAl_2O_4:Eu^{2+},\;Dy^{3+}$ 단결정은 지름이 5 mm, 길이는 55 mm이다. 상온(300 K)과 저온(15 K)에서 각각 photoluminescence를 측정한 결과, 상온에서는 ${\lambda}=526nm$에서만 나타났으나, 저온에서는 454nm 영역과 526nm 영역에서 발광피크를 나타내었다. 이는 형광도료로 사용되는 분말과 유사한 결과이다. 결정성장 시 적외선 광고온계로 녹는점을 측정한 결과는 $1968^{\circ}C$였다. 결정을 성장시키는 최적의 조성은 $SrCO_3:Al(OH)_3:Eu_2O_3:Dy_2O_3$ = 1 : 2 : 0.015 : 0.02이고 $H_2:O_2$의 혼합비는 약 4 : 1이다. 성장속도는 시간당 5mm이다. 성장된 단결정의 결정구조는 XRD로 측정하였다.

Surgery for Bilateral Large Intracranial Traumatic Hematomas : Evacuation in a Single Session

  • Kompheak, Heng;Hwang, Sun-Chul;Kim, Dong-Sung;Shin, Dong-Sung;Kim, Bum-Tae
    • Journal of Korean Neurosurgical Society
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    • 제55권6호
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    • pp.348-352
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    • 2014
  • Objective : Management guidelines for single intracranial hematomas have been established, but the optimal management of multiple hematomas has little known. We present bilateral traumatic supratentorial hematomas that each has enough volume to be evacuated and discuss how to operate effectively it in a single anesthesia. Methods : In total, 203 patients underwent evacuation and/or decompressive craniectomies for acute intracranial hematomas over 5 years. Among them, only eight cases (3.9%) underwent operations for bilateral intracranial hematomas in a single session. Injury mechanism, initial Glasgow Coma Scale score, types of intracranial lesions, surgical methods, and Glasgow outcome scale were evaluated. Results : The most common injury mechanism was a fall (four cases). The types of intracranial lesions were epidural hematoma (EDH)/intracerebral hematoma (ICH) in five, EDH/EDH in one, EDH/subdural hematoma (SDH) in one, and ICH/SDH in one. All cases except one had an EDH. The EDH was addressed first in all cases. Then, the evacuation of the ICH was performed through a small craniotomy or burr hole. All patients except one survived. Conclusion : Bilateral intracranial hematomas that should be removed in a single-session operation are rare. Epidural hematomas almost always occur in these cases and should be removed first to prevent the hematoma from growing during the surgery. Then, the other hematoma, contralateral to the EDH, can be evacuated with a small craniotomy.

1.55${\mu}{\textrm}{m}$에서 최적화된 유전체 다층막의 미러 특성 (The Mirror Characteristics of Dielectric Multilayer Optimized at 1.55${\mu}{\textrm}{m}$ Wavelength)

  • 박태성;정홍배;김명진;윤대원
    • 한국전기전자재료학회:학술대회논문집
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    • 한국전기전자재료학회 1995년도 추계학술대회 논문집
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    • pp.183-186
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    • 1995
  • The fabrication of dielectric multilayer mirror(DMM) optimized at the wavelength of 1.55$\mu\textrm{m}$ and its spectral properties were investigated. The materials used in the fabrication of DMM are TiO$_2$-SiO$_2$, which have the advantage of yielding high reflectance for relatively small numbers of layers. The optical constants of TiO$_2$single film were obtained by using a modified envelope method. The reflectances of DMMs with 3,7,11 and 23 layers were 58%, 89%, 97% and 99.9% at the wavelength of 1.55$\mu\textrm{m}$, respectively.

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연료전지의 수소저장용 합금에 대한 수소확산반응의 속도론적 해석 (Kinetic Parameter Analysis of Hydrogen Diffusion Reaction for Hydrogen Storage Alloy of Fuel Cell System)

  • 김호성
    • 조명전기설비학회논문지
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    • 제20권2호
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    • pp.45-49
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    • 2006
  • 본 논문은 마이크로 전극 시스템에 의하여 연료전지 및 Ni-MH 전지로의 응용을 가정한 $AB_5$계 수소저장합금인 $MmNi_{3.55}Co_{0.75}Mn_{0.4}Al_{0.3}$의 단일 입자에 대하여 전기화학적인 평가를 수행하였다. 즉 Carbon fiber 마이크로 전극을 합금 입자 한개 위에 전기적인 접촉을 이루도록 조정하고, 합금 입자 내에서 수소원자의 겉보기 화학적 확산계수를 계산하기 위하여 Potential-Step 실험을 실시하였다. 여기에서 사용되는 합금입자는 치밀하고 전도성이 있는 구형이므로 데이터 해석을 위해 구형확산 모델을 적용하였다. 실험결과로서 겉보기 확산계수($D_{app}$)는 수소 흡장 및 방출되는 전 과정에서 $10^{-9}$$10^{-10}[cm^2/s]$ 수준인 것으로 확인되었다. 마이크로 전극 측정 시스템에 의한 단일 입자의 전기화학적 평가는 기존의 Composite Film 전극에 비해 수소저장합금에 대해 보다 상세하고 정확한 정보를 쉽게 얻을 수 있었다.

Spinal Arteriovenous Fistula with Progressive Paraplegia after Spinal Anaesthesia

  • Baltsavias, Gerasimos;Argyrakis, Nikolaos;Matis, Georgios K.;Mpata-Tshibemba, Stephanie
    • Journal of Korean Neurosurgical Society
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    • 제55권2호
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    • pp.106-109
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    • 2014
  • A case of an iatrogenic spinal arteriovenous fistula with progressive paraplegia in a young woman is reported. The fistula was eventually created after repetitive lumbar punctures performed in the process of spinal anaesthesia. Her symptoms were progressed to paraplegia over a period of 2 years. The digital subtraction angiography demonstrated a single-hole fistula, involving the anterior spinal artery and vein. The lesion was occluded by embolization with immediate improvement. The potential mechanism is discussed.

$\lambda=1.55\mu\textrm{m}$에서 계단형, 삼각형 분포-이중클래드 분산보상 광섬유의 설계 (Design of Double-clad, Dispersion-Compensated Fiber at$\lambda=1.55\mu\textrm{m}$ : Step & Triangular Index Profile)

  • 김수아;김창민
    • 전자공학회논문지D
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    • 제34D권11호
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    • pp.54-63
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    • 1997
  • The 1-D finite-element mehtod is applied for designing double-clad otpical fibers with dispersion-compensation capability. design parameters allowing only a $LP_{01}$ single mode are treated and macro-bending loss are taken into consideration. Design parameters are extracted to have the compensation ratio $(L_{SMF}/L_{DCF})$ of 6.2 for core structure with step-index profile, and of 5.2 for core with triangular-index profile.

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Development of an RSFQ 4-bit ALU

  • Kim, J.Y.;Baek, S.H.;Kim, S.H.;Jung, K.R.;Lim, H.Y.;Park, J.H.;Kang, J.H.;Han, T.S.
    • 한국초전도학회:학술대회논문집
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    • 한국초전도학회 2004년도 High Temperature Superconductivity Vol.XIV
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    • pp.55-55
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    • 2004
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