• Archives of Pharmacal Research
• /
• v.16 no.3
• /
• pp.237-243
• /
• 1993

These studies were performed to investigate the acting sites of ginseng total saponins (GTS) on the U-50, 488H-induced antinociception and the inhibitory effect of the development of tolerance to U-50, 488H-induced antinociception by GTS were studied. The U-50, 488H-induced antinociception was ntagonized in mice pretreated with GTS intraperitoneally, intracerebrally. These antagonisms were reversed by the pretratment iwth a serotonin precursor, 5-hydroxytrypophan (5-HTP), but not with a noradrenaline precursor, L-dihydroxyphenylalanine (L-DOPA). However, the intraplantar sites. On the other hand, GTS inhibited the development of tolerance to U-50, 488H-induced antinociception was reversed by pretreatment with 5-HTP, but not with L-DOPA. Therefore, the antagonism of U-50, 488H-induced antinociception and the inhibition of the development of tolerance to U-50, 488H-induced antinociception and the inhibition of the development of tolerance to U-50, 488H-induced antinociception by GTS are dependent on serotonegic mechanisms.

• Journal of Ginseng Research
• /
• v.19 no.3
• /
• pp.202-205
• /
• 1995

We have previously reported that the antagonism of U-50,488H-induced antinociception in mice pretreated with ginseng total saponins (GTS) Ivas abolished by pretreatment with a serotonin precursor, 5-hydroxytryptophan (5-HTP), but not by a noradrenaline precursor, L-dihydroxyphenylalanine (L-DOPA) in the tail flick test. In the present experiments, the effect of the same GTS on the development of tolerance to U-50,488H-induced antinociception was determined. GTS inhibited the development of tolerance to U-50,488H-induced antinociception. The inhibitory effect of GTS on the development of tolerance to U-50,488H-induced antinociception was reversed by 5-HTP, but not by L-DOPA. These findings suggest that the inhibitory effect of GTS on the development of tolerance to U-50,488H-induced antinociception is dependent on serotonergic mechanisms. Key words Ginseng total saponin, U-50,488H, tolerance, serotonin.

• The Journal of Internal Korean Medicine
• /
• v.37 no.5
• /
• pp.876-884
• /
• 2016

Objective: To report a case of a patient with a psychosomatic disorder who complained of hyperventilation and was treated with oriental medical treatments and emotional freedom techniques (EFTs). Methods: The patient was diagnosed as having a psychosomatic disorder through an interview and several psychological tests, such as the house-tree-person (HTP) and the person in the rain (PITR) tests. We treated the patient with oriental medical treatments that included herbal medications, western medications, moxibustion, cupping, and EFT. Results: After the treatments, the clinical symptoms of the patient were improved. Conclusions: Oriental medical treatments and EFT may be effective treatments for psychosomatic disorders.

• Proceedings of the Korean Society of Propulsion Engineers Conference
• /
• 2008.11a
• /
• pp.371-374
• /
• 2008

The performance of several catalysts to decompose the high test peroxide (HTP) was described in this paper. Manganese oxide, Platinum and Iridium were coated on the gamma alumina. The response time of various catalysts was measured with a 50 Newton class thruster. Ir/$Al_2O_3$ that showed the fastest response time at the thruster, failed the reaction when continuous mode test was carried out with the thruster. Pt/$Al_2O_3$ and MnO_2/Al_2O_3$ can be substitutes to decompose the HTP. In addition, for larger thruster, MnO_2/Al_2O_3$ can be a good catalyst because its cost is below 5 % of Pt/$Al_2O_3$.

• The Korean Journal of Pharmacology
• /
• v.23 no.2
• /
• pp.95-100
• /
• 1987

The effects of various drugs on muricide and hyperirritability induced by bilateral lesions of the nucleus accumbens septi (NAB) were investigated in comparison with those on aggression induced by midbrain raphe nuclei-lesioned rats (raphe) and olfactory bulbectomized rats (OB). Muricide in NAB, raphe and OB rats were markedly suppressed by atropine. Muricide in NAB and raphe rats were significantly suppressed by L-DOPA, L-5-HTP, but muricide in OB rats was scarcely suppressed by L-DOPA and L-5-HTP. Hyperirritability in NAB, raphe and OB rats were significantly reduced by L-DOPA and haloperidol but not suppressed by atropine. On the other hand, muricide in NAB rats was markedly suppressed by antidepressants, particularily, nomifensine, clomipramine and desipramine. Muricide in raphe rats was markedly inhibited by nomifensine and clomipramine but only slightly inhibited by desipramine. Muricide in OB rats was markedly suppressed by imipramine. Hyperirritability in NAB, raphe and OB rats were slightly suppressed by antidepressants. These results suggested that the pharmacological characteristics of aggression induced by NAB rats resembles that induced by raphe rats, but differs from that induced by OB rats. It is also suggested that employment of different types of experimentally induced muricide in rats can be useful for the evaluation of antidepressants.

• Journal of Life Science
• /
• v.34 no.5
• /
• pp.320-332
• /
• 2024

The aims of this study were to compare the differences in hemodynamics between cigarette smoking and using heated tobacco products (HTPs) and to determine the acute effects of using HTPs on cardiac autonomic regulation. Another goal was to examine the acute cardiac autonomic responses when using different tobacco sticks in HTPs. Sixteen healthy male smokers completed an open-label, randomized, crossover trial consisting of non-smoking (NS), cigarette smoking, and the use of two different HTPs (IQOS with HEETS; lil SOLID with Fiit). Sub-trials, which included NS, lil SOLID with Fiit, and lil SOLID with HEET, were performed on eight smokers among the total subjects. Hemodynamic variables, such as systolic blood pressure (SBP) and diastolic blood pressure (DBP), and heart rate variability were measured before, during, and 30 minutes after using each tobacco product. Using HTPs resulted in a significant increase in both SBP and DBP, comparable to smoking cigarettes. Cardiac sympathetic activity significantly increased, and cardiac vagal tone (CVT) significantly decreased after acute exposure to HTP aerosol, similar to the effects of cigarette smoke exposure. Furthermore, differences in the withdrawal of CVT were observed when using different tobacco sticks in the same HTPs. The findings of this study indicate that acute exposure to HTP aerosol increases the hemodynamic burden and disrupts cardiac autonomic balance, similar to exposure to cigarette smoke. Moreover, depending on the type of tobacco stick inserted into the HTP device, acute withdrawal of CVT may have been enhanced.

• Journal of the Korean BIBLIA Society for library and Information Science
• /
• v.24 no.2
• /
• pp.93-111
• /
• 2013

The purpose of the study is to prove the effectiveness of bibliotherapy program to overcome of the excessive absorption on games for children. A 12-week programs were developed and managed in 1-2 grade, 3-4 grade, 5-6 grade for the elementary school student. Also MGUS (Maladaptive Game Use Scale), Self-Esteem Inventory, Self-Control Inventory, and HTP(House, Tree, Person) Diagnosis Tool were measured prior to the bibliotherapy and post-tests were followed to the participants statistically by t-test. According to analysis results, the bibliotherapy program was effectiveness to overcome of the excessive absorption on games for children.

• Journal of the Korean Society of Propulsion Engineers
• /
• v.12 no.5
• /
• pp.26-34
• /
• 2008

The performance of several catalysts to decompose the high test peroxide (HTP) was described in this paper. Manganese oxide, Platinum and Iridium were coated on the gamma alumina. The catalyst activity as active materials was measured at the flask reactor. The response time of various catalysts was also measured with a 50 Newton class thruster. $Ir/Al_2O_3$ that showed the best activity in the flask reactor and response time at the thruster, failed the reaction when continuous mode test was carried out with the thruster. $Pt/Al_2O_3$ and $MnO_2/Al_2O_3$ can be substitutes to decompose the HTP. In addition, for larger thruster, $MnO_2/Al_2O_3$ can be a good catalyst because its cost is below 5 % of $Pt/Al_2O_3$.

• Journal of Oriental Neuropsychiatry
• /
• v.20 no.2
• /
• pp.229-242
• /
• 2009

Objectives : This article aims to find how effective the art therapy is on the improvement of the self expression and the interpersonal relations with others, as medium for verbal communication of schizophrenic patients. Methods : The subject of this study was one schizophrenic patient who had been treated with drugs for five years in W university hospital, as well as counseled by an art therapy oo counsel office in J city. The art therapy had been performed the total 25 sessions, fifty minute per session, one session per week, from November 28 in 2008 to April 27 in 2009. The test was by HTP. Results : The results of this study are as follows: First, in the pretest of HTP, the subject showed a little lethargy, painting very simple house-shaped figures and too simple rectangular figures corresponding to those painted by 4 or 5-year-old children. In the post-test, however, the structures of houses were described concretely and three-dimensionally, and the descriptions of people were changed into concrete figure, by which we could see the improvement effect on the self expression and the interpersonal relations. Second, in the earlier stage, there was little verbal self expression, and little self respect, staring into space and showing passive attitude without positive assertion and expression. In the later stage, however, there were positive assertion and expression, even showing sense of humor. Lastly, in the earlier stage, there were few interpersonal relations. In the later stage, however, eye contacts and the interpersonal relations were increased during conversation and in the art work process, respectively. Conclusions : These results suggest that the art therapy can be effective on improvement of the self expression and the interpersonal relations with others, as medium for verbal communication of schizophrenic patients.

• Biomolecules & Therapeutics
• /
• v.20 no.5
• /
• pp.482-486
• /
• 2012

Cerebral monoamines play important roles as neurotransmitters that are associated with various stressful stimuli. Some components such as ginsenosides (triterpenoidal glycosides derived from the Ginseng Radix) may interact with monoamine systems. The aim of this study was to determine whether ginsenoside Rb1 can modulate levels of the monoamines such as dihydroxyphenylalanine (DOPA), dopamine (DA), norepinephrine (NE), epinephrine (EP), 3,4-dihydroxyphenylacetic acid (DOPAC), 5-hydorxytryptamine (5-HT), 5-hydroxindole-3-acetic acid (5-HIAA), and 5-hydroxytryptophan (5-HTP) in mice frontal cortex and cerebellum in response to immobilization stress. Mice were treated with ginsenoside Rb1 (10 mg/kg, oral) before a single 30 min immobilization stress. Acute immobilization stress resulted in elevation of monoamine levels in frontal cortex and cerebellum. Pretreatment with ginsenoside Rb1 attenuated the stress-induced changes in the levels of monoamines in each region. The present findings showed the anti-stress potential of ginsenoside Rb1 in relation to regulation effects on the cerebral monoaminergic systems. Therefore, the ginsenoside Rb1 may be a useful candidate for treating several brain symptoms related with stress.