• Title/Summary/Keyword: 5,8-Quinazolinediones

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Synthesis and Antifungal Activity of 5,8-Quinazolinedione Derivatives Modified at Positions 6 and 7

  • Ryu, Chung-Kyu;Shim, Ju-Yeon;Yi, You-Jin;Choi, Ik Hwa;Chae, Mi-Jin;Han, Ja-Young;Jung , Ok-Jai
    • Archives of Pharmacal Research
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    • v.27 no.10
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    • pp.990-996
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    • 2004
  • 5,8-Quinazolinediones modified at positions 6 and 7 were synthesized and tested for in vitro antifungal activities against Candida species and Aspergillus niger. Most of 5,8-quinazolinediones 3-5 generally exhibited potent antifungal activity. 6-Arylamino-7-chloro-5,8-quinazolinediones (3) generally showed more potent antifungal activity than 7-arylthio-5,8-quinzolinediones (4) and 6,7-bis-(arylthio)-5,8-quinazolinediones (5).