• 약학회지
• /
• 제43권6호
• /
• pp.751-755
• /
• 1999

3,4-Difluoroamphetamine.HCI and 5,6-difluoro-2-aminoindan.HCI were synthesized as serotonergic agents. 3,4-Difluorobenzaldehyde was condensed with nitroethane and reduced with $LiAlH_4$ to obtain 3,4-difluoroamphetamine. And 5,6-difluoro-2-aminoidan.HCI was synthesizd through reactions of condensation with malonic acid, 10% Pd-C reduction, cyclization with polyphosphoric acid, oximation and catalytic hydrogenation.