• 제목/요약/키워드: 5,10-methyleneterahydrofolate reductase

검색결과 2건 처리시간 0.017초

$\beta$-Carotene 대체 급여 및 에탄올의 만성적 급여가 흰쥐가 엽산대사에 미치는 영향 (Effects of Dietary $\beta$-Crotene Substitution for Vitamin A and Chronic Consumption of Ethanol on Folate Metabolism in Rats)

  • 임은선
    • Journal of Nutrition and Health
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    • 제32권4호
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    • pp.376-383
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    • 1999
  • The effects of $\beta$-carotene substitutionl for vitamin A and the chronic consumption of ethanol of ethanol on hepatic folate metabolism were studied it rats. The substitution of $\beta$-carotene for vitamin A depressed hepatic 10-formyl-tetreahydrofolate dehydrogenase(10-formyl-tetrahydrofolate : NADP oxidoreductase, E.C. 1.5. 1.6)activity to 65% of controls(p<0.001) and enhanced hepatic 5, 10-methy-lenetetrahydrofolate reductase(E. C. 6.3.3.2)activity by 56% with respect to control levels(p<0.001). Hepatic activity of 10-formyltertrahydrofolate dehydrogenase was depressed to about half that of control levels by ethanol administration to rats(36% ethanol diet, p<0.001). The activity of 5, 10-methyleneterahydrofolate reductase was not changed by ethanol consumption. The increased activity of 5, 10-methyleneterahydrofolate reductase and the decreased activity of 10-formyltetrahydrofolate dehydrogenase appeared to decrease the level of nonmethyl folate conezyme and the rate of one-carbon metabolism. Plasma homocysteine concentrations were significantly higher in rats fed ethanol(p<0.01) o $\beta$-carotene(p<0.001) than in controls, which suggests that increased activity of 5, 10-methylenetetrahydrofolate reductase can depress homocysteine metabolism. We concluded that dietary substitution of $\beta$-carotene for vitamin A or chronic administration of ethanol resulted in changes in the activity of hepatic folate-dependent enzymes, which could affect the distribution of folate derivatives, plasma homocysteine levels and one-carbon metabolism.

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MTHFR의 점돌연변이로 인한 과호모시스테인혈증 환자에서 발생한 폐색전증 2예 (Two Cases of Pulmonary Thromboembolism in Young Patients with Hyperhomocysteinemia)

  • 이욱현;박철홍;고훈영;안호정;권순석;김용현
    • Tuberculosis and Respiratory Diseases
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    • 제64권6호
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    • pp.460-465
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    • 2008
  • 저자들은 비교적 젊은 연령이며 호모시스테인혈증이 있는 환자들에서 발생한 폐혈전색전증 및 심부정맥혈전증 2예를 문헌과 함께 고찰하였다. 폐혈전색전증이 연령이 증가할수록 발생률이 증가한다는 점과 다른 위험요소가 존재하지 않는다는 점으로 보아 증례들에서 호모시스테인혈증이 폐혈전색전증을 일으킨 원인으로 보인다. 위험요소가 없으며 젊은 연령에서 생긴 폐혈전색전증에 있어 호모시스테인혈증을 원인의 하나로 고려하여야 할 것이다.