• YAKHAK HOEJI
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• v.38 no.4
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• pp.440-450
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• 1994

Due to the limited bioavailability of $[D-Ala^6]$LHRH from nonparenteral transmucosal sites of administration, enhancement of mucosal permeability by coadministration of several protease inhibitors and/or penetration enhancers were studied in rabbit mucosa. As a reliable bioassay method for $[D-Ala^6]$LHRH, ovulation-inducing effect were measured after vaginal administration in the rat. The permeation of $[D-Ala^6]$LHRH through the mucosal membrane of rabbit mounted on George-Grass diffusion cells were examined in the presence of polyoxyethylene 9-lauryl ether (POE), ${\beta}$-cyclodextrin$({\beta}-CyD)$ or ethylene diamine tetra acetate disodium salt(EDTA). The vaginal membrane showed higher permeability of $[D-Ala^6]$LHRH than the rectal and nasal membrane. POE and ${\beta}-CyD$ showed a small promoting effect on the membrane permeation of $[D-Ala^6]$LHRH, but EDTA showed significant enhancement. Ovaluation was enhanced by the coadministration of sodium laurate(0.5%), a protease inhibitor but was not enhanced by EDTA, a penetration enhancer. On the other hands, coadministration of sodium tauro 24,25 dihydrofusidate(1%) and EDTA(2%) enhanced the ovulation inducing-effect 2.8 times. These results suggest that the vaginal administration of $[D-Ala^6]$LHRH with STDHF or sodium laurate as a protease inhibitor, and EDTA as a penetration enhancer, may become an elective method for transmucosal delivery of $[D-Ala^6]$ LHRH.

• The Korean Journal of Food And Nutrition
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• v.27 no.4
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• pp.570-580
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• 2014

The purpose of this study was to investigate the effect of calcium (Ca) and vitamin D (vit. D) levels on metabolism of various minerals such as Ca, P, Mg, Fe, Zn, Cu, and Cr. The comparison was made on the rats that were placed on diet containing powdered skim milk with different Ca and vit. D levels for 5 weeks. A total of 42 5-week-old Sprague-Dawley rats were divided into 7 groups as follows: Control group consisted of normal Ca and normal vit. D (0.5% Ca, 1,000 IU vit. D); Experimental groups were divided into low (0.25%) and high (1.0%) calcium levels; and vit. D group was divided into low (10 IU), normal (1,000 IU), and high (5,000 IU) subgroups. The weight gain and food efficiency ratios of the rats were not significantly different with increasing dietary Ca levels. The absorption rates of 7 minerals (Ca, P, Mg, Fe, Zn, Cu, and Cr) were significantly decreased with increasing dietary Ca levels. Also, fecal excretion of P significantly increased with increasing dietary vit. D levels (p<0.05), and urine excretion of Fe was significantly increased with increasing dietary vit. D levels (p<0.001). The result indicated that higher Ca intake affected on bioavailability of other minerals, due to interactions among minerals in the process of intestinal absorption. However, vitamin D intake had no effect on bioavailability of several minerals. Therefore, it could be suggested that adequate Ca intake is important for balance of the minerals.

• The Journal of the Korean dental association
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• v.16 no.7 s.110
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• pp.531-536
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• 1978

Adult cats were light anesthetized with ethyl ether and heart was removed fastly. cardiac papillary muscle was dissected from heart in organ bath con taining Tyrode solution saturated with 95% O₂+5% CO₂, and prepared papillary muscles were placed in Tyrode solution that was continuously circulated and gassed with 95% O₂+5% CO₂at 32℃. The isolated papillary muscle was stimulated continuously with platinum pin electrode at frequency of 15/min and 90/min by means of electric stimulator and transmembrane action potentials were recorded with microelectrdes on the oscilloscope. The drug used was d-propranolol and its concentration was 0.5, 1.5 and 5.0 mg/L. The results obtained were as follows: 1. D-propranolol increased the threshold voltage of papillary muscle and raised by average of 213.6% of control. 2. D-propranolol had no effect on duration of action potential. 3. Conduction time of isolated papillary muscle was increased by d-propranolol and its effect was prominent at frequency of 90/min. 4. the maximum upstroke velocity was decreased by d-propranolol and its effect was dose-depndent decrease.

• Geomechanics and Engineering
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• v.31 no.1
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• pp.71-86
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• 2022

In Taiwan, an efficient approach for enhancing the stability of colluvium slopes is the drilled shaft method. For slopes with drilled shafts, the soil arching effect is one of the primary factors influencing slope stability and intertwines to the failure mechanism of the pile-soil system. In this study, the contribution of soil arching effect to slope stability is evaluated using the FEM software (Plaxis 3D) with the built-in strength reduction technique. The result indicates the depth of the failure surface is influenced by the S/D ratio (the distance to the diameter of piles), which can reflect the contribution of the soil arching effect to soil stability. When α (rock inclination angles)=β (slope angles) is considered and the S/D ratio=4, the failure surface of the slope is not significantly influenced by the piles. Overall, the soil arching effect is more significant on α=β, especially for the steep slopes. Additionally, the soil arching effect has been included in the proposed stability charts. The proposed charts were validated through two case studies, including that of the well-known Woo-Wan-Chai field in Taiwan. The differences in safety factor (FoS) values between the referenced literature and this study was approximately 4.9%.

• 대한상한금궤의학회지
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• v.4 no.1
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• pp.29-36
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• 2012

Aim : To investigate the hepatotective effect of Gardenia jsaminodes and Glycine max aqueous extract against D-galactosamine (d-GalN, 300mg/kg body weight) was administered to the male Sprague Dawley (SD) rats. Materials and Methods : The study was carried out on male SD rats (age matched, weight $250{\pm}10g$). Experimental groups divided four: Normal group (Nor) was administered saline, Control (Con) group was administered saline after d-GalN treatment. Experimental group (Exp) was administered Gardenia jsaminodes (200 mg/kg; Ga group), Glycine max (700 mg/kg; Gl group), and Gardenia jsaminodes+Glycine max (200 mg/kg+700 mg/kg, GG group) during 14 days(n=5). Results : d-GalN administration induced hepatotoxicity in rats which was manifested by increased levels of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase but decreased total cholesterol and triglyceride. Treatment with Gardenia jsaminodes extract significantly protected the liver in d-GalN administered rats. Conclusion : Gardenia jsaminodes aqueous extract and Gardenia jsaminodes+Glycine max extract possesses hepatoprotective potential, thus validating its use in alleviating toxic effects of d-GalN.

• The Journal of Korean Academy of Orthopedic Manual Physical Therapy
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• v.17 no.2
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• pp.33-39
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• 2011

Background: The purpose of this study was to verify the most effective spinal stabilization exercise program by comparing the activities of muscles contributing to spinal stabilization during 2 types of exercises using 3-D NEWTON and a Gym-ball. Methods: We divided sixteen healthy students to two groups in D city were recruited and each subjects performed two type of exercise. Exercise 1 was performed 3-D NEWTON spinal stabilization training during 4 weeks (n=8). Exercise 2 was performed special training program that use a Gym-ball during 4 weeks (n=8). Results: The group of 3-D NEWTON applying lumbar stabilization kinetic program was increased 18.8s after training. Conclusions: It was revealed the statically significant difference between 3-D NEWTON and Gym-ball lumbar stabilization exercise groups. Therefore it has been turned out that 3-D NEWTON and Gym-ball lumbar stabilization exercise has an effect on the abdominis and trunk muscle strengthening and balance.

• JSTS:Journal of Semiconductor Technology and Science
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• v.12 no.4
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• pp.473-481
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• 2012

For a mesa-isolated small geometry SOI MOSFET, the potentials in the silicon film, front, back, and side-wall oxide layers can be derived three-dimensionally. Using Taylor's series expansions of the trigonometric functions, the derived potentials are written in terms of the natural length that can be determined by using the derived formula. From the derived 3-D potentials, the minimum values of the front and the back surface potentials are derived and used to obtain the closed-form expressions for the front and back gate threshold voltages as functions of various device parameters and applied bias voltages. Obtained results can be found to explain the drain-induced threshold voltage roll-off and the narrow width effect of a fully depleted small geometry SOI MOSFET in a unified manner.

• Journal of the Korean Society for Advanced Composite Structures
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• v.5 no.4
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• pp.18-23
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• 2014

In this paper. the effects of the aspect ratio on the natural frequency of the advanced composite road structures is studied. The advanced composite structures are too difficult for such design engineers for construction and some simple but accurate enough methods are necessary. Some laminate orientations have decreasing values of $D_{16}$, $B_{16}$, $D_{26}$ and $B_{26}$ stiffnesses as the ply number increases. The plate aspect ratio considered is from 1 to 5. Most of the road structures have large aspect ratios, for such cases further simplification is possible by neglecting the effect of the longitudinal moment terms.

• YAKHAK HOEJI
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• v.40 no.3
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• pp.340-342
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• 1996

To investigate the antialopecic effect of N-4-salicylomide-2-amino-6-piperidinopyrimidine 3-oxide(SALMI) and its salt on the hair of black mouse (C57BL/6), this study was carrie d out. When salmi and its salt in ethanol solution were administered to the black mouse (C57BL/6) by route of skin, both of them promoted the growth of hair.

• Journal of the Korean Chemical Society
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• v.47 no.1
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• pp.43-46
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• 2003

From Portulaca oleracea which is widely distributed in Korea and has long been used as a folk medicine, two biophenolic glycosides, 3-hydroxy-1-(2-hydroxyethyl)phenyl-4-O-${\beta}$-D-glucopyranoside (1) and 2-(3,4-dihydroxyphenyl) ethyl-O-${\beta}$-D-glucopyranoside (2) were isolated using column chromatography and reversed-phase HPLC. $^{13}C$ NMR spectral assignment for these compounds was revised by the extensive 2-D NMR experiments such as NOESY, HMQC, and HMBC. These compounds showed a considerable antioxidant effect in DPPH assay system.