• The Korean Journal of Physiology
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• 제29권1호
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• pp.61-67
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• 1995

The extract of Ginkgo bibloba (EGb) is a complex mixture of natural products from the Ginkgo leaves and clinically used for the treatment of cerebral and peripheral circulatory disturbances due to its combined activity of several vasoactive principles. In this study we investigated the action of EGb and its mechanism in isolated rabbit corporal smooth muscle to evaluate the possibility of using this material as a pharmacoerecting agent. Strips of rabbit corpus cavernosum were mounted in organ chambers to measure isometric tension. EGb began to exert an relaxing effect at 1 mg/ml in the submaximally precontracted muscle strips with phenylephrine $(PHE,\;5{\times}10^{-6}\;M)$; causing concentration-dependent relaxation with maximal effect at $3{\sim}5\;mg/ml$. That relaxation was partially inhibited by removal of the smooth muscle endothelium or by pretreatment with a NO scavenger, pyrogallol $(10^{-4}\;M)$ or the guanylate cyclase inhibitor, methylene blue $(10^{-4}\;M)$. Pretreatment with EGb (3 mg/ml) inhibited PHE- $(5{\times}10^{-6}\;M)$ or KCI- (20 and 40 mM) induced contraction of muscle strip. In calcium-free high potassium solution EGb depressed the basal tone of the depolarized muscle strip and inhibited calcium-induced contraction when $CaCl_2$ $(10^{-4}\;M)$ was added. These results suggest that EGb relaxes rabbit corpus cavernosal smooth muscle through multiple action mechanisms that include increasing the release of nitric oxide from the corporal sinusoidal endothelium, sequestration of intracytosolic calcium, and maybe a hyperpolarizing action.

• Journal of Gastric Cancer
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• 제16권2호
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• pp.120-124
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• 2016

Primary squamous cell carcinoma (SCC) of the stomach is a very rare disease. However, the pathogenesis, clinical characteristics, and prognosis of gastric SCC are controversial and remain to be elucidated. Herein, we report a case of primary gastric SCC of the remnant stomach after subtotal gastrectomy. A 65-year-old man was admitted to our hospital due to epigastric discomfort and dizziness. He had undergone subtotal gastrectomy 40 years previously for gastric ulcer perforation. Endoscopy revealed a normal esophagus and a large mass in the remnant stomach. Abdominal computed tomography revealed enhanced wall thickening of the anastomotic site and suspected metachronous gastric cancer. Endoscopic biopsy revealed SCC. Total gastrectomy was performed with Roux-en-Y esophagojejunostomy. A 10-cm tumor was located at the remnant stomach just proximal to the previous area of anastomosis. Pathologic examination showed well-differentiated SCC extended into the subserosa without lymph node involvement (T3N0M0). The patient received adjuvant systemic chemotherapy with 6 cycles of 5-FU and cisplatin regimen, and he is still alive at the 54-month follow-up. According to the treatment principles of gastric cancer, early detection and radical surgical resection can improve the prognosis.

• 디자인학연구
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• 16호
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• pp.125-134
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• 1996

국가 경쟁력을 제고하기 위한 방법의 하나로 산업디자인의 진흥이 중요한 관심사로 떠오르는 시점에서 20c초 우리 나라와 유사한 상황에 처했던 영국 디자인 운동이 성립과정과 그 역할을 살펴보는 것은 매우 의미 있고 시의 적절한 일이라고 생각된다. 그리고 반드시 이러한 현실적인 요구가 아니라 하더라도 영국의 디자인 운동과 이에 따른 디자인 정책을 살펴보는 것은 우리의 입장에서 디자인 개선을 위한 정책수립과 디자인운동의 방향을 설정하는데 크게 참고가 되리라고 생각된다. 이런 측면에서 먼저 D.I.A. 설립 당시의 시대적 상황을 살펴보고 설립의 배경이 된 독일의 디자인 운동 및 D.I.A 의 활동에 대해서는 설립초기의 상황에서부터 20년대, 30년대, 40년대 순 으로 각 시대별 활동상황 및 중요인물들의 역할에 대해 기술하였다. 끝으로 결론부분에서는 D.I.A 가 수행한 역할을 긍정적 측면과 부정적 측면으로 나누어 지적하였다.

• Computers and Concrete
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• 제17권6호
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• pp.787-799
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• 2016

Climate anomalies in recent years, numerous natural disasters caused by landslides and a large amount of entrained sands and stones in Taiwan have created significant disasters and greater difficulties in subsequent reconstruction. How to respond to these problems efficaciously is an important issue. In this study, the sands and stones were doped with recycled materials (waste LCD glass sand, slag powder), and material was mixed for recycled ready-mixed soil. The study is based on security and economic principles, using flowability test to determine the water-binder ratio (W/B=2.4, 2.6, and 2.8), a fixed soil: sand ratio of 6:4 and a soil: sand: glass ratio of 6:2:2 as fine aggregate. Slag (at concentrations of 0%, 20%, and 40%) replaced the cement. The following tests were conducted: flowability, initial setting time, unit weight, drop-weight and compressive strength. The results show that the slump values are 220 -290 mm, the slump flow values are 460 -1030 mm, and the tube flow values are 240-590 mm, all conforming to the objectives of the design. The initial setting times are 945-1695 min. The unit weight deviations are 0.1-0.6%. The three groups of mixtures conform to the specification, being below 7.6 cm in the drop-weight test. In the compressive strength test, the water-binder ratios for 2.4 are optimal ($13.78-17.84kgf/cm^2$). The results show that Recycled ready-mixed soil materials (RRMSM) possesses excellent flowability. The other properties, applied to backfill engineering, can effectively save costs and are conducive to environmental protection.

• 기록학연구
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• 제70호
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• pp.5-40
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• 2021

업무를 위해서 설계된 다양한 시스템에서 생산되는 행정정보데이터 세트 기록은 건 단위로 관리하기 어렵기 때문에 별도로 데이터세트를 식별하고 평가하는 절차가 필요하다. 식별된 데이터세트기록은 평가를 거쳐 기록관리시스템으로 이관하거나 폐기 등의 처분이 일어난다. 이러한 과정에서 기록관리원칙을 지키기 위해서는 생산시스템 자체에 충분한 기록관리요소가 반영되어야 한다. 본 논문에서는 데이터세트를 정확하게 식별하고 안전하게 관리하기 위한 생산시스템의 기능요건을 도출하고 KR 재산관리시스템의 사례를 토대로 적용하였다. 이러한 생산시스템 기능요건의 연구가 더해져 데이터세트 생산시스템의 기능요건 표준의 도출까지 이어지길 기대해 본다.

• International Journal of Computer Science & Network Security
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• 제22권7호
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• pp.327-331
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• 2022

The article aims at studying the institution of human rights in an ever-evolving world in the context of the interdisciplinary approach. The main scientific method was deduction that allowed examining the specific interdisciplinary approach in relation to the institution of human rights on the global scale. To solve the issue set, it is necessary to study legal foundations and features of the interdisciplinary approach to the institution of human rights in the modern world. The article proves there is no theoretical anthropological understanding of the institution of human rights. It has been concluded that the appeal to anthropological jurisprudence requires the identification of the initial theoretical and methodological principles, parameters and axioms of cognition, the integration of a person into the subject field of legal science, linking jurisprudence with the chosen external environment (philosophy, sociology, theology, etc.), predetermining the existence (understanding) of a person, causing qualitative differences and the structure of subject-methodological phenomena. In addition to the identification of such hypotheses, prerequisites and axioms, the basic method (principle) of cognition and its heuristic potential are also being searched (defined). The terminological designation of the formed subject-methodological phenomenon (legal anthropology, anthropology of law, anthropological approach, etc.) reveals its role in the system of interdisciplinary relations of legal science.

• 대한융합한의학회지
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• 제4권1호
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• pp.13-17
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• 2022

원발성 월경곤란은 내장 통증을 일으키는 대표적인 질환으로, 오랫동안 침 치료가 효과적인 질환으로 알려져왔다. 이번 연구는 기존의 체계적 문헌고찰에 보고된 경혈을 이용하여 네트워크 분석을 수행하였고, 이를 통해 원발성 월경곤란을 치료하기 위해 이용되는 경혈과 경혈의 조합을 분석하였다. 총 60편 중 이침을 이용한 논문을 제외하고 의 논문을 분석 결과에 따르면 신수, 위중, 대장수, 곤륜, 환도, 아시혈, 관원수, 양릉천, 기해수, 요양관이었으며, 태계혈이 함께 조합되어 사용되었다. 이를 통해 요통에 대한 침 치료 효과를 밝히기 위한 이전의 연구들에서 족태양방광경의 경혈들이 주로 사용된 것, 그리고 근위와 원위의 경혈이 사용된 것을 알 수 있다. 추후 연구를 통해 경혈과 치료 효과 간의 상관 관계를 밝히고 경혈을 선정하고 조합하는 원리에 대한 가이드라인을 제시하기 위해서는 치료 효과에 대한 정량적인 분석 방법과 이용한 경혈에 대한 자세한 보고가 필수적이다.

• 한국분말재료학회지
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• 제30권3호
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• pp.268-275
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• 2023

The demand for energy is steadily rising because of rapid population growth and improvements in living standards. Consequently, extensive research is being conducted worldwide to enhance the energy supply. Transpiration power generation technology utilizes the vast availability of water, which encompasses more than 70% of the Earth's surface, offering the unique advantage of minimal temporal and spatial constraints over other forms of power generation. Various principles are involved in water-based energy harvesting. In this study, we focused on explaining the generation of energy through the streaming potential within the generator component. The generator was fabricated using sugar cubes, PDMS, carbon black, CTAB, and DI water. In addition, a straightforward and rapid manufacturing method for the generator was proposed. The PDMS generator developed in this study exhibits high performance with a voltage of 29.6 mV and a current of 8.29 µA and can generate power for over 40h. This study contributes to the future development of generators that can achieve high performance and long-term power generation.

• Journal of Cerebrovascular and Endovascular Neurosurgery
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• 제26권1호
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• pp.46-50
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• 2024

Objective: Diagnostic cerebral angiograms (DCAs) are widely used in neurosurgery due to their high sensitivity and specificity to diagnose and characterize pathology using ionizing radiation. Eliminating unnecessary radiation is critical to reduce risk to patients, providers, and health care staff. We investigated if reducing pulse and frame rates during routine DCAs would decrease radiation burden without compromising image quality. Methods: We performed a retrospective review of prospectively acquired data after implementing a quality improvement protocol in which pulse rate and frame rate were reduced from 15 p/s to 7.5 p/s and 7.5 f/s to 4.0 f/s respectively. Radiation doses and exposures were calculated. Two endovascular neurosurgeons reviewed randomly selected angiograms of both doses and blindly assessed their quality. Results: A total of 40 consecutive angiograms were retrospectively analyzed, 20 prior to the protocol change and 20 after. After the intervention, radiation dose, radiation per run, total exposure, and exposure per run were all significantly decreased even after adjustment for BMI (all p<0.05). On multivariable analysis, we identified a 46% decrease in total radiation dose and 39% decrease in exposure without compromising image quality or procedure time. Conclusions: We demonstrated that for routine DCAs, pulse rate of 7.5 with a frame rate of 4.0 is sufficient to obtain diagnostic information without compromising image quality or elongating procedure time. In the interest of patient, provider, and health care staff safety, we strongly encourage all interventionalists to be cognizant of radiation usage to avoid unnecessary radiation exposure and consequential health risks.

• 기본간호학회지
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• 제1권1호
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• pp.37-49
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• 1994

The purpose of this study was to measure the oral temperature, skin temperature, and subjective discomfort according to the application time of ice bag on thigh, head, and abdomen. This study was also intended to suggest nursing principles about ice bag application by exploring the recovery time of skin temperature after the removal of ice bag. The design of this study was $8{\times}3$ factorial design with one sample repeated measure. Here, the application time of ice bag(criteria, 5min, 10min, 20min, 30min, 40min, 50min, 60min) and the application site of ice bag(thigh, head, abdomen) were independent variables. The subjects were 10 university woman students, and data collection was made from July, 1 to August 30, 1992. Rubber ice bag halfly filled with ice was covered with towel and applied on thigh, head and abdomen in other three days. Before applying the ice bag, oral temperature and skin temperature were checked for criteria. After ice bag was applied, skin temperature, oral temperature and VAS score were checked at first 5 minutes elapsed, and every 10 minutes until 60 minutes. After that, ice bag was removed, and oral temperature and skin temperature were also measured every ten minutes until 60 minutes. In this study, skin temperature and core temperature were measured by thermistor probe, and subjective discomfort was measured by 200mm VAS (Visual Analogue Scale). Some of the findings were as follows : 1. There were significant differences in skin temperature among the three application sites of ice bag as time go by. It was most decreased to $15.87^{\circ}C$ in thigh, and $19.47^{\circ}C$ in abdomen at 50 minutes after the application of ice bag, whereas $26.1^{\circ}C$ at 40 minutes in head. Before the application of ice bag, skin temperature showed significant differences in three sites, so that they were compared after the criteria was covariated. In other words, there was significantly more decrease of skin temperature in thigh and abdomen than head, after ice bag was applied for 20 minutes and more. 2. There was no significant difference in core temperature among the three application sites of ice bag during the time of application 3. There was no significant difference in subjective discomfort (VAS) among the three application sites of ice bag. 4. After the removal of ice bag, the recovery of skin temperature was significantly different in three sites during first 30 minutes. In head, skin temperature came up to criteria at 30 minutes after the removal of ice bag, but it was not recovered In thigh and abdomen even 60 minutes elapsed. 5. After the removal of ice bag, there was no significant difference in oral temperature among the three application sites of ice bag. 6. There was significant correlation between the skin temperature and VAS score only in thigh. In conclusion, it is suggested that head in more suitable site for the application of ice bag if it is used for the relief of fever or pain. When we apply ice bag on thigh or abdomen for the relief of pain, careful attention is required.