• Title/Summary/Keyword: 4-oxochroman

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Synthesis of 6- Hydroxy-7 -methoxychroman-2-carboxylic Acid Dialkylaminoalkylamides (6-하이드록시-7-메톡시크로만-2-카복실산 디알킬아미노알킬아마이드 합성)

  • Kwak, Jae-Hwan;Lee, Keum-Ho;Jung, Jae-Kyeong;Cho, Jung-Sook;Lee, Hee-Soon
    • YAKHAK HOEJI
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    • v.50 no.5
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    • pp.322-325
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    • 2006
  • In the course of developing novel antioxidants, we synthesized four of 6-hydroxy-7-methoxy-4-oxochroman-2carboxylic acid dialkylamides (3a-d) $(13{\sim}18%)$ and four of 6-hydroxy-7-methoxychroman-2-carboxylic acid dialkylamides (4a-d) $(52{\sim}89%)$, incorporating the basic amine functionality. None of these compounds exhibited significant antioxidant activity possibly due to the hydrophilic character of the basic amine side chains.