• Journal of Applied Biological Chemistry
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• v.62 no.4
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• pp.355-359
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• 2019

In vivo micronucleus tests were performed to investigate the mutagenic potential of 4-butylaniline and N-butylaniline, which are used in dye intermediates and organic intermediates respectively. Groups of 5 male ICR mice were treated with vehicle or 4-butylaniline for 2 consecutive days by oral gavage at concentrations of 0 (control), 64, 160, 400, and 1000 mg/kg. Statistically significant and dose-dependent increases were found for micronuclei frequencies in male mice (p <0.05). These results suggest that 4-butylaniline can induce genetic effects in the micronuclei of male mouse bone marrow cells. Based on the positive results obtained in cytogenetic analyses of somatic cells in vivo, Globally Harmonized System of Classification and Labelling of Chemicals Category 2 was assigned. N-butylaniline was administered for 2 consecutive days by oral gavage to male ICR mice at dose of 0 (control), 64, 160, 400, and 800 mg/kg. N-butylaniline tested negative for micronuclei induction in mice, although N-butylaniline was associated with micronucleus induction at the highest dose. Based on the negative results obtained for cytogenetic analyses of somatic cells in vivo, "Not Classified" was assigned.

• Journal of the Korean Chemical Society
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• v.18 no.4
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• pp.239-243
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• 1974

By means of NMR spectrum analysis of the synthesized MBBA and EBBA, it has been found that benzene rings of p-n-butylaniline in both MBBA and EBBA molecules do not conjugate with the central double bond and the benzene ring is twisted from molecular plane of N-(p-methoxy or ethoxy benzylidene) group. And as a result of MO studies, the minimum energy conformation is found for the conformation of $30^{\circ}$ twisted angle. One sees reasonable agreement between theory and experiment.

• Bulletin of the Korean Chemical Society
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• v.12 no.5
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• pp.583-588
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• 1991

A series of dimesogenic compounds having two identical, terminal Schiff base type mesogens and a central polymethylene spacer were prepared and their properties were compared with those of the corresponding monomesogenic compounds. The mesomorphic properties of the compounds were studied by differential scanning calorimetry and on a hot-stage of a polarizing microscope. All of the dimesogenic compounds formed mesophases enantiotropically with the exception of pentamethylene-1,5-bis(4-oxybenzylidene 4-n-butylaniline). This compound was monotropic and formed only a nematic phase on heating the solid, whereas it formed nematic as well as smectic A phases on cooling the isotropic liquid. Those compounds containing longer (octamethylene and decamethylene) spacers favored the formation of nematic phase whereas those having shorter (dimethylene and tetramethylene) spacers formed smectic phases. In general, the variety of mesophase forms exhibited by the dimesogenic compounds was significantly less than that shown by the corresponding monomesogenic compounds.

• Bulletin of the Korean Chemical Society
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• v.11 no.3
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• pp.209-214
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• 1990

A series of compounds consisting of 4'-oxybenzylidene-4-n-butylaniline, a mesogen, and a p-substituted phenoxyterephthaloyl structure a non-mesogen, interconnected through a central hexamethylene spacer were synthesized and their thermal behavior and liquid crystallinity were studied. p-Substituents included in this study are H, Cl, CN, $NO_2,\;n-C_4H_9O$ and phenyl groups. The compounds having phenyl and $n-C_4H_9O$ substituents are enantiotropic and form smectic-A(SA) and nematic (N) phases. The compound with $NO_2$ substituent is monotropic and forms only a nematic phase on heating the solid, whereas it forms nematic as well as $S_A$ phases on cooling the isotropic liquid. The rest compounds were found to be non-liquid crystalline. This is in great contrast to the fact that the monomesogenic model compound 4'-n-hexyloxybenzylidine-4-n-butylaniline forms $S_B,\;S_C,\;S_A$ and N phases enantiotropically.

• Journal of radiological science and technology
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• v.27 no.4
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• pp.31-35
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• 2004

A new measuring system for ultrasonic spectroscopy was constructed, utilizing PVDF [poly(vinylidene fluoride)] polymer films as wideband transducers. In a test of its performance, this measuring system was successfully applied to study of the nematic-isotropic phase transition in MBBA(p-methoxybenzylidene-p-n-butylan iline) liquid crystal. We could be confirmed that the phase transition in MBBA is $47^{\circ}C$, which is agree with the exciting optical method. The dependence of frequency on the phase transition was not observed, and but Maximum ultrasonic amplitude is measured for the resonance frequency 2MHz in PVDF transducers, These results shows that the spectroscopy with PVDF transducers takes advantage of studying the transient phenomena. When our apparatus is applied in medical purposes, It will be possible diagnostic for sickle-cell anemia and arterial sclerosis.