• Journal of Korean Neurosurgical Society
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• 제62권4호
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• pp.389-397
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• 2019

Objective : Mechanical thrombectomies with balloon-guide catheters (BGC) are thought to improve successful recanalization rates and to decrease the incidence of distal emboli compared to thrombectomies without BGC. We aimed to assess the effects of BGC on the outcomes of mechanical thrombectomy in acute ischemic strokes. Methods : Studies from PubMed, EMBASE, and the Cochrane library database from January 2010 to February 2018 were reviewed. Random effect model for meta-analysis was used. Analyses such as meta-regression and the "trim-and-fill" method were additionally carried out. Results : A total of seven articles involving 2223 patients were analyzed. Mechanical thrombectomy with BGC was associated with higher rates of successful recanalization (odds ratio [OR], 1.632; 95% confidence interval [CI], 1.293-2.059). BGC did not significantly decrease distal emboli, both before (OR, 0.404; 95% CI, 0.108-1.505) and after correcting for bias (adjusted OR, 1.165; 95% CI, 0.310-4.382). Good outcomes were observed more frequently in the BGC group (OR, 1.886; 95% CI, 1.564-2.273). Symptomatic intracranial hemorrhage and mortality did not differ significantly with BGC use. Conclusion : Our meta-analysis demonstrates that BGC enhance recanalization rates. However, BGC use did not decrease distal emboli after mechanical thrombectomies. This should be interpreted with caution due to possible publication bias and heterogeneity. Additional meta-analyses based on individual patient data are needed to clarify the role of BGC in mechanical thrombectomies.

• 대한간호학회지
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• 제49권4호
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• pp.361-374
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• 2019

Purpose: This study was conducted to evaluate the effectiveness of autogenic training on stress responses through a systematic review and meta-analysis. Methods: A systematic search was conducted using eight core electronic databases (Embase, CENTRAL, Medline, CINAHL, PsycInfo, DBpia, KISS, and RISS). To estimate the effect size, a meta-analysis of the studies was performed using RevMan 5.3.5 program. Results: A total 21 studies out of 950 studies were included in the review, and 11 were included for meta-analysis. These studies showed that autogenic training decreased anxiety and depression, and increased the high frequency of heart rate variability. Calculations to understand the effect of autogenic training on anxiety, through a meta-analysis, observed a reduction effect of anxiety score by 1.37 points (n=85, SMD=-1.37: 95% CI -2.07 to -0.67), in the studies on short-term intervention targeting healthy adults. On the other hand, similar calculations to understand the effect of autogenic training on depression observed, a reduction effect on the depression score by 0.29 point (n=327, SMD=-0.29: 95% CI -0.50 to -0.07), in the studies on long term intervention targeting the patient group. Conclusion: Autogenic training is effective for adults' stress management, and nurses will be able to effectively perform autogenic training programs for workers' stress relief at the workplace.

• 한국방사선학회논문지
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• 제13권3호
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• pp.407-414
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• 2019

최근 NCS 교육기반으로 개편된 이후 NCS에서 요구하는 직업기초능력과 직무능력을 향상하기 위한 다양한 학습방법이 모색되고 있으며, 그에 따른 평가방법이 절실히 필요하다. 본 연구에서는 전문대학 방사선과 학생들을 대상으로 NCS 교육과정에서 요구하는 직무능력과 직업기초능력을 향상시키기 위하여 평가 사례로 메타인지 학습과 하브루타 학습을 적용하여 평가하였다. 적용한 결과, 메타인지 학습 대응 표본 통계량에서는 사전 메타인지학습 설문을 5점 척도로 했을 경우 평균 2.6883, 사후 메타인지 학습 설문 평균은 4.2468로 나타나 약 1.55점 향상되었다. 상관계수는 0.782, 유의확률은 0.045로 유의하게 나타났다. 하브루타 학습 대응 표본 통계량에서는 사전 하브루타 학습 설문을 5점 척도로 했을 경우 평균 3.1515, 사후 하브루타 학습 설문 평균은 4.3853으로 나타나 약 1.23점 향상되었다. 상관계수는 0.631, 유의확률은 0.049로 유의하게 나타났다. 메타인지 학습과 하브루타 학습이 상관관계가 있는지 이변량 상관계수를 통하여 알아 본 결과, 메타인지의 평균은 3.4675, 하브루타의 평균은 3.7684로 나타났으며 메타인지 학습과 하브루타 학습은 -0.042의 상관관계를 가지며 통계적으로 유의한 차이는 없는 것으로 나타났다. 따라서 직무능력을 향상시키기 위한 학습방법은 교과목 특성을 고려하여 적용해야 할 것이다.

• 한국컴퓨터정보학회논문지
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• 제22권4호
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• pp.115-122
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• 2017

The purpose of this study was to evaluate the effect of job satisfaction on turnover intention and organizational commitment in nurses through a systematic literature review and meta-analysis. For the study purpose, 26 studies were selected through a systematic process of using several databases and used to estimate the effect size of correlation between 3 variables. Meta-analysis was applied by usingcrandom effects model, and effect sizes on three types were calculated. Results are as follows. First, the effect size of correlation between job satisfaction and turnover intention is -.58. Second, the effect size of correlation between job satisfaction and organizational commitment is .77. Third, for the organizational commitment and turnover intention relationship, the effect of correlation is -0.68. Furthermore, publication bias analysis were assessed the results by using the funnel plot, Egger's regression test, fail-safe N, and trim-and-fill test. Based on these results, implications for the study were discussed.

• 한국산업정보학회논문지
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• 제10권4호
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• pp.97-109
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• 2005

본 연구는 메타 분석적 방법론을 통해 최근 국내에서 소개된 인터넷 쇼핑몰에서의 고객 신뢰에 관한 연구를 종합적으로 분석한다. 이를 위해 기존 연구의 흐름을 조사하고, 메타 분석적 절차에 따른 연구 방법을 적용한다. 분석 결과, 신뢰의 원인변수와 결과변수 대부분에 대한 통계적 유의성이 통합적으로 입증되었다. 아울러 해당 분야에 대한 실증연구가 아직도 더 많이 필요한 것으로 드러났다.

• Journal of information and communication convergence engineering
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• 제6권4호
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• pp.470-474
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• 2008

A well-designed computer network technology produces benefits on several fields within the organization, between the organizations(suborganizations) or among different organizations(suborganizations). Network technology streamlines business processes, decision process. Graphs are useful data structures capable of efficiently representing a variety of networks in the various fields. Metagraph is a like graph theoretic construct introduced recently by Basu and Blanning in which there is set to set mapping in place of node to node as in a conventional graph structure. Metagraph is thus a new type of data structure occupying its popularity among the computer scientists very fast. Every graph is special case of Metagraph. In this paper the authors introduce the notion of Meta-Networking as a new network technological representation, which is having all the capabilities of crisp network as well as few additional capabilities. It is expected that the notion of meta-networking will have huge applications in due course. This paper will play the role of introducing this new concept to the network technologists and scientists.

• 미생물학회지
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• 제38권4호
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• pp.245-245
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• 2002

Catabolic pathways for the degradation of various aromatics by Sphingomonas yanoikuyae Bl are intertwined, joining at the level of substituted benzoates, which are further degraded vita ring cleavage reactions. The mutant strain EK497, which was constructed by deleting a large DNA region containing most of the genes for biphenyl, naphthalene, m-xylene, and m-toluate degradation, was unable to grow on all of the aromatics tested except for benzoate as the sole source of carbon and energy.S. yanoikuyae EK497 was found to possess only catechol ortho-ring cleavage activity due to deletion of the genes for the meta-cleavage pathway. Wild-type S. yanoikuyae Bl grown on benzoate has both catechol orthoand meta-cleavage activity. However, m-xylene and m-toluate, which are metabolized through methylbenzoate, and biphenyl, which is metabolized through benzoate, induce only the meta-cleavage pathway, suggesting the presence of a substrate-dependent induction mechanism.

• 생명과학회지
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• 제25권5호
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• pp.515-522
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• 2015

Treculia africana Decne는 빵나무종으로 뽕나무과, Treculia 속에 속하는 식물로서, 이 식물의 다양한 부위에서 추출한 물질은 항염증, 항균등의 효과를 가지고 있어 백일해의 치료등 다양한 질환에서 민간요법으로 사용되어 왔다. 하지만 정확한 생리활성에 관한 연구는 보고된 바가 없다. 따라서 본 연구에서는 T. africana Decne 메탄올추출물(META)을 사용하여 항산화능 및 인체 대장암 세포주인 HT29에 대한 항암활성에 관하여 분석하였다. DPPH radical scavenging activity를 통해 분석한 결과, META의 IC₅₀가 4.53 μg/ml로 강력한 항산화능을 보유하 였음을 확인하였다. 또한 META 처리에 의해 HT29의 생존율이 감소함과 더불어 IC₅₀가 66.41 μg/ml로 강력한 세포사멸효과를 나타냈다. META 처리에 의해 HT29의 subG1 세포비율 및 Annexin V⁺ 세포의 비율이 증가하고, DAPI로 염색된 apoptotic body가 증가하였다. 또한 apoptosis 관련 단백질인 Fas, Bax, cytochrome c의 발현이 증가하였으며, 이는 caspase 3, 8, 9를 활성화 시켜 최종적으로 PARP가 분해되어 apoptosis가 유도되었음을 확인하였다. 이러한 결과들을 통해 META는 강한 항산화 활성과, 대장암세포에서 apoptosis 유도에 의한 높은 항암활성을 보유한 물질임을 확인하였다.

• Asian Pacific Journal of Cancer Prevention
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• 제14권4호
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• pp.2583-2589
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• 2013

Purpose: Studies have indicated that diabetes mellitus (DM) is a risk factor for bladder cancer; however, not all evidence supports this conclusion. The aim of this meta-analysis was to collate and evaluate all primary observational studies investigating the risk of bladder cancer associated with DM. Methods: The PubMed and Google Scholar databases were searched to identify studies that estimated the association of DM and bladder cancer. Summary effect estimates were derived using a random-effects meta-analysis model. Results: A total of 23 studies (8 case-control studies, 15 cohort studies) including 643,683 DM and 4,819,656 non-DM cases were identified. Analysis of all studies showed that DM was associated with an increased risk of bladder cancer compared with non-DM overall (OR=1.68, 95% CI 1.32-2.13). Analysis of subgroups demonstrated this to be the case in both case-control studies (OR=1.59, 95% CI 1.28-1.97, $I^2$=58%) and cohort studies (RR=1.70, 95% CI 1.23-2.33, $I^2$=96%). There was no gender difference in DM-associated bladder cancer risk. Bladder cancer risk was increased in Asia and the North America region, but not in Europe. Furthermore, DM-associated bladder cancer risk was obviously higher in Asia than North America and Europe or in those with Caucasian ethnicity. With extension of follow-up time, the bladder cancer risk was not increased for the patients with DM. Conclusions: This meta-analysis provided further evidence supporting theDM association with a significantly higher risk of bladder cancer obtained from observational studies.

• 한국임상약학회지
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• 제27권4호
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• pp.267-275
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• 2017

Background and Objective: Whabyung is a Korean cultural disorder characterized by a combination of emotional stress and physical symptoms. Acupuncture, herbal medicines and other complementary medicinal treatments are used to treat the symptoms of whabyung. The purpose of this study is to investigate the effects of acupuncture treatment and herbal medicine treatments on anger, anxiety and depression of whabyung. Methods: Using PubMed, CENTRAL, AMED, MEDLINE, EMBASE, MEDLINE, CINAHL, Cnii, CNKI, J-SATGE, PsycArticles, KISS, KoreaMed, kmbase, NDSL, RISS, OASIS and Korean Traditional Knowledge Portal, articles published by March 2017 for whabyung or whabyung-related syndrome were searched. The quality of selected articles was evaluated using RoB and RoBANS. The effects of acupuncture and herbal medicines on anger, anxiety, and depression levels of whabyung patients were considered for meta-analyses. Results: Of the total 2408 articles retrieved from the database, 11 were finally selected and 4 articles were used for meta-analyses. Acupuncture reduced whabyung patients' anger and anxiety. Especially, the state anxiety was significantly reduced (effect size= -0.676, p= .026). Herbal medicine had effects on reducing anxiety and state anger while trait anger was increased without statistical significance. Conclusion: The present study showed the effectiveness of acupuncture and herbal medicines for whabyung patients in general. However, considering the limited availability of articles and the heterogeneity between them included for the meta-analysis, the results should be generalized with caution. In the future, more studies within the structure of evidence-based medicine need to be conducted to generate objective and valid evidences of korean medicine.