• 제목/요약/키워드: 4-HPR. Retinoid

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Synthesis and Preliminary Biological Studies of Novel Retinamide Derivatives

  • Sin, Hong-S.;Kwon, Youn-J.;Han, Hye-S.;Park, Si-H.;Park, Moong-S.;Rho, Young-S.;Um, Soo-J.
    • Bulletin of the Korean Chemical Society
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    • 제23권12호
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    • pp.1806-1810
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    • 2002
  • We have described the synthesis and biological activity of novel retinamide . The retinamide derivatives were synthesized by introducing functional side chains into the 4-hydroxy group of 4-HPR. The activities could be dependent on the side chain length, functional group, and hetero atom. The antiprolife-rative potential of the derivatives was assessed by MTT assay in HCT116 cancer cell lines.