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A Study on the Synthesis and Antibacterial Activities of 3-[(4-Carboxy-5-ethylthioisothiazo1-3-yl) oxymethyl] cephalosporin Derivatives (3-[(4-카르복시-5-레틸티오이소티아졸-3-일)옥시메틸] 세파로스포린 유도체들의 합성 및 항균력에 관한 연구)

  • 최원식;박의석;박규종;이영행
    • YAKHAK HOEJI
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    • v.44 no.2
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    • pp.155-161
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    • 2000
  • New cephalosporin antibiotics , 3-[(4-carboxy-5-ethylthioisothiazol-3-yl)oxymethyl]-7-[(1H-tetra-zol-1-yl)acetamido]-3-cephem-4-carboxylic acid 2, 3-[(4-carboxy-5-ethylthioisothiazol-3-yl) oxymethyl]-7-[(2-aminothiazol-4-yl)acetamido]-3-cephem-4-carboxylic acid 3, 3-[(4-carb oxy-5-ethylthioisothiazol-3-yl)-oxymethyl]-7-[5-(ethylthio-3-hydroxyisothiazol-4-yl)carboxamido]-3-cephem-4-carboxylic acid 4, 3-[(4-car-boxy-5-ethylthioisothiazo1-3-yl)oxymethy1]-7-[(Z)-2-(fur-2-yl)-2-(methoxyimino)acetamido]-3-cephem-4-carboxylic acid 5, 7-[(Z)-2-(2-aminothiazol-4-yl)-2-[(alkoxyimino)acetamido]-3-[(4-carboxy-5-ethylthioisothiazol-3-yl)oxymethyl]-3-cephem-4-carboxylic acid 6-8 were synthesized. Antibacterial activities and structure-activity relationships of these new cephalosporin derivatives were examined. Among them, 7-[(Z)-2-(2-aminothiazol-4-yl)-2-(1-carboxy-1-methylethoxyimino)acetamido]-3-[(4-carboxy-5-ethylthylth-ioisothiazol-3-yl)oxymethyl]-3-cephem-4-carboxylic acid 7 exhibited good antibacterial activities compared to cefotaxime and ceftriaxone.

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Electrochemical Properties of Lithium Anode for Thermal Batteries (열전지용 리튬음극의 전기화학적 특성)

  • Im, Chae-Nam;Yoon, Hyun Ki;Ahn, Tae-Young;Yeo, Jae Seong;Ha, Sang Hyeon;Yu, Hye-Ryeon;Baek, Seungsu;Cho, Jang Hyeon
    • Applied Chemistry for Engineering
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    • v.29 no.6
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    • pp.696-702
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    • 2018
  • Recently, the current thermal battery technology needs new materials for electrodes in the power and energy density to meet various space and defense requirements. In this paper, to replace the pellet type Li(Si) anode having limitations of the formability and capacity, electrochemical properties of the lithium anode with high density for thermal batteries were investigated. The lithium anode (Li 17, 15, 13 wt%) was fabricated by mixing the molten lithium and iron powder used as a binder to hold the molten lithium at $500^{\circ}C$. The single cell with 13 wt% lithium showed a stable performance. The 2.06 V (OCV) of the lithium anode was significantly improved compared to 1.93 V (OCV) of the Li(Si) anode. Specific capacities during the first phase of the lithium anode and Li(Si) were 1,632 and $1,181As{\cdot}g^{-1}$, respectively. As a result of the thermal battery performance test at both room and high temperatures, the voltage and operating time of lithium anode thermal batteries were superior to those of using Li(Si) anode thermal batteries. The power and energy densities of Li anode thermal batteries were also remarkably improved.

Efficient Coding Technique for 4X4 Intra Prediction Modes using the Statistical Distribution of Intra Modes of Adjacent Intra Blocks (주변 인트라 블록 예측 모드의 통계적 분포를 이용한 효율적인 인트라 4X4 예측 모드 부호화 방법)

  • Kim, Jae-Min;Kang, Hyun-Soo
    • The Journal of the Korea Contents Association
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    • v.9 no.4
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    • pp.12-18
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    • 2009
  • In this paper, we propose a novel method which efficiently codes $4{\times}4$ intra prediction modes in H.264/ AVC video encoding. There are nine optional prediction modes for each $4{\times}4$luma block and 4 modes for each $16{\times}16$luma block. To code each $4{\times}4$ intra prediction mode, lots of bits are required. To efficiently compress the intra mode bits in H.264/AVC, the most probable mode(MPM) is estimated by using the intra modes of the adjacent blocks, since intra modes for neighboring $4{\times}4$luma blocks are correlated. In this paper, a novel method for estimating the MPM is proposed by using the statistical distribution of intra modes of adjacent intra blocks. Experimental results show that the proposed method can achieve a coding gain of about 0.1dB.

Up-Regulation of Interleukin-4 Receptor Expression by Interleukin-4 and CD40 Ligation via Tyrosine Kinase-Dependent Pathway

  • Kim, Hyun-Il;So, Eui-Young;Yoon, Suk-Ran;Han, Mi-Young;Lee, Choong-Eun
    • BMB Reports
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    • v.31 no.1
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    • pp.83-88
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    • 1998
  • Recently a B cell surface molecule, CD40, has emerged as a receptor mediating a co-stimulatory signal for B cell proliferation and differentiation. To investigate the mechanism of synergy between interleukin-4 (IL-4) and CD40 ligation in B cell activation, we have examined the effect of CE40 cross-linking on the IL-4 receptor expression in human B cells using anti-CE40 antibody. We observed that IL-4 and anti-CD40 both induce IL-4 receptor gene expression with a rapid kinetics resulting in a noticeable accumulation of IL-4 receptor mRNA within 4 h. While IL-4 caused a dose-dependent induction of surface IL-4 receptor expression, the inclusion of anti-CD40 in the IL-4-treated culture, further up-regulated the IL-4-induced IL-4 receptor expression as analyzed by flow cytometry. Pretreatment of B cells with inhibitors of protein tyrosine kinase (PTK) resulted in a significant inhibition of both the IL-4- and anti-CD40-induced IL-4 receptor mRNA levels, while protein kinase C (PKC) inhibitors had no effects. These results suggest that IL-4 and CD40 ligation generate B cell signals, which via PTK-dependent pathways, lead to the synergistic induction of IL-4 receptor gene expression. The rapid induction of IL-4 receptor gene expression through the tyrosine kinase-mediated signal transduction by B cell activating stimuli, would provide cells capacity for an efficient response to IL-4 in the early phase of IL-4 action, and may in part constitute the molecular basis of the reported anti-CD40 co-stimulatory effect on the IL-4-induced response.

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4S Framework Construction Structure for Interoperability of Spatial Information (공간 정보의 상호운용성을 위한 4S 기반 프레임워크 구축)

  • Oh, Byoung-Woo;Kim, Min-Soo;Joo, In-Hak;Lee, Jong-Hun;Yang, Young-Kyu
    • Journal of Korea Spatial Information System Society
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    • v.3 no.1 s.5
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    • pp.95-108
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    • 2001
  • The provision of spatial data is a key infrastructural requirement for the promotion of economic growth, environmental quality, social progress, etc. 4S technology integrates 4 kinds of systems that process spatial data: GIS (Geographic Information System), GNSS (Global Navigation Satellite System), ITS (Intelligent Transport System), and SIIS (Spatial Imagery Information System). Spatial data processing field is expected to get synergy effect and overcomes development limit of individual unit technology via 4S technology. This paper discusses both the development of 4S-kernel technology and the construction of 4S-based framework, In the development of 4S kernel technology, we will concentrate on the following issues: the development of 4S base components for reciprocity integration among GIS, SIIS, GNSS and ITS technologies, the development of 4S-Mobile S/W and H/W, 4S-Van components, and national LBS technologies. And in the construction of 4S-based framework, we will especially concentrate on the ISP for overall 4S technologies, the international cooperative research center, and the guide model deduction for supervision and certification of 4S projects. Finally, we examine about how the construction of 4S-baed framework affects 4S industry.

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A Convenient Preparation of Polychloroanisidine and Fluorochloroanisole Derivatives (Polychloroanisidine 및 Fluorochloroanisole 유도체의 간편한 합성)

  • Kim, Yu Seon;Kim, Tae Yeong;Kim, Yun Hui
    • Journal of the Korean Chemical Society
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    • v.18 no.4
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    • pp.278-288
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    • 1974
  • Starting from p-dichlorobenzene, 2-amino-4-chloroanisole could be prepared via a nitration, a methoxylation, and subsequent reduction. The repeated chlorination of 2-amino-4-chloroanisole resulted 2-amino-3,4,5-trichloroanisole without any isomeric products. The chlorination of 4-chloro-2-nitroanisole could easily give 2,4-dichloro-6-nitroanisole but polychlorination of the product could not be achieved at the atmospherical pressure. The repeated chlorination of 2-amino-4,6-dichloroanisole could give 2-amino-3,4,5,6-tetrachloroanisole, The Schiemann reaction of 2-amino-4-chloroanisole and 2-amino-4,6-dichloroanisole could give 2-fluoro-4-chloroanisole and 2-fluoro-4,6-dichloroanisole, respectively. The repeated chlorination of these fluorochloroanisoles could give 2-fluoro-3,4,5,6-tetrachloroanisole. In each chlorination process, the components of products were examined by means of NMR spectrometry and the chlorination reaction was repeated without isolating each isomeric product. The feasibility of the present routes of preparations was discussed in respects to the conveniency of reaction conditions and respective overall yields of the processes.

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Residual Stress Behavior of High Temperature Polyimide Thin Films depending on the Structural Isomers of Diamine (Diamine의 구조적 이성질체에 따른 내열성 폴리이미드 박막의 잔류응력거동)

  • 임창호;정현수;한학수
    • Journal of the Microelectronics and Packaging Society
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    • v.6 no.2
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    • pp.23-30
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    • 1999
  • The relationships between morphological structures and residual stress behaviors of polyimide thin films depending on isomeric diamines were investigated. For this study, Poly(phenylene biphenyltetracarboximide) (BPDA-PDA) and poly(oxydiphenylene biphenyltetracarboximide) (BPDA-ODA) films were prepared from their isomeric diamines: 1,3-phenylene diamine (1,3-PDA) 1,4-phenylene diamine (1.4-PDA), 3,4'-oxydiphenylene diamine (3,4'-ODA), and 4,4'-oxydiphenylene diamine (4,4'-ODA), respectively. For those films, residual stresses were detected in-situ during thermal imidization of the isomeric polyimide as a function of processing temperature over the range of 25~$400^{\circ}C$ using. Thin Film Stress Analyzer (TFSA). In comparison, residual stress of BPDA-1.4PDA having better in-plain orientation and chain order was the lowest value of 7MPa whereas those of BPDA-1,3-PDA, BPDA-3,4'-ODA, and BPDA-4,4'-ODA were in the range of 40-50MPa. Conclusively, the effect of morphological nature (chain rigidity, chain order, orientation) and chain mobility relating to the g1ass transition behavior on the residual stress of isomeric polyimide thin films wart analyzed.

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Design and Implementation of 2.4 GHz Beamforming antenna using 4×4 Butler Matrix (4×4 버틀러 매트릭스를 이용한 2.4 GHz 빔포밍 안테나 설계 및 구현)

  • Kim, Young-Jin
    • Journal of the Korea Institute of Information and Communication Engineering
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    • v.25 no.11
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    • pp.1687-1695
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    • 2021
  • In this paper, it is designed and analyzed the beamforming antenna using the butler matrix. The operating frequency of the proposed beamforing antenna is ISM band of 2.4 GHz band and the component of the beamforing antenna consisted of a 1×4 array antenna and a 4×4 butler matrix. Each output port of 4×4 butler matrix outputs the signal having a different phase, it is provided to each input port of 1×4 array antenna. The beamforming antenna with four output ports forms a total of four beams. In order to analyze the radiation pattern of the beamforming antenna, it was provided by switching the signal to the input port and proceeded the Individual analysis for the input port 1 to 4. The main beams of the proposed beamforming antenna were formed in the -12°, 40°, -40° and 12° directions according to each input port, respectively.

development of Loader Equipped with 4WD and 4WS (I) (4 Wheel Driving Transmission) (4WD 및 4WS이 가능한 로더 개발(I) (4륜 구동 변속기))

  • 조현덕
    • Journal of the Korean Society of Manufacturing Technology Engineers
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    • v.7 no.6
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    • pp.141-148
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    • 1998
  • A loader is construction & road or agricultural machinery for lifting, moving, and mixing. This study deals with the agricultural mini loader for stock raising farming. The performance of the machine is established by pulling power, working lifting capacity, and minimum circling radius, etc. Also, driving easiness and endurance are very important in manufacturing. Thus, this study has developed the loader with the 4-wheel driving equipment by gear transmission, the 4-wheel steering equipment by power handle steering type, and the equipment making four wheels touch simultaneously on the rugged ground. The developed loader having these functions was very fit in a small cattle shed or a rugged ground. This study is divided into two parts; (I) development of 4WS transmission and (II) construction of the loader by 4WS system and other equipments.

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Real-time H.264/AVC High 4:4:4 Predictive Decoder Using Multi-Thread and SIMD Instructions (멀티쓰레드와 SIMD 명령어를 이용한 실시간 H.264/AVC High 4:4:4 Predictive 디코더의 구현)

  • Kim, Yong-Hwan;Kim, Je-Woo;Choi, Byeong-Ho;Lee, Seok-Pil;Paik, Joon-Ki
    • 한국정보통신설비학회:학술대회논문집
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    • 2007.08a
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    • pp.350-353
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    • 2007
  • This paper presents an real-time implementation of H.264/AVC High 4:4:4 Predictive profile decoder using general-purpose processors by exploiting multi-threading technique and Single Instruction Multiple Data (SIMD) instructions without any quality degradation. We analyze differences between the existing High profile and High 4:4:4 Predictive profile decoder, and show various optimization techniques to decode high fidelity and high definition (HD) video in real-time. Simulation results show that the proposed decoder can play high fidelity HD video at average 40 frames per seconds (fps) for the IBBrBP bistream and about 50 fps for the Intra-only bitstream.

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