• 한국분무공학회지
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• 제18권3호
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• pp.146-154
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• 2013

The flow of a liquid film on spin coating is investigated in the case that the fixed volume of a liquid is placed on the center of a stationary disk. Thin film equations that are well approximated when the characteristic length in the vertical direction is much smaller than that in the radial direction (${\varepsilon}{\ll}1$) and have already been proposed in the work of T.-S. Kim & M.-U. Kim (2009), are used. The differential equation that governs the free surface of a liquid when ${\varepsilon}{\ll}1$ and ${\varepsilon}Re{\ll}1$ is also derived. The basic flow is analyzed using the thin film equations and their results are compared to the results of Navier-Stokes equations.

• 한국한의학연구원논문집
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• 제2권1호
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• pp.146-176
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• 1996

Through the study of successive literatures from the Han-dynasty(漢代) when ${\\ll}$Keumkweyeuliak(金궤要略)${\gg}$ was written to modern age, we inspected many types of Onkyuatgtang(溫經湯) and prescriptions including the term of 'Okywg(溫湯)' or 'Chokyung(調經), and look into their composition and symptoms respond to administration of this medicine, The results of this study were as follows; 1. The medicine which makes up Onkyuatgtang was 38kinds from the Han-dynasty to the Ching-dynasty(淸代), and up to the present it summed into 43kinds. 2. Onkywgtang which was composed of different kinds of medicine was 10types from the Hun-dynasty to the Chung-dynasty and added 11types in modern days. Therefore it sumed up into 21types. 3. No Onkyuatgtang is seen more common than that of the same composition as in ${\\ll}$Keumkweyeuliak${\gg}$ in successive literature. The next is the same constituents as in ${\\ll}$Buinyangbangdaejeun(婦人良方大全)${\gg}$ Others were rare. 4. Onkywgtang in ${\\ll}$Keumkweyeuliak${\gg}$ was used to treat cold syndrome of the penetration and conception vessles or uterus of deficiency type(衛任 胞宮의 虛寒) and that in Buinyangbangdaejeun was for cold syndrome of the penetration and conception vessels or uterus of excess type(衛任 胞宮의 虛寒). 5. Other names of Ohylmgtang in ${\\ll}$Keumkweyeuliak${\gg}$ were Daeonrkyungtang(大溫經湯), Chokyungsan(調經散), Chokyungtang(調經湯), Chunkeumchokyungtang(千金調經湯), Chunkeumchokyungsan(千金調經散) and Soonkyungtang(小溫經湯), And the prescription in the same constitution was also called Chokyungonkyungtang(仲景溫經湯), Keumkweonkyungtang(千궤溫經湯) and Sibbionkyunghwan(十二溫經丸). 6. Onkywgtang in ${\\ll}$Buinyangbongdaejeun${\gg}$ of Yangbangonkyungtang(良方溫經湯), Jimionkyungtang(指迷溫經湯), Kyunkwionkyungtang(穹歸溫經湯) and Jinssionkyungtang(陣氏溫經湯).

• Korean Journal of Acupuncture
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• 제23권3호
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• pp.17-27
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• 2006

Objectives : This study is aimed to search for the effective application of the Sa-Am acupuncture(舍岩鍼法) for the treatment of diarrhea. Methods : The classification and the treatment for diarrhea in ${\ll}$Sa-Am-Do-In-Chim-Gu-Yo-Kyul(舍岩道人鍼灸要訣)${\gg}$ was compared with those of ${\ll}$Dong-Eui-Bo-Kham(東醫寶鑑)${\gg}$ and ${\ll}$Chim-Gu-Dae-Sung(鍼灸大成)${\gg}$ Results & Conclusions : In ${\ll}$Dong-Eui-Bo-Kham(東醫寶鑑)${\gg}$, diarrhrea was classified into 20 classes and mainly treated with herbal medicine and additionally with acupuncture treatment. Ashi (nearby) points in lower abdomen and sacral region were often used as well as the points on Spleen meridian(SP) and Stomach meridian(ST) to treat diarrhea in ${\ll}$Chim-Gu-Dae-Sung(鍼灸大成)${\gg}$ According to ${\ll}$Sa-Am-Do-In-Chim-Gu-Yo-Kyul(舍岩道人鍼灸要訣)${\gg}$, Diarrhrea was classified into 6 classes; wet diarrhrea (濡泄; kidney damage), abrupt diarrhrea (暴泄; spleen damage), damp diarrhrea (濕泄; stomach damage), fire diarrhrea (火泄; heart dryness), ki(qi) diarrhrea (氣泄; lung damage) and cold diarrhrea (冷泄; liver damage). Sa-Am acupuncture seems to be applied on the basis of more precise diagnoses of organs and meridians and provide with more fundamental treatments in comparison with classical acupuncture.

• Journal of Nutrition and Health
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• 제24권4호
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• pp.314-325
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• 1991

식이지방의 수준에 따라 n6 와 n3 불포화지방산이 혈장 지질조성에 미치는 영향과 또 그 기전이 다른지를 연구하고자 Sprague Dawley 종 수컷쥐에게 저지방(LF, 10% Cal)식이와 고지방식이(HF, 40% Cal)를 각각 6주동안 투여하였으며, 사용된 기름은 포화지방산 급원으로는 쇠기름, n6 linoleic acid(LA) 급원으로 corn oil, n3 ${\alpha}-linolenic$ acid(LL) 급원으로 perilla oil, n3 eicosapentaenoic acid(EPA)와 docosahexaenoic acid(DHA) 급원으로 fish oil이었다. Ultracentrifugation 방법으로 VLDL fraction을 분리하여 thin layer chromatography에 의해서 화학적조성을 구하였다. Plasma cholestere 수준은 LF 와 HF 모두 n6 LA에 의해서는 오히려 증가되었고 n3 LL과 n3 EPA에 의해서는 감소되었으며, HF 에서 n3 EPA가 가장 cholesterol 저하효과가 있었다. HDL-Chol 농도는 n6 LA에 의해서 증가되었으나, HF 경우 n3 EPA에 의해서 유의성있게 감소되었다. Plasma TG 농도는 n3 EPA에 의해서 가장 감소되었고 간의 lipogenic enzyme 활성을 억제하였으며 VLDL fraction의 TG상대적양(%)이 유의성 있게 낮아졌다. 이때 LF 군에서는VLDL fraction의 apo-B의 상대적양(%)이 감소되지 않았으나 HF군에서 n3 EPA에 의해서 유의성 있게 낮았다. 그러므로 n3 EPA의 hvpotriglyceridemic effect는 간에서 lipogenesis를 억제하여 plasma VLDL로 TG 분비가 억제되었을 것이며, HF일 경우는 간에서 apo-B 생성도 억제되었다. 관상동맥성심장질환의 예방적 차원에서 평상시에도 쇠기름과 corn oil 보다는 n3 PUFA가 풍부한 들기름이나 생선을 더욱 이용하는 것이 바람직하다.

• IMMUNE NETWORK
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• 제5권1호
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• pp.36-44
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• 2005

Background: The anti-tumor therapeutic effect of autologous tumor cell lysate pulseddendritic cells (DCs) was studied for non-immunogenic and immune suppressive lung cancer model. To test the possibility as an adjuvant therapy, minimal residual disease model was considered in mouse in vivo experiments. Methods: Syngeneic 3LL lung cancer cells were inoculated intravenously into the C57BL/6 mouse. Autologous tumor cell (3LL) or allogeneic leukemia cell (WEHI-3) lysate pulsed-DCs were injected twice in two weeks. Intraperitoneal DC injection was started one day (MRD model) after tumor cell inoculation. Two weeks after the final DC injection, tumor formation in the lung and the tumor-specific systemic immunity were observed. Tumor-specific lymphocyte proliferation and the IFN-${\gamma}$ secretion were analyzed for the immune monitoring. Therapeutic DCs were cultured from the bone marrow myeloid lineage cells with GM-CSF and IL-4 for 7 days and pulsed with tumor cell lysate for 18 hrs. Results: Compared to the saline treated group, tumor formation was suppressed in 3LL tumor cell lysate pulsed-DC treated group, while 3LL-specific immune stimulation was minimum. WEHI-3-specific immune stimulation occurred in WEHI-3 lysate-pulsed DC treated group, which had no correlation with tumor regression. Conclusion: The data suggest the possible anti-tumor effect of cultured DCs as an adjuvant therapy for minimal residual disease state of lung cancer. The significance of immune modulation in DC therapy including the possible involvement of NK cell as well as antigen-specific cytotoxic T cell activity induction was discussed.

• Asian-Australasian Journal of Animal Sciences
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• 제20권8호
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• pp.1297-1304
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• 2007

We conducted a series of investigations in order to elucidate role of nutritional status in regulating GLUT expression and energy metabolism in porcine muscle. Firstly, the role of mild undernutrition in regulating muscle GLUT gene expression and function was studied in growing pigs (3 wk of age) on a high (H) or low (L) food intake (H = 2L) at $35^{\circ}C$ or $26^{\circ}C$. Low food intake selectively upregulates GLUT1 and GLUT4 gene expression; mRNA levels were elevated in longissimus dorsi (L. dorsi) and rhomboideus muscles but not in diaphragm or cardiac muscles. Our next step was to determine whether dietary lysine, a major primary limiting amino acid in diets for pigs, affects muscle GLUT4 expression. Pigs of 6 wk of age were pair-fed a control or low lysine (LL) diet. The control diet contained optimal amounts of all essential amino acids, including 1.15% lysine. The LL diet was similar but contained only 0.70% lysine. GLUT4 mRNA expression was upregulated by the LL diet in L. dorsi and rhomboideus muscles, whereas that in cardiac muscle was unaffected. GLUT4 protein abundance was also higher in rhomboideus muscle of animals on the LL diet. We conducted another investigation in order to elucidate effects of the LL diet on post-GLUT4 glucose metabolism. Activity of hexokinase was unaffected by dietary lysine levels while that of citrate synthase was higher both in L. dorsi and rhomboideus muscles of pigs fed on the LL diet. Glucose 6-phosphate content was higher in L. dorsi msucle in the LL group. Glycogen content was higher both in L. dorsi and rhomboideus muscles in the LL group. Further, we determined the effects of dietary lysine levels on accumulation of intramuscular fat (IMF) in L. dorsi muscle of finishing pigs. A low lysine diet (lysine content was 0.40%) meeting approximately 70% of the requirement of lysine was given to finishing pigs for two months. IMF contents in L. dorsi of the pigs given the low lysine diet were twice higher than those of the pigs fed on a control diet (lysine content was 0.65%). Finally, we proved that a well known effect of breadcrumbs feeding to enhance IMF of finishing pigs could be attributed to shortage of amino acids in diets including breadcrumbs.

• Animal cells and systems
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• 제6권3호
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• pp.277-282
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• 2002

Topoisomearse II is an essential enzyme in all organisms with several independent roles in DNA metabolism. Recently, it has been demonstrated that the C-terminal region of topoisomerases II is associated with hetero-logous protein-protein interactions in human and yeast. In this study, we identified that RTP1, a rat homologue of EIA binding protein BS69, is another topoisomerae II interacting protein by yeast two-hybrid screening. RTP1 has an E1A-binding domain and a MYND motif, which are known to be required for transcriptional regulation by binding to other proteins and interaction with the leucine zipper motif of topoisomerase II. The physical interaction between RTP1 and topoisomerase ll$\alpha$ was examined by GST pull-down assay in vitro. The expression level of RTP1 peaks in S phase as that of topoisomerase ll$\alpha$. These results suggest that the interaction between topoisomerase ll$\alpha$ and RTP1 might play an important role in regulating the transcription of genes involved in DNA metabolism in higher eukaryotes.

• 한방안이비인후피부과학회지
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• 제14권1호
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• pp.154-166
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• 2001

Naesosan(NSS) has been used in Oriental Medicine as a drug that treated carbuncle and cellulitis. So, the purpose of this Study was to investigate effects of NSS on the cytotoxicity of cancer cell lines and lymphocytes in vitro, proliferation of Ll210 cells and lymphocytes in L1210 cells transplanted mice, improvement of blood count in Ll210 cells transplanted mice, tumor weight and body weight in sarcoma-180 cells transplanted mice, survival prolongation in sarcoma-180 cells transplanted mice. We used NSS extract with freeze-dried, 8wks-old male mice(balb/c and ICR mouse $18{\pm}2g$). Ll210 cell lines, and sarcoma-180 cell lines for this Study, The proliferation of cells was tested using a colorimetric tetrazoliun assay(MTT assay). The results of this Study were obtained as follows ; 1. NSS showed significantly cytotoxicitic effects of cancer cell lines, did not show cytotoxicitic effects of lymphocytes. 2, Proliferation of lymphocytes in L1210 cells transplanted mice did not effects by NSS. 3. NSS inhibited significantly the proliferation of L1210 cells in L1210 cells transplanted mice. 4. NSS improved significantly the blood count in Ll210 cells transplanted mice. 5. NSS increased significantly th body weight in sarcoma-180 cells transplanted mice. 6. NSS dereased significantly the tumor weight in sarcoma-180 cells transplanted mice. 7. NSS prolonged significantly the survival time in sarcoma-180 cells transplanted mice.

• 공기청정기술
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• 제4권3호통권15호
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• pp.66-92
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• 1991

• 융합신호처리학회논문지
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• 제11권4호
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• pp.310-319
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• 2010

본 논문에서는 웨이브렛 변환과 쿼드트리 알고리즘을 이용한 디지털 워터마킹 알고리즘을 제안하였다. 제안한 알고리즘은 웨이블렛 변환과 웨이블렛 패킷 변환을 이용하여 입력영상을 변환하고, 쿼드트리와 Cox 알고리즘을 이용하여 워터마크를 삽입하였다. 제안한 알고리즘의 성능 평가를 위한 시뮬레이션은 DWT 변환 레벨과 대역(HH, LH, HL)에 따른 워터마킹 효과와 AWPT 변환 레벨에 따른 워터마킹의 효과에 대하여 수행하였고, DWT를 이용한 결과와 AWPT를 이용한 결과를 비교하였다. 또한 최저주파수대역(LL)의 워터마킹의 효과에 대하여 알아보았다. 시뮬레이션 결과에서 6 레벨 DWT의 HH, HL, LH 대역에 동시에 워터마크를 삽입하였을 경우에 다른 경우들과 비교하여 가장 좋은 결과를 보였다. 3 레벨의 AWPT의 결과는 3레벨의 DWT 결과와 비교하여 향상된 상관도 값을 보였다. 또한 전체 워터마크 중 30~60%를 LL 대역에 삽입하였을 경우에 PSNR 성능은 1~2dB 정도 떨어지나 추출한 워터마크의 상관도 값은 향상된 결과를 보였다.