• Investigative Magnetic Resonance Imaging
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• 제12권2호
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• pp.142-147
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• 2008

목적 : 본 연구는 핵자기공명 분광기를 개조한 미세영상 기법을 이용하여, 동물실험에 주류를 이루는 mouse를 대상으로, 0.1 mm 이내의 초고해상도 자기공명영상을 5분 정도 시간 안에 획득할 수 있는 방법을 개발하고자 하였다. 대상 및 방법 : 사용된 mouse는 C57BL/6로서 무게 50 그램 이내의 mouse를 사용하였다. 본 연구에 활용된 초전도 자석은 구경 89 mm, 4.7 T의 자기장 세기를 가진 수직형 자석이며, 사용된 샘플 코일의 직경은 30 mm 이고, 사용된 펄스시퀀스는 fast spin echo (FSE) 및 gradient echo (GE) 기법들이다. 결과 : 최적의 자기공명영상 파라미터를 확보하면서 2차원 영상으로서 수소밀도 및 T2 강조 영상을 획득하였다. 영상으로부터 mouse 뇌의 미세부분까지 상세히 해부학적 구조를 확인할 수 있었고, 또한 입체적인 정보를 획득하기 위하여 3D 영상도 부가적으로 획득하였다. 조영제를 이용한 dynamic contrast 연구에 3D 영상이 매우 유용하였다. 결론 : 본 연구를 통하여 mouse 뇌에 대한 고해상도 자기공명영상 획득을 위한 최적의 파라미터를 확보할 수 있었고, 또한 성공적인 자기공명영상도 획득하였다. 즉, 사람이나 다른 소동물뇌의 경우와 같이 mouse 뇌 조직의 다양한 부위의 미세부분을 확인할 수 있는 충분한 고해상도의 영상을 획득하였다. 최근 국내에서 mouse를 이용한 자기공명영상 연구가 시작되었으나 아직 초기단계라고 평가할 수 있고, mouse는 다른 동물에 비하여 취급/관리하기 쉬우므로 향후 mouse를 이용한 뇌 연구가 활성화 될 것으로 사료된다.

• Structural Engineering and Mechanics
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• 제57권2호
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• pp.369-387
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• 2016

In this work, random homogenization analysis for the effective thermal properties of a three-dimensional composite material with unidirectional fibers is presented by combining the equivalent inclusion method with Random Factor Method (RFM). The randomness of the micro-structural morphology and constituent material properties as well as the correlation among these random parameters are completely accounted for, and stochastic effective thermal properties as thermal expansion coefficients as well as their correlation are then sought. Results from the RFM and the Monte-Carlo Method (MCM) are compared. The impact of randomness and correlation of the micro-structural parameters on the random homogenized results is revealed by two methods simultaneously, and some important conclusions are obtained.

• 대한기계학회논문집B
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• 제29권12호
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• pp.1352-1359
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• 2005

Unsteady simulations were performed to investigate the flame structure and the dynamic behavior of a premixed flame exposed to the wall heat loss. A 3-step global reaction mechanism was adopted in this study. Simulations were performed for two tube combustors with inner diameters($d_i$) of 1mm and 4mm. The material of tube combustor was assumed to be a Silicon Nitride($Si_{3}N_4$). The heat loss from the outer tube wall was controlled by adjusting the amount of convective and radiative heat loss. A conical premixed flame could be stabilized inside a tube of $d_i=4mm$. The flame stability inside a tube of $d_i=4mm$ combustor was not much sensitive to the amount of heat loss. In case of a tube of $d_i=1mm$, an oscillating flame was observed in very low heat loss condition and a flame could not be sustained in realistic heat loss condition.

• Design & Manufacturing
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• 제15권2호
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• pp.11-16
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• 2021

Recently, three-dimensional (3D) cell culture systems, which are superior to conventional two-dimensional (2D) vascular systems that mimic the in vivo environment, are being actively studied to reproduce drug responses and cell differentiation in organisms. Conventional two-dimensional cell culture methods (scaffold-based and non-scaffold-based) have a limited cell growth rate because the culture cannot supply the culture medium as consistently as microvessels. To solve this problem, we would like to propose a 3D culture system with an environment similar to living cells by continuously supplying the culture medium to the bottom of the 3D cell support. The 3D culture system is a structure in which microvascular structures are combined under a scaffold (agar, collagen, etc.) where cells can settle and grow. First, we have manufactured molds for the formation of four types of microvessel-mimicking chips: width / height ①100 ㎛ / 100 ㎛, ②100 ㎛ / 50 ㎛, ③ 150 ㎛ / 100 ㎛, and ④ 200 ㎛ / 100 ㎛. By injection molding, four types of microfluidic chips were made with GPPS (general purpose polystyrene), and a 100㎛-thick PDMS (polydimethylsiloxane) film was attached to the top of each microfluidic chip. As a result of observing the flow of the culture medium in the microchannel, it was confirmed that when the aspect ratio (height/width) of the microchannel is 1.5 or more, the fluid flows from the inlet to the outlet without a backflow phenomenon. In addition, the culture efficiency experiments of colorectal cancer cells (SW490) were performed in a 3D culture system in which PDMS films with different pore diameters (1/25/45 ㎛) were combined on a microfluidic chip. As a result, it was found that the cell growth rate increased up to 1.3 times and the cell death rate decreased by 71% as a result of the 3D culture system having a hole membrane with a diameter of 10 ㎛ or more compared to the conventional commercial. Based on the results of this study, it is possible to expand and build various 3D cell culture systems that can maximize cell culture efficiency by cell type by adjusting the shape of the microchannel, the size of the film hole, and the flow rate of the inlet.

• 한국정밀공학회지
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• 제21권5호
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• pp.174-181
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• 2004

This paper presents the development of a magnetostrictive microactuator. The structural and functional requirements are as follows: it must be a millimeter structure and must achieve controllable displacement with nanometer resolution. Finite Element Analysis(FEA) is used to determine the structure with the most uniform and highest magnetic flux density along the Terfenol-D rod. The microactuator prototype 1 is designed and made based on the FEA. It is observed that the microactuator show some level of hysteresis and that it produces 25 newton in force and 3 ${\mu}{\textrm}{m}$ in displacement with 1.5 amperes of current, and resolution of 250 nm per 0.1 amperes. To improve the performance of the microactuator prototype 1, microactuator prototype 2 is made again with a permanent magnet (PM). It is observed that the microactuator prototype 2 gene.ates 3.3 ${\mu}{\textrm}{m}$ in displacement with 0.9 amperes of current. It means that the microactuator prototype 2 performs better than the microactuator prototype 1.

• 한국정밀공학회지
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• 제25권2호
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• pp.123-130
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• 2008

A 3D structure production method for microstereolithography is a useful way that produces complex structures with flexible processes and low cost. Several UV curable resins were blended and the optimal resin for micro-lens fabricate was selected through viscosity, workability and transmission tests. It consists of 1, 6 - Hexanediol diacrylate with 15 Apha and Isobornyl acrylate for reducing some shrinkage. When fabricating a micro-lens array on large surface, some distortion of shape occurred because of the surface tension between cured part. To overcome this problem, the optimal processing conditions were derived from considering amount of the resin and surface tension. Large surface Micro-lens array, which are a type of elliptical convex and consist of 18,000 micro-lens in the range of 2cm*2cm were fabricated. The focal length to the X-axis and Y-axis were calculated. To verify the performance, measure an energy distribution of transmitted light from the Large surface Micro-lens array.

• 한국소성가공학회:학술대회논문집
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• 한국소성가공학회 2004년도 춘계학술대회 논문집
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• pp.118-121
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• 2004

Manufacturing process for milli components has recently gained researcher's focus with the increasing tendency toward highly integrated and micro-scaled parts for electronic devices. The milli-components cannot be formed by the conventional manufacturing process since the parts require higher dimensional accuracy than the conventional ones. In order to enhance the forming accuracy and productivity, various forming procedures proposed and studied by many researchers. In this paper, forming analysis of milli-components has been studied with a new micro-former. In modeling of progressive dies, multi-stage forming sequence has been analyzed with finite element analysis by LS-DYNA3D. The analysis proposes the sequential die and part shapes with the corresponding punch force and dimensional accuracy. The analysis also considers the effect of elastic dies on the dimensional accuracy of the formed parts. The analysis result demonstrates that the elastic analysis in the milli-forming process is indispensable fur accurate forming analysis. The analysis procedure in the paper will provide good information in design of a new micro-former and milli-component.

• Composites Research
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• 제18권4호
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• pp.44-51
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• 2005

본 논문에서는 3차원 직교 직물 복합재료의 구성성분인 얀(Yarn)의 기하학적인 형상을 고려하여 직접수치모사(DNS) 모델을 개발하고 이를 이용하여 직교 직물 복합재료 평판의 저속충격 현상을 모사하였다. 미시구조를 보다 상세하고 정확하게 고려하기 위하여 토우 간격과 굴곡 등을 고려한 단위 구조를 제시하고 이를 이용하여 DNS 기반의 평판모델을 구현하였다. 정적 가상 실험을 통하여 얻은 DNS 모델의 거시적 등가 물성치를 바탕으로 한 거시기계학적 해석과의 비교하였고, DNS 모델을 이용하여 기존의 거시기계학적 모델에서 구현이 어려운 기하학적인 형상 차이에 따른 저속충격 현상의 영향을 고찰하였다. 그리고 보다 실제 실험에 가까운 가상 시편의 크기를 고려하고 해석의 효율성을 높이기 위하여 DNS개념에 기반한 멀티스케일 모델을 개발하여 거시/미시 해석 결과 특성을 함께 고찰하였다.

• 마이크로전자및패키징학회지
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• 제30권3호
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• pp.102-110
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• 2023

본 연구에서는 플렉서블 레이저 투과 용접 (flexible laser transmission welding, f-LTW)을 이용한 박형 기판의 사면 접합 (scarf welding) 공정을 개발하였다. 플렉서블 응용을 위해 경사면의 기울기에 따른 인장 강도의 거동을 조사하였다. 박형 기판으로써 100 ㎛ 이하 두께의 플라스틱 기판이 사용되었으며, 사면 접합을 위해서 기판의 말단에 경사면을 형성하는 지그 장치를 개발하였다. 플렉서블 고분자 기판에 대한 경사면 맞대기 접합을 개발함으로써 공정 후 접합부 두께가 증가하지 않는 유연 접합 기술 개발에 성공하였다. 단축 인장시험을 통해 접합부의 인장 강도를 평가하였으며, 그 결과 경사면의 기울기가 완만할수록 인장 강도가 증가함을 확인하였다. 경사각에 따른 접합 계면에서의 응력 분석을 수행하여 접합 구조 설계 인자를 규명하였다. 본 결과는 동일한 공정 조건에서 접합부의 형상에 따라서 인장 강도가 크게 달라질 수 있음을 시사하므로 접합 공정에서 접합부 형상을 고려하는 것에 대한 중요성을 확인할 수 있다.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2005년도 춘계학술대회 논문집
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• pp.1518-1521
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• 2005

The application of focused ion beam (FIB) technology in micro/nano machining has become increasingly popular. Its usage in micro/nano machining has advantages over contemporary photolithography or other micro/nano machining technologies such as small feature resolution, the ability to process without masks and being accommodating for a variety of materials and geometries This paper focus to apply the sputtering technology accumulated by experiments to 3d structure fabrication with high resolution. Therefore some verifications and discussions of the characteristics of FIB sputtering results according to focal length were described in this paper. And we suggested the definition of rectangular pattern profile and made the verifications of sputtering results based on definition of it.