• Investigative Magnetic Resonance Imaging
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• v.12 no.2
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• pp.142-147
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• 2008

Purpose : By using the micro-imaging unit modified from NMR spectrometer, the high resolution MRI protocols of finer than 100 micron in 5 minutes, is sought for mouse, which plays a central role in animal studies Materials and Methods : C57BL/6 mouse, lighter than 50 gram, is used for the experiments. The superconducting magnet is vertical type with 89 mm inner diameter at 4.9 Tesla. The diameter of rf-coil is 30 mm. Mostly used techniques are the fast spin echo and the gradient echo pulse sequence. Results : For 2D images, proton density and T2 weighted images are obtained and their optimum experimental variables were sought. Minute structure of mouse brain can be recognized and 3D brain image is also obtained additionally. 3D image will be useful particularly for the dynamic contrast study using various contrast agents. Conclusion : Like the case of human and other small animals, the high resolution of mouse brain is enough to recognize the minute structure of it. Recently, similar studies are reported domestically, but it seems only a beginning stage. Due to easiness of breeding/control, mouse MRI study will soon play a vital part in brain study.

• Structural Engineering and Mechanics
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• v.57 no.2
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• pp.369-387
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• 2016

In this work, random homogenization analysis for the effective thermal properties of a three-dimensional composite material with unidirectional fibers is presented by combining the equivalent inclusion method with Random Factor Method (RFM). The randomness of the micro-structural morphology and constituent material properties as well as the correlation among these random parameters are completely accounted for, and stochastic effective thermal properties as thermal expansion coefficients as well as their correlation are then sought. Results from the RFM and the Monte-Carlo Method (MCM) are compared. The impact of randomness and correlation of the micro-structural parameters on the random homogenized results is revealed by two methods simultaneously, and some important conclusions are obtained.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.29 no.12 s.243
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• pp.1352-1359
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• 2005

Unsteady simulations were performed to investigate the flame structure and the dynamic behavior of a premixed flame exposed to the wall heat loss. A 3-step global reaction mechanism was adopted in this study. Simulations were performed for two tube combustors with inner diameters($d_i$) of 1mm and 4mm. The material of tube combustor was assumed to be a Silicon Nitride($Si_{3}N_4$). The heat loss from the outer tube wall was controlled by adjusting the amount of convective and radiative heat loss. A conical premixed flame could be stabilized inside a tube of $d_i=4mm$. The flame stability inside a tube of $d_i=4mm$ combustor was not much sensitive to the amount of heat loss. In case of a tube of $d_i=1mm$, an oscillating flame was observed in very low heat loss condition and a flame could not be sustained in realistic heat loss condition.

• Design & Manufacturing
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• v.15 no.2
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• pp.11-16
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• 2021

Recently, three-dimensional (3D) cell culture systems, which are superior to conventional two-dimensional (2D) vascular systems that mimic the in vivo environment, are being actively studied to reproduce drug responses and cell differentiation in organisms. Conventional two-dimensional cell culture methods (scaffold-based and non-scaffold-based) have a limited cell growth rate because the culture cannot supply the culture medium as consistently as microvessels. To solve this problem, we would like to propose a 3D culture system with an environment similar to living cells by continuously supplying the culture medium to the bottom of the 3D cell support. The 3D culture system is a structure in which microvascular structures are combined under a scaffold (agar, collagen, etc.) where cells can settle and grow. First, we have manufactured molds for the formation of four types of microvessel-mimicking chips: width / height ①100 ㎛ / 100 ㎛, ②100 ㎛ / 50 ㎛, ③ 150 ㎛ / 100 ㎛, and ④ 200 ㎛ / 100 ㎛. By injection molding, four types of microfluidic chips were made with GPPS (general purpose polystyrene), and a 100㎛-thick PDMS (polydimethylsiloxane) film was attached to the top of each microfluidic chip. As a result of observing the flow of the culture medium in the microchannel, it was confirmed that when the aspect ratio (height/width) of the microchannel is 1.5 or more, the fluid flows from the inlet to the outlet without a backflow phenomenon. In addition, the culture efficiency experiments of colorectal cancer cells (SW490) were performed in a 3D culture system in which PDMS films with different pore diameters (1/25/45 ㎛) were combined on a microfluidic chip. As a result, it was found that the cell growth rate increased up to 1.3 times and the cell death rate decreased by 71% as a result of the 3D culture system having a hole membrane with a diameter of 10 ㎛ or more compared to the conventional commercial. Based on the results of this study, it is possible to expand and build various 3D cell culture systems that can maximize cell culture efficiency by cell type by adjusting the shape of the microchannel, the size of the film hole, and the flow rate of the inlet.

• Journal of the Korean Society for Precision Engineering
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• v.21 no.5
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• pp.174-181
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• 2004

This paper presents the development of a magnetostrictive microactuator. The structural and functional requirements are as follows: it must be a millimeter structure and must achieve controllable displacement with nanometer resolution. Finite Element Analysis(FEA) is used to determine the structure with the most uniform and highest magnetic flux density along the Terfenol-D rod. The microactuator prototype 1 is designed and made based on the FEA. It is observed that the microactuator show some level of hysteresis and that it produces 25 newton in force and 3 ${\mu}{\textrm}{m}$ in displacement with 1.5 amperes of current, and resolution of 250 nm per 0.1 amperes. To improve the performance of the microactuator prototype 1, microactuator prototype 2 is made again with a permanent magnet (PM). It is observed that the microactuator prototype 2 gene.ates 3.3 ${\mu}{\textrm}{m}$ in displacement with 0.9 amperes of current. It means that the microactuator prototype 2 performs better than the microactuator prototype 1.

• Journal of the Korean Society for Precision Engineering
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• v.25 no.2
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• pp.123-130
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• 2008

A 3D structure production method for microstereolithography is a useful way that produces complex structures with flexible processes and low cost. Several UV curable resins were blended and the optimal resin for micro-lens fabricate was selected through viscosity, workability and transmission tests. It consists of 1, 6 - Hexanediol diacrylate with 15 Apha and Isobornyl acrylate for reducing some shrinkage. When fabricating a micro-lens array on large surface, some distortion of shape occurred because of the surface tension between cured part. To overcome this problem, the optimal processing conditions were derived from considering amount of the resin and surface tension. Large surface Micro-lens array, which are a type of elliptical convex and consist of 18,000 micro-lens in the range of 2cm*2cm were fabricated. The focal length to the X-axis and Y-axis were calculated. To verify the performance, measure an energy distribution of transmitted light from the Large surface Micro-lens array.

• Proceedings of the Korean Society for Technology of Plasticity Conference
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• 2004.05a
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• pp.118-121
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• 2004

Manufacturing process for milli components has recently gained researcher's focus with the increasing tendency toward highly integrated and micro-scaled parts for electronic devices. The milli-components cannot be formed by the conventional manufacturing process since the parts require higher dimensional accuracy than the conventional ones. In order to enhance the forming accuracy and productivity, various forming procedures proposed and studied by many researchers. In this paper, forming analysis of milli-components has been studied with a new micro-former. In modeling of progressive dies, multi-stage forming sequence has been analyzed with finite element analysis by LS-DYNA3D. The analysis proposes the sequential die and part shapes with the corresponding punch force and dimensional accuracy. The analysis also considers the effect of elastic dies on the dimensional accuracy of the formed parts. The analysis result demonstrates that the elastic analysis in the milli-forming process is indispensable fur accurate forming analysis. The analysis procedure in the paper will provide good information in design of a new micro-former and milli-component.

• Composites Research
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• v.18 no.4
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• pp.44-51
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• 2005

In this paper, we developed the direct numerical simulation(DNS) model considering the geometry of yams which consist of 3D orthogonal woven composite materials, and using this model, the dynamic behavior of under transverse low-velocity impact has been studied. To build up the micromechanical model considering tow spacing and waviness, an accurate unit structure is presented and used in building structural plate model based on DNS. For comparison, DNS results are compared with those of the micromechanical approach which is based on the global equivalent material properties obtained by DNS static numerical tests. The effects with yarn geometrical irregularities which are difficult to consider in a macroscopic approach are also investigated by the DNS model. Finally, the multiscale model based on the DNS concepts is developed to enhance efficiency of analysis with real sized numerical specimen and macro/micro characteristics are presented.

• Journal of the Microelectronics and Packaging Society
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• v.30 no.3
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• pp.102-110
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• 2023

This paper introduces scarf welding process of thin substrates using flexible laser transmission welding (f-LTW) technology. We examined the behavior of tensile strength relative to the scarf angle for flexible applications. Thin plastic substrates with the thickness of less than 100 ㎛ were bonded and a jig to form a slope at the edge of the substrate was developed. By developing the scarf welding process, we successfully created a flexible bonding technology that maintains joint's thickness after the process. The tensile strength of the joint was assessed through uniaxial test, and we found that the tensile strength increases as the slope of bonding interface decreases. By conducting stress analysis at the bonding interface with respect to the slope angle, design factor of bonding structure was investigated. These findings suggest that the tensile strength depends on the geometry of the joint, even under the same process conditions, and highlights the significance of considering the geometry of the joint in welding processes.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2005.06a
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• pp.1518-1521
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• 2005

The application of focused ion beam (FIB) technology in micro/nano machining has become increasingly popular. Its usage in micro/nano machining has advantages over contemporary photolithography or other micro/nano machining technologies such as small feature resolution, the ability to process without masks and being accommodating for a variety of materials and geometries This paper focus to apply the sputtering technology accumulated by experiments to 3d structure fabrication with high resolution. Therefore some verifications and discussions of the characteristics of FIB sputtering results according to focal length were described in this paper. And we suggested the definition of rectangular pattern profile and made the verifications of sputtering results based on definition of it.