• Journal of computational fluids engineering
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• v.18 no.2
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• pp.66-71
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• 2013

In this paper, the supersonic flows around space launch vehicles have been numerically simulated by using a 3-D RANS flow solver. The focus of the study was made for investigating plume-induced flow separation(PIFS). For this purpose, a vertex-centered finite-volume method was utilized in conjunction with 2nd-order Roe's FDS to discretize the inviscid fluxes. The viscous fluxes were computed based on central differencing. The Spalart-Allmaras model was employed for the closure of turbulence. The Gauss-Seidel iteration was used for time integration. To validate the flow solver, calculation was made for the 0.04 scale model of the Saturn-5 launch vehicle at the supersonic flow condition without exhaust plume, and the predicted results were compared with the experimental data. Good agreements were obtained between the present results and the experiment for the surface pressure coefficient and the Mach number distribution inside the boundary layer. Additional calculations were made for the real scale of the Saturn-5 configuration with exhaust plume. The flow characteristics were analyzed, and the PIFS distances were validated by comparing with the flight data. The KSLV-1 is also simulated at the several altitude conditions. In case of the KSLV-1, PIFS was not observed at all conditions, and it is expected that PIFS is affected by the nozzle position.

• The Korean Journal of Physiology and Pharmacology
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• v.24 no.6
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• pp.441-452
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• 2020

In vivo animal models are limited in their ability to mimic the extremely complex systems of the human body, and there is increasing disquiet about the ethics of animal research. Many authorities in different geographical areas are considering implementing a ban on animal testing, including testing for cosmetics and pharmaceuticals. Therefore, there is a need for research into systems that can replicate the responses of laboratory animals and simulate environments similar to the human body in a laboratory. An in vitro two-dimensional cell culture model is widely used, because such a system is relatively inexpensive, easy to implement, and can gather considerable amounts of reference data. However, these models lack a real physiological extracellular environment. Recent advances in stem cell biology, tissue engineering, and microfabrication techniques have facilitated the development of various 3D cell culture models. These include multicellular spheroids, organoids, and organs-on-chips, each of which has its own advantages and limitations. Organoids are organ-specific cell clusters created by aggregating cells derived from pluripotent, adult, and cancer stem cells. Patient-derived organoids can be used as models of human disease in a culture dish. Biomimetic organ chips are models that replicate the physiological and mechanical functions of human organs. Many organoids and organ-on-a-chips have been developed for drug screening and testing, so competition for patents between countries is also intensifying. We analyzed the scientific and technological trends underlying these cutting-edge models, which are developed for use as non-animal models for testing safety and efficacy at the nonclinical stages of drug development.

• Geomechanics and Engineering
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• v.22 no.5
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• pp.449-460
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• 2020

The double-lane arrangement model is frequently used in underground coal mines because it is beneficial to improve the mining efficiency of the working face. When the double-lane arrangement is used, the service time of the reserved roadway increases by twice, which causes several difficulties for the maintenance of the roadway. Given the severe non-uniform deformation of the reserved roadway in the Buertai Coal Mine, the stress distribution law in the mining area, the failure characteristics of roadway and the control effect of support resistance (SR) were systematically studied through on-site monitoring, FLAC 3D numerical simulation, mechanical model analysis. The research shows that the deformation and failure of the reserved roadway mainly manifested as asymmetrical roof sag and floor heave in the region behind the working face, and the roof dripping phenomenon occurred in the severe roof sag area. After the coal is mined out, the stress adjustment around goaf will happen to some extent. For example, the magnitude, direction, and confining pressure ratio of the principal stress at different positions will change. Under the influence of high-stress rotation, the plastic zone of the weak surrounding rock is expanded asymmetrically, which finally leads to the asymmetric failure of roadway. The existing roadway support has a limited effect on the control of the stress field and plastic zone, i.e., the anchor cable reinforcement cannot fully control the roadway deformation under given conditions. Based on obtained results, using roadway grouting and advanced hydraulic support during the secondary mining of the panel 22205 is proposed to ensure roadway safety. This study provides a reference for the stability control of roadway with similar geological conditions.

• Wind and Structures
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• v.29 no.4
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• pp.247-270
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• 2019

Wind-resistant design of existing cooling tower structures overlooks the impacts of rainfall. However, rainstorm will influence aerodynamic force on the tower surface directly. Under this circumstance, the structural response of the super-large cooling tower (SLCT) will become more complicated, and then the stability and safety of SLCT will receive significant impact. In this paper, surrounding wind fields of the world highest (210 m) cooling tower in Northwest China underthree typical wind velocities were simulated based on the wind-rain two-way coupling algorithm. Next, wind-rain coupling synchronous iteration calculations were conducted under 9 different wind speed-rainfall intensity combinations by adding the discrete phase model (DPM). On this basis, the influencing laws of different wind speed-rainfall intensity combinations on wind-driving rain, adhesive force of rain drops and rain pressure coefficients were discussed. The acting mechanisms of speed line, turbulence energy strength as well as running speed and trajectory of rain drops on structural surface in the wind-rain coupling field were disclosed. Moreover, the fitting formula of wind-rain coupling equivalent pressure coefficient of the cooling tower was proposed. A systematic contrast analysis on its 3D distribution pattern was carried out. Finally, coupling model of SLCT under different working conditions was constructed by combining the finite element method. Structural response, buckling stability and local stability of SLCT under different wind velocities and wind speed-rainfall intensity combinations were compared and analyzed. Major research conclusions can provide references to determine loads of similar SLCT accurately under extremely complicated working conditions.

• Journal of Ginseng Research
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• v.37 no.4
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• pp.435-441
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• 2013

This study investigated the effects of Korean Red Ginseng (KRG) on radiation-induced bone loss in C3H/HeN mice. C3H/HeN mice were divided into sham and irradiation (3 Gy, gamma-ray) groups. The irradiated mice were treated for 12 wk with vehicle, KRG (per os, p.o.) or KRG (intraperitoneal). Serum alkaline phosphatase (ALP), tartrate-resistant acid phosphatase, estradiol level, and biomechanical properties were measured. Tibiae were analyzed using micro-computed tomography. Treatment of KRG (p.o., 250 mg/kg of body weight/d) significantly preserved trabecular bone volume, trabecular number, structure model index, and bone mineral density of proximal tibia metaphysic, but did not alter the uterus weight of the mice. Serum ALP level was slightly reduced by KRG treatment. However, grip strength, mechanical property, and cortical bone architecture did not differ among the experimental groups. The results indicate that KRG can prevent radiation-induced bone loss in mice.

• Restorative Dentistry and Endodontics
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• v.47 no.3
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• pp.29.1-29.10
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• 2022

Objectives: This study aimed to investigate the anti-erosive/abrasive effect of resin infiltration of previous deproteinized dentin. Materials and Methods: Dentin slabs were randomly assigned to 3 groups (n = 15): Control (no deproteinization; no resin infiltrant applied), RI (no deproteinization; resin infiltrant applied), and DRI (deproteinization; resin infiltrant applied). After undergoing the assigned treatment, all slabs were subjected to an in vitro cycling model for 5 days. The specimens were immersed in citric acid (0.05 M, pH = 3.75; 60 seconds; 3 times/day) and brushed (150 strokes). Between the challenges, the specimens were exposed to a remineralizing solution (60 minutes). The morphological alterations were analyzed by mechanical profilometry (㎛) and scanning electron microscopy (SEM). Data were submitted to one-way analysis of variance (ANOVA) and Tukey tests (p < 0.05). Results: Control and RI groups presented mineral wear and did not significantly differ from each other (p = 0.063). DRI maintained a protective layer preserving the dentin (p < 0.001). After erosive/abrasive cycles, it was observed that in group RI, only 25% of the slabs partially evidenced the presence of the infiltrating, while, in the DRI group, 80% of the slabs presented the treated surface entirely covered by a resin-component layer protecting the dentin surface as observed in SEM images. Conclusions: The removal of the organic content allows the resin infiltrant to efficiently protect the dentin surface against erosive/abrasive lesions.

• Journal of Mechanical Science and Technology
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• v.20 no.12
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• pp.2292-2314
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• 2006

Efficient numerical method is developed for the prediction of aerodynamic noise generation and propagation in low Mach number flows such as aeolian tone noise. The proposed numerical method is based on acoustic/viscous splitting techniques of which acoustic solvers use simplified linearised Euler equations, full linearised Euler equations and nonlinear perturbation equations as acoustic governing equations. All of acoustic equations are forced with immersed surface dipole model which is developed for the efficient computation of aerodynamic noise generation and propagation in low Mach number flows in which dipole source, originating from unsteady pressure fluctuation on a solid surface, is known to be more efficient than quadrupole sources. Multi-scale overset grid technique is also utilized to resolve the complex geometries. Initially, aeolian tone from single cylinder is considered to examine the effects that the immersed surface dipole models combined with the different acoustic governing equations have on the overall accuracy of the method. Then, the current numerical method is applied to the simulation of the aeolian tones from twin cylinders aligned perpendicularly to the mean flow and separated 3 diameters between their centers. In this configuration, symmetric vortices are shed from twin cylinders, which leads to the anti-phase of the lift dipoles and the in-phase of the drag dipoles. Due to these phase differences, the directivity of the fluctuating pressure from the lift dipoles shows the comparable magnitude with that from the drag dipoles at 10 diameters apart from the origin. However, the directivity at 100 diameters shows that the lift-dipole originated noise has larger magnitude than, but still comparable to, that of the drag-dipole one. Comparison of the numerical results with and without mean flow effects on the acoustic wave emphasizes the effects of the sheared background flows around the cylinders on the propagating acoustic waves, which is not generally considered by the classic acoustic analogy methods. Through the comparison of the results using the immersed surface dipole models with those using point sources, it is demonstrated that the current methods can allow for the complex interactions between the acoustic wave and the solid wall and the effects of the mean flow on the acoustic waves.

• Journal of Biomedical Engineering Research
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• v.25 no.5
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• pp.421-430
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• 2004

Clinically, it is almost impossible for a physician to distinguish subtle changes of frequency spectrum by using a stethoscope alone especially in the early stage of thrombus formation. Considering that reliability of mechanical valve is paramount because the failure might end up with patient death, early detection of valve thrombus using noninvasive technique is important. Thus the study was designed to provide a tool for early noninvasive detection of valve thrombus by observing shift of frequency spectrum of acoustic signals with computer aid diagnosis system. A thrombus model was constructed on commercialized mechanical valves using polyurethane or silicon. Polyurethane coating was made on the valve surface, and silicon coating on the sewing ring of the valve. To simulate pannus formation, which is fibrous tissue overgrowth obstructing the valve orifice, the degree of silicone coating on the sewing ring varied from 20％, 40％, 60％ of orifice obstruction. In experiment system, acoustic signals from the valve were measured using microphone and amplifier. The microphone was attached to a coupler to remove environmental noise. Acoustic signals were sampled by an AID converter, frequency spectrum was obtained by the algorithm of spectral analysis. To quantitatively distinguish the frequency peak of the normal valve from that of the thrombosed valves, analysis using a neural network was employed. A return map was applied to evaluate continuous monitoring of valve motion cycle. The in-vivo data also obtained from animals with mechanical valves in circulatory devices as well as patients with mechanical valve replacement for 1 year or longer before. Each spectrum wave showed a primary and secondary peak. The secondary peak showed changes according to the thrombus model. In the mock as well as the animal study, both spectral analysis and 3-layer neural network could differentiate the normal valves from thrombosed valves. In the human study, one of 10 patients showed shift of frequency spectrum, however the presence of valve thrombus was yet to be determined. Conclusively, acoustic signal measurement can be of suggestive as a noninvasive diagnostic tool in early detection of mechanical valve thrombosis.

• Journal of the Korean Magnetics Society
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• v.15 no.6
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• pp.325-331
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• 2005

The magnetic Hut leakage (MFL) type nondestructive testing (NDT) method is widely used to detect corrosion and defects, mechanical deformation of the underground gas pipelines. The object pipeline is magnetically saturated by the magnetic system with permanent magnet and yokes. Because of the strong magnetic field enough to saturate the pipe, there could be distortion of the sensing signals because of the magnetization of the pipeline itself, To detect the defects precisely, the sensing signals are need to be compensated to eliminate the distortions coming from the media hysteresis. In this paper, the magnetizations of the pipeline in MFL type NDT are analyzed by Preisach model and 3D FEM. The distortions of the sensing signals are analyzed.

• Journal of Periodontal and Implant Science
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• v.36 no.2
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• pp.531-554
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• 2006

Oral implants must fulfill certain criteria arising from special demands of function, which include biocompatibility, adequate mechanical strength, optimum soft and hard tissue integration, and transmission of functional forces to bone within physiological limits. And one of the critical elements influencing the long-term uncompromise functioning of oral implants is load distribution at the implant- bone interface, Factors that affect the load transfer at the bone-implant interface include the type of loading, material properties of the implant and prosthesis, implant geometry, surface structure, quality and quantity of the surrounding bone, and nature of the bone-implant interface. To understand the biomechanical behavior of dental implants, validation of stress and strain measurements is required. The finite element analysis (FEA) has been applied to the dental implant field to predict stress distribution patterns in the implant-bone interface by comparison of various implant designs. This method offers the advantage of solving complex structural problems by dividing them into smaller and simpler interrelated sections by using mathematical techniques. The purpose of this study was to evaluate the stresses induced around the implants in bone using FEA, A 3D FEA computer software (SOLIDWORKS 2004, DASSO SYSTEM, France) was used for the analysis of clinical simulations. Two types (external and internal) of implants of 4.1 mm diameter, 12.0 mm length were buried in 4 types of bone modeled. Vertical and oblique forces of lOON were applied on the center of the abutment, and the values of von Mises equivalent stress at the implant-bone interface were computed. The results showed that von Mises stresses at the marginal. bone were higher under oblique load than under vertical load, and the stresses were higher at the lingual marginal bone than at the buccal marginal bone under oblique load. Under vertical and oblique load, the stress in type I, II, III bone was found to be the highest at the marginal bone and the lowest at the bone around apical portions of implant. Higher stresses occurred at the top of the crestal region and lower stresses occurred near the tip of the implant with greater thickness of the cortical shell while high stresses surrounded the fixture apex for type N. The stresses in the crestal region were higher in Model 2 than in Model 1, the stresses near the tip of the implant were higher in Model 1 than Model 2, and Model 2 showed more effective stress distribution than Model.