• Journal of International Society for Simulation Surgery
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• v.2 no.1
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• pp.26-32
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• 2015

Purpose When a surgeon examines the morphology of skull of patient, locations of craniometric landmarks of 3D computed tomography(CT) volume are one of the most important information for surgical purpose. The locations of craniometric landmarks can be found manually by surgeon from the 3D rendered volume or 2D sagittal, axial, and coronal slices which are taken by CT. Since there are many landmarks on the skull, finding these manually is time-consuming, exhaustive, and occasionally inexact. These inefficiencies raise a demand for a automatic localization technique for craniometric landmark points. So in this paper, we propose a novel method through which we can automatically find these landmark points, which are useful for surgical purpose. Materials and Methods At first, we align the experimental data (CT volumes) using Frankfurt Horizontal Plane (FHP) and Mid Sagittal Plane(MSP) which are defined by 3 and 2 cranial landmark points each. The target landmark of our experiment is the anterior nasal spine. Prior to constructing a statistical cubic model which would be used for detecting the location of the landmark from a given CT volume, reference points for the anterior nasal spine were manually chosen by a surgeon from several CT volume sets. The statistical cubic model is constructed by calculating weighted intensity means of these CT sets around the reference points. By finding the location where similarity function (squared difference function) has the minimal value with this model, the location of the landmark can be found from any given CT volume. Results In this paper, we used 5 CT volumes to construct the statistical cubic model. The 20 CT volumes including the volumes, which were used to construct the model, were used for testing. The range of age of subjects is up to 2 years (24 months) old. The found points of each data are almost close to the reference point which were manually chosen by surgeon. Also it has been seen that the similarity function always has the global minimum at the detection point. Conclusion Through the experiment, we have seen the proposed method shows the outstanding performance in searching the landmark point. This algorithm would make surgeons efficiently work with morphological informations of skull. We also expect the potential of our algorithm for searching the anatomic landmarks not only cranial landmarks.

• Journal of the Korean Society for Precision Engineering
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• v.25 no.3
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• pp.157-164
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• 2008

While developing physical prototype from CAD model, rapid prototyping mainly focuses on two key points reducing time and material consumption. So, we have to change from a traditional solid model to building a hollowed prototype. In this paper, a new method is presented to hollow out solid objects with uniform wall thickness to increase RP efficiency. To achieve uniform wall thickness, it is necessary to generate internal contour by slicing the offset model of an STL model. Due to many difficulties in this method, this paper proposes a new algorithm that computes internal contours computing offset model which is generated from external contour using wall thickness. Proposed method can easily compute the internal contour by slicing the offset surface defined by the sum of circle swept volumes of external contours without actual offset and the circle wept volumes. Internal contour existences are confirmed by using the external point. Presented algorithm uses the 2D geometric algorithm allowing RP implementation more efficient. Various examples have been tested with implementation of the algorithm, and some examples are presented for illustration.

• Journal of the Korean Society of Radiology
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• v.13 no.2
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• pp.153-158
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• 2019

The purpose of this study is to compare and analyse the differences between a customized small finger made by 3D printing technology, a real small finger, and the other made from plaster of an orthotic company. The areas and the volumes of each cross-section were measured by Computer tomography(CT) and a 3D scanner and analysis of variance was performed to find out the differences of each shape. The areas of the point of 15.69mm, Distal Interphalangel Joints, were measured 30 times respectively using the caliper toll function of Picture Archiving Communication System(PASC) program. The volumes were measured by Configure Units of Meshmixer Program. There was no significant difference in the areas between three of them and there was 0.2 mm gap in the volume, which was more than the significance probability. Therefore, the result of this study shows the availability of finger orthoses made by 3D printing technology in the medical field.

• Korean Journal of Computational Design and Engineering
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• v.22 no.1
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• pp.37-43
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• 2017

3D printing techniques can be used in various application fields and many researches have been reported. FDM (Fused Deposition modeling) can make multi-material or multi-color models with the simultaneous use of two or more filaments. In a dual-nozzle FDM printers, while the active nozzle is working, the remaining nozzle will be idle. The remaining molten resins inside an idle nozzle can ooze out unwantedly. The spill over from the resting nozzle produces unwanted remaining on the fabricated product. In this research, we suggest a method for optimizing building position of a model to minimize the unwanted spill-over that could possibly contaminate the final product. The method is based on minimizing the two intersection volumes. The first intersection volume is obtained by intersecting the volume defined by the first material and the Minkowski sum between the volume of the first material and the vector obtained by subtracting the center point of the first nozzle from the center point of the second nozzle. The second intersection volume can be obtained by reversing the role of the first and second volumes and nozzles. Some results obtained from the implementation using the Parasolid (Siemens) geometric modeling kernel is presented.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.8
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• pp.3365-3370
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• 2015

Radiotherapy has an important role in the treatment of prostate cancer. Three-dimensional conformal radiation therapy (3D-CRT), intensity modulated radiation therapy (IMRT) and volumetric modulated arc therapy (VMAT) techniques are all applied for this purpose. However, the risk of secondary radiation-induced bladder cancer is significantly elevated in irradiated patients compared surgery-only or watchful waiting groups. There are also reports of risk of secondary cancer with low doses to normal tissues. This study was designed to compare received volumes of low doses among 3D-CRT, IMRT and VMAT techniques for prostate patients. Ten prostate cancer patients were selected retrospectively for this planning study. Treatment plans were generated using 3D-CRT, IMRT and VMAT techniques. Conformity index (CI), homogenity index (HI), receiving 5 Gy of the volume (V5%), receiving 2 Gy of the volume (V2%), receiving 1 Gy of the volume (V1%) and monitor units (MUs) were compared. This study confirms that VMAT has slightly better CI while thev olume of low doses was higher. VMAT had lower MUs than IMRT. 3D-CRT had the lowest MU, CI and HI. If target coverage and normal tissue sparing are comparable between different treatment techniques, the risk of second malignancy should be a important factor in the selection of treatment.

• Proceedings of the Korea Information Processing Society Conference
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• 2017.11a
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• pp.691-693
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• 2017

하둡 시스템은 대용량의 데이터를 처리할 수 있는 클러스터 기반 개방형 소프트웨어 프레임워크이다. 이는 하둡 분산 파일시스템(HDFS)과 MapReduce 모델을 활용하여 데이터의 병렬 처리를 지원한다. 본 연구에서는 3D 프린터를 위한 3D 모델 데이터를 G-code로 변환하는 알고리즘을 하둡을 활용하여 구현하였다. 4대의 컴퓨터에 하둡 시스템을 설치한 후 전처리-Map-Shuffling-Reduce의 과정을 거쳐 변환작업이 효율적으로 처리하였음을 보일 수 있었다.

• Proceedings of the KSRS Conference
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• 2003.11a
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• pp.153-155
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• 2003

Laser scanning has become a viable technique for the collection of a large amount of accurate 3D point data densely distributed on the scanned object surface. The inherent 3D nature of the sub-randomly distributed point cloud provides abundant spatial information. To explore valuable spatial information from laser scanned data becomes an active research topic, for instance extracting digital elevation model, building models, and vegetation volumes. The sub-randomly distributed point cloud should be segmented and classified before the extraction of spatial information. This paper investigates some exist segmentation methods, and then proposes an octree-based split-and-merge segmentation method to divide lidar data into clusters belonging to 3D planes. Therefore, the classification of lidar data can be performed based on the derived attributes of extracted 3D planes. The test results of both ground and airborne lidar data show the potential of applying this method to extract spatial features from lidar data.

• Proceedings of the Korea Information Processing Society Conference
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• 2019.05a
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• pp.72-74
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• 2019

Hadoop은 대용량 데이터의 분산 처리 응용을 지원하는 프레임워크이다. 이는 마스터 노드와 데이터 노드간에 Map-Reduce 과정을 거쳐 분산 처리를 지원한다. 이에 본 연구에서는 3D 프린팅을 위해 생성한 3D 모델을 프린터가 인식할 수 있는 G-code로 변환하는 작업을 Hadoop에서 수행하였다. 3D 모델은 대개 2차원 개체(페이셋)를 이용하여 표면을 표현하는데, 이 개체를 높이(Z 축)에 따라 슬라이싱한 후각 레이어별로 G-code를 생성하여야 한다. 우선 5대의 컴퓨터에 Hadoop 클러스터를 설치한 후, 대상 3D 모델에 다양한 속성값을 변경하면서 변환작업을 진행하여 Hadoop 프로그래밍의 장점을 확인할 수 있었다.

• Journal of Korean Neurosurgical Society
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• v.61 no.5
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• pp.548-558
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• 2018

Objective : Diagnosing acute cerebral infarction is crucial in determining prognosis of stroke patients. Although many serologic tests for prompt diagnosis are available, the clinical application of serologic tests is currently limited. We investigated whether $S100{\beta}$, matrix metalloproteinase-9 (MMP-9), D-dimer, and heat shock protein 70 (HSP70) can be used as biomarkers for acute cerebral infarction. Methods : Focal cerebral ischemia was induced using the modified intraluminal filament technique. Mice were randomly assigned to 30-minute occlusion (n=10), 60-minute occlusion (n=10), or sham (n=5) groups. Four hours later, neurological deficits were evaluated and blood samples were obtained. Infarction volumes were calculated and plasma $S100{\beta}$, MMP-9, D-dimer, and HSP70 levels were measured using enzyme-linked immunosorbent assay. Results : The average infarction volume was $12.32{\pm}2.31mm^3$ and $46.9{\pm}7.43mm^3$ in the 30- and 60-minute groups, respectively. The mean neurological score in the two ischemic groups was $1.6{\pm}0.55$ and $3.2{\pm}0.70$, respectively. $S100{\beta}$, MMP-9, and HSP70 expressions significantly increased after 4 hours of ischemia (p=0.001). Furthermore, $S100{\beta}$ and MMP-9 expressions correlated with infarction volumes (p<0.001) and neurological deficits (p<0.001). There was no significant difference in D-dimer expression between groups (p=0.843). The area under the receiver operating characteristic curve (AUC) showed high sensitivity and specificity for MMP-9, HSP70 (AUC=1), and $S100{\beta}$ (AUC=0.98). Conclusion : $S100{\beta}$, MMP-9, and HSP70 can complement current diagnostic tools to assess cerebral infarction, suggesting their use as potential biomarkers for acute cerebral infarction.

• Investigative Magnetic Resonance Imaging
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• v.24 no.2
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• pp.76-84
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• 2020

Background: Determination of inter-method differences between clinically available volumetry methods are essential for the clinical application of brain volumetry in a wider context. Purpose: The purpose of this study was to examine the inter-method reliability and differences between the Siemens morphometry (SM) software and the NeuroQuant (NQ) software. Materials and Methods: MR images of 86 subjects with subjective or objective cognitive impairment were included in this retrospective study. For this study, 3D T1 volume images were obtained in all subjects using a 3T MR scanner (Skyra 3T, Siemens). Volumetric analysis of the 3D T1 volume images was performed using SM and NQ. To analyze the inter-method difference, correlation, and reliability, we used the paired t-test, Bland-Altman plot, Pearson's correlation coefficient, intraclass correlation coefficient (ICC), and effect size (ES) using the MedCalc and SPSS software. Results: SM and NQ showed excellent reliability for cortical gray matter, cerebral white matter, and cerebrospinal fluid; and good reliability for intracranial volume, whole brain volume, both thalami, and both hippocampi. In contrast, poor reliability was observed for both basal ganglia including the caudate nucleus, putamen, and pallidum. Paired comparison revealed that while the mean volume of the right hippocampus was not different between the two software, the mean difference in the left hippocampus volume between the two methods was 0.17 ml (P < 0.001). The other brain regions showed significant differences in terms of measured volumes between the two software. Conclusion: SM and NQ provided good-to-excellent reliability in evaluating most brain structures, except for the basal ganglia in patients with cognitive impairment. Researchers and clinicians should be aware of the potential differences in the measured volumes when using these two different software interchangeably.