• Asian Pacific Journal of Cancer Prevention
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• 제14권1호
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• pp.293-297
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• 2013

Background: : Chemotherapy-induced thrombocytopenia (CIT) is an important cause of morbitity in patients with cancer. Aim: To investigate the effect of the baseline plasma D-dimer level, an important marker for thrombotic activity, on chemotherapy-induced thrombocytopenia in patients with stage III colon cancer. Materials and Methods: A total of 43 (28 men) eligible patients were divided into two groups according to whether they exhibited chemotherapy-induced thrombocytopenia: Group 1 (n=21) and Group 2 (n=22). Comparison was made using demographic, histopathologic, and laboratory variables. Additionally, baseline plasma D-dimer levels underwent receiver operation characteristics curve analysis, and areas under the curve were calculated. Sensitivity, specificity, and positive and negative likelihood rates were then determined. Results: The incidence of chemotherapy-induced thrombocytopenia had a significant correlation with baseline platelet count (r=0.568, P=0.031) and baseline plasma D-dimer levels (r=0.617, P=0.036). When the cut-off point for the latter was set as 498 ng/mL, the area under the curve was 0.89 (95%CI: 0.74-0.93), the sensitivity was 91.4%, the specificity was 89.7%, the positive likelihood rate was 3.64 and the negative likelihood rate was 0.24 for chemotherapy-induced thrombocytopenia diagnosis. Conclusions: The baseline level of plasma D-dimer could help to differentiate high-risk patients for chemotherapy-induced thrombocytopenia.

• 한국소음진동공학회논문집
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• 제17권5호
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• pp.398-404
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• 2007

In this study, the sensitivity of annoyance was investigated by the subjective jury test for the variations of the frequency components along with various sound pressure levels of sixteen environmental noise sources. Annoyance was, also, evaluated for the road traffic noises. Sound pressure levels were $54{\sim}84\;dB$ which individually divided frequency components with eight bands of equally three bark bands. The results show that vehicle traffic noise is recognized as the most serious environment noise source. The sensitivity of human perception of annoyance in frequency bands is quite different from A-weighting curve. The annoyance found out to be more sensitive in high frequency region and reached its maximum in 3.4 kHz.

• 전자공학회논문지A
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• 제31A권2호
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• pp.26-38
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• 1994

We demonstrate a repeatless transmission of 2.5 Gbps digital signal over 98 km opticla filbers using optical transmitter and optcial receiver which are designed and implemented using commercially available devices. The optical transmitter is realized by using a distributed feedback(DFB) laser. Temperature of the laser is thermoelectrically stabilized and the output optical power is also stabilized by using negative feedback. The output power of the transmitter is 0 dBm. The optical receiver consists of an InGaAs avalanche photodiode, a preamplifier. an automatic gain control amplifier, and a clock/data regenerator. We find an optimum decision threshold that gives the best receiver sensitivity form the measured V curve. The best sensitivity is -35.5dBm( BER-1*10S010T, PRBS=2S023T -1 ) and the overload power is -9 dBm. Finally, we achieve error free optical transmission with 98 km optical fibers. The exinction ration penalty of 2 dB. the chromatic dispersion penalty of 1 dB, and the total power penalty of 3.0 dB are measured. These results satisfy CCITT recommendation.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제21권2호
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• pp.118-126
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• 2018

Purpose: Classical criteria for diagnosis of autoimmune hepatitis (AIH) are intended as research tool and are difficult to apply at patient's bedside. We aimed to study the accuracy of simplified criteria and the concordance with the expert diagnosis based on the original criteria. Methods: A cohort of children under study for liver disorder was selected through consecutive sampling to obtain the prevalence of AIH within the group of differential diagnoses. AIH was defined, based on classical criteria, through committee review of medical reports. Validity indicators of the simplified criteria were obtained in an intention to diagnose approach. Optimal cut-off and the area under the receiver operating characteristic (ROC) curve were calculated. Results: Out of 212 cases reviewed, 47.2% were AIH. For the optimal cut-off (6 points), the simplified criteria showed a sensitivity of 72.0% and a specificity of 96.4%, with a 94.7% positive and a 79.4% negative predictive value. The area under the ROC curve was 94.3%. There was a good agreement in the pre-treatment concordance between the classical and the simplified criteria (kappa index, 0.775). Conclusion: Simplified criteria provide a moderate sensitivity for the diagnosis of AIH, but may help in indicating treatment in cases under suspicion with 6 or more points.

• Journal of Korean Neurosurgical Society
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• 제42권2호
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• pp.103-111
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• 2007

Objective : We evaluated the accuracy of multislice computerized tomographic angiography (MCTA) in the postoperative evaluation of clipped aneurysms by comparising it with three dimensional digital subtraction angiography (3D-DSA). Methods : Between May 2004 and September 2006, we included patients with ruptured cerebral aneurysm of the anterior circulation that was surgically clipped and evaluated by both postoperative MCTA and postoperative 3D-DSA. We measured the diagnostic performance and calculated the sensitivity and specificity of postoperative MCTA compared to 3D-DSA in the detection of aneurysm remnants. Results : A total of 11 neck remnants among the 92 clipped aneurysms (11.9%) were confirmed by 3D-DSA. According to Sindou's classification of aneurysm remnants, 8.7% of clipped aneurysms (8/92) had only neck remnant on 3D-DSA and 3.2% (3/92 aneurysms) had residuum of the neck and sac on 3D-DSA. There were 12 (13.04%) equivocal cases that were difficult to interpret based on the postoperative MCTA. The reasons for the equivocal cases included multiple clips (6 cases, 50.0%). beam-hardening effect (4 cases, 33.3%), motion artifact (1 case, 8.3%), fenestrated clip (1 case, 8.3%) and other combined causes. The sensitivity and specificity of the postoperative MCTA was 81.8% and 88.9%, respectively by ROC curve (p=0.000). Conclusion : MCTA is an accurate noninvasive imaging method used for the assessment of clipped aneurysms in the anterior circulation. If the image quality of postoperative MCTA is good quality and the patient has been treated with a single titanium clip, except a fenestrated clip, the absence of an aneurysm remnant can be diagnosed by MCTA alone and the need for postoperative DSA can be reduced in a large percentage of cases.

• Clinical and Experimental Pediatrics
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• 제62권6호
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• pp.217-223
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• 2019

Purpose: To determine the diagnostic value of eosinopenia and the neutrophil-to-lymphocyte ratio (NLR) in the diagnosis of early onset neonatal sepsis (EONS). Methods: This cross-sectional study was conducted in the Neonatology Ward of R.D. Kandou General Hospital Manado between July and October 2017. Samples were obtained from all neonates meeting the inclusion criteria for EONS. Data were encoded using logistic regression analysis, the point-biserial correlation coefficient, chi-square test, and receiver operating characteristic curve analysis, with a P value <0.05 considered significant. Results: Of 120 neonates who met the inclusion criteria, 73 (60.8%) were males and 47 (39.2%) were females. Ninety (75%) were included in the sepsis group and 30 (25%) in the nonsepsis group. The mean eosinophil count in EONS and non-EONS groups was $169.8{\pm}197.1cells/mm^3$ and $405.7{\pm}288.9cells/mm^3$, respectively, with statistically significant difference (P<0.001). The diagnostic value of eosinopenia in the EONS group (cutoff point: $140cells/mm^3$) showed 60.0% sensitivity and 90.0% specificity. The mean NLR in EONS and non-EONS groups was $2.82{\pm}2.29$ and $0.82{\pm}0.32$, respectively, with statistically significant difference (P<0.001). The diagnostic value of NLR in the EONS group (cutoff point, 1.24) showed 83.3% sensitivity and 93.3% specificity. Conclusion: Eosinopenia has high specificity as a diagnostic marker for EONS and an increased NLR has high sensitivity and specificity as a diagnostic marker for EONS.

• Korean Journal of Radiology
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• 제22권3호
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• pp.435-441
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• 2021

Objective: To evaluate the usefulness of the ventricular volume percentage quantified using three-dimensional (3D) brain computed tomography (CT) data for interpreting serial changes in hydrocephalus. Materials and Methods: Intracranial and ventricular volumes were quantified using the semiautomatic 3D threshold-based segmentation approach for 113 brain CT examinations (age at brain CT examination ≤ 18 years) in 38 patients with hydrocephalus. Changes in ventricular volume percentage were calculated using 75 serial brain CT pairs (time interval 173.6 ± 234.9 days) and compared with the conventional assessment of changes in hydrocephalus (increased, unchanged, or decreased). A cut-off value for the diagnosis of no change in hydrocephalus was calculated using receiver operating characteristic curve analysis. The reproducibility of the volumetric measurements was assessed using the intraclass correlation coefficient on a subset of 20 brain CT examinations. Results: Mean intracranial volume, ventricular volume, and ventricular volume percentage were 1284.6 ± 297.1 cm³, 249.0 ± 150.8 cm³, and 19.9 ± 12.8%, respectively. The volumetric measurements were highly reproducible (intraclass correlation coefficient = 1.0). Serial changes (0.8 ± 0.6%) in ventricular volume percentage in the unchanged group (n = 28) were significantly smaller than those in the increased and decreased groups (6.8 ± 4.3% and 5.6 ± 4.2%, respectively; p = 0.001 and p < 0.001, respectively; n = 11 and n = 36, respectively). The ventricular volume percentage was an excellent parameter for evaluating the degree of hydrocephalus (area under the receiver operating characteristic curve = 0.975; 95% confidence interval, 0.948-1.000; p < 0.001). With a cut-off value of 2.4%, the diagnosis of unchanged hydrocephalus could be made with 83.0% sensitivity and 100.0% specificity. Conclusion: The ventricular volume percentage quantified using 3D brain CT data is useful for interpreting serial changes in hydrocephalus.

• Asian Pacific Journal of Cancer Prevention
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• 제17권5호
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• pp.2507-2511
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• 2016

Purpose: To study the diagnostic accuracies of serum human epididymis protein 4 (HE-4) levels, virtual organ computer-aided analysis (VOCAL) parameters and endometrial volume in endometrial cancer cases. Materials and Methods: One hundred and seven patients (37 with endometrial cancer and 70 with benign endometrial pathology) were included in this study. VOCAL parameters and serum HE-4 levels were compared between the groups. Results: Area under the curve (AUC) values were 0.702, 0.658, 0.706 for vascularization index (VI), the flow index (FI) and the vascularization flow index (VFI), respectively. A cut off value of 0.568 for VI demonstrated 70% sensitivity, 72% specificity, 56% positive predictive value (PPV) and a81% negative predictive value (NPV). A cut off value of 25.8 for showed a senitivith of 70% and a specificity of 58% with aPPV of 46% and NPV of 78%, and with a cut off value of 0.12 for VFI 70%, 69%, 54% and 81%, respectively. The area under the curve for HE-4 was 0.814. A cut off value of 458 pmol/L was predictive of malignancy with 86% sensitivity and 63% specificity. Conclusions: VOCAL parameters and serum HE-4 levels were statistically significantly higher in the endometrial cancer patients. Serum HE-4 levels provided a greater sensitivity compared to power doppler angiography for predicting malignancy or benign endometrial pathology.

• 한국임상수의학회지
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• 제23권2호
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• pp.105-110
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• 2006

2003년 5월부터 2005년 11월까지 산란계의 전염성기관지염(IB) 예찰 프로그램에 등록한 농장에 대한 역학조사에서 얻은 자료에 근거하여 IB 감염을 확인할 수 있는 모형을 구축하기 위하여 16개의 입력 뉴런, 3 개의 은닉 뉴런, 1개의 출력 뉴런으로 구성된 3층 인공신경망 모형을 개발하였다. 총 86개의 계군 중 77개는 훈련자료에 할당하고 나머지 9개는 검정자료로 무작위로 할당하여 back-propagation algorithm으로 신경망 훈련을 수행하였다. 입력 뉴런은 산란계군의 특성, 사양관리, 계군의 크기 등 16개의 역학조사 항목을 사용하였으며 출력 뉴런은 IB 감염의 유무로 투입하였다. 훈련된 신경망을 검정자료에 적용하여 민감도와 특이도를 산출하였으며 진단의 정확도는 receiver operating characteristic (ROC) 곡선을 사용하여 곡선 밑의 면적(AUC)을 계산하여 평가하였다. 입력 뉴런의 특성과 훈련모수를 변경하면서 다양한 신경망을 구성하였으며 최적의 신경망으로 확인된 IBV_D1 신경망의 경우 훈련자료에 대하여 77건 중 73건을 올바르게 판단하여 94.8%의 정확도를 보였다. 민감도와 특이도는 각각 95.5% (42/44, 95% CI, 84.5-99.4)와 93.9% (31/33, 95% CI, 79.8-99.3)로 나타났다. 훈련된 신경망을 검정자료에 적용하여 ROC 곡선을 작성한 결과 AUC는 전체의 94.8% (SE=0.086, 95% CI 0.592-0.961)를 차지하는 우수한 모형으로 나타났다. ROC 곡선에서 기준을 0.7149 이상으로 판단할 때 진단의 정확도가 88.9%로 가장 높았으며 100%의 민감도를 달성하였다. 이러한 민감도와 특이도에서 44%의 IB 유병률을 가정할 때 IBV_D1 모형은 80%의 양성예측도와 100%의 음성예측도를 보였다. 이러한 소견에 근거할 때 본 연구에서 구축한 신경망 모형은 산란계군에서 IB의 존재를 확인하기 위한 목적에 성공적으로 응용될 수 있을 것으로 판단되었다.

• The Korean Journal of Pain
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• 제36권2호
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• pp.208-215
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• 2023

Background: To evaluate the feasibility, inter-reader reliability, and intra-reader reliability for various morphological features reported to be related to iliotibial band friction syndrome (ITBFS) on knee magnetic resonance imaging (MRI). Methods: A total of 145 patients with a clinical diagnosis and knee MRI findings consistent with ITBFS were included in the "study group" and 232 patients without knee pathology on both physical examination and MRI were included in the "control group". Various morphologic features on knee MRI were assessed including the patella shape, patella height, lateral epicondyle anterior-posterior (AP) width, lateral epicondyle height, ITB diameter (ITB-d), and ITB area (ITB-a). Results: Patients in the study group had significantly higher lateral epicondyle height (13.9 mm vs. 12.92 mm, P = 0.003), ITB-d (2.9 mm vs. 2.0 mm, P = 0.022), and ITB-a (38.5 mm² vs. 23.8 mm², P < 0.001) than the control group. ITB-a showed higher area under the curve index (0.849 with 74.1% sensitivity and 72.4% specificity at a 30.3 mm² cutoff) than ITB-d (0.710 with 70.8% sensitivity and 61.2% specificity at 2.4 mm cutoff) and lateral epicondyle height (0.776 with 72.4% sensitivity and 67.8% specificity at 13.4 mm cutoff). However, only the inter-reader agreement for ITB-a (intraclass correlation coefficient = 0.65) was moderate, while the agreements for other morphologic features were good or excellent. Conclusions: Lateral epicondyle height seems to be a reliable and feasible morphologic feature for diagnosis of ITBFS.