• Proceedings of the Korean Society of Precision Engineering Conference
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• 2006.05a
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• pp.173-174
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• 2006

Understanding chondrocyte behavior inside complex, three-dimensional environments with controlled patterning of geometrical factors would provide significant insights into the basic biology of tissue regenerations. One of the fundamental limitations in studying such behavior has been the inability to fabricate controlled 3D structures. To overcome this problem, we have developed a three-dimensional microfabrication system. This system allows fabrication of predesigned internal architectures and pore size by stacking up the photopolymerized materials. Photopolymer SL5180 was used as the material for 3D scaffolds. The results demonstrate that controllable and reproducible inner-architecture can be fabricated. Chondrocytes harvested from human nasal septum were cultured in two kinds of 3D scaffolds to observe cell adhesion behavior. Such 3D scaffolds might provide effective key factors to study cell behavior in complex environments and could eventually lead to optimum design of scaffolds in various tissue regenerations such as cartilage, bone, etc. in a near future.

• Bulletin of the Korean Chemical Society
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• v.34 no.4
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• pp.1212-1220
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• 2013

The human coagulation factor XI (FXI) is a serine protease that plays a significant role in blocking of the blood coagulation cascade as an attractive antithrombotic target. Selective inhibition of FXIa (an activated form of factor XI) disrupts the intrinsic coagulation pathway without affecting the extrinsic pathway or other coagulation factors such as FXa, FIIa, FVIIa. Furthermore, targeting the FXIa might significantly reduce the bleeding side effects and improve the safety index. This paper reports on a docking-based three dimensional quantitative structure activity relationship (3D-QSAR) study of the potent FXIa inhibitors, the chloro-phenyl tetrazole scaffold series, using comparative molecular field analysis (CoMFA) and comparative molecular similarity analysis (CoMSIA) methods. Due to the characterization of FXIa binding site, we classified the alignment of the known FXIa inhibitors into two groups according to the docked pose: S1-S2-S4 and S1-S1'-S2'. Consequently, highly predictive 3D-QSAR models of our result will provide insight for designing new potent FXIa inhibitors.

• Fashion & Textile Research Journal
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• v.12 no.1
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• pp.80-85
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• 2010

The purpose of this study was to examine the characteristics of armscye circumference which will be used to develop total contents for the apparel industry. The subjects of this study were 16- to 49-year-old women whose 3D body shape data were analyzed. 72 length and length-ratio measurements were taken to each subject' armscye circumference. The used analysis methods are descriptive statistics, principal component analysis, and cluster analysis. The results are follows; 1. Considering the Length of armscye circumference, the result of principal component analysis were extracted 3 factors and those factors comprised 95% of total variance. As the result of the cluster analysis of factor scores, subjects were classified into 4 cluster by their size characteristic. 2. Considering the length-ratio of armscye circumference, the result of principal component analysis were extracted 5 factors and those factors comprised 96.45% of total variance. As the result of the cluster analysis of factor scores, subjects were classified into 5 cluster by their shape characteristic. So that, this research could be useful to manufacture garment which reflected 3D body figure and improved fitting.

• Proceedings of the PSK Conference
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• 2002.10a
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• pp.357.1-357.1
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• 2002

Three-dimensional quantitative activity relationship (3D-QSAR) study for a series of arylsulfonylimidazolidinone derivatives with antitumor activity was conducted using comparative molecular field analysis (CoMFA) and comparative molecular similarity indices anaysis (CoMSIA). The in vitro cytotoxicity against human lung carcinoma (A549) exhibited a strong correlation with steric and electrostatic factors of the molecules. (omitted)

• Electronics and Telecommunications Trends
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• v.35 no.6
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• pp.24-36
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• 2020

To solve social problems such as traffic accidents caused by human driver factors and to guarantee the convenience of movement, research on the commercialization of automated vehicles is being actively conducted worldwide. In automated driving levels 2 and 3, the driver must be ready to drive at any time as the automated driving system sometimes requires manual driving by the driver. The purpose of this research is to analyze the trends in global automated vehicle guidelines and prepare guidelines for the characteristics of human factors necessary for the control rights transition system of automated vehicles. To this end, we reviewed at the guidelines for automated vehicles in the US, Germany, and Japan; ISO international standards; domestic automated vehicle standards; and the EU AdaptiVe project. In addition, a guideline is presented that can be referenced and applied by organizations related to automated vehicle manufacturing and operation. It was developed by utilizing the results of our studies on the human factors affecting the guideline of control rights transition. As national laws and regulations and continuous technology development for commercialization of automated vehicles are in progress, further research into and the revision of guidelines for safe automated vehicle production and use should be continued.

• Fashion & Textile Research Journal
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• v.11 no.5
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• pp.779-787
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• 2009

The purpose of this study was to classify the head shape for the apparel industry and to suggest standard head model for korean women. The 23 measurement items of 891 females, aged more than 18 years were used to analysis by statistical methods. Factor analysis, cluster analysis and duncan test were performed using these data. Through factor analysis, 5 factors were extracted upon factor scores and those factors comprised 68.76% for the total variances. 5 clusters as their head and face shape were categorized. We decided for the type 3 to standard head shape. 24 participants were measured using computed tomography(CT). The measured data of skin and skeleton and the standard head shapes were illustrated.

• The Journal of Korean Institute for Practical Engineering Education
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• v.2 no.2
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• pp.137-146
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• 2010

The purposes of this study are 1)to analyze a needs of re-education & continuous education for R&D human resources 2)to systemize the existing education program and 3)to provide useful implications to help the politics for re-education & continuous education for R&D human resources. The survey to R&D human resources in universities, government-supported research institutes and industries was conducted for analyzing the needs of R&D human resources for the existing education programs through investigation for the current state and importance & satisfaction level for the existing program. For proposing the effective education program, the barrier and improvement factors of re-education program were examined as well. In addition, the needs for the government support policies for re-education program were also analyzed.

• Journal of Applied Biological Chemistry
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• v.65 no.4
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• pp.269-275
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• 2022

Betula platyphylla extract includes various materials which showed biological activity such as terpenoids. For this reason, Betula platyphylla extract has been used to alleviate inflammation. In this study, extract of Betula platyphylla was obtained and purified using several solvents and evaluated whether they showed effect on prevention of hair loss. Cell cytotoxicity assay was performed to investigate the effect of extracts on cell proliferation. Western blotting was performed to observe the changes in expression of several related growth factors such as β-catenin, VEGF, IGF1, and cyclin D. Also, 5-α-reductase activity was measured. The ethyl acetate extract was divided into four partial extracts and named as H3-1, H3-2, H3-3, and H3-4. The H3-2 extract showed proliferation activity of human derma papilla cell and increased the protein expression of several related growth factors such as β-catenin, VEGF, IGF1, and cyclin D, comparable to the effect of Ethyl 3,4,5-Trimethoxy Benzoate (ETB)and Lupeol (LPO). Moreover, we found that the fraction H3 was shown to decrease 5-α-reductase activity while ETB and LPO had no significant effect on 5-α-reductase activity.

• The Korean Journal of Physiology and Pharmacology
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• v.22 no.5
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• pp.555-566
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• 2018

Human umbilical cord blood mesenchymal stem cells (hUCB-MSCs) are used in tissue repair and regeneration; however, the mechanisms involved are not well understood. We investigated the hair growth-promoting effects of hUCB-MSCs treatment to determine whether hUCB-MSCs enhance the promotion of hair growth. Furthermore, we attempted to identify the factors responsible for hair growth. The effects of hUCB-MSCs on hair growth were investigated in vivo, and hUCB-MSCs advanced anagen onset and hair follicle neogeneration. We found that hUCB-MSCs co-culture increased the viability and up-regulated hair induction-related proteins of human dermal papilla cells (hDPCs) in vitro. A growth factor antibody array revealed that secretory factors from hUCB-MSCs are related to hair growth. Insulin-like growth factor binding protein-1 (IGFBP-1) and vascular endothelial growth factor (VEGF) were increased in co-culture medium. Finally, we found that IGFBP-1, through the co-localization of an IGF-1 and IGFBP-1, had positive effects on cell viability; VEGF secretion; expression of alkaline phosphatase (ALP), CD133, and ${\beta}-catenin$; and formation of hDPCs 3D spheroids. Taken together, these data suggest that hUCB-MSCs promote hair growth via a paracrine mechanism.

• Biomedical Science Letters
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• v.24 no.1
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• pp.23-29
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• 2018

Abdominal obesity is considered as one of the most risky factors governing the development of metabolic diseases. Here we identify that human chitinase 3-like 1 (CHI3L1, also called YKL-40 in human) single nucleotide polymorphism (SNP), rs883125, is associated with abdominal obesity in Korean women. Korean women subjects with the rs883125 G/G or C/G genotype present higher waist-hip ratio than subjects with C/C genotype suggesting that human subjects who G nucleotide substitution at the rs883125 tended to more accumulate intra-abdominal fat at the abdominal cavity. In addition, Chi3l1 gene expression is increased in adipose tissue from obese mice and pro-inflammatory cytokine enhances Chi3l1 expression in adipocytes, indicating that Chi3l1 is greatly related with obesity and obesity-induced pro-inflammatory responses. Taken together, the minor allele of rs883125 is associated with a higher prevalence of abdominal obesity in Korean women. These findings suggest that genotype of rs883125 can be a biomarker of incident abdominal obesity and abdominal obesity-related metabolic diseases.