• Title/Summary/Keyword: 3-HPMA

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Association of Metabolic Syndrome with Urinary Concentration of Acrolein Biomarker 3-Hydroxypropyl Mercapturic Acid (3-HPMA): Korea National Health and Nutrition Examination Survey 2020~2021 (아크롤레인의 생체 지표인 3-Hydroxypropyl Mercapturic Acid (3-HPMA)의 소변 농도와 대사증후군과의 연관성: 국민건강영양조사 2020~2021)

  • Hyunsik Mo;Sangshin Park
    • Journal of Environmental Health Sciences
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    • v.50 no.5
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    • pp.351-358
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    • 2024
  • Background: There are many published studies on the association between urinary concentration of 3-hydroxypropylmercapturic acid (3-HPMA), a metabolite of acrolein, and metabolic syndrome. However, inconsistent results have been reported. Additionally, there are currently no studies that have been conducted on Koreans. Objectives: The purpose of this study is to investigate the association between the urinary concentration of 3-HPMA, a metabolite of acrolein, and metabolic syndrome. Methods: We analyzed data from 1,559 Korean adults aged 19 and older who participated in the Korea National Health and Nutrition Examination Survey from 2020 to 2021. The criteria for metabolic syndrome were based on the National Cholesterol Education Program Adult Treatment Panel III, and the concentration of urinary 3-HPMA was divided into quartiles. The least squares means of the components of metabolic syndrome were calculated based on the concentration of 3-HPMA, and logistic regression analysis was performed to provide odds ratios (OR) and 95% confidence intervals (CI). Results: The median concentration of 3-HPMA in the participants' urine was 420.02 (IQR: 690.51~257.30) ㎍/mL, and the prevalence of metabolic syndrome was 37.8%. In the comparison of quartiles, an increase in 3-HPMA concentration was associated with a higher prevalence of components of metabolic syndrome (OR: 3.05, 95% CI: 2.02~4.62). However, after adjusting for all covariates, no significant difference was found between the urinary concentration of 3-HPMA and the components of metabolic syndrome (OR: 1.38, 95% CI: 0.74~2.54). Conclusions: We did not find a significant association between the urinary concentration of 3-HPMA, a metabolite of acrolein, and metabolic syndrome.

A Study on Protein Adsorption-resistant Soft Contact Lens (단백질흡착을 막는 소프트콘택트렌즈에 관한 연구)

  • 조종수;정영일
    • Journal of Biomedical Engineering Research
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    • v.17 no.3
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    • pp.291-296
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    • 1996
  • Poly(ethylene glycol)(PEG) macromers terminated with diacrylate Iyoups and interpenetrating poly- mer networks(IPN) composed of poly(hydroxyethyl methacrylate)(PHEMA) or poly(hydroxyethyl methacrylate-co-hydronypropyl methacrylate-co- N-vinyl pyrrolidone ) [ P( HEM A-co- HPM A-co- NVP) ] and PEG macromer were synthesized with the aim of obtaining protein adsorption resistant soft contact lens. Polymerization of PEC macromer resulted in the formation of cross-linked gels due to the multifunctionality of macromer. Crosslinked P(HEMA) or P(HEMA-co-HPMA-co-WVP) chains were interpenetrated into the cross-linked three-dimensional networks of PEG. It was found that albumin adsorption onto the contact lens prepared by P(HEMA-co-HPMA-co-NVP) /PEG IPW decreases with an increase of molecular weight of PEG. Also, it was found that albumin adsorption onto the both contact lens decreases with an increase of concentration of PEC macromer in the IPN preparation. There are also more adequate in the bioinertnen for the contact lens by P(HEMA)/PEG IPN or P (HEMA-co-HPMA-co-NVP)/PEG IPN than that by P(HEMA) or P(HEMA-co-HPMA-co-NVP)

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Humidity Sensitive Properties of Humidity Sensor Using Quaternized Cross-linked Copolymers of 4-Vinylpyridine (4차 염화 가교화된 4-vinylpyridine 공중합체들을 사용한 습도센서의 감습 특성)

  • 공명선;이성수;이임렬
    • Journal of the Korean Institute of Electrical and Electronic Material Engineers
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    • v.14 no.4
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    • pp.302-308
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    • 2001
  • The polymers with various composition of 4-vinylpyridine (4-VP) with n-butyl acrylate (n-BA) and 2-hydroxypropyl methacrylate (HPMA) were synthesized as a humidity sensitive material and quaternized with 1.5-dibromopentane. Resistance versus relative humidity decreased with increase in the content of n-BA in the copolymer. The introduction of HPMA increased the resistance of the humidity sensor as well as enhanced the adherence to the alumina substrate. In the case of 4-VP/n-BA/HPMA=80/10.10, the hysteresis and temperature coefficient were $\pm$2%RH and -0.42∼0.46%RH/$\^{C}$. The average resistance at 30%RH, 60%RH and 90%RH are 3.1㏁, 155 ㏀ and 7.9 ㏀, respectively.

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Characterization and Application for Hydrogel Lens Material of Acrylate Monomers Containing Hydroxyl Group (하이드록시기를 포함한 아크릴레이트계 모노머들의 하이드로젤 친수성 렌즈 소재로의 응용 및 특성)

  • Lee, Min-Jae;Kim, Tae-Hun;Sung, A-Young
    • Journal of the Korean Chemical Society
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    • v.60 no.3
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    • pp.181-186
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    • 2016
  • The hydrophilic ophthalmic lens with addition of 2-hydroxyethyl acrylate (HEA), 2-hydroxyethyl methacrylate (HEMA), hydroxypropyl methacrylate (HPMA) and Ag nanoparticles were manufactured. And also, the cross-linker ethylene glycol dimethacrylate (EGDMA) and the initiator azobisisobutyronitrile (AIBN) were used for polymerization. The polymerization of the hydrogel lens material was conducted through thermal polymerization in 100 ℃ for 1h. The optical and physical characteristics of hydrogel lens were evaluated by measuring water content, refractive index and optical transmittance. The water content of sample containing HEA, HEMA and HPMA was in the average of 82.12%, 37.06% and 21.57%, respectively. And also, refractive index of the sample containing HEA, HEMA and HPMA was in the average of 1.3540, 1.4330 and 1.4649, respectively. In case of the optical properties of the sample, the results showed that the near-UV transmittance was 82.67%, 80.32% and 79.83%, and the visible transmittance was 89.72%, 88.24% and 86.89%, respectively. And also, optical transmittance of the sample containing Ag nanoparticles showed that the near-UV transmittance of 10.59% and visible transmittance of 43.74% were obtained. From the results, the molecular length influenced on the water content and refractive index of the polymerized material.

Humidity Sensitive Properties of Humidity Sensor using Quaternized Cross-linked Copolymers of Vinylbenzyl chloride (4차 염화 가교화된 Vinylbenzyl chloride 공중합체를 감습막으로 이용한 습도센서의 감습 특성)

  • Lee, Seong-Su;Gong, Myeong-Seon
    • Korean Journal of Materials Research
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    • v.10 no.12
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    • pp.825-830
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    • 2000
  • The copolymers with various composition of vinylbenzyl chloride (VBC), methyl methacrylate (MMA), and 2-hydroxyethyl methacrylate(HEMA) were synthesized as a humidity sensitive material and quaternized with N, N, N', N'-tetraethylene diamine.. Resistance versus relative humidity decreased with increase in the content of MMA in the copolymer. The introduction of HPMA increased the resistance of the humidity sensor as well as enhanced the adherence to the alumina substrate. In the case of VBC/MMA/HEMA=80/10/10, the hysteresis and temperature dependency coefficient were $\pm$2%RH and -0.46~0.42%RH/$^{\circ}C$. The average resistance at 30%RH, 60%RH and 90%RH were 3.0M$\Omega$ ,200k$\Omega$ and 9k$\Omega$, respectively.

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A Study on the Hazardous Area Management using the RTLS (RTLS를 이용한 위험구역 관리방안에 관한 연구)

  • Ock, Young-Seok;Lee, Chang-Hee;Lee, Jong-Bin;Chang, Seong-Rok
    • Journal of the Korean Society of Safety
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    • v.25 no.2
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    • pp.65-70
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    • 2010
  • Interest to the RTLS is increasing recently, and the RTLS is used in various fields. It is one of applications for locating and tracking using RFID tags which are attached to something like container, pallet, or all thing. In this study, a RTLS system was developed for efficient safe management in chemical industry. This system could manage dangerous substance and a personal history regarding entry. Detailed results of this study are as follows: (1) Through RTLS entry management system which is developed this study, the events along a movement of dangerous substances and the person in charge could be grasped and recorded. (2) A user, goods and a warehouse could be managed and monitored efficiently as using the developed RTLS history system. (3) RTLS system will contribute to efficient safety management of the chemical industry. Besides, RTLS system might be applied to the other industries like shipbuilding and car industry.