• Proceedings of the PSK Conference
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• 2002.10a
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• pp.344.1-344.1
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• 2002

We report the synthesis of several new 3-aminohydantoinyl-1.2-benzothiazine derivatives and propose an another mechanism of the cyclization to the hydantoins for the development candidates of COX-2 inhibitors. 3-Aminohydantoins 3a-d were prepared through cyclization of the condensation products that were formed by heating amino acids and tert-bytyl carbazate in quinoline according to the method of Lalezari. (omitted)

• Bulletin of the Korean Chemical Society
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• v.23 no.12
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• pp.1836-1838
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• 2002