• Journal of Animal Science and Technology
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• 제46권5호
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• pp.783-798
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• 2004

본 시험은 oil 첨가시 알팔파건초를 기질로 하여 반추위 내에서 유리된 지방산과 양이온이 결합하여 형성되는 지방산염, 반추위 발효성상 및 소화율에 미치는 영향에 대하여 살펴보고자 시험을 실시하였다. 면양 3두를 이용하여 $\circled1$ oil 무첨기구, $\circled2$ 대두유 7% 첨기구 및 $\circled3$ 옥수수유 7% 첨가구로 하여 3${\times}$3 라틴방각법으로 수행하였다. 면양에게는 알팔파건초와 농후사료를 70 : 30의 비율로 급여하였다. 위액은 오전사료 급여 전 1시간, 사료 급여 후 1, 3, 6 및 9시간째 채취하였다. pH는 사료급여 후 3시간까지 감소하다가 그 이후에는 증가하였다{P<0.0001). $NH_3$-N는 pH 와는 반대의 경향을 나타내었다(P<0.0001). 총 휘발성 지방산, acetate, propionate 및 butyrate의 농도에는 변화가 없었다. A/P 비율은 배양시간이 증가함에 따라 감소하다가 9시간에서는 사료급여 1시간 수준이었다{P<0.0001). 건물, total-N, 조섬유, 회분, 기용무질소물, NDF 및 ADF의 소화율은 차이가 없었다. FAS의 형성은 사료급여 1시간에 비하여 사료급여 후에 증가하였으며(P<0.05), 대조구에 비해 oil 첨가구가 높았다(P<0.05). 장쇄지방산이 주로 지방산염을 형성하였다. 그래서 oil 첨가가 반추위 발효특생과 소화율에 미치는 유해한 영향을 방지할 수 있었던 것으로 사료 된다.

• 생약학회지
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• 제39권3호
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• pp.249-254
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• 2008

An 80% EtOH extract and the solvent fractions of the seeds of Cornus officinalis were evaluated for their inhibitory activities against advanced glycation end products (AGEs) formation and AGEs-induced protein cross-linking in vitro. In vitro assay for AGEs-bovine serum albumin (BSA) formation showed that the 80% EtOH extract, n-hexane, EtOAc, n-BuOH and water fractions significantly inhibited AGEs formation with observed $IC_{50}$ values of 1.13, 17.64, 1.52, 1.24 and $3.27{\mu}g/ml$, respectively. In indirect AGEs-ELISA assay, the 800% EtOH extract, EtOAc and n-BuOH fractions exhibited more potent inhibitory activity on AGEs-BSA formation than aminoguanidine, a well know AGEs inhibitor. Furthermore, the 80% EtOH extract and all the solvent fractions inhibited concentration-dependently AGE-BSA cross-linking to collagen. The 80% EtOH extract, EtOAc, n-BuOH and water fractions also had a breaking activity against preformed AGE-BSA cross-linking concentration dependently. Thus these results suggest that the 80% EtOH extract and fractions of the seeds of C. officinalis could be an inhibitor as well as breaker of AGE-BSA cross-linking.

• Bulletin of the Korean Chemical Society
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• 제18권2호
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• pp.164-170
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• 1997

Via hydrosilation-alkenylation approach using hydrosilanes (HSiMeCl2 and HSiCl3) and allylmagnesium bromide with siloxane tetramer (MeCH2=CHSiO)4 as core molecule, noble carbosilane dendrimers with 12, 24, 48 and 96 allylic end groups have been prepared. The reaction path of the repetitive alkenylation and hydrosilation was monitored by means of NMR spectroscopic measurements. Every step for the formation of dendrimer provided almost quantitative yields as pure dendrimers. Based on the observation of UV spectroscopic measurements of Gn (n=1-4) molecules containing allylic end groups, the maximal molal absorption coefficients (εmax) at λmax and the number of double bonds proved an exponentially increased correlation.

• 한국지반공학회:학술대회논문집
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• 한국지반공학회 2010년도 춘계 학술발표회
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• pp.415-426
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• 2010

Post-grouting for the drilled shaft is known to increase the end bearing capacity of pile 2~3 times higher by consolidating and reinforcing the disturbed ground containing slime around the pile end. However, the general design guideline for post-grouting has not been established yet in Korea. Especially in the domestic application, the post-grouting is employed just for repairing the pile with the unacceptable resistance rather than for increasing the design resistance of pile. Therefore, little is reported about the effect of post-grouting on the pile resistance itself. In this study, the effect of post-grouting on the resistance of drilled shafts installed in the weathered rock in Korea was estimated by performing the bi-directional load tests on the piles with and without the post-grouting. The test results presented that the initial slope of end bearing-base displacement curve in the pile with post-grouting was 4 times higher than that without post-grouting. At the acceptable settlement (1% of pile diameter), the end bearing capacities of piles with and without the post-grouting were estimated to be 12.0 MPa and 7.0 MPa, respectively, indicating that the post-grouting could increase the end bearing resistance of pile in weathered rock more than 70%.

• 한국식품영양과학회지
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• 제45권8호
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• pp.1208-1213
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• 2016

천연물로부터 당뇨합병증에 효과적인 소재를 개발하기 위하여 본 연구를 수행하였으며, 울릉도산 마가목 열매의 80% methyl alcohol 추출물의 ethyl acetate 가용부로부터 최종 당화산물 생성 억제능($IC_{50}$; $181.2{\pm}2.8{\mu}g/mL$)을 확인하였다. 효능성분의 동정을 위하여 $C_{18}$ 겔 등을 활용한 column chromatography를 수행하여 3종의 페놀성 화합물을 분리하였고, 각 화합물의 화학구조는 NMR 스펙트럼 데이터 해석 및 표품과의 HPLC 직접 비교를 통하여 neochlorogenic acid(1), cryptochlorogenic acid(2) 및 chlorogenic acid (3)로 동정하였다. 이들 화합물에 대해 최종당화산물 생성억제능을 평가한 결과 neochlorogenic acid(1)가 가장 강한 $167.5{\pm}3.5{\mu}M$의 $IC_{50}$ 값을 나타내었고, cryptochlorogenic acid(2)는 $185.9{\pm}3.7{\mu}M$의 $IC_{50}$ 값을 나타내었다. 또한, 이들 물질에 대해 $ONOO^-$ 소거 활성을 평가한 결과 cryptochlorogenic acid(2)가 가장 강한 라디칼 소거 활성인 $4.0{\pm}0.2{\mu}M$의 $IC_{50}$ 값을 나타내었고, 구조이성질체인 neochlorogenic acid(1)가 $4.5{\pm}0.3{\mu}M$의 $IC_{50}$ 값을 나타내었으며, 이들 활성은 caffeic acid가 결합 양상에 따른 화합물의 구조에 따라 다름이 시사되었다. 향후 이들 활성 물질의 활성 기작에 대한 연구가 필요하며 본 연구 결과는 더욱 우수한 최종당화산물 생성 억제능을 가지는 새로운 선도화합물 발굴을 위한 기초자료로 이용될 수 있을 뿐만 아니라 당뇨합병증 예방 및 치료에 효과적인 천연물질의 상업화를 위한 기초자료로 이용될 수 있을 것으로 생각한다.

• Journal of the Korean Wood Science and Technology
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• 제36권6호
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• pp.59-68
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• 2008

본 연구에서는 엔드테이핑(End-taping) 처리가 두께가 20~75 mm이고, 직경이 120~470 mm인 백합나무 원반들의 고주파진공건조중 건조결함 예방 미치는 영향에 대하여 조사하였다. Inside end-taping (Inside-ET)과 Outside end-taping (Outside-ET)의 경우 두께 33 mm, 직경 270 mm 이하 원반에서 할렬의 예방효과가 우수하게 나타났다. 직경이 30 cm 이하이고, 두께 60 mm와 두께 75 mm의 원반에서도 전처리을 통하여 경계할렬을 예방할 수 있을 것으로 기대되었다. 경계할렬의 발생위치는 0.50~0.63 diameter 지점으로서 직경에 따라서 상이하였으며, 따라서 횡단면의 부분 엔드테이핑 처리의 경계선도 원반의 직경 따라 적정하게 선정할 필요가 있는 것으로 조사되었다. 중경재의 경우 0.3 diameter 지점이 경계할렬 예방을 위한 전처리의 경계점일 가능성이 높을 것으로 해석된다. 대경재의 경우 경계할렬과 V형 크랙에 의한 손상이 매우 심하였으며, 이는 방사방향으로의 함수율 분포변이가 극심한 백합나무 고유의 재질특성에 기인한 것으로 해석된다. 따라서 대경재의 경우 원반으로 활용하는 것은 적절하지 않는 것으로 생각된다.

• Advances in Computational Design
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• 제5권1호
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• pp.13-34
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• 2020

As small size and complex metal machining components demand increases, cutting processes in microscale become necessary. Ball-end milling is a commonly used finishing process, which nowadays can be applied in the microscale size. Surface quality and dimensional accuracy are two basic parameters that affect small size components in their assembly and functionality. Thus, good quality can be achieved by optimizing the cutting conditions of the procedure. This study presents a 3D simulation model of ball-end milling in microscale developed in a commercial CAD software and its optical and computing results. These carried out results are resumed to surface topomorphy, surface roughness, chip geometry and cutting forces calculations that arising during the cutting process. A great number of simulations were performed in a milling machine centre, applying the discretized kinematics of the procedure and the final results were compared with measurements of Al7075-T651 experiments.

• 반도체디스플레이기술학회지
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• 제17권1호
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• pp.84-87
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• 2018

As the propeller end speed increases, the propeller surface is damaged in the process of bubble formation and dropout. It is intended to prevent the corrosion of the propeller by modifying the shape of the end through the winglet structure to mitigate the cavitation phenomenon. In the case of conventional SUS materials, the cost of production is so high that plastic materials are used to prevent corrosion. This paper aims to mitigate the cavitation by deforming the shape of the end through the winglet structure by using the SMC composite material of the propeller using the existing SUS.

• 대한수의학회지
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• 제26권2호
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• pp.265-276
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• 1986

The bovine serum factor influencing the growth of swine testicle (ST) cell and the END effect of hog cholera SN test was studied. Throughout the experimental studies. following results were obtained and summarized. 1. Bovine whole serum of 16(76.2%) and 4(19.0%) samples out of 21 have shown a positive ST cell growth and the END effect, respectively. However, all of 21(100%) and 8(38.1%) samples out of 21 serum supernatant fractions, prepared from the bovine whole serum, have shown positive ST cell growth and END effect, respectively. 2. In the SDS-polyacrylamide gel electrophoretic analysis of the bovine whole serum and the supernatant fractions, ST cell growth inhibiting factor was proved present in globulin fraction and in whole gel plate as a diffusible component. 3. The END ineffective component present in the whole serum and its supernatant fraction was proved to be BVDV neutralizing antibody. 4. The difference of osmolarity, optical density, pH, degree of precipitant formation following heat cold treatment, A/G ratio as we11 as electrophoretic pattern and NDV SN index of the samples were not correlated to the degree of 57 cell growth and to the END effectiveness.

• 한국식품저장유통학회지
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• 제24권4호
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• pp.536-541
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• 2017

Hyperglycemia found in diabetes mellitus causes several physiological abnormalities including the formation of advanced glycation end products (AGEs) and oxidative stress. Accumulation of AGEs and elevation of oxidative stress plays major roles in the development of diabetic complications. Adiponectin secreted from adipocytes is known to improve insulin sensitivity and blood glucose level. Curcumin (CCM), a bioactive component of turmeric, has been reported as a potent antioxidant. Present work aimed to elucidate the roles of CCM in high glucose-induced protein glycation and intracellular events in mature adipocytes. The results demonstrated that CCM inhibited the formation of fluorescent AGEs by approximated 52% at 3 weeks of bovine serum albumin (BSA) glycation with glucose. Correspondingly, CCM decreased the levels of fructosamine and ${\alpha}-dicarbonyl$ compounds during BSA glycation with glucose. These data suggested that CCM might be a new promising anti-glycation agent. Also, CCM reduced high glucose-induced oxidative stress in a dose dependent manner, whereas CCM treatment time-dependently elevated the expression of adiponectin gene in 3T3-L1 adipocytes. The findings from this study suggested the possibility of therapeutic use of CCM for the prevention of diabetic complications and obesity-related diseases.