• 제목/요약/키워드: 3,4-dihydro-3-oxo-2H-1,2,4-benthothiadiazine-1

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3,4-디히드로-3-옥소-2H-1,2,4-벤조치아디아진-1,1-디옥사이드 유도체의 합성 및 세포 독성 (Synthesis and Cytotoxic Properties of 3,4-dihydro-3-oxo-2H-1,2,4-benzothiadiazine-1,1-dioxides)

  • 박혜영;한윤정;이정옥
    • 약학회지
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    • 제39권6호
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    • pp.631-635
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    • 1995

  • A series of 3, 4-dihydro-3-oxo-2H-1, 2, 4-benzothiadiazine-1, 1, dioxides with cytotoxic activity against human solid tumors is described. Synthesized compounds showed mild but broad spectrum cytotoxicity in vitro. The lipophilic substituents like alkyl, alkoxy and chloro on benzene ring increased the activity. Also hydrophobic group on 3 or 4 position of benzothiadiazine was important for the activity.

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