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Evaluation of Ovary Dose of Childbearing age Woman with Breast cancer in Radiation therapy (가임기 여성의 방사선 치료 시 난소 선량 평가)

  • Park, Sung Jun;Lee, Yeong Cheol;Kim, Seon Myeong;Kim, Young Bum
    • The Journal of Korean Society for Radiation Therapy
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    • v.33
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    • pp.145-153
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    • 2021
  • Purpose: The purpose of this study is to evaluate the ovarian dose during radiation therapy for breast cancer in women of childbearing age through an experiment. The ovarian dose is evaluated by comparing and analyzing between the calculated dose in the treatment planning system according to the treatment technique and the measured dose using a thermoluminescence dosimeter (TLD). The clinical usefulness of lead (Pb) apron is investigated through dose analysis according to whether or not it is used. Materials and Methods: Rando humanoid phantom was used for measurement, and wedge filter radiation therapy, 3D conformal radiation therapy, and intensity modulated radiation therapy were used as treatment techniques. A treatment plan was established so that 95% of the prescribed dose could be delivered to the right breast of the Rando humanoid phantom 3D image obtained using the CT simulator. TLD was inserted into the surface and depth of the virtual ovary of the Rando hunmanoid phantom and irradiated with radiation. The measurement location was the center of treatment and the point moved 2 cm to the opposite breast from the center of the Rando hunmanoid phantom, 5cm, 10cm, 12.5cm, 15cm, 17.5cm, 20cm from the boundary of the right breast to the center of treatment and downward, and the surface and depth of the right ovary. Measurements were made at a total of 9 central points. In the dose comparison of treatment planning systems, two wedge filter treatment techniques, three-dimensional conformal radiotherapy, and intensity-modulated radiation therapy were established and compared. Treatments were compared, and dose measurements according to the use of lead apron were compared and analyzed in intensity-modulated radiation therapy. The measured value was calculated by averaging three TLD values for each point and converting using the TLD calibration value, which was calculated as the point dose mean value. In order to compare the treatment plan value with the actual measured value, the absolute dose value was measured and compared at each point (%Diff). Results: At Point A, the center of treatment, a maximum of 201.7cGy was obtained in the treatment planning system, and a maximum of 200.6cGy was obtained in the TLD. In all treatment planning systems, 0cGy was calculated from Point G, which is a point 17.5cm downward from the breast interface. As a result of TLD, a maximum of 2.6cGy was obtained at Point G, and a maximum of 0.9cGy was obtained at Point J, which is the ovarian dose, and the absolute dose was 0.3%~1.3%. The difference in dose according to the use of lead aprons was from a maximum of 2.1cGy to a minimum of 0.1cGy, and the %Diff value was 0.1%~1.1%. Conclusion: In the treatment planning system, the difference in dose according to the three treatment plans did not show a significant difference from 0.85% to 2.45%. In the ovary, the difference between the Rando humanoid phantom's treatment planning system and the actual measured dose was within 0.9%, and the actual measured dose was slightly higher. This did not accurately reflect the effect of scattered radiation in the treatment planning system, and it is thought that the dose of scattered radiation and the dose taken by CBCT with TLD inserted were reflected in the actual measurement. In dosimetry according to the with or without a lead apron, when a lead apron was used, the closer the distance from the treatment range, the more effective the shielding was. Although it is not clinically appropriate for pregnancy or artificial insemination during radiotherapy, the dose irradiated to the ovaries during treatment is not expected to significantly affect the reproductive function of women of childbearing age after radiotherapy. However, since women of childbearing age have constant anxiety, it is thought that psychological stability can be promoted by presenting the data from this study.

Modernist painting style in Disney animation (디즈니 애니메이션에 나타난 모더니즘 회화스타일 : 색, 형태, 공간을 중심으로)

  • Moon, Jae-Cheol;Kim, Yu-Mi
    • Cartoon and Animation Studies
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    • s.33
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    • pp.31-53
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    • 2013
  • In the early twentieth century, history of animation began by modern artists, they produced various experimental images with the newly invented film and cameras. Artists in the field of movie, photography, paintings and others manipulated images in motion. But as some animated movies won industrial success and popularity, they became the trend but experimental style of early animation preserved by so-called non-mainstreamers or experimental animators, counteracting commercialism. Disney animation also followed the trend by applying realistic Hollywood film style, the worse critics placed a low value on the animation and it tarnished the image, although it was profitable investment from a business standpoint. To make images realistic, they opened a drawing class that animators developed skills to imitate motions and forms from subjects in real life. Also some techniques and gizmos were used to mimic and simulate three dimensional objects and spaces, multiplane camera and compositing 3D CG images with 2D drawings. Moreover, they brought animation stories from fairly tales or folk tales, and Walt's personal interest in live-action movies, they applied Hollywood-film-like narratives and realistic visual, and harsh criticism ensued. On the surface early disney animations' potential seems to be weakened, but in reality it still exists by simplifying and exaggerating forms and color as modern arts. Disney animation employs concepts of the modernism paintings such as simplified shapes and colors to a character design, when their characters are placed together in a scene, that visual elements cause mental reaction. This modification gives a new internal experience to audiences. As conceptual colors in abstract paintings make images appeared to be flat, coloring characters with no shading make them look flat and comparing to them, background images are also appeared to be flat. On top of that, multi-perspective at background images recalls modernist paintings. This essay goes in details with the animation pioneers' works and how Disney animation developed its techniques to emulate real life and analyses color schemes, forms, and spaces in Disney animation compared with modern artists' works, in that the visual language of Disney animation reminds of impression from abstract paintings in the beginning of the twentieth centuries.

The Effects on the Thermal Changes of Five-Shu-Points(五輸穴) and Yonghyang$(LI_{20}$,迎香) of the Large Intestine Meridian with the Rotated Acupuncture-Bu-Xie(捻轉補瀉) on the Hapkok$(LI_4$,合谷), Using the D.I.T.I. (합곡(合谷)$(LI_4)$에 행(行)한 염전보사(捻轉補瀉) 침자극(鍼刺戟)이 적외선(赤外線) 체열(體熱) 촬영(撮影)을 이용(利用)한 수양명대장경(手陽明大腸經)의 오수혈(五輸穴)과 영향(迎香)($(LI_{20})$)영역(領域)의 온도변화(溫度變化)에 미치는 영향(影響))

  • Song Beom-Yong;Kim Kyung-Sik;Sohn In-Chul
    • Korean Journal of Acupuncture
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    • v.17 no.1
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    • pp.47-65
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    • 2000
  • The meridian, the meridian point and the Acupuncture-Bu-Xie(鍼灸補瀉) of oriental medicine are very important in the Department of Acupuncture and Moxibustion. Until now it has been confused at the practical use, and it showed up many transformation to the ages and many scholars. And then, I made a study of effects on the thermal changes of Sangyang($LI_1$,商陽), Igan($LI_2$,二間), Samgan($LI_3$,三間), Hapkok($LI_4$,合谷), Yanggye($LI_5$,陽谿), Kokchi($LI_{11}$,曲池), Yonghyang($LI_{20}$,迎香) following acupuncture on the Hapkok with the Rotated Acupuncture-Bu-Xie(捻轉補瀉) stimulation. This study researched into clinical statistics for 140 men who are in good health, and they are studying oriental medicine at Woosuk university in Korea. This study was covered a period of 3 months form June, 1999 to August, 1999. The objective was divided into seven groups, those are the control group(CON, N=20), the acupuncture stimulation group with non-rotation on Hapkok of left hand(A-I, N=20), the acupuncture stimulation group with non-rotation on non-meridian point(NA) of left hand(A-II, N=20), the acupuncture stimulation group with Bu-rotation(捻轉補法) on Hapkok of left hand(B-I, N=20), the acupuncture stimulation group with Bu-rotation on non-meridian point(NA) of left hand(B-II, N=20), the acupuncture stimulation group with Xie-rotation(捻轉瀉法) on Hapkok of left hand(C-I, N=20), and the acupuncture stimulation group with Xie-rotation on non-meridian point of left hand(C-II, N=20). The first, I took a picture for 140 men with the Digital infrared thermal image(D.I.T.I.). After 10 minutes, I took a second picture for each group following experimental methods, those were followed acupuncture on the Hapkok and the non-meridian point with the retentive and Rotated Acupuncture-Bu-Xie stimulation. The results are summarized as follows : 1. The thermal changes of the area which is a meridian point in the Large Intestine Meridian of the acupuncture stimulation group on Hapkok different from the control groups with significantly change. 2.The thermal changes of the area which is a meridian point in the Large Intestine Meridian of acupuncture stimulation groups on non-meridian point was not significantly different from the control group. 3. The thermal changes of the area which is a meridian point in the Large Intestine Meridian of the acupuncture stimulation group with Bu-rotation on Hapkok different from the control group with significant increase. 4. The thermal changes of the area which is a meridian point in the Large Intestine Meridian of acupuncture stimulation group with Bu-rotation on non-meridian point was not significantly different from the control group. 5. The thermal changes of the area which is a meridian point in the Large Intestine Meridian of the acupuncture stimulation group with Xie-rotation on Hapkok different from the control group with significant decrease and increase following the decreasing or increasing temperature class, and the increasing temperature class of the acupuncture stimulation group with Xie-rotation on Hapkok significantly different from the acupuncture stimulation group with Bu-rotation on Hapkok. 6. The thermal changes of the area which is a meridian point in the Large Intestine Meridian of acupuncture stimulation group with Xie-rotation on non-meridian point was not significantly different from the control group. As a conclusion, I could think that the acupuncture stimulation with Bu-rotation or Xie-rotation on Hapkok affected the thermal change of the area which is a meridian point in the Large Intestine Meridian. And then I could relate these results with the existence of the meridian and meridian point, and with the Rotated Acupuncture-Bu-Xie theory of oriental medicine.

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Strength Evaluation of Pinus rigida Miller Wooden Retaining Wall Using Steel Bar (Steel Bar를 이용한 리기다소나무 목재옹벽의 내력 평가)

  • Song, Yo-Jin;Kim, Keon-Ho;Lee, Dong-Heub;Hwang, Won-Joung;Hong, Soon-Il
    • Journal of the Korean Wood Science and Technology
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    • v.39 no.4
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    • pp.318-325
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    • 2011
  • Pitch pine (Pinus rigida Miller) retaining walls using Steel bar, of which the constructability and strength performance are good at the construction site, were manufactured and their strength properties were evaluated. The wooden retaining wall using Steel bar was piled into four stories stretcher and three stories header, which is 770 mm high, 2,890 mm length and 782 mm width. Retaining wall was made by inserting stretchers into Steel bar after making 18 mm diameter of holes at top and bottom stretcher, and then stacking other stretchers and headers which have a slit of 66 mm depth and 18 mm width. The strength properties of retaining walls were investigated by horizontal loading test, and the deformation of structure by image processing (AlCON 3D OPA-PRO system). Joint (Type-A) made with a single long stretcher and two headers, and joint (Type-B) made with two short stretchers connected with half lap joint and two headers were in the retaining wall using Steel bar. The compressive shear strength of joint was tested. Three replicates were used in each test. In horizontal loading test the strength was 1.6 times stronger in wooden retaining wall using Steel bar than in wooden retaining wall using square timber. The timber and joints were not fractured in the test. When testing compressive shear strength, the maximum load of type-A and Type-B was 130.13 kN and 130.6 kN, respectively. Constructability and strength were better in the wooden retaining wall using Steel bar than in wooden retaining wall using square timber.

Comparison of Attenuation Correction Methods for Brain SPECT Ima (Brain SPECT 영상의 Attenuation Correction 방법들에 대한 비교)

  • Jo, Jin U;Kim, Chang Ho;Na, Soo Kyung;Lee, Gui Won
    • The Korean Journal of Nuclear Medicine Technology
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    • v.16 no.2
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    • pp.120-125
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    • 2012
  • Purpose : The purpose of this study was to compare count between Chang's method and CT-based attenuation correction (AC-CT) among the attenuation correction (AC) methods for non-attenuation correction (AC-non) images of Brain SPECT (Single Photon Emission Computed Tomography). Materials and Methods : We injected $^{99m}Tc$ 37Mbq in a Hoffman 3D phantom filled with distilled water in the phantom study, and injected intravenously $^{99m}Tc$-HMPAO 740Mbq in a normal volunteer in the patient study, and then obtained Brain SPECT images with Symbia T6 of Siemens and conducted quantitative brain analysis. Transverse images to which each method was applied were rebuilt at the same position, and 6 regions of interest (ROI) were drawn on each of Slice No. 10, 20 and 30 and then the counts of AC-non, AC-CT and Chang's method were compared. Results : The mean counts of AC-non, AC-CT and Chang's method were $4606.8{\pm}511.3$, $16794.6{\pm}2429.4$, and $8752.6{\pm}896.5$, respectively, in the phantom study and $5460.8{\pm}519.6$, $15320{\pm}1171.6$ and $12795{\pm}1422.1$, respectively, in the patient study. In the phantom study, the ratio of AC-CT to AC-non was 3.70 and the ratio of Chang's method to AC-non was 1.92, and in the patient study, they were 2.85 and 2.38, respectively. Conclusion : From this study, we found that AC-CT makes higher AC than Chang's method. In addition, when Chang's method was used, AC in the patient study was higher than that in the phantom study. These results need to be considered also in other examinations.

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Effects of Motion Correction for Dynamic $[^{11}C]Raclopride$ Brain PET Data on the Evaluation of Endogenous Dopamine Release in Striatum (동적 $[^{11}C]Raclopride$ 뇌 PET의 움직임 보정이 선조체 내인성 도파민 유리 정량화에 미치는 영향)

  • Lee, Jae-Sung;Kim, Yu-Kyeong;Cho, Sang-Soo;Choe, Yearn-Seong;Kang, Eun-Joo;Lee, Dong-Soo;Chung, June-Key;Lee, Myung-Chul;Kim, Sang-Eun
    • The Korean Journal of Nuclear Medicine
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    • v.39 no.6
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    • pp.413-420
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    • 2005
  • Purpose: Neuroreceptor PET studies require 60-120 minutes to complete and head motion of the subject during the PET scan increases the uncertainty in measured activity. In this study, we investigated the effects of the data-driven head mutton correction on the evaluation of endogenous dopamine release (DAR) in the striatum during the motor task which might have caused significant head motion artifact. Materials and Methods: $[^{11}C]raclopride$ PET scans on 4 normal volunteers acquired with bolus plus constant infusion protocol were retrospectively analyzed. Following the 50 min resting period, the participants played a video game with a monetary reward for 40 min. Dynamic frames acquired during the equilibrium condition (pre-task: 30-50 min, task: 70-90 min, post-task: 110-120 min) were realigned to the first frame in pre-task condition. Intra-condition registrations between the frames were performed, and average image for each condition was created and registered to the pre-task image (inter-condition registration). Pre-task PET image was then co-registered to own MRI of each participant and transformation parameters were reapplied to the others. Volumes of interest (VOI) for dorsal putamen (PU) and caudate (CA), ventral striatum (VS), and cerebellum were defined on the MRI. Binding potential (BP) was measured and DAR was calculated as the percent change of BP during and after the task. SPM analyses on the BP parametric images were also performed to explore the regional difference in the effects of head motion on BP and DAR estimation. Results: Changes in position and orientation of the striatum during the PET scans were observed before the head motion correction. BP values at pre-task condition were not changed significantly after the intra-condition registration. However, the BP values during and after the task and DAR were significantly changed after the correction. SPM analysis also showed that the extent and significance of the BP differences were significantly changed by the head motion correction and such changes were prominent in periphery of the striatum. Conclusion: The results suggest that misalignment of MRI-based VOI and the striatum in PET images and incorrect DAR estimation due to the head motion during the PET activation study were significant, but could be remedied by the data-driven head motion correction.

The study of MDCT of Radiation dose in the department of Radiology of general hospitals in the local area (일 지역 종합병원 영상의학과 MDCT선량에 대한 연구)

  • Shin, Jung-Sub
    • Journal of the Korean Society of Radiology
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    • v.6 no.4
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    • pp.281-290
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    • 2012
  • The difference of radiation dose of MDCT due to different protocols between hospitals was analyzed by CTDI, DLP, the number of Slice and the number of DLP/Slice in 30 cases of the head, the abdomen and the chest that have 10 cases each from MDCT examination of the department of diagnostic imaging of three general hospitals in Gyeongsangbuk-do. The difference of image quality, CTDI, DLP, radiation dose in the eye and radiation dose in thyroid was analyzed after both helical scan and normal scan for head CT were performed because a protocol of head CT is relatively simple and head CT is the most frequent case. Head CT was significantly higher in two-thirds of hospitals compared to A hospital that does not exceed a CTDI diagnostic reference level (IAEA 50mGy, Korea 60mGy) (p<0.001). DLP was higher in one-third of hospitals than a diagnostic reference level of IAEA 1,050mGy.cm and Korea 1,000mGy.cm and two-thirds exceeded the recommendation of Korea and those were significantly higher than A hospital that does not exceed a diagnostic reference level (p<0.001). Abdomen CT showed 119mGy that was higher than a diagnostic reference level of IAEA 25mGy and Korea 20mGy in one-third. DLP in all hospitals was higher that Korea recommendation of 700mGy.cm. Among target hospitals, C hospital showed high radiation dose in all tests because MPR and 3D were of great importance due to low pitch and high Tube Curren. To analyze the difference of radiation dose by scan methods, normal scan and helical scan for head CT of the same patient were performed. In the result, CTDI and DLP of helical CT were higher 63.4% and 93.7% than normal scan (p<0.05, p<0.01). However, normal scan of radiation dose in thyroid was higher 87.26% (p<0.01). Beam of helical CT looked like a bell in the deep part and the marginal part so thyroid was exposed with low radiation dose deviated from central beam. In addition, helical scan used Gantry angle perpendicularly and normal scan used it parallel to the orbitomeatal line. Therefore, radiation dose in thyroid decreased in helical scan. However, a protocol in this study showed higher radiation dose than diagnostic reference level of KFDA. To obey the recommendation of KFDA, low Tube Curren and high pitch were demanded. In this study, the difference of image quality between normal scan and helical scan was not significant. Therefore, a standardized protocol of normal scan was generally used and protective gear for thyroid was needed except a special case. We studied a part of CT cases in the local area. Therefore, the result could not represent the entire cases. However, we confirmed that patient's radiation dose in some cases exceeded the recommendation and the deviation between hospitals was observed. To improve this issue, doctors of diagnostic imaging or technologists of radiology should perform CT by the optimized protocol to decrease a level of CT radiation and also reveal radiation dose for the right to know of patients. However, they had little understanding of the situation. Therefore, the effort of relevant agencies with education program for CT radiation dose, release of radiation dose from CT examination and addition of radiation dose control and open CT contents into evaluation for hospital services and certification, and also the effort of health professionals with the best protocol to realize optimized CT examination.

Magnetic Tunnel Junctions with AlN and AlO Barriers

  • Yoon, Tae-Sick;Yoshimura, Satoru;Tsunoda, Masakiyo;Takahashi, Migaku;Park, Bum-Chan;Lee, Young-Woo;Li, Ying;Kim, Chong-Oh
    • Journal of Magnetics
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    • v.9 no.1
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    • pp.17-22
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    • 2004
  • We studied the magnetotransport properties of tunnel junctions with AlO and AlN barriers fabricated using microwave-excited plasma. The plasma nitridation process provided wider controllability than the plasma oxidization for the formation of MTJs with ultra-thin insulating layer, because of the slow nitriding rate of metal Al layers, comparing with the oxidizing rate of them. High tunnel magnetoresistance (TMR) ratios of 49 and 44% with respective resistance-area product $(R{\times}A) of 3 {\times} 10^4 and 6 {\times} 10^3 {\Omega}{\mu}m^2$ were obtained in the Co-Fe/Al-N/Co-Fe MTJs. We conclude that AlN is a hopeful barrier material to realize MTJs with high TMR ratio and low $R{\times}A$ for high performance MRAM cells. In addition, in order to clarify the annealing temperature dependence of TMR, the local transport properties were measured for Ta $50{\AA} /Cu 200 {\AA}/Ta 50 {\AA}/Ni_{76}Fe_{24} 20 {\AA}/Cu 50 {\AA}/Mn_{75}Ir_{25} 100 {\AA}/Co_{71}Fe_{29} 40 {\AA}/Al-O$ junction with $d_{Al}= 8 {\AA} and P_{O2}{\times}t_{0X}/ = 8.4 {\times} 10^4$ at various temperatures. The current histogram statistically calculated from the electrical current image was well in accord with the fitting result considering the Gaussian distribution and Fowler-Nordheim equation. After annealing at $340^{\circ}C$, where the TMR ratio of the corresponding MTJ had the maximum value of 44%, the average barrier height increased to 1.12 eV and its standard deviation decreased to 0.1 eV. The increase of TMR ratio after annealing could be well explained by the enhancement of the average barrier height and the reduction of its fluctuation.

Development of a vestibulo-ocular reflex measurement system for the study of cybersickness (사이버멀미 경감 연구를 위한 전정안구반사 측정 시스템 개발)

  • Jeon, Hyeonjin;Chang, EunHee;Wendimagegn, Tariku Weldtsadik;Park, Chan Hyun;Jeong, Ji Woon;Kim, Hyun Taek
    • Science of Emotion and Sensibility
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    • v.18 no.1
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    • pp.27-38
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    • 2015
  • Vestibulo-ocular reflex (VOR) is a compensatory response of the extraocular muscles generated by vestibular signals to stabilize images on the retina during head/body movements. It has been reported that mismatches between retinal and vestibular information, which cause motion sickness or cybersickness, modify VOR. To investigate the characteristic changes of VOR in subjects experiencing cybersickness, we developed a low-cost, multi-purpose VOR measurement system using LabVIEW and Arduino. To test the applicability of the system, we performed two experiments. In Experiment 1, horizontal and vertical VORs of four participants were measured using a vestibular autorotation task. In Experiment 2, eight participants were exposed to a virtual navigation to measure changes of VORs as an index of cybersickness. We observed significantly greater head rotations and eye movements while the participants were exposed to the virtual navigation than to a static image. The results suggest that the present system can help understand the psychophysiological mechanisms of cybersickness symptoms.

Automatic Extraction of Eye and Mouth Fields from Face Images using MultiLayer Perceptrons and Eigenfeatures (고유특징과 다층 신경망을 이용한 얼굴 영상에서의 눈과 입 영역 자동 추출)

  • Ryu, Yeon-Sik;O, Se-Yeong
    • Journal of the Institute of Electronics Engineers of Korea CI
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    • v.37 no.2
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    • pp.31-43
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    • 2000
  • This paper presents a novel algorithm lot extraction of the eye and mouth fields (facial features) from 2D gray level face images. First of all, it has been found that Eigenfeatures, derived from the eigenvalues and the eigenvectors of the binary edge data set constructed from the eye and mouth fields are very good features to locate these fields. The Eigenfeatures, extracted from the positive and negative training samples for the facial features, ate used to train a MultiLayer Perceptron(MLP) whose output indicates the degree to which a particular image window contains the eye or the mouth within itself. Second, to ensure robustness, the ensemble network consisting of multiple MLPs is used instead of a single MLP. The output of the ensemble network becomes the average of the multiple locations of the field each found by the constituent MLPs. Finally, in order to reduce the computation time, we extracted the coarse search region lot eyes and mouth by using prior information on face images. The advantages of the proposed approach includes that only a small number of frontal faces are sufficient to train the nets and furthermore, lends themselves to good generalization to non-frontal poses and even to other people's faces. It was also experimentally verified that the proposed algorithm is robust against slight variations of facial size and pose due to the generalization characteristics of neural networks.

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