• Title/Summary/Keyword: 24-ethylcholest-4-eng-3,6-dione

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Cytotoxic Constituents of Bombycis corpus (백강잠의 세포독성성분)

  • 권학철;문형인;최상훈;이정옥;조세연;정이연;김선여;이강노
    • YAKHAK HOEJI
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    • v.43 no.2
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    • pp.169-172
    • /
    • 1999

  • The acivity-guided fractionation on the MeOH extract of Bombycis corpus inoculated by Beauberia bassiana 101A led to the isolation of two steroids, 24-ethycholest-4-ene-3,6-dione (1) ergosterol peroxide (2), as active principles. Compounds 1 and 2 exhibited cytotoxicity against cultured human tumor cell lines, A-549, SK-OV-3, SK-MEL-2, XF-498 and HCT-15 with ED50 values ranging from 3.42 to $11.37{\;}\mu\textrm{g}/m$.

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