• Archives of Pharmacal Research
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• 제10권2호
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• pp.121-131
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• 1987

Four triterpenoids were isolated from the roots of Ilex pubescens : two new triterpenoids named pubescenolic acid (I) and pubescenic acid (II), and two known triterpenoids ilexolic acid (III) and oleanolic acid (IV). Chemical and spectroscopic studies have established I and II as 20-epipomolic acid and 24-carboxypomolic acid, repectively.

• Archives of Pharmacal Research
• /
• 제10권2호
• /
• pp.115-120
• /
• 1987

Methanol extract of Ilex pubescens roots prolonged bleeding time threefold, and inhibited the generation of malondialdehyde released during platelet aggregation inducted by thrombin. Through several purification procedures, its saponin, named ilexoside, was proved to be responsible for the antithrombotic activities of the plant. Ilexosides A, -D and -J and 24-carboxypomolic acid showed strong inhibitory activities on platelet aggregation induced by thrombin.