• Transactions of the Korean Society of Mechanical Engineers A
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• v.26 no.10
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• pp.2026-2033
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• 2002

The purpose of this study is to investigate the effect of mechanical properties of the FREI using horizontal stiffness and vertical stiffness by experiments. Two kinds of FREI are designed and fabricated. The steel plates of SREI are replaced with fibers in order to reduce the cost of fabrication and installation. At first, the Nylon fiber is adopted as feasibility study of FREI. The experimental results of Nylon FREI and SREI show that the vertical stiffness of Nylon FREI is lower than SREI, and effective damping is two times higher than SREI. Carbon is adopted, by these rusults, as strong reinforcement than Nylon and full scale of carbon FREI was designed and fabricated. By the experimental test results, it is shown that the vertical stiffness of carbon FREI is three times higher than SREI, and two times higher in effective damping. As a result, the proposed FREI can replace the SREI as a seismic isolator.

• Nuclear Engineering and Technology
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• v.54 no.2
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• pp.749-763
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• 2022

The fulcrum of economic development is a sustainable supply of electricity. Nigeria is plagued with blackouts, with one of the lowest per capita electricity consumption in the world (circa. 120 kWh per capita). Hence, policies have been instigated to integrate electricity generation from nuclear power plants (NPP) on or before 2027. However, a critical requirement for NPP generation is the implementation of robust human resource development (HRD) programs. This paper presents the perspective of Nigeria in assessing human resources needs over the entire NPP lifecycle following the milestone approach and employing the IAEA's Nuclear Power Human Resource (NPHR) modeling tool. Three workforce organizations are in focus including the owner/operator, regulators, and construction workers following three decades timeframe (2015-2045). The results indicate that for the study period, a maximum of approximately 9045 personnel (73% construction workers, 24% owner/operator, and 3% regulators) should be directly involved in the NPP program just before the commissioning of the third NPP in 2033. However, this number decreases by about 73% (2465 personnel including 94% operator and 6% regulator) at the end of the study timeframe. The results can potentially provide clarity and guidance in HRD decision-making programs.

• Journal of Microbiology and Biotechnology
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• v.17 no.12
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• pp.2033-2041
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• 2007

For many years, it has been demonstrated that neurotrophins regulate the adult nervous system, implicating their potential as therapeutic agents for the treatment of neurodegenerative diseases. We generated adenoviral vectors encoding brain-derived neutotrophin factor (BDNF) and neurotrophin-3 (NT3) and tested either separately or together for the ability to induce differentiation of neuronal precursor cells with two different origins. Separate transduction of adenovirus delivering BDNF (BDNF-Ad) or NT3 (NT3-Ad) induced the neuronal differentiation in hippocampal and cortical precursor cells. NT3-Ad infected cells extended short neurites, whereas BDNF-Ad infected cells had longer neurites. In the early differentiation of hippocampal precursor cells, simultaneous infection of BDNF-Ad and NT3-Ad promoted further differentiation and neurite elongation compared with the separate infection of each virus. In contrast, simultaneous infection did not show the synergistic effect in the cortical precursor cells, suggesting that the neurotrophins play distinct roles in different regions of the brain. However, the numbers of neurites and spines per differentiated cells were markedly increased in cortical as well as hippocampal precursor cells, indicating the promotion of efficient neurite elongation and formation of dendritic spine, when BDNF-Ad and NT3-Ad were co-infected. These results suggest more studies in the effect of a combinatorial use of neurotrophins on different sites of brain need to be carried out to develop gene therapy protocols for neurodegenerative diseases.

• Journal of the Korean Dietetic Association
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• v.11 no.2
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• pp.159-169
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• 2005

The purpose of this study was to assess the energy expenditure and investigate the relationship between related variables in 70 female university students. Resting energy expenditure estimated by Harris-Benedict formula, WHO/NAO/FAO formula and various formulas based on body weight and body surface area were 1366.9$\pm$74.4kcal/day, 1287.8$\pm$106.6kcal/day, 1171.4$\pm$155.8kcal/day and 1342.0$\pm$97.4kcal/day. Measured resting energy expenditure by indirect calorimetry(Model : Metavine and TrueOne2400) were 1582.0$\pm$150.1kcal/day and 1268.2$\pm$152.9kcal/day, respectively. Average step number per day was 11981.2$\pm$3014.4 steps and average step number per hour was 746.1$\pm$198.0 steps/hr. Daily energy expenditure by using Harris-Benedict formula, body weight formula, body surface area formula, WHO/NAO.FAO formula and 15-min check list formula were 2374.7$\pm$249.6kcal, 2033.5$\pm$313.2kcal, 2331.2$\pm$266.0kcal, 2240.8$\pm$185.5kcal and 2195.5$\pm$398.3kcal. Meanwhile energy intake of subjects was 1714.9$\pm$551.2 kcal. Daily energy expenditure has positive correlation(r=0.262) with daily step number. And there was significant positive correlations(r=0.35-0.68) between various daily energy expenditures and muscle mass. These results suggested that increase of daily step number by using pedometer is good method to increase daily energy expenditure. In particular, increase in step number can reinforce the amounts of muscle.

• Journal of Aquaculture
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• v.13 no.3
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• pp.245-251
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• 2000

Carapace width (CW) of main size class of the snow crab was 70~90 mm for females and 80~100 mm for males. The CW holds a stronger relation with body weight than that of carapace length (CL). The number of eggs attached to the pleopods was in the range of 35,000 and 114,000 eggs in crabs with 65 and 88 mm CW, respectively). The logistic maturity curve on morphometric measurements and gonad examination, defined by the presence of egg brooding in wide abdomen of the female and spermatophores inside the vasa deferentia of the male indicated that 50 % of crabs attained gonadal maturity at 54.2 mm and 58.8 mm CW for females and males, respectively. In the relationship between CW and body weight, a sharp break at 53~55 mm CW indicates that morphological changes associated with maturity have occurred.

• Proceedings of the Korea Water Resources Association Conference
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• 2008.05a
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• pp.2033-2037
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• 2008

최근 들어 국지성호우와 장마, 태풍에 의한 자연재해는 모든 분야에서 심각한 영향을 미치고 있다. 자연재해로 발생한 토사는 하천, 농업용 저수지, 댐 및 하구를 메워 흐름을 방해하고 저서생태계에 미치는 영향은 매우 크다. 이러한 토사는 농업용 저수지와 홍수 조절용 구조물의 사용 수명을 단축시키고, 하상을 높여 흐름을 방해하거나 변화시켜 하천 범람을 발생하기도 한다. 한편 하천범람과 제방 붕괴 등은 농지 침수는 물론 작물의 성장을 방해하는 등 많은 경제적 손실을 가져오고 있다. 본 연구에서는 토사의 농도와 분광반사특성의 상호관계를 알아보기 위하여 분광복사계(Li-1800)를 이용하여 미리 제작한 수조 안의 토사(실트질, 모래질) 농도를 변화시켜 토사농도에 따른 분광반사 특성을 파악하고, 그 특징에 대해 검토, 고찰하였다. 연구결과 실트질의 체적반사율이 모래에 비해 약 40% 높게 나타났으며, 실트와 모래 모두 $554{\sim}588nm$영역에서 최대반사율을 나타내었다. 상관분석 결과 각 토사의 상관계수는 실트질이 $0.63{\sim}0.99$, 모래가 $0.73{\sim}0.96$의 값을 나타냈으며, 두 토양 모두 $550{\sim}900nm$영역에서 r>0.90의 높은 상관성을 보였다. 또한, 토사농도에 따른 반사특성은 실트질의 경우 토사 농도가 $0{\sim}60%$까지 $470{\sim}740nm$영역에서 큰 상승폭을 보인 반면, 모래의 경우 토사농도가 25%까지 크게 증가하였으나 30%이상의 농도에서는 변화 폭이 매우 적어지는 특징을 보였다. 토사농도의 변화에 따른 탁수의 분광 반사특성은 토사의 종류에 따라 크게 다르다는 것을 확인할 수 있었다.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.5
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• pp.2027-2033
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• 2014

Background: We aimed to assess RET proto-oncogene polymorphisms in three different Iranian families with medullary thyroid cancer (MTC), and performed molecular dynamics simulations and free energy stability analysis of these mutations. Materials and Methods: This study consisted of 48 patients and their first-degree relatives with MTC confirmed by pathologic diagnosis and surgery. We performed molecular dynamics simulations and free energy stability analysis of mutations, and docking evaluation of known RET proto-oncogene inhibitors, including ZD-6474 and ponatinib, with wild-type and mutant forms. Results: The first family consisted of 27 people from four generations, in which nine had the C.G2901A (P.C634Y) mutation; the second family consisted of six people, of whom three had the C.G2901T (P.C634F) mutation, and the third family, who included 12 individuals from three generations, three having the C.G2251A (P.G691S) mutation. The automated 3D structure of RET protein was predicted using I-TASSER, and validated by various protein model verification programs that showed more than 96.3% of the residues in favored and allowed regions. The predicted instability indices of the mutated structures were greater than 40, which reveals that mutated RET protein is less thermo-stable compared to the wild-type form (35.4). Conclusions: Simultaneous study of the cancer mutations using both in silico and medical genetic procedures, as well as onco-protein inhibitor binding considering mutation-induced drug resistance, may help in better overcoming chemotherapy resistance and designing innovative drugs.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.4
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• pp.2031-2033
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• 2016

Background: Symptomatic multiple myeloma (MM) is an acquired B-cell malignant proliferation of antibody secreting plasma cells, characterized by end organ damage due to monoclonal immunoglobulin secretion. The aim of this study wa to determine the stage stratification according to an international scoring system in adult Pakistani MM patients at presentation. Materials and Methods: This single centre retrospective study extendedfrom January 2012 to December 2015. Data were retrieved from the departmental maintained records. Results: A total of 39 patients were diagnosed at our center with MM during the period of the study, 25 males and 14 females. Age ranged between 36 and 81 with a mean of $54.5{\pm}14.8$ and a median of 57 years. Common presenting complaints included fatigue (80.9%), backache (79.3%) and bone pain (66.2%). Overall, 9 patients were in ISS stage I (23%), 12 were in stage II (30.7%) and 18 were in stage III (46.1%). Out of the total, 29 (74.3%) had kappa immunoglobulin andthe remaining 10 (25.6%) had lambda type myelomas. IgG myeloma was commonest, seen in 26 (66.6%) followed by IgA in 11 (28.2%) with non secretory myeloma in one (2.5%) and light chain disease also in one patient (2.5%). Conclusions: MM in Pakistani patients is seen in a relatively young population with male predominance. Primarily patients are symptomatic and risk stratification revealed a predominance of advanced stage III disease in our setting.

• Proceedings of the Korea Water Resources Association Conference
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• 2007.05a
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• pp.2029-2033
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• 2007

오늘날 특정 유역에서의 수문현상 및 수문순환에 대한 분석을 위한 연구가 활발히 진행되고 있다. 이를 위해서는 수문자료의 관측은 반드시 수반되어야 하며, 관측자료의 품질관리 및 원시자료의 관리 등이 요구되고 있는 실정이다. 관측된 수문자료의 품질관리라 함은 자료의 신뢰도 분석과 자료의 보완의 두 과정을 포함한다. 여기서, 신뢰도 분석이라 함은 자료 속에 포함된 불확실성을 판별하는 작업을 의미하며, 자료의 불확실성은 위에서 언급된 자료의 불충분 및 불안정을 제외한 부정확, 불일관성에서 비롯된다. 자료의 보완이라 함은 자료의 신뢰도 분석을 통하여 자료 속에 포함된 불확실한 성분들을 찾아내고, 이를 제거한 후 완전한 자료로 대체하고, 자료가 결측된 경우 공백을 연결함으로써 자료의 완전성을 유지하거나 또는 불충분한 자료를 확장하는 일련의 보완작업이라고 정의한다. 자료의 품질을 결정하는 주요 인자는 크게 관측소 관리의 하드웨어적인 측면과 자료 분석의 소프트웨어적인 측면이 있다. 하드웨어적인 측면에서의 수문자료 품질관리를 위해서 본 과제에서는 현장에 설치된 수위계, 강우량계의 센서 등에 대한 장비를 점검하고, 현장실측을 통해 지속적으로 측정값을 보정해주는 역할을 수행하고 있으며, 소프트웨어적인 측면에서 수문자료의 품질관리를 위해서는 수문자료의 수집 단계부터 시작하여 데이터베이스 저장, 필터링, 통계분석, 웹 및 C/S(Client Server)를 통한 배포 등의 일련의 자료 처리 과정을 수행할 수 있는 수문자료관리 프로그램을 웹 시스템과 C/S로 분류하여 정의내릴 수 있다. 본 연구에서는 수문자료의 관리자 입장에서의 보다 효율적이고 체계적으로 자료를 관리하고 분석하기 위한 방안으로 수문자료관리시스템(Hydrologic Data Aquisition and Management System, HDAMS)을 개발하였다. 이 시스템은 안양천 유역에서 시범 적용하고 있으며, 범용성을 전제로 개발되었다. 또한 수문자료 관리 프로그램의 DB 구조 및 DB 자료를 활용한 다양한 분석기능은 갖도록 설계하였으며 계획된 데이터베이스 구조를 바탕으로 계측기 인터페이스와 사용자 인터페이스, 데이터베이스 간의 연동이 원활히 이루어지도록 개발하고자 한다.

• Microbiology and Biotechnology Letters
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• v.19 no.3
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• pp.215-221
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• 1991

An autonomous replication sequence (ARS) derived from Cephalosporium acremonium ATCC 20339 was cloned in Sarchuromyces cerevisiae SHY 3 using YIp5 as a cloning vector. A new recombinant plasmid, designated pCY-2, which contained a 3.7 kb BamHI fragment of C. acrenzonium DNA showed the highest stability among the 40 recombinant plasmids composed of the YIp5 2nd ARS of C. ucremoniztm. Also, Southern hybridization and transformation of E, cull with DNA purified from yeast transformants verified that pCY-2 autonomously replicates in yeasts. Transformation efficiency and plasmid stability of pCY-2 in yeast were higher than those ol YRp 7 containing ARS which originated from yeast. Detailed studies by subcloning revealed that two ARSs existed within 2.6 kb of the insert, which is a novel discovery. However, it was concluded that these two ARSs were ligated during the gene manipulation in vitro.