• 제목/요약/키워드: 2.8-Dioxoisoindolc(1,2,a) quinazoline 2(2-Carboxyphenyl)-1,4-2H quinazoline-4-onc,2(2N-Dimethyl carbamylphenyl)-1,4-2H quinazoline-4-one,2,8-Dioxopyrrolidino(2,1,a) 1,4-2H quinazoline

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2-Aminobenzamide로부터 Quinazoline 4-one계 유도체의 합성(III) -Acid anhydride와의 반응- (Synthesis of Quinazoline 4-one Derivatives from 2-Aminobenzamide (III) -Reaction with Acid Anhydrides-)

  • 서명은
    • 약학회지
    • /
    • 제34권2호
    • /
    • pp.133-138
    • /
    • 1990

  • The reaction of 2-aminobenzamide with phthalic acid anhydride In dioxane produced a bicyclic product 2,8-dioxoisoindole(1,2,a) quinazoline (I) in addition to hydrolysis product 2(2-Carboxyphenyl)-1,2-2H-quinazoline-4-one (II). The yields were 64% and 30% respectively. On the other hand, the same reaction in DMF afforded compound (I) and 2(2N-dimethyl carbamyl phenyl)-1,4-2H-quinazoline-4-one (III) in 30% and 60% yield respectively. The compound III was also obtained by the reaction of compound II with dimethylamine. However the reaction of 2-aminobenzamide with neat succinic acid anhydride gave only bicyclic product 2,8-oxopyrrolidine (2,1,a)-1,4-2H-quinazoline (IV) in 93%.

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